Family Search for PF03665 (UPF0172)
PF03665 hits 14 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
EMC8_HUMAN / O43402 ER membrane protein complex subunit 8; Neighbor of COX4; Protein FAM158B from Homo sapiens (Human) (see 6 papers)
Aligns to 3:202 / 210 (95.2%), covers 99.0% of PF03665, 221.9 bits
- function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N- terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
subunit: Component of the ER membrane protein complex (EMC) (PubMed:22119785, PubMed:29242231). EMC8 and EMC9 are mutually exclusive subunits of the EMC complex (PubMed:32459176, PubMed:32439656). - Proteomics analyses of human optic nerve head astrocytes following biomechanical strain
Rogers, Molecular & cellular proteomics : MCP 2012 - “...12% for 2 Hours Q96B97 Q92743 Q99584 Q15121 P02511 O43402 P25788 P63208 P54709 P18031 Q8TDX7 SH3K1 HTRA1 S10AD PEA15 CRYAB CX4NB PSA3 SKP1 AT1B3 PTN1 NEK7...”
- Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles.
Peterson, Proteomics 2008
O70378 ER membrane protein complex subunit 8 from Mus musculus
Aligns to 3:199 / 207 (95.2%), covers 99.0% of PF03665, 221.5 bits
- Proteomic Analysis of 3T3-L1 Adipocytes Treated with Insulin and TNF-α.
Chan, Proteomes 2019 - “...splicing factor 5 Srsf5 0.001389 + P02463 Collagen alpha-1(IV) chain Col4a1 0.001912 + + + O70378 ER membrane protein complex subunit 8 Emc8 0.003163 Q9ESW4 Acylglycerol kinase, mitochondrial Agk 0.003542 O35640 Annexin A8 Anxa8 0.003733 + + Q8BX10 Serine/threonine-protein phosphatase, mito. Pgam5 0.004051 + Q9WVA4 Transgelin-2...”
EMC89_DROME / Q9W1Y1 ER membrane protein complex subunit 8/9 homolog from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 3:192 / 203 (93.6%), covers 98.4% of PF03665, 212.2 bits
- function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized multi-pass membrane proteins like rhodopsins.
subunit: Component of the ER membrane protein complex (EMC).
XP_002522792 ER membrane protein complex subunit 8/9 homolog from Ricinus communis
Aligns to 8:202 / 204 (95.6%), covers 99.5% of PF03665, 198.9 bits
EMC9_HUMAN / Q9Y3B6 ER membrane protein complex subunit 9; Protein FAM158A from Homo sapiens (Human) (see 5 papers)
NP_057133 ER membrane protein complex subunit 9 isoform a from Homo sapiens
Aligns to 3:191 / 208 (90.9%), covers 100.0% of PF03665, 194.7 bits
- function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi- pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail- anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N- exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
subunit: Component of the ER membrane protein complex (EMC) (PubMed:22119785, PubMed:29242231, PubMed:32459176). EMC8 and EMC9 are mutually exclusive subunits of the EMC complex (PubMed:32459176). - Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis.
Zheng, Experimental eye research 2021 (PubMed)- GeneRIF: Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis.
- Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
Miller-Vedam, eLife 2020 - “...after R131; EMC6 Q9BV81), pBIG1c (EMC2 Q15006; EMC3 Q9P0I2-1; EMC7 Q9NPA0), pBIG1d (EMC8 O43402-1; EMC9 Q9Y3B6), pBIG1e (EMC10 Q5UCC4-1). These were subsequently combined into pBIG2abcde to yield a single expression vector containing all 10 hEMC subunits. Bacmid was generated in DH10 EMBacY E. coli and subsequently...”
AT5G55940 emb2731 (embryo defective 2731) (RefSeq) from Arabidopsis thaliana
Aligns to 10:206 / 208 (94.7%), covers 99.5% of PF03665, 189.8 bits
- Looking for a safe haven: tail-anchored proteins and their membrane insertion pathways
Mehlhorn, Plant physiology 2021 - “...At2g25310 AtEMC7 a ER membrane c PSI-BLAST, TAIR At4g32130 AtEMC7 b ER membrane c EMC8/9 At5g55940 EMB2731 ER membrane c PSI-BLAST, TAIR EMC10 Not found PSI-BLAST a Found annotated at TAIR (Arabidopsis.org) orif designated as unknown proteinour suggestion for future use. b Experimentally validated, see referenced...”
- Mediator of tolerance to abiotic stress ERF6 regulates susceptibility of Arabidopsis to Meloidogyne incognita
Warmerdam, Molecular plant pathology 2019 - “...At5G55840 22602265 G:T 17:332 4.3 8.07 At5G55840 19 5 22668012 A:G 63:286 4.9 5.24 At5G55970 At5G55940, At5G55950, At5G55960, At5G55970, At5G55980, At5G55990, At5G56000, At5G56010, At5G56020, At5G56030 At5G56040 22683923 C:G 31:318 4 5.72 At5G56010 22684613 C:T 29:320 4.1 5.89 At5G56020 *QTL1 to QTL4 have been identified previously (Warmerdam...”
- Modulation of the light-harvesting chlorophyll antenna size in Chlamydomonas reinhardtii by TLA1 gene over-expression and RNA interference
Mitra, Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012 - “...a lipid. Interestingly, the TLA1 homologue in Arabidopsis (AT5G55940) was predicted to be localized in the endoplasmic reticulum (ER) [61]. For many years, all...”
- Transcriptional profiling analysis in Populus yunnanensis provides insights into molecular mechanisms of sexual differences in salinity tolerance
Jiang, Journal of experimental botany 2012 - “...substances 1.46 1.68 eugene3.01470017 AT4G31480 F3L17.50; binding, clathrin binding, structural molecule activity 1.18 1.08 estExt_fgenesh4_pm.C_LG_I1158 AT5G55940 EMB2731; molecular function unknown 3.85 3.27 gw1.VII.1749.1 AT4G39970 T5J17.140; catalytic activity, hydrolase activity 2.3 1.25 estExt_fgenesh4_pm.C_LG_VI0047 AT4G16480 INT4; carbohydrate transmembrane transporter activity, myo-inositol:hydrogen symporter activity, sugar:hydrogen symporter activity 1.01 1.08...”
XP_001697758 uncharacterized protein from Chlamydomonas reinhardtii
Aligns to 4:200 / 213 (92.5%), covers 99.0% of PF03665, 181.1 bits
NP_001135760 ER membrane protein complex subunit 8 isoform 2 from Homo sapiens
Aligns to 3:126 / 126 (98.4%), covers 59.1% of PF03665, 151.1 bits
PF3D7_1139900 ER membrane protein complex subunit 8, putative from Plasmodium falciparum 3D7
Aligns to 5:193 / 198 (95.5%), covers 99.0% of PF03665, 149.4 bits
CNAG_03380 hypothetical protein from Cryptococcus neoformans var. grubii H99
Aligns to 5:199 / 208 (93.8%), covers 99.0% of PF03665, 117.3 bits
- Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta
Do, Mycobiology 2019 - “...dehydrogenase CNAG_03325 ChAPs family protein CNAG_03333 Cytoplasmic protein CNAG_03348 Hypothetical protein CNAG_03370 Calcium-binding protein NCS-1 CNAG_03380 Hypothetical protein CNAG_03528 AP-2 complex subunit alpha CNAG_04174 PEX6 Peroxin-6 CNAG_04388 SOD2 Mitochondrial manganese superoxide dismutase CNAG_04450 Chromodomain-helicase-DNA-binding protein 1 CNAG_04678 YPK1 Protein kinase CNAG_04751 Hypothetical protein CNAG_04804 SRE1 Sterol...”
TGME49_249310 hypothetical protein from Toxoplasma gondii ME49
2 alignments in 51:301 / 337 (67.7%), covering up to 59.6% of PF03665, 111.5 bits
AT5G51620 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 1:66 / 68 (97.1%), covers 19.7% of PF03665, 31.9 bits
- Alternative Splicing Regulation of Glycine-Rich Proteins via Target of Rapamycin-Reactive Oxygen Species Pathway in Arabidopsis Seedlings Upon Glucose Stress
Du, Frontiers in plant science 2022 - “...regulation might happen through glucose-GRP7-LAF3 regulatory module. Besides, another one of the 12 target genes, AT5G51620 encoding an unknown function protein (UPF0172), was also identified to exhibit AS change upon glucose stress by RT-PCR ( Supplementary Figure 8C ). Its biological function and its correlation with...”
- “...by RIP/iCLIP and DSGs controlled by grp7 8i . (B,C) AS events of LAF3 and AT5G51620 in WT_Ctr and WT_Glc samples. The left panels show the gene model, AS isoforms, and IGV coverage diagrams for each tested gene; the right panel shows the confirmation results of...”
- The plant microtubule-associated protein AtMAP65-3/PLE is essential for cytokinetic phragmoplast function
Müller, Current biology : CB 2004 - “...could be further narrowed to 10 kb, and this included three genes, At5g51600, At5g51610, and At5g51620 ( Figure 3B ). By using a combination of heteroduplex analysis and sequencing, we confirmed the At5g51600 open reading frame. PLE has 11 introns ( Figure 3C ); the transcriptional...”
6fjuA / E6N8B9 Rpn11 homolog from caldiarchaeum subterraneum (see paper)
Aligns to 3:159 / 176 (89.2%), covers 63.2% of PF03665, 30.0 bits
E6N8B9 26S proteasome regulatory subunit N11-like protein from Caldiarchaeum subterraneum
Aligns to 2:144 / 202 (70.8%), covers 63.2% of PF03665, 29.4 bits
- Proteolytic systems of archaea: slicing, dicing, and mincing in the extreme
Maupin-Furlow, Emerging topics in life sciences 2018 - “...JAMM1 (Q8U1Y4) [ 61 ]; Af JAMM (O28085) [ 179 , 180 ]; Cs Rpn11 (E6N8B9) [ 63 ] Methionine aminopeptidase (MAP) [M24A, EC 3.4.11.18] Intracellular 2dfi, 1wkm, 1xgm, 1xgs, 1xgn,1xgo Pf MAP (P56218) [ 181 ] [ 69 ]; Tn MAP (B6YTG0) [ 70 ]...”
Or search for genetic data about PF03665 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory