Family Search for PF03661 (TMEM33_Pom33)
PaperBLAST, GapMind, SitesBLAST, and Sites on a Tree will be down for server maintenance on Friday March 29.
PF03661 hits 21 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
TMM33_MOUSE / Q9CR67 Transmembrane protein 33; Protein DB83 from Mus musculus (Mouse) (see paper)
Aligns to 7:245 / 247 (96.8%), covers 97.5% of PF03661, 336.8 bits
- function: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (PubMed:31048699). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity).
subunit: Interacts with EIF2AK3 (By similarity). Interacts with RTN1, RTN2, RTN3, RTN4 and ARL6IP1 (By similarity). Interacts with RNF5. Interacts with RNF26 (By similarity). Interacts with PKD2 (PubMed:31048699).
disruption phenotype: Deletion mice show renal protection against acute kidney injury (AKI).
TMM33_HUMAN / P57088 Transmembrane protein 33; Protein DB83; SHINC-3 from Homo sapiens (Human) (see 6 papers)
Aligns to 7:245 / 247 (96.8%), covers 97.5% of PF03661, 334.2 bits
- function: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis (PubMed:30760708). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (PubMed:34487377).
subunit: Interacts with EIF2AK3 (PubMed:26268696). Interacts with ARL6IP1, isoform RTN1-A of RTN1, isoform RTN2-B of RTN2, isoform 3 of RTN3 and isoform 3 of RTN4 (PubMed:25612671). Interacts with RNF5 (PubMed:34487377). Interacts with RNF26 (PubMed:32614325). Interacts with PKD2 (By similarity).
KRH2_DROME / Q9V447 Krueppel homolog 2; Protein Kr-h2 from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 30:268 / 276 (86.6%), covers 97.5% of PF03661, 314.3 bits
- function: Member of the dosage-dependent hierarchy effective upon white gene expression.
TTS1_SCHPO / Q9Y7Z5 Tetra-spanning protein 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 5:258 / 279 (91.0%), covers 93.3% of PF03661, 119.7 bits
- function: Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator.
subunit: Interacts with RTN1 and YOP1.
POM33_YEAST / Q12164 Pore membrane protein of 33 kDa from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
Aligns to 14:265 / 279 (90.3%), covers 95.4% of PF03661, 79.7 bits
- function: Contributes to proper distribution and/or efficient assembly of nuclear pores. Required for normal pore density in the daughter nucleus during telophase.
subunit: Interacts with RTN1.
PER33_YEAST / Q12144 Pore and endoplasmic reticulum protein of 33 kDa from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Aligns to 9:268 / 273 (95.2%), covers 92.9% of PF03661, 54.6 bits
Or search for genetic data about PF03661 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory