Family Search for PF03661 (UPF0121)
PF03661.13 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
LOC659239 Krueppel homolog 2 from Tribolium castaneum
Aligns to 15:252 / 260 (91.5%), covers 97.9% of PF03661, 327.2 bits
Q9CR67 Transmembrane protein 33 from Mus musculus
NP_001272381 transmembrane protein 33 isoform 1 from Mus musculus
Aligns to 7:245 / 247 (96.8%), covers 96.7% of PF03661, 322.4 bits
TMM33_HUMAN / P57088 Transmembrane protein 33; Protein DB83; SHINC-3 from Homo sapiens (Human) (see 3 papers)
F7H2H1 Transmembrane protein 33 from Macaca mulatta
NP_060596 transmembrane protein 33 from Homo sapiens
Aligns to 7:245 / 247 (96.8%), covers 96.7% of PF03661, 319.8 bits
- function: Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).
subunit: Interacts with EIF2AK3 (PubMed:26268696). Interacts with ARL6IP1, isoform RTN1-A of RTN1, isoform RTN2-B of RTN2, isoform 3 of RTN3 and isoform 3 of RTN4 (PubMed:25612671). - Analysis of protein expression changes of the Vero E6 cells infected with classic PEDV strain CV777 by using quantitative proteomic technique.
Sun, Journal of virological methods 2015 - “...membrane cell communication; regulation of biological process; response to stimulus 1.51E02 0.82 57 Protein DB83 F7H2H1 membrane; cytoplasm 2.25E03 0.82 58 DORA reverse strand protein G7Q0P8 catalytic activity metabolic process 1.01E02 0.82 59 Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (Cyclizing) G7PPY4 catalytic activity; nucleotide binding membrane metabolic...”
- TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling.
Sakabe, Breast cancer research and treatment 2015 - GeneRIF: TMEM33 is a novel regulator of the PERK-eIE2alpha-ATF4 and IRE1-XBP1 axes of the UPR signaling.
- A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases
Choi, Scientific reports 2019 - “...GPR180 insoluble Q8TDY2 6.6 4.08E-04 183.1 RB1CC1 B/S e insoluble Q9NVH2 6.2 1.16E-08 106.8 INTS7 P57088 6.2 1.03E-06 28.0 TMEM33 S Q13371 6.2 5.62E-06 34.3 PDCL P43243 6.1 9.21E-07 94.6 MATR3 Q9Y6A5 6.0 2.72E-12 90.4 TACC3 P61978 5.9 8.39E-18 51.0 HNRNPK B/C Q04637 5.9 2.37E-08 175.5...”
- Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF
Marino, The Journal of biological chemistry 2019 - “...P62244 P18077 O95864 P61619 Q16643-3 P60842 Q99623 P57088 P61254 P04844-1 P62913 P51148-2 P60866-2 P62899-2 Q9UNF1 Q96CS3 P16615 P18085 Q9UBM7 Transcriptional...”
- LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.
Choi, Science (New York, N.Y.) 2019 - The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease.
Suárez-Arroyo, American journal of cancer research 2016 - Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases
Yang, Molecular & cellular proteomics : MCP 2015 - “...P07951 P08727 P11142 P12814 P36578 P42224 P42330 P57088 P62249 Tropomyosin alpha-3 chain-like protein Unconventional myosin-Ic Myosin regulatory light chain 12B...”
- Stable isotope labeling by amino acids in cell culture and differential plasma membrane proteome quantitation identify new substrates for the MARCH9 transmembrane E3 ligase.
Hör, Molecular & cellular proteomics : MCP 2009 - “...ADAM10 1.19 1 0.84 0.22 16.98 O14672 9 (10) TMM33 1.05 3 0.95 0.04 8.90 P57088 2 (2) CD99 a 1.19 1 0.84 0.07 5.40 P14209 1 (2) EVI2A a 1.05 1 0.95 0.35 8.19 P22794 1 (4) CD10 1.19 1 0.84 0.09 10.27 P08473 8...”
- Optimization of protein solubilization for the analysis of the CD14 human monocyte membrane proteome using LC-MS/MS.
Ye, Journal of proteomics 2009 - “...4 0.066 Endoplasmic reticulum membrane Q9BVC6 Transmembrane protein 109 precursor 5 0.541 Nucleus outer membrane P57088 Transmembrane protein 33 3 0.429 Membrane Q96CP4 Transporter 1, ATP-binding cassette, sub-family B 7 0.142 Integral to membrane Q6RW13 Type-1 angiotensin II receptor-associated protein 3 0.482 Endoplasmic reticulum membrane Q9H1C4...”
XP_017214478 transmembrane protein 33 isoform X1 from Danio rerio
Aligns to 11:250 / 252 (95.2%), covers 97.9% of PF03661, 319.6 bits
G1TD26 Transmembrane protein 33 from Oryctolagus cuniculus
Aligns to 7:245 / 246 (97.2%), covers 96.7% of PF03661, 319.1 bits
LOC110488950 transmembrane protein 33-like from Oncorhynchus mykiss
Aligns to 9:248 / 250 (96.0%), covers 96.7% of PF03661, 315.9 bits
KRH2_DROME / Q9V447 Krueppel homolog 2; Protein Kr-h2 from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 31:268 / 276 (86.2%), covers 97.5% of PF03661, 300.4 bits
- function: Member of the dosage-dependent hierarchy effective upon white gene expression.
D6RAA6 Transmembrane protein 33 (Fragment) from Homo sapiens
Aligns to 7:222 / 222 (97.3%), covers 87.6% of PF03661, 290.3 bits
Q9CWD1 Uncharacterized protein from Mus musculus
Aligns to 7:177 / 177 (96.6%), covers 68.5% of PF03661, 211.9 bits
CNAG_02753 endoplasmic reticulum protein from Cryptococcus neoformans var. grubii H99
Aligns to 6:248 / 278 (87.4%), covers 80.9% of PF03661, 132.8 bits
TTS1_SCHPO / Q9Y7Z5 Tetra-spanning protein 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
tts1 tetra spanning protein 1, Tts1 from Schizosaccharomyces pombe (see 4 papers)
NP_596818 tetra-spanning protein 1 from Schizosaccharomyces pombe
SPBC1539.04 conserved eukaryotic protein (RefSeq) from Schizosaccharomyces pombe
Aligns to 6:258 / 279 (90.7%), covers 93.4% of PF03661, 120.5 bits
C0ND33 Uncharacterized protein from Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
Aligns to 12:268 / 291 (88.3%), covers 93.4% of PF03661, 106.7 bits
TC 1.I.1.1.2 / G0S6T0 Nucleoporin POM33, component of Fungal Nuclear Pore Complex (NPC) with 29 components from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Aligns to 12:267 / 287 (89.2%), covers 90.5% of PF03661, 105.9 bits
- substrates: RNA, proteins
tcdb comment: Stuwe et al. 2015 presented the reconstitution of the ~425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT•Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three-dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. They proposed that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation (Stuwe et al. 2015 presented the reconstitution of the ~425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT•Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three-dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. They proposed that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation (Stuwe et al. 2015)
POM33_YEAST / Q12164 Pore membrane protein of 33 kDa from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
NP_013077 nucleoporin POM33 from Saccharomyces cerevisiae S288C
YLL023C Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum (RefSeq) from Saccharomyces cerevisiae
Aligns to 15:265 / 279 (90.0%), covers 93.8% of PF03661, 86.2 bits
- function: Contributes to proper distribution and/or efficient assembly of nuclear pores. Required for normal pore density in the daughter nucleus during telophase.
subunit: Interacts with RTN1. - Nuclear pore targeting of the yeast Pom33 nucleoporin depends on karyopherin and lipid binding.
Floch, Journal of cell science 2015 (PubMed)- GeneRIF: combined impairment of lipid and Kap123 binding affects targeting of Pom33 to NPCs. These data highlight the requirement of multiple determinants and mechanisms for proper NPC localization of Pom33.
- Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells
Rush, Current chemical biology 2015 - “...+ + Q12144 5 Pore and endoplasmic reticulum protein of 33 kDa PER33 + + Q12164 5 Pore membrane protein of 33 kDa POM33 + + P47154 4 CAAX prenyl protease 1 STE24 + + P35723 3 Endoplasmic reticulum transmembrane protein 1 YET1 + + Q07451...”
- Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits
Hua, Cell systems 2018 - “...YDR307W, YDR297W, YNL190W, YDR503C, YBR177C, YGR266W, YER019C-A, YLR034C, YOR322C, YGR260W, YDR349C, YJR015W, YPL246C, YMR058W, YBR290W, YLL023C, YDR205W, YHR123W, YJL024C, YJL212C, YLR292C, YPL207W, YKR027W, YIL076W, YBR288C, YJL183W, YKL008C, YJL207C, YML067C, YGR089W, YOR291W, YNL111C, YEL043W, YPL234C, YLR056W, YKL096W-A, YGR157W, YHR060W, YLR039C, YHR079C DATA AND SOFTWARE AVAILABILITY The experimental...”
- Global analysis of SUMO chain function reveals multiple roles in chromatin regulation
Srikumar, The Journal of cell biology 2013 - “...NPC componentsUlp1 localization NUP60 0.328 NUP133 0.228 nup145-R4 0.223 SRP1_damp 0.149 NUP84 0.113 GLE2 0.130 YLL023C 0.109 nup57-E17 0.094 NUP49_damp 0.091 Chromatin remodeling Histone chaperone ASF1 0.247 Chromatin silencing ESC2 0.294 RTT109 0.141 RAP1_damp 0.116 MOT3 0.110 YAP1 0.109 RIF1 0.099 Chromatin assembly factor (CAF-1) CAC2...”
- Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution
Chadrin, The Journal of cell biology 2010 - “...of the collection of nonessential gene deletions using the nup133 mutant as bait identified the YLL023c open reading frame (ORF), which encodes a 33 kD protein with several putative transmembrane helixes (subsequently termed Pom33, see the following paragraph). Although deletion of YLL023c/POM33 did not impair growth...”
- “...any temperature, its genetic interaction with NUP133 was confirmed by the enhanced growth defect of yll023c nup133 mutant cells as compared with nup133 , which was recorded at all temperatures tested (see Fig. 4 A ). Fluorescence microscopy analysis of Yll023c C-terminally tagged at its genomic...”
- Uncovering biological network function via graphlet degree signatures
Milenković, Cancer informatics 2008 - “...(YKL065C) 51 DIP 34 4 Cellular transport, transport facilities and transport routes 16 53.33% 0.00% YLL023C 22 DIP 17 2 Cellular transport, transport facilities and transport routes 10 66.67% 0.00% RAD33 (YML011C) 5 DIP 9 3 Metabolism 4 66.67% 0.00% YNL092W 29 DIP 3 1 Metabolism...”
- Selective inhibition of yeast regulons by daunorubicin: a transcriptome-wide analysis
Rojas, BMC genomics 2008 - “...NMD3 SPE3 YHR214C-C DED1 MOG1 TPS2 YNL212W YIR035C NOP12 SPE4 YIL127C DYN1 MRPL35 TRR2 YOL101C YLL023C NOP58 SSF1 YJR027W EHT1 MSF1' TSL1 YOR009W YLR112W NPI46 SSP120 YJR029W ENO1 MTF2 TUF1 YOR022C YLR356W NPT1 STS1 YKL014C ENO2 NCE102 UGP1 YOR062C YMR178W NRD1 SUI1 YKL054C ERG11 NCR1 URA1...”
- Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae
Arvas, BMC genomics 2006 - “...factor MBF1 13 3 1 17 HTA2 tre35558 histone H2A 9 4 1 2 16 YLL023C tre43299 putative ER membrane protein 10 5 15 pdi1 tre45146 ER-resident foldase 12 2 14 cip1 tre41957 esterase homologue 6 8 14 tre45203 Transcriptional coactivator p100 4 7 2 1...”
- A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation
Huang, Genetics 2005 - “...color) of the 12 wild-type controls (spo75, syn8, yll023c, yal068c, fun30, nup60, yal065c, tpo1, yll029w, yll020c, erv46, and cln3 (SGD, scope of this study,...”
- A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes
Stevenson, Proceedings of the National Academy of Sciences of the United States of America 2001 - “...content Stevenson et al. Phase increased TUB2 YCL028W YGR284C YIL041W YLL023C YLR057W YMR067C YNL224C Pre-M Early M Late M Late M Late M Late M None Late M %...”
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LOC104603094 transmembrane protein 33 homolog from Nelumbo nucifera
Aligns to 103:321 / 338 (64.8%), covers 75.5% of PF03661, 66.4 bits
- Gene Expression Profile in the Long-Living Lotus: Insights into the Heat Stress Response Mechanism
Liu, PloS one 2016 - “...LOC104587372 2.05 1.45E-02 glycine-rich cell wall structural protein - LOC104610879 2.82 5.88E-04 transmembrane protein Vacuole LOC104603094 1.74 8.42E-05 transmembrane protein Nucleus LOC104605640 2.49 3.68E-02 secretory carrier-associated membrane protein Plasma membrane LOC104608147 2.58 1.98E-02 extensin-2 Nucleus LOC104608452 3.73 1.99E-04 extensin-2 Secreted LOC104602657 1.80 1.83E-02 tetraspanin-6 Plasma membrane...”
Q9M898 AT3g02420/F16B3_5 from Arabidopsis thaliana
AT3G02420 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 113:327 / 348 (61.8%), covers 72.6% of PF03661, 59.1 bits
PVX_000960 secy-independent transporter protein, putative from Plasmodium vivax
Aligns to 85:308 / 315 (71.1%), covers 87.6% of PF03661, 37.9 bits
Or search for genetic data about PF03661 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory