Family Search for PF03649 (UPF0014)

PF03649 hits 21 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Teth39_1957 hypothetical protein from Thermoanaerobacter ethanolicus ATCC 33223
Aligns to 3:240 / 250 (95.2%), covers 99.6% of PF03649, 289.8 bits

• Expression of a heat-stable NADPH-dependent alcohol dehydrogenase in Caldicellulosiruptor bescii results in furan aldehyde detoxification
  Chung, Biotechnology for biofuels 2015
  • “...pDCW171 (see Additional file 1 : Figure S1 for details), which contains the P S-layer Teth39_1957 expression cassette and pyrF cassette for selection of transformants. Homologous recombination can occur at the upstream or downstream targeted chromosomal regions, integrating the plasmid into the genome and generating a...”
  • “...uracil prototroph. Counter-selection with 5-FOA selects for loss of the plasmid sequences, but not the Teth39_1957 expression cassette. Bent arrows depict primers used for verification of the integrated expression cassette. Ap r apramycin resistance gene cassette. b Gel depicting PCR products amplified from the targeted chromosome...”

HWX41_RS22925 iron export ABC transporter permease subunit FetB from Bacillus paramycoides
Aligns to 9:251 / 264 (92.0%), covers 100.0% of PF03649, 283.5 bits

• Genomic Analysis of Endophytic Bacillus cereus T4S and Its Plant Growth-Promoting Traits
  Adeleke, Plants (Basel, Switzerland) 2021
  • “...iron transport protein A HWX41_RS00335 fet B iron export ABC transporter permease subunit Fet B HWX41_RS22925 feo B ferrous iron transport protein B HWX41_RS00340 Siderophore transport fet B siderophore ABC transporter substrate-binding protein HWX41_RS24585 plants-10-01776-t005_Table 5 Table 5 Genes involved in the modulation of plant hormones....”

LMH90_015220 iron export ABC transporter permease subunit FetB from Enterobacter hormaechei
Aligns to 8:245 / 260 (91.5%), covers 99.2% of PF03649, 281.9 bits

• Genome Assembly of a Putative Plant Growth-Stimulating Bacterial Sweet Pepper Fruit Isolate, Enterobacter hormaechei SRU4.4
  Mamphogoro, Microbiology resource announcements 2023
  • “...feoC LMH90_003985 Fe-S-dependent transcriptional repressor FeoC fetA LMH90_015215 Iron ABC transporter ATP-binding protein FetA fetB LMH90_015220 Iron export ABC transporter permease subunit FetB Enterobactin production entD LMH90_012840 Enterobactin synthase subunit EntD entE LMH90_012895 (2,3-Dihydroxy benzoyl)adenylate synthase EntE entA LMH90_012905 2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase EntA entH LMH90_012910 Proofreading thioesterase...”

stu1665 predicted membrane protein of the YbbM family from Streptococcus thermophilus LMG 18311
Aligns to 7:244 / 251 (94.8%), covers 99.6% of PF03649, 275.5 bits

• Transcriptome analysis of adaptive heat shock response of Streptococcus thermophilus
  Li, PloS one 2011
  • “...2.8 4.3 hypothetical protein stu1666 R - 2.7 3.3 putative ABC transporter ATP binding protein stu1665 R - 3.3 2.1 putative ABC transporter permease protein stu1615 R - 3.5 3.7 hypothetical protein stu1005 P pstB2 5.3 5.6 phosphate transport system ATP-binding protein stu1002 P pstC1 4.5...”

YbbM / b0491 putative iron ABC exporter membrane subunit FetB from Escherichia coli K-12 substr. MG1655 (see 4 papers)
FETB_ECOLI / P77307 Probable iron export permease protein FetB from Escherichia coli (strain K12) (see paper)
TC 3.A.1.139.2 / P77307 UPF0014 inner membrane protein ybbM, component of The FetA (YbbL)/FetB (YbbM) iron exporter (SwissProt family UDF0014; 6 or 7 putative TMSs) from Escherichia coli (strain K12) (see 3 papers)
NP_415024 putative iron ABC exporter membrane subunit FetB from Escherichia coli str. K-12 substr. MG1655
b0491 putative metal resistance protein from Escherichia coli str. K-12 substr. MG1655
Aligns to 8:245 / 259 (91.9%), covers 99.2% of PF03649, 273.9 bits

• function: Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane.
  subunit: The complex is composed of two ATP-binding proteins (FetA) and two transmembrane proteins (FetB).
  disruption phenotype: Mutant exhibits increased sensitivity to H(2)O(2) stress.
• substrates: Fe2+
  tcdb comment: Expression enhances resistance to oxidative stress (Nicolaou et al. 2013)
• Overexpression of fetA (ybbL) and fetB (ybbM), Encoding an Iron Exporter, Enhances Resistance to Oxidative Stress in Escherichia coli.
  Nicolaou, Applied and environmental microbiology 2013
  • GeneRIF: These findings suggest that FetAB facilitates iron homeostasis to decrease oxidative stress.
• Genome-wide expression profiling in Escherichia coli K-12
  Richmond, Nucleic acids research 1999
  • “...13.7 b3022 b3022 8.7 6.7 ORF, hypothetical protein b0491 ybbM 8.7 2.0 Putative metal resistance protein b1829 *htpX 8.1 36.1 DNA-binding, ATP-dependent protease...”

TM0193 conserved hypothetical protein from Thermotoga maritima MSB8
Aligns to 9:255 / 263 (93.9%), covers 99.6% of PF03649, 271.9 bits

• Recombination in Thermotoga: implications for species concepts and biogeography
  Nesbø, Genetics 2006
  • “...and there are four extra ORFs positioned between TM0192 and TM0193, all of which have homologs in other positions in the T. maritima MSB8 genome. Three of these...”

SAK_RS04090, W903_RS03770 iron export ABC transporter permease subunit FetB from Streptococcus agalactiae A909
Aligns to 9:246 / 257 (92.6%), covers 99.6% of PF03649, 270.7 bits

• Nitric Oxide Production and Effects in Group B Streptococcus Chorioamnionitis
  Keith, Pathogens (Basel, Switzerland) 2022
  • “...in their NCBI-published genome annotations. FetB , a YBBM-related iron export transporter (A909 gene locus SAK_RS04090 and CNCTC 10/84 gene locus W903_RS03770) was the most downregulated gene, with a 16-fold decrease in gene expression following NO exposure. The cyl operon that influences H/C production was slightly...”
  • “...10/84 (Serotype V) Gene Locus PANTHER Consensus Gene Annotation A909 LFC 10/84 LFC Mean LFC SAK_RS04090 W903_RS03770 inner membrane protein YBBM-related iron transporter (fetB) 3.19 4.23 3.71 SAK_RS04085 W903_RS03765 hypothetical protein 3.02 4.18 3.60 SAK_RS07535 W903_RS07235 membrane component of amino acid ABC transporter 3.22 3.47 3.34...”
  • “..., a YBBM-related iron export transporter (A909 gene locus SAK_RS04090 and CNCTC 10/84 gene locus W903_RS03770) was the most downregulated gene, with a 16-fold decrease in gene expression following NO exposure. The cyl operon that influences H/C production was slightly downregulated in both CNCTC 10/84 and...”
  • “...(Serotype V) Gene Locus PANTHER Consensus Gene Annotation A909 LFC 10/84 LFC Mean LFC SAK_RS04090 W903_RS03770 inner membrane protein YBBM-related iron transporter (fetB) 3.19 4.23 3.71 SAK_RS04085 W903_RS03765 hypothetical protein 3.02 4.18 3.60 SAK_RS07535 W903_RS07235 membrane component of amino acid ABC transporter 3.22 3.47 3.34 SAK_RS07540...”

CND04990 hypothetical protein from Cryptococcus neoformans var. neoformans JEC21
Aligns to 10:252 / 311 (78.1%), covers 98.8% of PF03649, 247.3 bits

• Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans
  Sun, PLoS genetics 2014
  • “...EcoRV CND04340 22 1203443 JOHE23361 JOHE23362 Sau96I CND04760 23 1307202 JOHE27442 JOHE27443 Sau96I Inter- CND04980 CND04990 24 9 1365745 JOHE27494 JOHE27495 EcoRV Inter- CND05010 CND05020 25 1372992 JOHE27500 JOHE27501 HinfI CND05140 26 1407510 JOHE23367 JOHE23368 TfiI CND05310 27 1447724 JOHE23369 JOHE23370 AccI Inter- CND05360 CND05370 28...”
  • “...CND04050 CND04340 11.7 74 6.32 22/23 CND04340 CND04760 10.8 104 9.63 23/24 CND04760 Inter- CND04980 CND04990 2.2 59 26.82 24/25 Inter- CND04980 CND04990 Inter- CND05010 CND05020 0 7 >70 2 25/26 Inter- CND05010 CND05020 CND05140 2.2 35 15.91 26/27 CND05140 CND05310 2.2 40 18.18 27/28 CND05310...”

CNAG_01387 hypothetical protein from Cryptococcus neoformans var. grubii H99
Aligns to 10:252 / 311 (78.1%), covers 99.2% of PF03649, 247.1 bits

• Proteome signatures reveal homeostatic and adaptive oxidative responses by a putative co-chaperone, Wos2, to influence fungal virulence determinants in cryptococcosis
  Ball, Microbiology spectrum 2024
  • “...reactions ( 27 29 ). Furthermore, four uncharacterized proteins (CNAG_04585; >2.1 fold [log 2 ], CNAG_01387; >2.3 fold [log 2 ], CNAG_00848; >2.3 fold [log 2 ], and CNAG_03966; >2.7 fold [log 2 ]) were more abundant in the WT strain along with nuclease I (CNAG_00264;...”

Sb09g001990 No description from Sorghum bicolor
Aligns to 32:269 / 282 (84.4%), covers 98.3% of PF03649, 242.0 bits

• Identification of STOP1-Like Proteins Associated With Aluminum Tolerance in Sweet Sorghum (Sorghum bicolor L.)
  Huang, Frontiers in plant science 2018
  • “...reported Al tolerance genes in sorghum ( Magalhaes et al., 2007 ), and SbSTAR2 ( Sb09g001990 ), an ortholog of OsSTAR2 that is transcriptionally regulated by OsART1 ( Yamaji et al., 2009 ; Tsutsui et al., 2011 ), were both examined as potential downstream genes using...”

VV1373 ABC-type uncharacterized transport system, permease component from Vibrio vulnificus YJ016
Aligns to 39:280 / 294 (82.3%), covers 99.2% of PF03649, 231.7 bits

• Lrp, a global regulator, regulates the virulence of Vibrio vulnificus
  Ho, Journal of biomedical science 2017
  • “...were located in the open-reading-frames annotated as leucine-responsive regulatory protein (Lrp, VV1321), ABC transporter permease (VV1373), UDP-glucose pyrophosphorylase (VV2955) and hypothetical protein (VVA0001), respectively. Lrp is an important regulator for cytotoxicity, migration on soft agar and virulence in the mouse To determine which of the SNV-containing...”

STAR2_ORYSJ / Q5W7C1 UPF0014 membrane protein STAR2; Protein SENSITIVE TO ALUMINUM RHIZOTOXICITY 2 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
TC 3.A.1.139.1 / Q5W7C1 Os05g0119000 protein, component of UDP-glucose exporter, STAR1/STAR2 (sensitive to aluminum rhizotoxicity) (Probable Type I topology) from Oryza sativa subsp. japonica (see paper)
Aligns to 34:271 / 285 (83.5%), covers 98.3% of PF03649, 230.8 bits

• function: Associates with STAR2 to form a functional transmembrane ABC transporter required for detoxification of aluminum (Al) in roots. Can specifically transport UDP-glucose.
  subunit: Interacts with STAR2.
  disruption phenotype: No visible phenotype under normal growth condition, but strong inhibition of root elongation when grown in the presence of Al.
• substrates: UDP-glucose
• Aluminium-silicon interactions in higher plants: an update
  Hodson, Journal of experimental botany 2020
  • “...ALS1, Os06g0695800, LOC_ Os06g48060, P0622F03.26 Oryza sativa subsp. japonica (rice) 346 Huang et al. (2009) Q5W7C1 STAR2_ORYSJ UPF0014 membrane protein STAR2 partial ABC transporter STAR2 Os05g0119000, LOC_ Os05g02750, P0496H07.22 Oryza sativa subsp. japonica (rice) 285 Huang et al. (2009) Q6ZG85 NRAT1_ORYSJ Metal transporter NRAT1 NRAT1 Os02g0131800,...”
• Growth Stimulatory Effects and Genome-Wide Transcriptional Changes Produced by Protein Hydrolysates in Maize Seedlings.
  Santi, Frontiers in plant science 2017
  • “...2.29 GRMZM2G123884_T01 Q7XVB3 Probable sodium/metabolite cotransporter BASS1, chloroplastic 2.21 GRMZM2G056908_T01 Q9ATL8 Aquaporin TIP2-2 2.19 GRMZM2G053991_T01 Q5W7C1 UPF0014 membrane protein STAR2 2.04 GRMZM2G142924_T01 A0A096SDC7 Uncharacterized protein 2.00 GRMZM2G024808_T01 B6U7W3 Nitrate and chloride transporter 2.02 GRMZM2G072955_T01 M8CTF4 Chloride channel protein 2.06 2.02 GRMZM2G153920_T01 B4FQN6 Sorbitol transporter 2.07 GRMZM2G137421_T01...”

ALS3_ARATH / Q9ZUT3 Protein ALUMINUM SENSITIVE 3; ABC transporter I family member 16; ABC transporter ABCI.16; AtABCI16; ybbM homolog protein from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 3.A.1.139.4 / Q9ZUT3 Protein ALUMINUM SENSITIVE 3, component of Plasma membrane ABC exporter, sensitive to aluminum rhizotoxicity 1/2, STAR1/STAR2 (Larsen et al., 2005). Induced in response to aluminum exposure from Arabidopsis thaliana
NP_181270 aluminum sensitive 3 from Arabidopsis thaliana
AT2G37330 ALS3 (ALUMINUM SENSITIVE 3) from Arabidopsis thaliana
Aligns to 22:259 / 273 (87.2%), covers 98.3% of PF03649, 225.4 bits

• function: Required for aluminum (Al) resistance/tolerance, probably by translocating Al from sensitive tissues such as growing roots to tissues less sensisitive to the toxic effects of Al.
• substrates: Al3+
• Expression genome-wide association study identifies that phosphatidylinositol-derived signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots of Arabidopsis thaliana.
  Sadhukhan, Plant science : an international journal of experimental plant biology 2021 (PubMed)
  • GeneRIF: Expression genome-wide association study identifies that phosphatidylinositol-derived signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots of Arabidopsis thaliana.
• An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots.
  Dong, Molecular plant 2017 (PubMed)
  • GeneRIF: evidence showing that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeostasis in roots
• ALS3 encodes a phloem-localized ABC transporter-like protein that is required for aluminum tolerance in Arabidopsis.
  Larsen, The Plant journal : for cell and molecular biology 2005 (PubMed)
  • GeneRIF: The identification and expression of ALS3 gene, which encodes a transporter that is required for aluminum tolerance in Arabdiposis roots. [ALS3]
• An ABC transporter complex encoded by Aluminum Sensitive 3 and NAP3 is required for phosphate deficiency responses in Arabidopsis.
  Belal, Biochemical and biophysical research communications (PubMed)
  • GeneRIF: ALS3 and NAP3 protein form an ABC transporter complex that is required for sugar-dependent response to phosphate deficiency.
• Aluminium-silicon interactions in higher plants: an update
  Hodson, Journal of experimental botany 2020
  • “...( UniProt Consortium, 2019 ) Entry Entry name Protein names Gene names Organism Length Reference Q9ZUT3 ALS3_ARATH Protein ALUMINUM SENSITIVE 3 ABC family member, but lacking ATP binding cassette. ALS3 ABCI16, At2g37330, F3G5.12 Arabidopsis thaliana (mouse-ear cress) 273 Larsen et al. (2005) K0ITY9 K0ITY9_HYDMC Plasma membrane...”
• Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants
  Fang, International journal of molecular sciences 2024 (no snippet)
• Mitigating aluminum toxicity and promoting plant resilience in acidic soil with Penicillium olsonii TLL1
  , Frontiers in plant science 2024
  • “...1 0.435 0.0051 0.086 0.0054 AT5G39040 ALS1 ABC transporter, aluminum-sensitive 1 0.136 0.0254 -0.161 0.0498 AT2G37330 ALS3 ABC transporter-like protein -0.548 0.0049 0.016 0.0918 AT4G18910 NIP12 Al-malate transporter -0.211 0.0428 0.017 0.0894 In Al+POT1-treated roots, nutrient transporter genes for Cu, P, Na, and Mo were upregulated,...”
• Combined de novo transcriptomic and physiological analyses reveal RyALS3-mediated aluminum tolerance in Rhododendron yunnanense Franch
  Xu, Frontiers in plant science 2022
  • “...STOP2 AT5G22890 (50%) c107438.graph_c1 0.44 0.61 STAR1 AT1G67940 (58%) c300169.graph_c0 133.89 69.05 0.00 1.01 ALS3;1 AT2G37330 (87%) c341743.graph_c0 0.1 0.23 ALS3;2 AT2G37330 (58%) c321452.graph_c0 0.61 0.26 FDH;1 AT5G14780 (76%) c307333.graph_c1 3.03 2.76 0.89 0.22 FDH;2 AT5G14780 (82%) c236333.graph_c0 0.46 0.38 0.90 0.31 FDH;3 AT5G14780 (57%) c304242.graph_c0...”
  • “...Franch. (A) Amino acid sequence alignment of R. yunnanense Franch ALS3;1 protein with Arabidopsis ALS3 (At2g37330). (B) Phylogenetic analysis of R. yunnanense Franch ALS3;1 and its close homologs. (C) RyALS3;1 is localized to the tonoplast. (i) RyALS3;1-GFP (green); (ii) tonoplast marker, vac-rk CD3-975 (red); (iii) bright...”
• Aluminum stress signaling, response, and adaptive mechanisms in plants
  Liu, Plant signaling & behavior 2022
  • “...ALS1 At5g39040 The ATP-binding cassette (ABC) transporter, aluminum-sensitive 1 Vacuolar membrane Arabidopsis thaliana 105 ALS3 At2g37330 The ATP-binding cassette (ABC) transporter-like protein Plasma membrane Arabidopsis thaliana 6 , 93 Previous studies have shown that the ability of plants to tolerate Al stress is related to rhizosphere...”
• Identification of an ATP-Binding Cassette Transporter Implicated in Aluminum Tolerance in Wild Soybean (Glycine soja)
  Wen, International journal of molecular sciences 2021
  • “...). At the amino acid level, GsABCI1 shows 76% and 62% identity with AtALS3 ( At2g37330 , A. thaliana ) and OsSTAR2 ( Loc_Os01g0674700 , Oryza sativa ), respectively. Phvul.001G172900 from Phaseolus vulgaris shared 92.8% identity with GsABCI1 and is the closest homologue of Leguminosae sp....”
  • “...also identified [ 59 ]. Larsen discovered Al-sensitive mutants and isolated the gene ALS3 ( At2g37330 ), which caused this phenomenon of Al insensitivity [ 38 ]. Soybean is one of the most widely cultivated crops in the world, and it is also an important source...”
• Dynamic Development of White Lupin Rootlets Along a Cluster Root
  Le, Frontiers in plant science 2021
  • “...of rootlet development. Lupin gene code Arabidopsis gene code Gene description Element Profile number Lalb_Chr20g0113031 AT2G37330 Aluminum sensitive 3 (ALS3) Aluminum Profile 5 Lalb_Chr07g0185661 AT4G21120 Amino acid transporter 1 (AAT1) Amino acid Profile 6 Lalb_Chr14g0363171 AT5G40780 Lysine histidine transporter 1 (LHT1) Amino acid Profile 6 Lalb_Chr03g0042381...”
• A new genome allows the identification of genes associated with natural variation in aluminium tolerance in Brachiaria grasses
  Worthington, Journal of experimental botany 2021
  • “...4G165700 AT1G26130 ALA12_ARATH Involved in transport of phospholipids. 7361G2 2.26 1.39 STAR2/ALS3 3G099200 3G043600 3G044400 AT2G37330 STAR2_ORYSJ Associates with STAR2 to form a functional transmembrane ABC transporter required for detoxification of Al in roots. Can specifically transport UDP-glucose. Induced by Al in roots. Positively regulated by...”
• Aluminium-silicon interactions in higher plants: an update
  Hodson, Journal of experimental botany 2020
  • “...ALS3_ARATH Protein ALUMINUM SENSITIVE 3 ABC family member, but lacking ATP binding cassette. ALS3 ABCI16, At2g37330, F3G5.12 Arabidopsis thaliana (mouse-ear cress) 273 Larsen et al. (2005) K0ITY9 K0ITY9_HYDMC Plasma membrane aluminium transporter Aquaporin family PALT1 Hydrangea macrophylla (bigleaf hydrangea) ( Viburnum macrophyllum ) 304 Negishi et...”
• More

HMPREF3225_01307 iron export ABC transporter permease subunit FetB from Staphylococcus lugdunensis
Aligns to 3:241 / 258 (92.6%), covers 99.2% of PF03649, 223.5 bits

• Comparative proteomics analysis of biofilms and planktonic cells of Enterococcus faecalis and Staphylococcus lugdunensis with contrasting biofilm-forming ability
  Cho, PloS one 2024
  • “...sporulation protein J 24.79 A0A133QCC6 HMPREF3225_00114 Probable heme-iron transport system permease protein IsdF 24.77 A0A133Q5X1 HMPREF3225_01307 TIGR00245 family protein 24.64 A0A133Q7R7 HMPREF3225_00968 Hydratase/decarboxylase 24.23 A0A133Q3A3 HMPREF3225_01812 THUMP domain protein 23.88 A0A133QAF3 EQ812_09000 Putative hemin transport system permease protein HrtB 23.88 A0A4Q9W1N1 EQ812_13690 Thiamine diphosphokinase (Fragment) 23.66...”
  • “...followings; ARJ29876.1 = EQ812_07275, ARJ29789.1 = HMPREF3225_01770, ARJ30748.1 = HMPREF3225_01013, ARJ28486.1 = HMPREF3225_00114, ARJ28895.1 = HMPREF3225_01307, ARJ30727.1 = HMPREF3225_00968, ARJ29749.1 = HMPREF3225_01812, ARJ30201.1 = EQ812_03690, ARJ28833.1 = HMPREF3225_01241, ARJ30743.1 = EQ812_05230, ARJ28872.1 = EQ812_01650, ARJ30410.1 = EQ812_09225, ARJ29784.1 = EQ812_07770, ARJ28661.1 = HMPREF3225_02342, ARJ28536.1 = EQ812_06165,...”

SA2242 hypothetical protein from Staphylococcus aureus subsp. aureus N315
Aligns to 3:241 / 258 (92.6%), covers 99.2% of PF03649, 220.2 bits

• Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover
  Anderson, FEMS immunology and medical microbiology 2010
  • “...sa_c3326s2869_a_at 4.7 2.5 2.5 SA1803 pseudouridine synthase family 1 sa_c4896s4204_a_at * 4.7 2.5 2.5 15 SA2242 xanthine/uracil permease family Energy production and conversion sa_c4418s3765_a_at * 3.2 15 30 atpA SA2097 F0F1 ATP synthase subunit beta sa_c4434s3779_a_at * 4.2 15 30 atpB SA2101 F0F1 ATP synthase subunit...”
  • “...family protein sa_c3597s3080_at 2.6 2.5 15 SA1894 HIT family protein sa_c4896s4204_a_at * 7.1 2.5 2.5 SA2242 xanthine/uracil permease sa_c5009s4311_a_at 2.0 2.5 ND SA2276 inosine-uridine preferring nucleoside hydrolase Energy production and conversion sa_c3153s2701_a_at 2.0 2.5 2.5 ackA SA1760 acetate kinase sa_c4418s3765_a_at * 2.7 15 15 atpA SA2097...”
• Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus
  Schlag, Journal of bacteriology 2008
  • “...SA0653 SA0654 SA0655 SA1014 SA1675 SA1699 SA2167 SA2209 SA2242 SA2424 SA2425 SA2426 SA2427 SA2428 fruB fruA scrA hlgB arcC arcD arcB arcA Probable...”
• Genome-wide analysis of ruminant Staphylococcus aureus reveals diversification of the core genome
  Ben, Journal of bacteriology 2008
  • “...SAR2371 Membrane SA2142 Membrane SA2191 Membrane SA2242 Membrane SA2243 Cytoplasm SAR2632 Membrane/SP SAR2700 Membrane/CWA Putative membrane protein SAR2778...”
• Microarray transcription analysis of clinical Staphylococcus aureus isolates resistant to vancomycin
  Mongodin, Journal of bacteriology 2003
  • “...that of a xanthine/ uracil permease family gene (SA2242). In addition, seven cell wall-associated genes were found to have their expression increased in VP-32...”

SACOL2461 hypothetical protein from Staphylococcus aureus subsp. aureus COL
Aligns to 3:241 / 258 (92.6%), covers 99.2% of PF03649, 220.1 bits

• A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus
  Chen, Molecular microbiology 2009
  • “...- Conserved hypothetical protein SACOL1915 4.1 Glutamate ABC transporter SACOL1916 3.8 Amino acid ABC transporter SACOL2461 3.7 + Conserved hypothetical protein SACOL2579 3.6 Phytone dehydrogenase SACOL2585 4.0 -2.0 pfoS/R like regulatory protein SACOL2619 3.1 -2.4 Amino acid permiase SACOL2704 3.0 ATP phosphoribosyltransferase reguratory subunit SAS0383 2.2...”
• The fusidic acid stimulon of Staphylococcus aureus
  Delgado, The Journal of antimicrobial chemotherapy 2008
  • “...SACOL1777 SACOL0851 SACOL0921 SACOL1034 SACOL1074 SACOL2461 SACOL0225 SACOL2579 SACOL0922 SACOL2462 SACOL2241 SACOL1115 SACOL0688 SACOL1522 SACOL0781 SACOL1686...”
• Response of Staphylococcus aureus to salicylate challenge
  Riordan, Journal of bacteriology 2007
  • “...component (SACOL2462) of an ABC transporter putatively constituted by SACOL2461 and SACOL2462 (Table 2). The 3 region of the SACOL2462 ORF overlaps with the 5...”

K7B00_01590 iron export ABC transporter permease subunit FetB from Acidithiobacillus ferrooxidans
Aligns to 14:251 / 259 (91.9%), covers 97.5% of PF03649, 216.7 bits

• Phenomic and transcriptomic analyses reveal the sequential synthesis of Fe₃O₄ nanoparticles in Acidithiobacillus ferrooxidans BYM
  Yang, Microbiology spectrum 2023
  • “...K7B00_13060 1,263 NADH-quinone oxidoreductase subunit NuoF K7B00_12805 801 YdcF family protein K7B00_07875 837 Pantoate-beta-alanine ligase K7B00_01590 780 Iron export ABC transporter permease subunit K7B00_08905 MEblue 828 TonB family protein K7B00_11115 1,110 Hem-binding sites K7B00_09365 693 Glycosyltransferase K7B00_01680 1,128 FAD-dependent oxidoreductase K7B00_03900 801 DUF5666 domain-containing protein K7B00_06360...”

SAR2543 putative membrane protein from Staphylococcus aureus subsp. aureus MRSA252
Aligns to 3:241 / 258 (92.6%), covers 99.2% of PF03649, 216.2 bits

• Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus
  Overton, BMC systems biology 2011
  • “...ion transport (Fe, Zn, Mn, Mo) SAR0274, SAR0643, SAR2594, SAR2452 (4/9 genes) SAR1633, SAR1928, SAR2361, SAR2543, SAR2544 0.0062 - Virulence (inferred from network) SAR0292-SAR0294 (3/3 genes) - 0.025 - Cell division SAR1177-SAR1179 (3/4 genes) SAR1175 0.028 A prefix '+' in the first column indicates modules with...”
• The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications
  Kenny, PloS one 2009
  • “...protein 5.28 2.33E-05 SAR2532 CapD domain protein 2.48 4.16E-03 SAR2542 putative transport protein 2.01 5.64E-03 SAR2543 putative membrane protein 6.37 6.16E-04 SAR2568 hypothetical protein 4.66 1.65E-03 SAR2656 conserved hypothetical protein 3.35 6.16E-04 SAR2657 hypothetical protein 2.40 8.80E-04 SAR2658 TetR family regulatory protein 2.22 4.39E-04 SAR2660 conserved...”
• Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteria
  Brody, PloS one 2008
  • “...None detected SAR1911 SAB1691 Hypothetical novel protein None detected SAR2113 SAB1884c Hypothetical novel protein Phage SAR2543 SAB2336c ATP binding ABC transporter None detected SAR2596 SAB2390 Fructose 1,6 bisphosphatase None detected SAR2628 SAB2423 Putative ATP-dependent protease ATP-binding subunit ClpL None detected MRSA252 Listeria monocytogenes SAR0720 FSL R2-503...”

LPN03_11025 ABC transporter permease from Arthrobacter sp. A2-55
Aligns to 11:245 / 250 (94.0%), covers 97.1% of PF03649, 132.4 bits

• Genome mining to unravel potential metabolic pathways linked to gallium bioleaching ability of bacterial mine isolates
  Chung, Frontiers in microbiology 2022
  • “...COG4779 AfuA: ABC-type Fe 3+ transport system, periplasmic component, COG1840 LPN04_31840 LPN04_20770 LPN04_20775 LPN01_08195 LPN01_08200 LPN03_11025 LPN03_12020 LPN03_11610 LPN03_11625 LPN03_11615 LPN03_11620 LPN03_12025 IMW82_11125 LPB67_10940 LPB67_13650 LPB67_04440 LPB67_04415 LPB67_04410 LPB67_10935 Ferrous iron transport system of the Feo or Efe type Fe 2+ transport system protein FeoA, COG1918...”

MAB_2569c hypothetical protein from Mycobacterium abscessus ATCC 19977
Aligns to 10:244 / 252 (93.3%), covers 97.5% of PF03649, 131.4 bits

• A Simplified and Efficient Method for Himar-1 Transposon Sequencing in Bacteria, Demonstrated by Creation and Analysis of a Saturated Transposon-Mutant Library in Mycobacterium abscessus
  Foreman, mSystems 2020
  • “...CGGCCTATGCGG TA TACGCGCTGCCC MAB_2514c 765 694 GCACGCGCAAGC TA CACATTCCCGTC MAB_2545c 984 436 TGCCGCCAAACG TA TTGGTGCGAGCC MAB_2569c 759 251 ACGGACCGTCTG TA CGACGCGGGGAT MAB_2975c 1,047 894 GGCCGGCGCCGT TA AGTTCAAACGCA MAB_3040c 1,155 14 CGTCGGGTCAAG TA ACTGTTGATACG MAB_3049c 420 142 ATCACCGCCATG TA CGAAATGCACGC MAB_3073 657 510 + CCCCATGACTAC TA CTGGCGAGCGGG...”

MT3080 ABC transporter, ATP-binding protein from Mycobacterium tuberculosis CDC1551
Rv3000 POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN from Mycobacterium tuberculosis H37Rv
Aligns to 107:203 / 219 (44.3%), covers 38.0% of PF03649, 111.1 bits

• Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress
  Lin, Infection and immunity 2016
  • “...Rv2040c Rv2041c Rv2273 Rv2281 Rv2398c Rv2400c Rv2522c Rv2835c MT3080 MT3951 Rv3000 Rv3843c MT0691 MT0699 MT1338 MT1463 MT1589 MT2042 MT2247 MT2488 MT2535 MT2536...”
• Synthetic lethality reveals mechanisms of Mycobacterium tuberculosis resistance to β-lactams
  Lun, mBio 2014
  • “...innate -lactam resistance. The penicillin binding proteins (MT0019, MT3784), ABC transporters (MT1390, MT1789, MT1867, MT3006, MT3080), and fatty acid biosynthesis-, equilibrium-, integrity-, and metabolism-associated genes ( n = 11, Fig.S2 ) were also identified in the top-hit list ( TableS1 ). The GCSL screen also identified...”
• In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis
  Biswas, Applied biochemistry and biotechnology 2021
  • “...and it also helps in vitamin B 12 acquisition by the bacterium [ 27 ]. Rv3000 is also a putative efflux pump [ 28 ]. Rv1463 is an efflux pump of this family but the drugs extruded are still undetermined [ 29 ]. Rv1686c and Rv1687c...”
• Regulation of the CRISPR-Associated Genes by Rv2837c (CnpB) via an Orn-Like Activity in Tuberculosis Complex Mycobacteria
  Zhang, Journal of bacteriology 2018
  • “...Rv1639c Rv3824c Rv3171c Rv2006 Rv1757c Rv3000 N-acyl-D-glutamate amidohydrolase FAD-dependent NAD(P)-disulphide oxidoreductase Transcriptional regulator, TetR...”
• Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress
  Lin, Infection and immunity 2016
  • “...Rv2273 Rv2281 Rv2398c Rv2400c Rv2522c Rv2835c MT3080 MT3951 Rv3000 Rv3843c MT0691 MT0699 MT1338 MT1463 MT1589 MT2042 MT2247 MT2488 MT2535 MT2536 MT2741 MT2902...”
• Synthetic lethality reveals mechanisms of Mycobacterium tuberculosis resistance to β-lactams
  Lun, mBio 2014
  • “...play a role, as we identified five of them in our HTS (Rv2936, Rv1348, Rv1819c, Rv3000, and Rv1747). The ABC transporter encoded by Rv0194 has been identified to play a role in multidrug resistance, including -lactam resistance ( 28 ), and, interestingly, functions as an efflux...”
• Energy metabolism and drug efflux in Mycobacterium tuberculosis
  Black, Antimicrobial agents and chemotherapy 2014
  • “...(Rv0783) drrB (Rv2937) drrC (Rv2938) Rv2687c Rv2688c Rv2994 Rv3000 Rv3239c Rv3728 Rv2209 Rv2333c jefA (Rv2459) Rv2477c Rv2686c Description MFS MFS ABC ABC ABC...”
• Mature Epitope Density--a strategy for target selection based on immunoinformatics and exported prokaryotic proteins
  Santos, BMC genomics 2013
  • “...Rv1967 151 305 16,53 SEC favorable 10.1111/j.1574-695X.2010.00677.x Rv1620c 156 311 16,52 PSE favorable 10.1073/pnas.1003219107, 20090285847 Rv3000 86 167 16,04 PSE favorable 10.1016/j.tube.2006.01.014 Rv2690c 64 126 16,03 PSE favorable Patent 7393540 Rv0804 87 175 15,85 SEC favorable 10.1107/S1744309108031679 Rv0598c 58 104 15,85 SEC favorable PMID:12657046 Rv3693 203...”

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