Family Search for PF04019 (DUF359)

PF04019 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

rrnAC2831 unknown from Haloarcula marismortui ATCC 43049
Aligns to 2:124 / 136 (90.4%), covers 99.2% of PF04019, 138.7 bits

• Genome information management and integrated data analysis with HaloLex
  Pfeiffer, Archives of microbiology 2008
  • “...NP1576A rrnAC2818 1,344 1,479 Shortened NP2252A, HQ3104A, OE3882R rrnAC2822 951 309 Extended NP2248A, OE3879F, HQ3106A rrnAC2831 540 411 Extended NP5076A, HQ1339A, OE3871R rrnAC2834 1,032 1,677 Shortened NP1066A, OE4144R, HQ1407A rrnAC2836 1,206 1,359 Shortened HQ2439A, NP3538A rrnAC2851 744 786 Shortened NP0554A, OE4165R, HQ3686A rrnAC2857 2,196 2,238 Shortened...”

PAB1106 hypothetical protein from Pyrococcus abyssi GE5
Aligns to 51:173 / 179 (68.7%), covers 100.0% of PF04019, 135.6 bits

• Phylogenomic analysis of proteins that are distinctive of Archaea and its main subgroups and the origin of methanogenesis
  Gao, BMC genomics 2007
  • “...regulator COG1709 PAB1633 [NP_126790] PilT ATPase COG1855 PAB1040 [NP_127251] SpoU CDD6631 PAB1716 [NP_126666] NMD3 CDD16276 PAB1106 [NP_127361] CDD9578 PAB2291 [NP_125771] CDD6629 PAB1706 [NP_126677] COG1634 PAB0018a [NP_125721] RNA binding COG2888 PAB2062 [NP_126118] CDD16190 PAB0075 1 [NP_125817] dehydratase CDD23288 PAB2104 [NP_126058] HTH COG1395 (b) Archaea-specific proteins with gene...”

Q5JIY7 GTP-dependent dephospho-CoA kinase (EC 2.7.1.237) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
DPCKG_THEKO / Q5JIY7 GTP-dependent dephospho-CoA kinase; Dephospho-coenzyme A kinase; DPCK; EC 2.7.1.237 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see 2 papers)
Q5JIY7 dephospho-CoA kinase (EC 2.7.1.24) from Thermococcus kodakarensis (see paper)
TK1697 hypothetical protein from Thermococcus kodakaraensis KOD1
Aligns to 50:171 / 177 (68.9%), covers 100.0% of PF04019, 134.9 bits

• function: Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA) (PubMed:31337720, PubMed:38235908). Can also use UTP, with lower efficiency and has weak activity with ATP, but shows a strong preference for GTP as the phosphate donor (PubMed:31337720).
  catalytic activity: 3'-dephospho-CoA + GTP = GDP + CoA + H(+) (RHEA:61156)
  subunit: Monomer in solution.
  disruption phenotype: Disruption of the gene results in CoA auxotrophy.
• Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea
  Shimosaka, mBio 2019
  • “...fused to PPAT and standalone, could be the missing archaeal DPCKs. We purified the recombinant TK1697 protein, a standalone member of arCOG04076 from T. kodakarensis , and demonstrated its GTP-dependent DPCK activity. Disruption of the TK1697 resulted in CoA auxotrophy, indicating that TK1697 encodes a DPCK...”
  • “...kodakarensis are noted in parentheses. The reaction catalyzed by the novel DPCK encoded by the TK1697 gene is indicated in red, along with the genes (TK0517 and TK2128) evaluated in this study. THF, tetrahydrofolate. Other abbreviations are defined in the text. Until recently, the pathway for...”

8jvfA / Q5JIY7 Crystal structure of dephospho-coenzyme a kinase (see paper)
Aligns to 51:136 / 136 (63.2%), covers 61.7% of PF04019, 110.5 bits

• Ligand: guanosine-5'-triphosphate (8jvfA)

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