Family Search for PF02582 (DUF155)

Running HMMer for PF02582

PF02582 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

RMD1_YEAST / Q03441 Sporulation protein RMD1; Required for meiotic nuclear division protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YDL001W Cytoplasmic protein required for sporulation from Saccharomyces cerevisiae
Aligns to 205:377 / 430 (40.2%), covers 100.0% of PF02582, 202.9 bits

• function: Required for sporulation where it is believed to have a role in meiotic nuclear division.
• A Whole Genome Screen for Minisatellite Stability Genes in Stationary-Phase Yeast Cells
  Alver, G3 (Bethesda, Md.) 2013
  • “...RIC1 YLR039C STU1 a YBL034c YOR008C a YOR008c CSM3 b YMR048w MOB2 a YFL034c-b RMD1 YDL001w SWH1 YAR042w YPT31 YER031c DBF2 YGR092w MON1 YGL124c RPB3 a YIL021w TAF12 a YDR145w ZAP1 YJL056c DCG1 YIR030c MRC1 b YCL061c RPL22A YLR061w TEC1 YBR083w ZRT1 YGL255w DPB3 YBR278w MUP1...”
• The Antifungal Plant Defensin HsAFP1 from Heuchera sanguinea Induces Apoptosis in Candida albicans
  Aerts, Frontiers in microbiology 2011
  • “...the Snf1p protein kinase; involved in expression of glucose-repressed genes, sporulation, and peroxisome biogenesis 8 YDL001W RMD1 Cytoplasmic protein required for sporulation 64 YGL160W Putative protein of uknown function with sequence similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis 4 YGR131W Hypothetical protein 64...”
• Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
  Mok, Science signaling 2010
  • “...plasma membrane in a Ub-dependent manner YCR030C Syp1 Overexpression suppresses a pfy1 (profilin) null mutation YDL001W Rmd1 Cytoplasmic protein required for sporulation YDR159W Sac3 Nuclear pore-associated protein; suppressor of actin mutations YER155C Bem2 RhoGAP involved in the control of cytoskeleton and morphogenesis YGR094W Vas1 Mitochondrial and...”
• Extending bicluster analysis to annotate unclassified ORFs and predict novel functional modules using expression data
  Bryan, BMC genomics 2008
  • “...Elements (38) Putative protein of unknown function. Similarity ( p = 2.2e -21 ) to YDL001W required for sporulation. YGR266W Transport Routes (20.09) Protein of unknown function. Localizes to mitochondrial outer membrane and plasma membrane Predicted to have single trans-membrane domain. YIL039W Transport Routes (20.09) GFP-fusion...”
• Global analysis of the meiotic crossover landscape
  Chen, Developmental cell 2008
  • “...indicate major DSB sites. CEN4 is located adjacent to YDL001W , off the bottom of the gel. Quantification of DSB frequencies is provided in Figure S5 ....”
• Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae
  Enyenihi, Genetics 2003
  • “...Yes No No No ORF YAL056W YBL100C YCL010C YDL001W YDL118W YDR048C YDR117C YDR255C YDR433W YDR516C YER083C YGL020C YGL107C YGR226C YHR067W YIL017C YKL118W YLR021W...”
• Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors
  Albers, RNA (New York, N.Y.) 2003
  • “...YKR054c YLR320w YML103c YMR176w YNL243w YPR189w YBR114w YDL001w YDL116w YDR176w YGL026c YHR161c YJL103c YJL149w YLR187w YNL078w YNL271c YNR059w YOR156c YPR023c...”
• Localizing proteins in the cell from their phylogenetic profiles
  Marcotte, Proceedings of the National Academy of Sciences of the United States of America 2000
  • “...in the yeast genome (9): YBL060W, YCR059C, YDL001W, YDL201W, YDR196C, YDR282C, YDR336W, YDR539W, YER057C, YFR006W, YFR048W, YGR021W, YIL051C, YIL145C, YIR042C,...”

PICST_50504 hypothetical protein from Pichia stipitis CBS 6054
Aligns to 215:387 / 438 (39.5%), covers 100.0% of PF02582, 202.7 bits

• Chromosomal G + C content evolution in yeasts: systematic interspecies differences, and GC-poor troughs at centromeres
  Lynch, Genome biology and evolution 2010
  • “...7 36.9 235,679 324,031 PICST_33311 PICST_14352 PICST_73528 16,278 P. stipitis chromosome 8 37.0 265,747 351,425 PICST_50504 PICST_91563 PICST_33721 36,077 C. lusitaniae chromosome 1 38.3 1,045,088 1,078,544 CLUG_00526 CLUG_00522 CLUG_00523 4,853 C. lusitaniae chromosome 2 40.5 1,791,934 1,818,051 CLUG_02107 CLUG_02104 CLUG_02105 3,283 C. lusitaniae chromosome 3 38.6...”

RMD8_YEAST / P43620 Sporulation protein RMD8; Required for meiotic nuclear division protein 8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
YFR048W Cytosolic protein required for sporulation from Saccharomyces cerevisiae
Aligns to 427:605 / 662 (27.0%), covers 100.0% of PF02582, 185.6 bits

• function: Required for sporulation.
• Ascospore formation in the yeast Saccharomyces cerevisiae
  Neiman, Microbiology and molecular biology reviews : MMBR 2005
  • “...YDR207c YDR255c YDR285w YDR512c YER095w YER179w YFL033c YFR048w YGL033c YGL175c YGL240w YGL249w YHL023c YHL024w YHL027w YHR004c YHR014w YHR079c-a YHR086w...”
• Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae
  Enyenihi, Genetics 2003
  • “...YDL041W YDL151C YDR070C YDR126W YDR359C YDR512C YEL072W YFR048W YGL066W YGL218W YHL023C YHR116W YKL054C YKR089C YLR235C YML009W-B YMR158W-A YNL170W YOL071W...”
• Localizing proteins in the cell from their phylogenetic profiles
  Marcotte, Proceedings of the National Academy of Sciences of the United States of America 2000
  • “...YDR196C, YDR282C, YDR336W, YDR539W, YER057C, YFR006W, YFR048W, YGR021W, YIL051C, YIL145C, YIR042C, YJL060W, YKR087C, YLL027W, YLR401C, YLR405W, YLR426W,...”

SIF2_SCHPO / O74446 Sad1-interacting factor 2; Sporulation protein sif2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 158:330 / 382 (45.3%), covers 100.0% of PF02582, 183.6 bits

• function: Required for sporulation where it is believed to have a role in meiotic nuclear division.
  subunit: Interacts with sad1.

CNF02410 cytoplasm protein from Cryptococcus neoformans var. neoformans JEC21
Aligns to 385:559 / 636 (27.5%), covers 99.4% of PF02582, 176.9 bits

• Mechanisms of intron gain and loss in Cryptococcus
  Sharpton, Genome biology 2008
  • “...5 introns, lost its first intron in B1 and its fifth intron in A. Similarly, CNF02410 , a cytoplasmic protein containing five ancestral introns, lost its second intron in A and its fourth intron in B1. Both loci are single copy in the genome and are...”

Q9VXQ8 GM02445p from Drosophila melanogaster
CG11679 uncharacterized protein from Drosophila melanogaster
Aligns to 158:352 / 420 (46.4%), covers 100.0% of PF02582, 176.6 bits

• Comparative genomics of gene expression in the parasitic and free-living nematodes Strongyloides stercoralis and Caenorhabditis elegans
  Mitreva, Genome research 2004
  • “...SS00116.cl has homology to Drosophila melanogaster protein CG1167 (Q9VXQ8) as well as P. trichosuri and D. immitis ESTs, but lacks a C. elegans homolog....”
• An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila
  Li-Kroeger, eLife 2018
  • “...for four genes ( Nmnat (Nicotinamide mononucleotide adenylyltransferase), CG13390, Med27 (Mediator complex subunit 27), and CG11679, and tested for failure to complement molecularly defined deletions for two genes ( ubiquilin and Nmnat ) ( Zhai et al., 2006 ). In all cases, lethality mapped to the...”
  • “...Med27 yw iso#6; +/+; attP2(y-){nos-Cas9} 1 lethal Rescued by Genomic Fragment (this study) y wing2+ CG11679 yw iso#6; +/+; attP2(y-){nos-Cas9} 2 lethal Rescued by genomic duplication BSC Dp(1:3) 304 Y wing2+ rho y 1 M{nos-Cas9.P}ZH-2A w* 0 NA NA y wing2+ amx yw iso#6; +/+; attP2(y-){nos-Cas9}...”

Q8CI78 Required for meiotic nuclear division protein 1 homolog from Mus musculus
Aligns to 227:404 / 450 (39.6%), covers 100.0% of PF02582, 176.4 bits

• Improvement of Endothelial Dysfunction of Berberine in Atherosclerotic Mice and Mechanism Exploring through TMT-Based Proteomics.
  Tan, Oxidative medicine and cellular longevity 2020
  • “...Ighg3 Immunoglobulin heavy constant gamma 3 0.60 0.000317 Q8K2C8 Gpat4 Glycerol-3-phosphate acyltransferase 4 -0.63 0.000346 Q8CI78 Rmnd1 Required for meiotic nuclear division protein 1 homolog -0.38 0.000385 O70250 Pgam2 Phosphoglycerate mutase 2 0.60 0.000433 A0A0R4J0E1 Fgl1 Fibrinogen-like protein 1 -0.48 0.000537 P32261 Serpinc1 Antithrombin-III 0.36 0.000669...”

RMND1_HUMAN / Q9NWS8 Required for meiotic nuclear division protein 1 homolog from Homo sapiens (Human) (see 4 papers)
Aligns to 226:403 / 449 (39.6%), covers 100.0% of PF02582, 175.1 bits

• function: Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (PubMed:23022098, PubMed:25604853).
  subunit: Homooligomer (PubMed:23022098, PubMed:25604853).
• Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles
  Yoshikawa, Molecular & cellular proteomics : MCP 2011
  • “...Q8N9Z2 Q9Y4P3 Q9UJZ1 Q9P2N5 Q5T8P6 Q9NWS8 ZFP91_HUMAN ZN768_HUMAN ZN638_HUMAN ZN579_HUMAN ZMYM4_HUMAN YG034_HUMAN TBL2_HUMAN STML2_HUMAN RBM27_HUMAN RBM26_HUMAN...”

SIF3_SCHPO / Q09877 Sad1-interacting factor 3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 241:419 / 472 (37.9%), covers 100.0% of PF02582, 174.9 bits

• subunit: Interacts with sad1.

SPAC12G12.15 Sad1 interacting factor 3 from Schizosaccharomyces pombe
Aligns to 241:419 / 510 (35.1%), covers 100.0% of PF02582, 174.7 bits

• A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe
  Kennedy, Toxicological sciences : an official journal of the Society of Toxicology 2008
  • “...None None YKL137W SPAC977.14c SPAC14C4.06c SPAC12G12.15 SPAC17A5.16 SPBC336.15 SPAC1071.11 SPBC3H7.12 SPCC553.01c SPBC19G7.18c SPBC20F10.05 SPBPB2B2.19c...”

CT472 hypothetical protein from Chlamydia trachomatis D/UW-3/CX
Aligns to 48:215 / 264 (63.6%), covers 99.4% of PF02582, 169.0 bits

• Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer
  LaBrie, mBio 2019
  • “...ct690 , ct792 , ct793 , ct182 , ct328 , ct343 , ct387 , and ct472 ) of the diverging genes occurred within 80nucleotides (nt) of start codons. On the basis of the determinations of transcriptional start sites located on average 50nt upstream of start codons...”
• Outer membrane proteins preferentially load MHC class II peptides: implications for a Chlamydia trachomatis T cell vaccine
  Karunakaran, Vaccine 2015
  • “...FDGEKASVGAPTVGNAVVKG CT420 50S ribosomal protein L21 33 Rl21 KLDGVSSPAVQESISESL CT424 Sigma regulatory factor RsbV TPSAVNPLPNPEIDS CT472 Hypothetical protein CT472 DSTHGSFAPQATFSDG CT505 Glyceraldehyde-3-phosphate dehydrogenase GapA VKGNEVFVTPAAHVVDRPG CT514 50S ribosomal protein L6 RplF ETPGAAEGAEAQTASEQPSKENAEKQEENNED CT559 Yop proteins translocation lipoprotein CdsJ ADVLLLSPKASVSPGG CT561 Type III secretion translocase 46 CdsL...”

MRX10_YEAST / Q05648 MIOREX complex component 10; Mitochondrial organization of gene expression protein 10 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
YDR282C Putative protein of unknown function from Saccharomyces cerevisiae
Aligns to 154:350 / 414 (47.6%), covers 99.4% of PF02582, 161.4 bits

• function: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post- transcriptional gene expression.
  subunit: Associates with the mitochondrial ribosome.
• VID22 counteracts G-quadruplex-induced genome instability
  Galati, Nucleic acids research 2021
  • “...required for DNA replication PHO5 YBR093C 0.14925 0.12743 0.03574 0.0803 0.0825 Repressible acid phosphatase MRX10 YDR282C 0.09352 0.0926 0.04064 0.0756 0.0247 Mitochondrial inner membrane protein of unknown function RPL40A YIL148W 0.10568 0.16715 0.16321 0.0749 0.1277 Ubiquitin-ribosomal 60S subunit protein L40A fusion protein XDJ1 YLR090W 0.0167 0.08185...”
• Selection maintains signaling function of a highly diverged intrinsically disordered region
  Zarin, Proceedings of the National Academy of Sciences of the United States of America 2017
  • “...as the Ste50 IDR (YBL081W, YBR033W, YBR081C, YDR282C, YDR527W, YIL105C, YJL090C, YLL027W, YLR399C, YML045W, YMR266W, YMR277W, YNL047C, YNL288W, YOR153W,...”
• Infantile encephaloneuromyopathy and defective mitochondrial translation are due to a homozygous RMND1 mutation
  Garcia-Diaz, American journal of human genetics 2012
  • “...protein (Figure S4 ). In accordance with data on the ydr282c mutant strain in the yeast genome collection, yeast containing the ydr282c -null allele showed a...”
  • “...mitochondrial protein. We sublocalized the yeast ortholog, Ydr282c, to the inner mitochondrial membrane with the C terminus facing the intermembrane space....”
• Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection
  Oh, PLoS pathogens 2010
  • “...CPP1 ). orf19.1617 , an uncategorized gene in both C. albicans and S. cerevisiae (Sc- YDR282C ), has also been shown to have a filamentation defect [22] . Because these categories encompass the roles of nutrient scavenging, initiation of filamentation, and cell wall remodeling necessary to...”
• Extending bicluster analysis to annotate unclassified ORFs and predict novel functional modules using expression data
  Bryan, BMC genomics 2008
  • “...(20) Interacts with Sup45p (eRF1) and Sup35p (eRF3) and Pab1p; role in translation termination efficiency. YDR282C Transported Compounds(20.01)/ Tansposable Elements (38) Putative protein of unknown function. Similarity ( p = 2.2e -21 ) to YDL001W required for sporulation. YGR266W Transport Routes (20.09) Protein of unknown function....”
• Rate of promoter class turn-over in yeast evolution
  Bazykin, BMC evolutionary biology 2006
  • “...- (3) + 1 TATA YMR315W Hypothetical ORF + + - (3) GA 1 ? YDR282C Hypothetical ORF + - (2) - (4) + 2 ? YKL216W URA1 Catalyzes the conversion of dihydroorotic acid to orotic acid + - (2) + + 1 TATA YNR033W ABZ1...”
• Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeast
  Jesch, The Journal of biological chemistry 2005
  • “...California, Berkeley on February 16, 2017 FDH2 UBP9 YMR111C YDR282C KAR3 DMC1 RNY1 YNL119W VPS16 YSW1 SUL1 MSC1 YDR223W VMR1 VPS30 RAD4 CHK1 UBP11 CTR86 VIK1...”
• Localizing proteins in the cell from their phylogenetic profiles
  Marcotte, Proceedings of the National Academy of Sciences of the United States of America 2000
  • “...(9): YBL060W, YCR059C, YDL001W, YDL201W, YDR196C, YDR282C, YDR336W, YDR539W, YER057C, YFR006W, YFR048W, YGR021W, YIL051C, YIL145C, YIR042C, YJL060W, YKR087C,...”

A0A100I816 YagE family protein from Aspergillus niger
Aligns to 180:373 / 435 (44.6%), covers 100.0% of PF02582, 157.4 bits

• Proteomic analysis of Aspergillus niger 3.316 under heat stress
  Deng, MicrobiologyOpen 2020
  • “...Ump1 A0A100IKA7 .0076 0.633 Cell division cycle protein 48 A0A124BW77 .00036 0.704 YagE family protein A0A100I816 .0378 0.643 Nucleoside diphosphate kinase A0A100IMC3 .005 0.758 Rho GDPdissociation inhibitor A0A100INZ0 .000308 0.569 Coproporphyrinogen III oxidase A0A100ICH3 .0047 0.584 Serine palmitoyltransferase 2 A0A124BY35 .0013 0.641 Actinrelated protein 2/3 complex...”

orf19.1617 putative uncharacterized protein from Candida albicans (see paper)
Aligns to 145:328 / 390 (47.2%), covers 99.4% of PF02582, 152.8 bits

• CharProtDB CGD description: Protein similar to S. cerevisiae Ydr282cp; transposon mutation affects filamentous growth

lpg0107 Hypothetical protein from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
lpp0121 hypothetical protein from Legionella pneumophila str. Paris
Aligns to 49:222 / 268 (64.9%), covers 100.0% of PF02582, 137.5 bits

• Host Adaptation in Legionellales Is 1.9 Ga, Coincident with Eukaryogenesis
  Hugoson, Molecular biology and evolution 2022
  • “...( fig. 2 ): LegA3/AnkH/AnkW (lpg2300), found in Legionellales ss and Berkiella , and RavC (lpg0107), found in most Legionellales ss, but not in Berkiella . MavN (lpg2815), which is conserved in Legionella spp. and was found in Rickettsiella ( Burstein et al. 2016 ), is...”
  • “...which promote intracellular bacterial growth ( Dwingelo et al. 2019 ). The function of RavC (lpg0107) is currently unknown, but it is foundbeyond Legionellales in Chlamydiales ( Burstein et al. 2016 ) and has homologs throughout bacteria. The protein belongs to the required for meiotic division...”
• The Legionella genus core effectors display functional conservation among orthologs by themselves or combined with an accessory protein
  Wexler, Current research in microbial sciences 2022
  • “...). The information regarding the five other validated core effectors (VipF - lpg0103, RavC - lpg0107, CetLp1 - lpg0140, lpg2832 and lpg3000) and the two putative core effectors (lpg0086 and lpg1356) is limited. Most of these core effectors are not required for intracellular growth in host...”
• More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells
  Gomez-Valero, Proceedings of the National Academy of Sciences of the United States of America 2019
  • “...of the two studies confirmed Lpg0103 (VipF), Lpg0107 (RavC), Lpg2300 (LegA3/AnkH/AnkW), and Lpg2815 (IroT/MavN) as core substrates (14) (SI Appendix, Fig....”
• Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires
  Burstein, Nature genetics 2016
  • “...and LOG_01049 (RavC), represented in L. pneumophila by lpg2832 and lpg0107, respectively--had 1.0 0.9 0.8 0.6 0.5 0.4 0.3 10 2 3 69 eff. 8 Lqua 7 213 eff....”
  • “...use a type IVA secretion system for symbiosis27,28. lpg0107 (RavC) has homologs in several members of the Chlamydiae phylum, such as Diplorickettsia...”
• Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease
  Gomez-Valero, Genome biology 2014
  • “...75 68 68 lpg0103 / lpp0117 N-terminal acetyltransferase, GNAT family vipF 62 61 50 47 lpg0107 / lpp0121 b Conserved protein of unknown function ravC 84 80 72 47 lpg0140 / lpp0155 Membrane protein of unknown function cetLP1 53 45 39 36 lpg0376 / lpp0443 Protein...”
• The E Block motif is associated with Legionella pneumophila translocated substrates
  Huang, Cellular microbiology 2011
  • “...efficiency (%) a P -value b Reference Lpg0008 ravA Coiled-coil 66.6+5.7 Lpg0030 ravB Coiled-coil 69.713.9 Lpg0107 ravC COG1723 72.26.6 Lpg0160 ravD 28.52.1 P <0.023 Lpg0195 ravE 43.16.5 P <0.017 Lpg0196 ravF Lpg1752,Lpg1387 paralog 57.73.0 Lpg0210 ravG 44.22.4 P <0.0003 Lpg0401 ceg11 33.41.6 P <0.004 Zusman etal...”
• Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease
  Gomez-Valero, Genome biology 2014
  • “...68 lpg0103 / lpp0117 N-terminal acetyltransferase, GNAT family vipF 62 61 50 47 lpg0107 / lpp0121 b Conserved protein of unknown function ravC 84 80 72 47 lpg0140 / lpp0155 Membrane protein of unknown function cetLP1 53 45 39 36 lpg0376 / lpp0443 Protein of unknown...”

RRG_ARATH / Q9C565 Protein RETARDED ROOT GROWTH, mitochondrial from Arabidopsis thaliana (Mouse-ear cress) (see paper)
NP_564963 sporulation protein (DUF155) from Arabidopsis thaliana
AT1G69380 hypothetical protein from Arabidopsis thaliana
Aligns to 149:320 / 373 (46.1%), covers 98.3% of PF02582, 117.7 bits

• function: Required for the maintenance of mitochondrial structure (PubMed:21984726). Positive regulator of cell division and endoreduplication but negative regulator of cell expansion in the postembryonic root meristem, thus leading to the promotion of root growth (PubMed:21984726).
  disruption phenotype: Reduced number of dividing cells and slower rate of cell production and endoreduplication, thus affecting root meristem size and delaying postembryonic root growth (PubMed:21984726). Decreased expression of several cell cycle genes indicating a defect in cell cycle progression (PubMed:21984726). Extensive vacuolization in mitochondria (PubMed:21984726).
• The Arabidopsis RETARDED ROOT GROWTH gene encodes a mitochondria-localized protein that is required for cell division in the root meristem.
  Zhou, Plant physiology 2011
  • GeneRIF: RRG is a mitochondria-localized protein conserved in plants and shares a DUF155 domain with proteins related to cell division in yeast, and rrg mutants displayed extensive vacuolization in mitochondria.
• H₂ O₂ , NO, and H₂ S networks during root development and signalling under physiological and challenging environments: Beneficial or toxic?
  Mukherjee, Plant, cell & environment 2023
  • “...Chi, et al. ( 2022 ) H 2 O 2 regulators Retarded root growth (RRG) (AT1G69380) Root meristem, primary and lateral root tip, quiescent centre, root meristem and stele Promotes cell division in root apical meristem, negatively regulates cell expansion in apex Zhou et al. (...”
• Highlighting reactive oxygen species as multitaskers in root development
  Eljebbawi, iScience 2021
  • “...unique to plants. ( Wu et al., 2020 ) ROS regulators Retarded root growth (RRG) (AT1G69380) Root meristem, primary and lateral root tips. Also present in leaves and pollen. In root tips, is preferentially expressed in QC cells, cortex/endodermis stem cells and endodermal and stele cells...”
• An Arabidopsis mitochondria-localized RRL protein mediates abscisic acid signal transduction through mitochondrial retrograde regulation involving ABI4
  Yao, Journal of experimental botany 2015
  • “...like RRG (RETARDED ROOT GROWTH) A previous study revealed that an Arabidopsis mitochondria-localized protein RRG (At1G69380) with a domain of unknown function (DUF155) is required for cell division in the root meristem. Disruption of RRG causes the reduction of dividing cells, the rate of cell production,...”
  • “...growth rate ( Zhou et al. , 2011 ). At5G13610 is a homologous gene of At1G69380 and encodes another protein containing the DUF155 domain. At5G13610 shares 54% and 57% identity in nucleotide and amino acid sequences, respectively, with RRG (At1g69380) (see Supplementary Fig. S1A at JXB...”

RRL_ARATH / Q9FNB2 Protein RETARDED ROOT GROWTH-LIKE from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT5G13610 hypothetical protein from Arabidopsis thaliana
NP_196865 sporulation RMD1-like protein, putative (DUF155) from Arabidopsis thaliana
Aligns to 182:353 / 402 (42.8%), covers 99.4% of PF02582, 113.1 bits

• function: Mediates abscisic acid (ABA) signal transduction through mitochondrial retrograde regulation involving ABI4 during seed germination and seedling growth, and leading to the production of reactive oxygen species (ROS) by the alternative respiratory pathway (PubMed:26163700). Required for the maintenance of mitochondrial structure (PubMed:26163700).
  disruption phenotype: Decreased abscisic acid (ABA) sensitivity during seed germination and seedling growth (PubMed:26163700). Abnormal mitochondria extensively internally vacuolated and characterized by a reduced ABA-stimulated reactive oxygen species (ROS) production associated with the inhibition of ABA-induced AOX1a and ABI4 gene expression (PubMed:26163700).
• Genome-wide identification and analysis of the ALTERNATIVE OXIDASE gene family in diploid and hexaploid wheat
  Brew-Appiah, PloS one 2018
  • “...94 ] as well as known positive and negative regulators of A . thaliana AOX, At5g13610, At5g63610, At5g12290, At5g07690 and At1g32230 [ 95 99 ] were missing from both the hexaploid and diploid promoters (Tables 6 , 7 , S3 and S4 ). It is possible...”
• An Arabidopsis mitochondria-localized RRL protein mediates abscisic acid signal transduction through mitochondrial retrograde regulation involving ABI4
  Yao, Journal of experimental botany 2015
  • “...decreases the meristem size and root growth rate ( Zhou et al. , 2011 ). At5G13610 is a homologous gene of At1G69380 and encodes another protein containing the DUF155 domain. At5G13610 shares 54% and 57% identity in nucleotide and amino acid sequences, respectively, with RRG (At1g69380)...”
  • “...exon of the RRL gene (+1492) was obtained from the ABRC ( Fig. 2A ). At5G13610 transcripts were detected in the wild type (Col-0) but not in the rrl mutant ( Fig. 2B ), suggesting that rrl is a null mutant. The rrl mutants showed normal...”
• An Arabidopsis mitochondria-localized RRL protein mediates abscisic acid signal transduction through mitochondrial retrograde regulation involving ABI4.
  Yao, Journal of experimental botany 2015
  • GeneRIF: Disruption of RETARDED ROOT GROWTH-LIKE (RRL) decreased while overexpression increased ABA sensitivity during seed germination and seedling growth. ABI4 is a downstream regulatory factor in this RRL-mediated ABA signalling.

PF3D7_1018800 uncharacterized protein from Plasmodium falciparum 3D7
Aligns to 396:660 / 708 (37.4%), covers 100.0% of PF02582, 91.7 bits

• Widespread occurrence of lysine methylation in Plasmodium falciparum proteins at asexual blood stages
  Kaur, Scientific reports 2016
  • “...8, putative (PPP8) C-Term(Methyl) IP NSTWcNNDLMcLPAILTKPYECYEDSSLnLENkVQYPNVYYDSLK PF3D7_1018300 conserved Plasmodium protein, unknown function K33(Dimethyl) HILIC TKkCIHIIkNNSRqNDK PF3D7_1018800 conserved protein, unknown function K3(Dimethyl); K9(Trimethyl) IP ILQNIIPLLFSk PF3D7_1018900 conserved Plasmodium protein, unknown function K12(Dimethyl) IP SLDQEKnKTEIEnTGSKSIPnDSNEGANNk PF3D7_1021900 conserved Plasmodium protein (10b antigen), unknown function K30(Dimethyl) IP KVTPNSNSNSNSNSSSSSNSSSSNNNHFEk PF3D7_1022000 RNA-binding...”

Or search for genetic data about PF02582 in the Fitness Browser