Family Search for PF03891 (DUF333)

PF03891 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

A1S_1321 putative hemolysin (RefSeq) from Acinetobacter baumannii ATCC 17978
Aligns to 31:77 / 144 (32.6%), covers 93.8% of PF03891, 81.8 bits

• Using comparative genomics to understand molecular features of carbapenem-resistant Acinetobacter baumannii from South Korea causing invasive infections and their clinical implications
  Kim, PloS one 2020
  • “...22(100) 1 50(92.6) 39(88.6) 0.37 A1S_1180 46(10) 13(100) 1 37(100) 22(100) 1 54(100) 44(100) 1 A1S_1321 45(97.8) 13(100) 0.78 36(97.3) 22(100) 0.63 53(98.1) 44(100) 0.55 A1S_1386 46(10) 13(100) 1 37(100) 22(100) 1 54(100) 44(100) 1 A1S_1510 46(10) 13(100) 1 37(100) 22(100) 1 53(98.1) 44(100) 0.55 A1S_1921...”
• Identification of novel regulatory small RNAs in Acinetobacter baumannii
  Sharma, PloS one 2014
  • “...of AbsR25 sRNA predicted by bioinformatic approaches is 333 nts and the location is between A1S_1321 and A1S_1322 genes, encoding putative hemolysin and dihydro-dipicolinate synthetase respectively. Northern blotting and RACE mapping showed that the transcript of AbsR25 sRNA was about 164 nts ( Figure S1 )....”
• Acinetobacter baumannii secretes cytotoxic outer membrane protein A via outer membrane vesicles
  Jin, PloS one 2011
  • “...( n =57). Virulence-associated proteins, including AbOmpA, CsuA/B (A1S_2218), CsuC (A1S_2215), CsuD (A1S_2214), putative hemolysin (A1S_1321), putative serine protease (A1S_2525), Cu/Zn superoxide dismutase (A1S_3143), fimbrial protein (A1S_1510), bacterioferritin (A1S_3175), RND superfamily transporter (A1S_0116), putative RND type efflux pump (A1S_0009), and putative protease (A1S_2470), were found in...”

ABAYE2389 hypothetical protein (RefSeq) from Acinetobacter baumannii AYE
B0VB25 DUF333 domain-containing protein from Acinetobacter baumannii (strain AYE)
Aligns to 31:77 / 144 (32.6%), covers 93.8% of PF03891, 79.7 bits

• A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins
  Acar, Frontiers in immunology 2022
  • “...bamD Cell outer membrane Gram-negative-bacterium-type cell outer membrane assembly 25. B0VB25 Uncharacterized protein 15,778 144 ABAYE2389 26. B0V5U8 Putative membrane-bound lytic murein transglycosylase 46,973 430 ABAYE3869 27. B0VDR4 Uncharacterized protein 366,110 3,369 ABAYE0821 Calcium ion binding 28. A0A0R4J8Q3 Peptidyl-prolyl cis-trans isomerase 25,601 235 fklB Membrane Peptidyl-prolyl...”
• Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii
  Moriel, PloS one 2013
  • “...Unknown SpII Alpha/beta hydrolase (PF12697) ABAYE2043 - + Metallopeptidase 678 Unknown SpI Metalloprotease M3 (PF01432) ABAYE2389 + + Hypothetical protein 145 Unknown SpII DUF (PF03891), hemolysin-like ABAYE2590 - + Hypothetical protein 260 Unknown SpII Metalloprotease M48 (PF01435) ACICU_01891 + - RTX toxin 1451 EC - Hemolysin...”
• A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins
  Acar, Frontiers in immunology 2022
  • “...assembly factor BamD 42,829 385 bamD Cell outer membrane Gram-negative-bacterium-type cell outer membrane assembly 25. B0VB25 Uncharacterized protein 15,778 144 ABAYE2389 26. B0V5U8 Putative membrane-bound lytic murein transglycosylase 46,973 430 ABAYE3869 27. B0VDR4 Uncharacterized protein 366,110 3,369 ABAYE0821 Calcium ion binding 28. A0A0R4J8Q3 Peptidyl-prolyl cis-trans isomerase...”

ABUW_2554 I78 family peptidase inhibitor from Acinetobacter baumannii
Aligns to 31:77 / 144 (32.6%), covers 93.8% of PF03891, 79.7 bits

• In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
  Wu, Nature communications 2016
  • “...with metabolic enzymes including superoxide dismutase SodC, pathogenesis-related proteins including entericidin EcnB, two haemolysin-like proteins (ABUW_2554 and ABUW_2845) and four uncharacterized proteins including ABUW_1536, ABUW_2143, ABUW_2336 and ABUW_2898. Phyre2 homology modelling 50 further identified that ABUW_2898 contains an 18-stranded -barrel structure homologous to capsule protein Wzi...”

VCA0594 hemolysin (NCBI ptt file) from Vibrio cholerae O1 biovar eltor str. N16961
Aligns to 43:89 / 93 (50.5%), covers 100.0% of PF03891, 77.5 bits

• Structural and Proteomic Changes in Viable but Non-culturable Vibrio cholerae
  Brenzinger, Frontiers in microbiology 2019
  • “...these, only the putative hemolysin secretion protein VC0199, a putative hemolysin (VC0578), the hemolysin Hlx VCA0594 and the T2SS proteins EpsCEFGL were found with a slightly increased abundance in VBNC cells ( Figure 4 ). Figure 4 Relative protein abundances of proteins associated with pathogenicity. Depicted...”
• A bistable switch and anatomical site control Vibrio cholerae virulence gene expression in the intestine
  Nielsen, PLoS pathogens 2010
  • “...tcpP (VC0826), hapR (VC0583), tcpH (VC0827), toxS (VC0983), cyaA (VC0122), hapA (VCA0865), hlyA (VCA00219), hlx (VCA0594), cheA1 (VC1397), cheA2 (VC02063), cheA3 (VCA1095) and rrnB (E. coli b3968). Supporting Information Figure S1 V. cholerae rpoS fails to down regulate tcpA expression and to detach from epithelium. The...”
• The Vibrio cholerae flagellar regulatory hierarchy controls expression of virulence factors
  Syed, Journal of bacteriology 2009
  • “...activity (14); an additional hemolysin gene (hlx; VCA0594) (45); the gene encoding the chitin-binding protein GbpA (VCA0811), which mediates binding to...”
  • “...are upregulated in the flagellar mutants: VCA0218, VCA0219, and VCA0594 (Fig. 2B; see also Table S1 in the supplemental material). VCA0219 encodes the "El Tor"...”

SC1286 putative hemolysin (NCBI) from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67
STM1275 putative hemolysin (NCBI ptt file) from Salmonella typhimurium LT2
Aligns to 31:77 / 83 (56.6%), covers 100.0% of PF03891, 72.4 bits

• SMM-system: A mining tool to identify specific markers in Salmonella enterica
  Yu, Journal of microbiological methods 2011 (PubMed)
  • “...generated specific amplicons with a size of 180bp (SC1286), 238bp (SC1598) and 405bp (SC4361), respectively. This study demonstrates that SMM-system is a...”
  • “...Fig.5 Multiplex PCR assay targeting SC4361 , SC1598 and SC1286 genes in S. enterica that produced amplicons of 180 bp, 238 bp and 405 bp, respectively. M,...”
• Salmonella enterica highly expressed genes are disease specific
  Rollenhagen, Infection and immunity 2006
  • “...STM1330 STM1672 PSLT046 STM1633 STM1088 STM0617 STM3195 STM1275 STM0701 STM2666 STM1224 STM0972 STM1583 STM2875 STM2328 STM1269 mig-5 Gene First locusa TABLE...”

YoaF / b1793 DUF333 domain-containing lipoprotein YoaF from Escherichia coli K-12 substr. MG1655 (see paper)
b1793 conserved outer membrane protein (NCBI) from Escherichia coli str. K-12 substr. MG1655
Aligns to 32:78 / 84 (56.0%), covers 100.0% of PF03891, 72.2 bits

• A screening pipeline identifies a broad-spectrum inhibitor of bacterial AB toxins with cross protection against influenza A virus H1N1 and SARS-CoV-2
  Wu, 2021
• MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate.
  Gutierrez-Prat, Proceedings of the National Academy of Sciences of the United States of America 2021 (secret)
• Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy
  Iqbal, Autophagy 2021 (secret)

NMBNZ0533_0823 DUF333 domain-containing protein from Neisseria meningitidis NZ-05/33
Aligns to 1:47 / 48 (97.9%), covers 95.8% of PF03891, 71.0 bits

• Genomic, Transcriptomic, and Phenotypic Analyses of Neisseria meningitidis Isolates from Disease Patients and Their Household Contacts.
  Ren, mSystems 2017
  • “...between all three carriage-associated isolates, compared to NZ97/192, was a conserved hypothetical protein encoded by NMBNZ0533_0823. This gene encodes a small protein with a putative hemolysin domain. However, this predicted open reading frame (ORF) was of low quality and, like many of the transcripts predicted to...”

Z2835 orf, hypothetical protein (NCBI ptt file) from Escherichia coli O157:H7 EDL933
Aligns to 32:78 / 84 (56.0%), covers 95.8% of PF03891, 70.2 bits

• Characterizing the Escherichia coli O157:H7 proteome including protein associations with higher order assemblies
  Pieper, PloS one 2011
  • “...L (no hydr LS) unkn 858 0 MKAC 44 S 2 conserved membrane lipoprotein YoaF Z2835 yoaF 8899 L (IM or OM) unkn 853 0 LAGC 17 S 2 predicted lipoprotein YceB Z1700 yceB 20469 L (IM or OM) unkn 833 67 LVGC 19 N 3*...”

VPA0257 hemolysin (NCBI ptt file) from Vibrio parahaemolyticus RIMD 2210633
FORC22_3317 DUF333 domain-containing protein from Vibrio parahaemolyticus
Aligns to 33:79 / 86 (54.7%), covers 97.9% of PF03891, 70.0 bits

• iTRAQ-based proteomic profiling of Vibrio parahaemolyticus under various culture conditions
  Yang, Proteome science 2015
  • “...11 general secretion pathway proteins. Other virulence related proteins such as three hemolysins(GN VP0730, VP2536, VPA0257) and regulator proteins Hfq and rsmA were also significantly identified. Protein quantification and differentiation analysis Proteins with iTRAQ ratios <0.50 or >2.0, p <0.05 were considered significantly different in protein...”
  • “...this study. Three hemolysin proteins including putative hemolysins (GN VP0730, GN VP2536) and hemolysin (GN VPA0257) were identified, although TDH production was reported to be affected by environmental factors, such as pH, temperature, and chemicals [ 40 , 41 ], but significant differences in abundance have...”
• Potential Survival and Pathogenesis of a Novel Strain, Vibrio parahaemolyticus FORC_022, Isolated From a Soy Sauce Marinated Crab by Genome and Transcriptome Analyses
  Chung, Frontiers in microbiology 2018
  • “...ORFs encoding various hemolysin genes (FORC22_0344, FORC22_0414, FORC22_1716, FORC22_2576, and FORC22_3059 in chromosome I; FORC22_3287, FORC22_3317, and FORC22_3346 in chromosome II) were detected; these genes may be responsible for the virulence of the FORC_022 strain. In addition, various secretion systems including types I, II, III, IV,...”

NGO0350 hypothetical protein (NCBI) from Neisseria gonorrhoeae FA 1090
Aligns to 23:70 / 71 (67.6%), covers 97.9% of PF03891, 69.3 bits

• Global Network Analysis of Neisseria gonorrhoeae Identifies Coordination between Pathways, Processes, and Regulators Expressed during Human Infection.
  McClure, mSystems 2020
  • “...putative membrane protein), NGO1518, NGO0791 (containing a domain with lipoic acid-binding regulatory protein homology), and NGO0350 (containing a domain with hemolysin binding homology). Degree and betweenness values for all genes in the network are shown in TableS2 . We also examined what processes in N. gonorrhoeae...”

M892_26640 DUF333 domain-containing protein from Vibrio campbellii ATCC BAA-1116
Aligns to 33:79 / 86 (54.7%), covers 95.8% of PF03891, 63.5 bits

• Vibrio campbellii hmgA-mediated pyomelanization impairs quorum sensing, virulence, and cellular fitness
  Wang, Frontiers in microbiology 2013
  • “...protein Hfq 1.46E-06 2.94 1.96 1.50 R M892_18180 Ecotin precursor 6.37E-05 1.51 0.99 1.53 R M892_26640 Hemolysin 6.13E-08 1.93 0.54 3.57 R M892_05800 Lipoprotein-related protein 6.13E-08 1.20 0.24 5.00 S M892_08695 Hypothetical protein 3.42E-05 1.09 0.40 2.73 S M892_13325 Hypothetical protein 4.02E-07 3.90 1.96 1.99 S...”
  • “...down-regulation of several virulence factors in hmgA . However, with the exception of two [hemolysin (M892_26640) and azurin (M892_25430)], the genes encoding these factors were not differentially expressed suggesting that the decreased virulence potential of hmgA was not caused by an overt down-regulation of accepted virulence...”

YdbJ / b4529 DUF333 domain-containing protein YdbJ from Escherichia coli K-12 substr. MG1655 (see paper)
b4529 hypothetical protein (NCBI) from Escherichia coli str. K-12 substr. MG1655
Aligns to 37:84 / 88 (54.5%), covers 95.8% of PF03891, 53.2 bits

• Genomic SELEX for Hfq-binding RNAs identifies genomic aptamers predominantly in antisense transcripts
  Lorenz, Nucleic acids research 2010
  • “...cvrA b1191 Sense Predicted cation/proton antiporter 1044 157 1 439 032 1 439 135 ydbJ b4529 Antisense Predicted protein 1277 149 3 199 820 3 199 959 ygiM; cca b3055; b3056 Antisense; antisense Predicted signal transduction protein (SH3 domain); fused tRNA nucleotidyl transferase/23-cyclic phosphodiesterase/2-nt and phosphatase...”

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