Family Search for PF02696 (SelO)
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Running HMMer for PF02696
PF02696 hits 24 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
YdiU / b1706 UPF0061 family protein YdiU from Escherichia coli K-12 substr. MG1655 (see 4 papers)
selO / P77649 protein adenylyltransferase SelO (EC 2.7.7.108) from Escherichia coli (strain K12) (see 4 papers)
SELO_ECOLI / P77649 Protein adenylyltransferase SelO; Selenoprotein O homolog; SelO; EC 2.7.7.108 from Escherichia coli (strain K12) (see paper)
Aligns to 1:451 / 478 (94.4%), covers 99.1% of PF02696, 511.1 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). Cannot use GTP, CTP or UTP as cosubstrate. AMPylates SucA at 'Thr-405' and GrxA on 'Tyr-13'. Regulates protein S-glutathionylation levels probably by AMPylation of deglutathionylation enzymes such as GrxA. Probably involved in redox homeostasis.
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
catalytic activity: ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate (RHEA:54292)
catalytic activity: ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate (RHEA:58120)
cofactor: Mg(2+)
disruption phenotype: Moderate decrease in global protein S- glutathionylation.
SELO_PSESM / Q87VB1 Protein adenylyltransferase SelO; EC 2.7.7.108 from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) (see paper)
Aligns to 3:458 / 487 (93.6%), covers 98.9% of PF02696, 500.2 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
catalytic activity: ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate (RHEA:54292)
catalytic activity: ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate (RHEA:58120)
cofactor: Mg(2+)
FMP40 / Q08968 protein adenylyltransferase SelO, mitochondrial (EC 2.7.7.108) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 7 papers)
SELO_YEAST / Q08968 Protein adenylyltransferase SelO, mitochondrial; Selenoprotein O; SelO; EC 2.7.7.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
Aligns to 48:649 / 688 (87.5%), covers 99.1% of PF02696, 486.2 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Tyr residues of target mitochondrial proteins (AMPylation) (PubMed:30270044). Involved in redox homeostasis by regulating the cellular response to oxidative stress (PubMed:30270044). Regulates protein S-glutathionylation levels possibly by AMPylation of deglutathionylation enzymes such as glutaredoxins (PubMed:30270044).
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
cofactor: Mg(2+)
disruption phenotype: Reduced growth and survival in presence of oxygen reactive species.
SELENOO / Q9BVL4 protein adenylyltransferase SelO, mitochondrial (EC 2.7.7.108) from Homo sapiens (see 4 papers)
SELO_HUMAN / Q9BVL4 Protein adenylyltransferase SelO, mitochondrial; Selenoprotein O; SelO; EC 2.7.7.-; EC 2.7.7.108 from Homo sapiens (Human) (see 2 papers)
Aligns to 76:624 / 669 (82.1%), covers 95.5% of PF02696, 388.0 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation) (PubMed:30270044). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein (PubMed:24751718).
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
catalytic activity: ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate (RHEA:54292)
catalytic activity: ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate (RHEA:58120)
cofactor: Mg(2+)
Or search for genetic data about PF02696 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory