Family Search for PF02696 (UPF0061)
PF02696.14 hits 21 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
SELO_YEAST / Q08968 Protein adenylyltransferase SelO, mitochondrial; Selenoprotein O; SelO; EC 2.7.7.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
YPL222W Fmp40p (RefSeq) from Saccharomyces cerevisiae
Aligns to 48:649 / 688 (87.5%), covers 99.6% of PF02696, 561.1 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Tyr residues of target mitochondrial proteins (AMPylation) (PubMed:30270044). Involved in redox homeostasis by regulating the cellular response to oxidative stress (PubMed:30270044). Regulates protein S-glutathionylation levels possibly by AMPylation of deglutathionylation enzymes such as glutaredoxins (PubMed:30270044).
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
cofactor: Mg(2+)
disruption phenotype: Reduced growth and survival in presence of oxygen reactive species. - Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes
Fitzpatrick, PloS one 2011 - “...K535TAA171 amino acid truncation YOR183W FYV12 Protein of unknown function 678,996 E42TAA87 amino acid truncation YPL222W b FMP40 Proposed to be involved in responding to stresses 130,893 Q245TAA443 amino acid truncation a Information obtained from Saccharomyces Genome Database. b ISCM unique to 74-D694. 10.1371/journal.pone.0028684.t003 Table 3...”
- From complete genome sequence to 'complete' understanding?
Galperin, Trends in biotechnology 2010 - “...Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis Predicted RNA-modifying enzyme [ 80 ] ydiU YPL222w SELO PF02696 0397 n/a Selenoprotein O, in yeast localized to mitochondria; not found in archaea No news Modified from Table 3 from Ref [ 39 ] with permission from Oxford...”
- Saccharomyces cerevisiae signature genes for predicting nitrogen deficiency during alcoholic fermentation
Mendes-Ferreira, Applied and environmental microbiology 2007 - “...Gene name YNL270c YMR280c YGL166w YOR180c YKR076w YPL222w YDL222c YMR250w YDL223c YOR391c YLR174w YML128c YPL134c YDR313c YDL204w YIL113w YDR238c YMR175w...”
- 'Conserved hypothetical' proteins: prioritization of targets for experimental study
Galperin, Nucleic acids research 2004 - “...1690 01205 1739 03853 0062 02410 0799 01784 0327 01709 0217 YPL222w SELO 02696 0397 2542 3274 3326 3140 3833 3299 2585 3212 4131 2972 n/a n/a n/a n/a 1UC2 1VI7...”
- Genome-wide amplifications caused by chromosomal rearrangements play a major role in the adaptive evolution of natural yeast
Infante, Genetics 2003 (secret)
UTI89_C1899 hypothetical protein YdiU (NCBI) from Escherichia coli UTI89
c2102 Hypothetical protein ydiU (NCBI ptt file) from Escherichia coli CFT073
Aligns to 1:451 / 478 (94.4%), covers 99.1% of PF02696, 523.7 bits
YdiU / b1706 UPF0061 family protein YdiU from Escherichia coli K-12 substr. MG1655 (see 4 papers)
SELO_ECOLI / P77649 Protein adenylyltransferase SelO; Selenoprotein O homolog; SelO; EC 2.7.7.-; EC 2.7.7.n1 from Escherichia coli (strain K12) (see paper)
ydiU / RF|NP_416221 UPF0061 protein ydiU from Escherichia coli K12 (see paper)
b1706 hypothetical protein (NCBI) from Escherichia coli str. K-12 substr. MG1655
Aligns to 1:451 / 478 (94.4%), covers 99.1% of PF02696, 521.6 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). Cannot use GTP, CTP or UTP as cosubstrate. AMPylates SucA at 'Thr-405' and GrxA on 'Tyr-13'. Regulates protein S-glutathionylation levels probably by AMPylation of deglutathionylation enzymes such as GrxA. Probably involved in redox homeostasis.
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
catalytic activity: ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate (RHEA:54292)
catalytic activity: ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate (RHEA:58120)
cofactor: Mg(2+)
disruption phenotype: Moderate decrease in global protein S- glutathionylation. - 18th Congress of the European Hematology Association, Stockholm, Sweden, June 13–16, 2013
, Haematologica 2013
SELO_PSESM / Q87VB1 Protein adenylyltransferase SelO; EC 2.7.7.-; EC 2.7.7.n1 from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) (see paper)
Aligns to 3:458 / 487 (93.6%), covers 98.9% of PF02696, 511.2 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
catalytic activity: ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate (RHEA:54292)
catalytic activity: ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate (RHEA:58120)
cofactor: Mg(2+)
PA5023 hypothetical protein (NCBI) from Pseudomonas aeruginosa PAO1
Aligns to 3:457 / 486 (93.6%), covers 98.9% of PF02696, 502.9 bits
PBPRA2020 hypothetical protein (NCBI) from Photobacterium profundum SS9
Aligns to 11:493 / 522 (92.5%), covers 99.4% of PF02696, 470.7 bits
- Protein evolution in deep sea bacteria: an analysis of amino acids substitution rates
Campanaro, BMC evolutionary biology 2008 - “...q (%) 1 Putative Phosphate ABC Transporter, Permease Protein PBPRA1392 0581P 4.3 2 Hypothetical Protein PBPRA2020 - 4.8 3 Hypothetical Phosphoribosylaminoimidazole Carboxylase, Catalytic Subunit PBPRA3574 0041F 0.0 4 Dithiobiotin Synthetase PBPRA2326 0132H 8.3 5 Putative Xanthine/Uracil Permease PBPRA0186 2233F 8.3 6 Hypothetical TonB Protein PBPRA2103 0810M...”
Galf_2424 YdiU family protein from Gallionella capsiferriformans ES-2
Aligns to 18:486 / 518 (90.5%), covers 97.6% of PF02696, 454.4 bits
NP_196807 selenoprotein O from Arabidopsis thaliana
AT5G13030 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 114:601 / 633 (77.1%), covers 96.2% of PF02696, 450.8 bits
- SELENOPROTEIN O is a chloroplast protein involved in ROS scavenging and its absence increases dehydration tolerance in Arabidopsis thaliana.
Fichman, Plant science : an international journal of experimental plant biology 2018 (PubMed)- GeneRIF: The study elucidates SELO as a PSI-related component involved in regulating ROS levels and stress responses.
- Small RNA and PARE sequencing in flower bud reveal the involvement of sRNAs in endodormancy release of Japanese pear (Pyrus pyrifolia 'Kosui')
Bai, BMC genomics 2016 - “...miRn46 Pbr035452.1 735 3 3 0.02 AT4G05320 polyubiquitin 10 miRn54 Pbr000659.1 966 2 2.5 0.02 AT5G13030 NA miRn54 Pbr005201.1 1526 1 4 0 AT5G35690 NA miRn55 Pbr009389.1 551 1 4.5 0.04 AT3G12380 actin-related protein 5 miRn57 Pbr039571.2 962 2 2.5 0.03 AT2G34470 urease accessory protein G...”
- A genome-scale mining strategy for recovering novel rapidly-evolving nuclear single-copy genes for addressing shallow-scale phylogenetics in Hydrangea
Granados, BMC evolutionary biology 2015 - “...were randomly selected from the pool for primer design: AT1G10840, AT1G63900, AT2G17975, AT3G54170, AT4G35850, AT5G12040, AT5G13030, AT5G48470, AT5G57410 and AT5G64860. These genes were subsequently aligned to the A. thaliana full length genomic sequence obtained from TAIR ( http://www.arabidopsis.org/ ). Alignments were screened for regions with high...”
TTHERM_00852990 selenoprotein O from Tetrahymena thermophila SB210
Aligns to 38:602 / 634 (89.1%), covers 97.2% of PF02696, 439.3 bits
An07g10280 YdiU domain protein from Aspergillus niger CBS 513.88
Aligns to 68:603 / 637 (84.1%), covers 95.9% of PF02696, 433.7 bits
SPAC20G4.05c UPF0061 family protein (RefSeq) from Schizosaccharomyces pombe
Aligns to 35:534 / 568 (88.0%), covers 98.3% of PF02696, 423.4 bits
KT99_20194 hypothetical protein (RefSeq) from Shewanella benthica KT99
Aligns to 7:484 / 513 (93.2%), covers 98.7% of PF02696, 420.8 bits
MGG_03159 YdiU domain-containing protein from Pyricularia oryzae 70-15
Aligns to 106:661 / 705 (78.9%), covers 95.9% of PF02696, 420.1 bits
Q9DBC0 Protein adenylyltransferase SelO, mitochondrial from Mus musculus
Aligns to 79:625 / 667 (82.0%), covers 94.7% of PF02696, 414.2 bits
BP1090 conserved hypothetical protein (NCBI) from Bordetella pertussis Tohama I
Aligns to 5:458 / 487 (93.2%), covers 98.1% of PF02696, 410.7 bits
- Genomic epidemiology of Iranian Bordetella pertussis: 50 years after the implementation of whole cell vaccine
Safarchi, Emerging microbes & infections 2019 - “...isolates Different provinces Genic (25) 13 nsSNPs: BP0194, BP0292, BP0518, BP0854 ( nuoN ), BP0891, BP1090, BP1261, BP1471, BP2249 ( bscI ), BP2485 Deletions: BP0880 (8), BP2946 (31), fim2 p (5) 11 sSNPs: BP0184, BP0215 ( ppc ), BP0505, BP0507, BP0678 ( prfA ), BP1054 (...”
- Mutations in the bvgA gene of Bordetella pertussis that differentially affect regulation of virulence determinants
Stibitz, Journal of bacteriology 1994 - “...cross the mutant alleles into BP953 to create BP1090 and BP1091, respectively, essentially as described previously (29). Mutagenesis and screening of BP953....”
- “...Tohama I BP953 BP1056 BP1060 BP1074 BP1078 BP1079 BP1090 BP1091 B. PERTUSSIS bvgA MUTATIONS AFFECT VIRULENCE REGULATION VOL. 176, 1994 TABLE 2. TABLE 3....”
SELO_HUMAN / Q9BVL4 Protein adenylyltransferase SelO, mitochondrial; Selenoprotein O; SelO; EC 2.7.7.-; EC 2.7.7.n1 from Homo sapiens (Human) (see 2 papers)
NP_113642 protein adenylyltransferase SelO, mitochondrial from Homo sapiens
Aligns to 76:624 / 669 (82.1%), covers 95.5% of PF02696, 406.6 bits
RSP_2375 hypothetical protein (NCBI) from Rhodobacter sphaeroides 2.4.1
Aligns to 1:451 / 481 (93.8%), covers 98.7% of PF02696, 391.7 bits
- Convergence of the transcriptional responses to heat shock and singlet oxygen stresses
Dufour, PLoS genetics 2012 - “...Energy metabolism Amino acids and amines RSP_3957 Electron transport RSP_0296, RSP_0610, RSP_1194, RSP_1489, RSP_1529, RSP_1576, RSP_2375, RSP_2685, RSP_2945 Glycolysis/gluconeogenesis RSP_0361 Fatty acid and cell envelope Biosynthesis RSP_0720, RSP_0929, RSP_2776 Biosynthesis and degradation of murein sacculus and peptidoglycan RSP_1240 Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides...”
AFLA_022590 YdiU domain protein from Aspergillus flavus NRRL3357
Aligns to 36:488 / 522 (86.8%), covers 80.8% of PF02696, 365.1 bits
thalar_00489 YdiU family protein from Litoreibacter arenae DSM 19593
Aligns to 2:442 / 471 (93.6%), covers 98.1% of PF02696, 355.2 bits
CC3334 conserved hypothetical protein, interruption (NCBI ptt file) from Caulobacter crescentus CB15
Aligns to 8:160 / 160 (95.6%), covers 30.3% of PF02696, 163.1 bits
LOC101880049 LOW QUALITY PROTEIN: protein adenylyltransferase SelO-like from Melopsittacus undulatus
Aligns to 12:224 / 224 (95.1%), covers 40.4% of PF02696, 99.2 bits
Or search for genetic data about PF02696 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory