Family Search for PF03691 (UPF0167)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF03691 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

YieJ / b3717 UPF0167 family colicin E2 tolerance protein CbrC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
CBRC_ECOLI / P31469 UPF0167 protein CbrC; CreB-regulated gene C protein from Escherichia coli (strain K12) (see paper)
NP_418173 PF03691 family colicin E2 tolerance protein CbrC from Escherichia coli str. K-12 substr. MG1655
b3717 hypothetical protein from Escherichia coli str. K-12 substr. MG1655
Aligns to 8:194 / 195 (95.9%), covers 100.0% of PF03691, 234.3 bits

• YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli.
  Cariss, Journal of bacteriology 2010
  • GeneRIF: Data show that overexpression of another CreBC-regulated gene, yieJ (also known as cbrC), causes the Cet2 phenotype.
• About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature
  Tantoso, Biology direct 2023
  • “...( casC/ GF_9628), b2782 ( mazF /GF_2500), b3501 ( arsR /GF_510), b3531 ( bcsZ /GF_9943), b3717 ( cbrC /GF_3491), b4011 ( yjaA /GF_20677), b4031 ( xylE /GF_10135), b4348 ( hsdS /GF_3705), and b4351 ( mrr /GF_10255). Similarly, 32 intensively studied GFs from the softcore genome do...”
• Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling
  O'Rourke, Antimicrobial agents and chemotherapy 2020
  • “...signature included yjbFG (b4027 and b4028), ymgDG (b1171 and b1172), and cbrABC (b3690, b3716, and b3717). FIG 3 Unsupervised clustering. (A) Hierarchical clustering analysis of 37 antimicrobial-induced transcriptomes identified three distinct gene signatures. Gene expression fold change values (log 2 ) are shown with genes as...”
  • “...signature included yjbFG (b4027 and b4028), ymgDG (b1171 and b1172), and cbrABC (b3690, b3716, and b3717), which have putative functions in exopolysaccharide biosynthesis, biofilm modulation, and bacteriocin resistance, respectively ( 21 , 22 ). The RcsAB transcription complex regulates capsule biosynthesis ( wca ), biofilm formation...”
• YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli
  Cariss, Journal of bacteriology 2010
  • “...creD 50.6 b1330 ynaI 37.4 b3690 yidS 34.5 b1329 mppA 15.6 b3717 b0218 yieJ yafU 14.1 6.8 b0210 yafE 3.4 b1420 mokB 3.2 a P value (103)c 0.001 0.001 0.01 0.002...”
• Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)
  González, Journal of bacteriology 2006
  • “...ais yraI ytfK ycgW yciE yidS ybbY yciF yahO yjcH ydcV b3717 b1511 b2252 b3143 b4217 b1160 b1257 b3690 b0513 b1258 b0329 b4068 b1443 yncG spf yjcO ymgB ymgC yeaQ...”
• Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system
  Nishino, Journal of bacteriology 2005
  • “...sulA b4037 b4036 b2615 b3716 b2076 b4355 b2078 b3035 b3717 b0399 b2267 b2989 b1886 b1923 b3128 b1885 b3126 b1884 b3690 b2473 b4105 b4033 b0958 aroF b2601 flgL...”

Y2295_MYCTU / P9WFL7 UPF0167 protein Rv2295 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Aligns to 12:186 / 187 (93.6%), covers 100.0% of PF03691, 222.6 bits

• function: Probably plays a role in host phagosome maturation arrest (PubMed:20844580).
  disruption phenotype: Grows normally in liquid culture, traffics into host (human and mouse) acidified compartments early after phagocytosis, suggesting it no longer arrests phagosome maturation as well as wild- type, impaired growth in mouse macrophages (PubMed:20844580).

Rv2295 hypothetical protein from Mycobacterium tuberculosis H37Rv
Aligns to 37:211 / 212 (82.5%), covers 100.0% of PF03691, 222.0 bits

• Screening Mycobacterium tuberculosis Secreted Proteins Identifies Mpt64 as a Eukaryotic Membrane-Binding Bacterial Effector
  Stamm, mSphere 2019
  • “...bound eukaryotic membranes and identified five proteins with overlapping activities: Rv0594, Rv1646, Rv1810, Rv1980c, and Rv2295 ( Fig.3D ). During expression in HeLa cells, all but one protein localized to the ER, and all five proteins reduced hGH release ( Fig.3E ). FIG3 M. tuberculosis secreted...”
• High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
  Brodin, PLoS pathogens 2010
  • “...Rv1506c (211) Methyltransferase 833 321 P65B12 lppM (272) Lipoprotein of unknown function 835 332 P1E07 Rv2295 (-35) Unknown 624 70.5 P58C04 fadD28 (1252) DIM biosynthesis 913 00 P32E07 moaC1 (507) Molybdopterin biosynthesis 692 00 P36D07 moaD1 (49) Molybdopterin biosynthesis 722 00 P55C04 ppe54 (1126) Unknown 556...”
  • “...(1653-1697) Rv1446-506c P2E07 Rv1506c (Rv1506c) IE586 (1653-1697) Rv1446-506c P65B12 lppM (Rv2171) I135 (2409-2442) Rv2151c-78 P1E07 Rv2295 (Rv2295) I238 (2563-2599) Rv2264c-98 P58C04 fadD28 (Rv2941) I49 (3258-3292) Rv2934-45c P32E07 moaC1 (Rv3111) I528 (3454-3485) Rv3088-117 P36D07 moaD1 (Rv3112) I528 (3454-3485) Rv3088-117 P55C04 ppe54 (Rv3343c) I275(3729-3761) Rv3343c-9c P39E07 Rv3880c (Rv3880c)...”
• Phylogenetic detection of horizontal gene transfer during the step-wise genesis of Mycobacterium tuberculosis
  Veyrier, BMC evolutionary biology 2009
  • “...63.4 Y Rv1673c/74c transglutaminase-like/ArsR 64 N Rv2003c, Rv2008c and Rv2011c Methyltransferase/ATPase, AAA+/H.P. GI4 NA Y Rv2295 H.P. 64.5 N Rv2336/37c/38c Molybdoterine thyamine synthesis (38c: in vitro ) 58.8 N Rv2432c/33c H.P. 63.8 N Rv2491/92 H.P. 54.8 Y Rv2735 H.P. 56.5 Y Rv2804c and Rv2816c to Rv2826c...”

Or search for genetic data about PF03691 in the Fitness Browser