Family Search for PF04190 (DUF410)
PF04190.13 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
GET4_YEAST / Q12125 Golgi to ER traffic protein 4; Guided entry of tail-anchored proteins 4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
TC 3.A.21.1.1 / Q12125 Golgi to ER traffic protein 4, component of The C-terminal Tail-anchored (TA) membrane protein biogenesis/ insertion complex, Get1/Get2/Get3 (Stefer et al., 2011; Kubota et al. 2012; Wang et al. 2014). The ATPase (Get3) is homologous to ArsA of the arsenite exporters (Castillo and Saier, 2010). Get1 and Get2 but not Get3 are required for mitochondrial autophagy, either because of a requirement for Get1/2-dependent TA protein(s), or because the Get1/2 complex itself acts specifically in mitophagy from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
NP_014807 Get4p from Saccharomyces cerevisiae S288C
YOR164C Protein of unknown function; interacts with Mdy2p (RefSeq) from Saccharomyces cerevisiae
Aligns to 46:308 / 312 (84.3%), covers 100.0% of PF04190, 269.0 bits
- function: May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
subunit: Interacts with MDY2/GET5. - substrates: proteins
- Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2
Lee, Experimental & molecular medicine 2014 - “...1.571 O15347 HMGB3 High mobility group protein B3 1.571 A5D7K0 BLVRA Biliverdin reductase A 1.565 Q12125 GET4 Isoform 2 of Golgi to ER traffic protein 4 homolog 1.552 P35659 DEK Protein DEK 1.547 Q96CD2 PPCDC Isoform 1 of Phosphopantothenoylcysteine decarboxylase 1.547 P31949 S100-A11 Protein S100-A11 1.541...”
- Exploring hierarchical and overlapping modular structure in the yeast protein interaction network
Liu, BMC genomics 2010 - “...transcription P38768 13.03 RNA metabolic process P38182 23.45 vesicle-mediated transport P53094 13.03 RNA metabolic process Q12125 23.45 vesicle-mediated transport P53212 13.03 RNA metabolic process Q04562 20.50 vesicle-mediated transport P53952 13.03 RNA metabolic process Q12327 20.50 vesicle-mediated transport The Swiss-Prot ID of proteins is listed in the...”
- Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance
Xing, Proceedings of the National Academy of Sciences of the United States of America 2017 - “...348 NP_004618 NP_057033 AAT93183 354 NP_011495 NP_014807 XP_004368068 330 XP_004353131 XP_004367722 XP_003289495 330 Not found XP_003283186 NP_563640...”
- Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum.
Chang, The Journal of biological chemistry 2012 - GeneRIF: Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum
- Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex.
Chartron, The Journal of biological chemistry 2012 - GeneRIF: Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex.
- A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex.
Chartron, The Journal of biological chemistry 2011 - GeneRIF: a structural model of the Sgt2-Get4/Get5-HSC complex.
- Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1.
Chang, The Journal of biological chemistry 2010 - GeneRIF: the Get4-Get5 complex interacts with Sgt2, Get3, and Ydj1
- Structural characterization of the Get4/Get5 complex and its interaction with Get3.
Chartron, Proceedings of the National Academy of Sciences of the United States of America 2010 - GeneRIF: Data provide further evidence for a model in which Get4/5 operates upstream of Get3 and mediates the specific delivery of a TA substrate.
- Analysis of tail-anchored protein translocation pathway in plants
Manu, Biochemistry and biophysics reports 2018 - “...A2YAC8 M0ZME5 Get2 YER083C Get3 YDL100C M1AE77 B8BDK7 M1A99 A28V0 M0ZFY4 B8AIG1 M1AND2 M0ZJQ4 Get4 YOR164C B8ADF2 M1ACL9 Get5 Q12285 3.10 Structural analysis of GET pathway members in O. sativa and S. tuberosum To extend the understanding of GET pathway in O. sativa and S. tuberosum...”
- A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology
Ricarte, PloS one 2011 - “...Cytosolic small ribosomal subunit ENV7 (YPL236C) Unknown Protein serine/threonine kinase activity Fungal-type vacuole membrane GET4/ENV8 (YOR164C) Posttranslational protein targeting to membrane; protein insertion into ER membrane Unknown Cytoplasm ENV9 (YOR246C) Unknown Oxidoreductase activity Lipid particle ENV10 (YLR065C) Unknown Unknown unknown ENV11 (YGR071C) Unknown Unknown Nucleus VPS...”
- Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1
Chang, The Journal of biological chemistry 2010 - “...chemicals may be scored and clustered together. MDY2 and YOR164C are the two genes that have the highest score for homozygous co-sensitivity with SGT2. The...”
- “...but details of the interaction between Sgt2 and Yor164c have not been elucidated. Interestingly, the genes showing co-sensitivity with MDY2 and YOR164C are...”
- Structural characterization of the Get4/Get5 complex and its interaction with Get3
Chartron, Proceedings of the National Academy of Sciences of the United States of America 2010 - “...that are the subjects of this study. Get4 [yeast locus Yor164c, human locus C7orf20 and cee in fish (16)] is a highly conserved protein that is estimated to...”
- Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control
Copic, Genetics 2009 - “...YIL039W YOR154W YGL020C YJL077C YDL100C YMR214W YHR078W YOR164C YER083C YGL228W YBL082C YBR276C YJL183W YLR087C YBR106W YNL080C YHR181W YLR268W YDR310C YLR065C...”
- “...SGA YMR214W Scj1 SGA SGA YHR078W ORF cross/SGA SGA YOR164C ORF cross/SGA SGA YER083C Get2 SGA SGA YGL228W She10 cross/SGA SGA YBL082C Alg3 SGA SGA YBR276C Pps1...”
- Uncovering biological network function via graphlet degree signatures
Milenković, Cancer informatics 2008 - “...PRM1 (YNL279W) 6 DIP 4 1 Metabolism 2 66.67% 33.33% Biogenesis of cellular components 2 YOR164C 6 DIP 6 2 Biogenesis of cellular components 3 75.00% 25.00% YOR220W 6 DIP 5 2 Protein with binding function or cofactor requirement (structural or catalytic) 3 100.00% 0.00% Cellular...”
- Cophenetic correlation analysis as a strategy to select phylogenetically informative proteins: an example from the fungal kingdom
Kuramae, BMC evolutionary biology 2007 - “...YIL083c inviable IX 0.90 KOG3111 YJL121c viable X 0.89 KOG3800 YDR460w inviable IV 0.89 KOG3024 YOR164c viable XV 0.89 KOG0816 YKL009w viable XI 0.89 KOG2905 YGR005c inviable VII 0.89 KOG3013 YHR069c inviable VIII 0.89 KOG1416 YNL062c inviable XIV 0.88 KOG2299 YNL072w viable XIV 0.88 KOG3045 YDR083w...”
- Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes
Fleischer, Genes & development 2006 - “...J. Maddock, unpubl.). Lastly, TMA24 interacted with YOR164C, an uncharacterized protein. Additional proteins with high PAFs and RAFs were identified, including...”
- “...YHR121W YGR178C YER007C-A YJR014W YER007C-A YJR014W YOL111C YOR164C YOL111C YOR164C YAL036C YOR091W YAL036C YOR091W LSM12 PBP1 PBP4 PBP4 LSM12 PBP1 TMA20...”
F1LXF5 Guided entry of tail-anchored proteins factor 4 from Rattus norvegicus
Aligns to 59:309 / 330 (76.1%), covers 100.0% of PF04190, 255.8 bits
Q9D1H7 Golgi to ER traffic protein 4 homolog from Mus musculus
Aligns to 56:306 / 327 (76.8%), covers 100.0% of PF04190, 254.8 bits
GET4_HUMAN / Q7L5D6 Golgi to ER traffic protein 4 homolog; Conserved edge-expressed protein; Transmembrane domain recognition complex 35 kDa subunit; TRC35 from Homo sapiens (Human) (see 6 papers)
NP_057033 Golgi to ER traffic protein 4 homolog from Homo sapiens
Aligns to 56:306 / 327 (76.8%), covers 99.6% of PF04190, 253.6 bits
- function: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).
subunit: Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083, PubMed:25535373). Interacts with BAG6; the interaction is direct and localizes BAG6 to the cytosol (PubMed:21636303, PubMed:29042515, PubMed:25535373). - Exploring the Human-Nipah Virus Protein-Protein Interactome.
Martinez-Gil, Journal of virology 2017 - VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase
Baron, BMC biology 2014 - “...(32) 0.870.06 (35) BAG6 P46379 119,409 1.470.18 (36) 0.770.11 (36) 1.430.19 (52) 0.940.10 (43) GET4 Q7L5D6 36,504 1.390.11 (8) 0.730.06 (11) 1.300.08 (9) 0.840.03 (13) UBL4A P11441 17,777 1.500.10 (7) 0.740.04 (9) 1.510.15 (7) 0.890.04 (10) a Light- (L) and heavy-labeled (H) cells were treated with...”
- “...MG 6hr ASNA1 O43681 38,793 0.11% 0.30% 0.18% BAG6 P46379 119,409 0.50% 0.56% 0.49% GET4 Q7L5D6 36,504 0.05% 0.10% 0.08% UBL4A P11441 17,777 0.11% 0.13% 0.08% a Flag-FAF1 was immunoprecipitated from U2OS cells treated with MG132 (MG) for 0, 2 or 6hr as indicated. The share...”
- Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance
Xing, Proceedings of the National Academy of Sciences of the United States of America 2017 - “...Not found Not found NP_004308 348 NP_004618 NP_057033 AAT93183 354 NP_011495 NP_014807 XP_004368068 330 XP_004353131 XP_004367722 XP_003289495 330 Not found...”
- Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
Mock, Proceedings of the National Academy of Sciences of the United States of America 2015 - GeneRIF: Both TRC35 and Ubl4A have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex.
- Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.
Gristick, Nature structural & molecular biology 2014 - GeneRIF: The crystal structure of the Get3-Get4-Get5 complex in an ATP-bound state is presented.
- A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.
Xu, The Journal of biological chemistry 2013 - GeneRIF: Data indicate that the Bag6-Ubl4A-Trc35 complex is localized to the endoplasmic reticulum (ER) membrane to regulate ER-associated degradation (ERAD).
- Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.
Krenciute, The Journal of biological chemistry 2013 - GeneRIF: Data indicate that BCL2-associated athanogene 6 (BAG6) appears to be the central component for the process, as depletion of BAG6 leads to the loss of both UBL4A and GET4 proteins and resistance to cell killing by DNA-damaging agents.
- SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.
Xu, Cell reports 2012 - GeneRIF: SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.
GET4_ARATH / Q6GKV1 Protein GET4; AtGET4; Guided entry of tail-anchored proteins 4 homolog from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT5G63220 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 46:320 / 324 (84.9%), covers 99.6% of PF04190, 234.9 bits
- function: Involved in the regulation of root hair growth.
subunit: Interacts with GET3A.
disruption phenotype: Strong reduction of root hair length. - Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance
Xing, Proceedings of the National Academy of Sciences of the United States of America 2017 - “...the putative upstream binding partner of AtGET3a, AtGET4 (At5g63220), which we identified through in silico analysis. The expression pattern of AtGET4 resembles...”
- “...AtGET3a (At1g01910), AtGET3b (At3g10350), AtGET3c (At5g60730), and AtGET4 (At5g63220). More details and other methods are in SI Materials and Methods. Xing et...”
M1ACL9 Uncharacterized protein from Solanum tuberosum
Aligns to 47:324 / 328 (84.8%), covers 99.6% of PF04190, 232.1 bits
- Analysis of tail-anchored protein translocation pathway in plants
Manu, Biochemistry and biophysics reports 2018 - “...Get2 YER083C Get3 YDL100C M1AE77 B8BDK7 M1A99 A28V0 M0ZFY4 B8AIG1 M1AND2 M0ZJQ4 Get4 YOR164C B8ADF2 M1ACL9 Get5 Q12285 3.10 Structural analysis of GET pathway members in O. sativa and S. tuberosum To extend the understanding of GET pathway in O. sativa and S. tuberosum , we...”
GET4_SCHPO / O74432 Golgi to ER traffic protein 4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 33:290 / 303 (85.1%), covers 100.0% of PF04190, 230.0 bits
- function: May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
B8ADF2 Uncharacterized protein from Oryza sativa subsp. indica
Aligns to 55:328 / 330 (83.0%), covers 99.6% of PF04190, 226.4 bits
- Analysis of tail-anchored protein translocation pathway in plants
Manu, Biochemistry and biophysics reports 2018 - “...M0ZME5 Get2 YER083C Get3 YDL100C M1AE77 B8BDK7 M1A99 A28V0 M0ZFY4 B8AIG1 M1AND2 M0ZJQ4 Get4 YOR164C B8ADF2 M1ACL9 Get5 Q12285 3.10 Structural analysis of GET pathway members in O. sativa and S. tuberosum To extend the understanding of GET pathway in O. sativa and S. tuberosum ,...”
CNAG_00673 cytoplasmic protein from Cryptococcus neoformans var. grubii H99
Aligns to 43:334 / 338 (86.4%), covers 99.2% of PF04190, 192.4 bits
- Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta
Do, Mycobiology 2019 - “...Vacuolar-sorting protein 53 long isoform CNAG_00561 Histone acetyltransferase type B catalytic subunit CNAG_00609 Hypothetical protein CNAG_00673 Cytoplasmic protein CNAG_00760 Methylenetetrahydrofolate reductase CNAG_00977 VHS domain-containing protein CNAG_01309 arf/Sar family protein CNAG_01399 Hypothetical protein CNAG_01556 Cytoplasmic protein CNAG_01923 ATPase GET3 CNAG_02007 ADK1 Adenylate kinase 1 CNAG_02029 WSP1 Wiskott-Aldrich...”
Or search for genetic data about PF04190 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory