Family Search for PF01973 (MptE-like)

April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)

Running HMMer for PF01973

PF01973 hits 56 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

mptE / Q59028 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (EC 2.7.6.3) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
MPTE_METJA / Q59028 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; HPPK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin diphosphokinase; 6-HMPDK; 7,8-dihydro-6-hydroxymethylpterin diphosphokinase; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; PPPK; EC 2.7.6.3 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Aligns to 30:199 / 241 (70.5%), covers 98.2% of PF01973, 146.5 bits

• function: Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP).
  catalytic activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin- 6-yl)methyl diphosphate + AMP + H(+) (RHEA:11412)
  cofactor: Mg(2+)

MPTE_PYRFU / Q8U2A9 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; HPPK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin diphosphokinase; 6-HMPDK; 7,8-dihydro-6-hydroxymethylpterin diphosphokinase; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; PPPK; EC 2.7.6.3 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see paper)
Aligns to 33:186 / 231 (66.7%), covers 95.9% of PF01973, 95.4 bits

• function: Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). To a lesser extent, can also use CTP, UTP, and GTP as the nucleotide triphosphate substrate.
  catalytic activity: 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin- 6-yl)methyl diphosphate + AMP + H(+) (RHEA:11412)
  cofactor: Mg(2+)

Or search for genetic data about PF01973 in the Fitness Browser