Family Search for PF01969 (Ni_insertion)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF01969

PF01969 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

larC2 / F9UST1 pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase (EC 4.99.1.12) from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (see 3 papers)
LARC_LACPL / F9UST1 Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein; P2TMN nickel insertion protein; Lactate racemase accessory protein LarC; Lactate racemase activation protein LarC; Lactate racemase maturation protein LarC; Lactate racemization operon protein LarC; Nickel-pincer cofactor biosynthesis protein LarC; EC 4.99.1.12 from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see 3 papers)
F9UST1 pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase (EC 4.99.1.12) from Lactiplantibacillus plantarum (see 2 papers)
Aligns to 4:406 / 420 (96.0%), covers 100.0% of PF01969, 455.6 bits

• function: Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is required for the activation of the lactate racemase LarA. May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes.
  catalytic activity: Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide (RHEA:54784)
  disruption phenotype: Deletion of this gene leads to a loss of lactate racemase activity.

Or search for genetic data about PF01969 in the Fitness Browser