Family Search for PF04418 (DUF543)
PF04418 hits 14 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
MIC10_YEAST / Q96VH5 MICOS complex subunit MIC10; Mitochondrial contact site complex 10 kDa subunit; Mitochondrial inner membrane organization component of 10 kDa; Mitochondrial organizing structure protein 1; MitOS1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
NP_065435 Mic10p from Saccharomyces cerevisiae S288C
YCL057C-A Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies (RefSeq) from Saccharomyces cerevisiae
Aligns to 3:87 / 97 (87.6%), covers 94.7% of PF04418, 112.3 bits
- function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex. Interacts with OM45 and POR1.
disruption phenotype: Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 60-70% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane. - Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin.
Rampelt, Journal of molecular biology 2018 (PubMed)- GeneRIF: Results indicate that Mic10 assembly is controlled by at least two distinct pathways, Mic26-Mic27 antagonism and cardiolipin binding. Simultaneous deficiency of destabilizing Mic26 and stabilizing cardiolipin leads to an intermediate effect on Mic10 oligomers.
- Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F1Fo-ATP Synthase.
Rampelt, Journal of molecular biology 2017 (PubMed)- GeneRIF: Mic10 interacts with the dimeric form of mitochondrial F1Fo-ATP synthase.
- Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology.
Itoh, Molecular biology of the cell 2013 - GeneRIF: Data indicate that Fcj1 and Mos1 are required for maintaining mitochondrial DNA (mtDNA) nucleoid size.
- MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.
Alkhaja, Molecular biology of the cell 2012 - GeneRIF: Proteomic analyses reveal MINOS1/Mio10 as a novel constituent of Mitofilin/Fcj1 complexes in human and yeast mitochondria.
- Pathways shaping the mitochondrial inner membrane
Klecker, Open biology 2021 - “...fusion, generation of lamellar cristae [ 42 45 ] MICOS subunits Mic10 (Mcs10; Mio10; Mos1; Ycl057c-a) MIC10 (MINOS1) membrane-shaping core subunit of Mic10 subcomplex [ 46 51 ] Mic12 (Aim5; Fmp51; Mcs12; Ybr262c) MIC12 (MIC13; QIL1) coupling of Mic10 and Mic60 subcomplexes [ 46 48 ,...”
- Integrated genomic analysis reveals key features of long undecoded transcript isoform-based gene repression
Tresenrider, Molecular cell 2021 - “...between 4 and 17 ( Figure3 A). The two without a uORF ( PLM2 and YCL057C-A ) displayed an increase in TE (translational efficiency= ribosome footprints reads per kilobase of transcript, per million mapped reads [RPKM]/transcript abundance RPKM), indicating that they should not be categorized as...”
- A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin
Santos, Cancer & metabolism 2019 - “...that binds mitochondrial ribosomes and influences cytochrome oxidase assembly [ 83 ] ; and MIC10 (YCL057C-A) , encoding a component of the MICOS complex, functioning in inner membrane organization and membrane contact site formation [ 84 ]. Protein folding, localization, and modification pathways Protein biogenesis and...”
- Uniform nomenclature for the mitochondrial contact site and cristae organizing system
Pfanner, The Journal of cell biology 2014 - “...et al., 2013 ; Weber et al., 2013 Subunits Mic10 Mcs10, Mio10, Mos1, and MINOS1 YCL057C-A Harner et al., 2011 ; Hoppins et al., 2011 ; von der Malsburg et al., 2011 ; Alkhaja et al., 2012 ; Itoh et al., 2013 ; Jans et al.,...”
- MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization
Alkhaja, Molecular biology of the cell 2012 - “...and displayed significant sequence similarity to a human protein (Supplemental Figure S1B). Here we analyzed YCL057C-A (Mio10, Mos1, Mcs10), which displayed similarity with human C1orf151 ( Figure 1A ). We later refer to these proteins as Mio10 (yeast) and MINOS1 (human). Mio10 and MINOS1 are highly...”
- “...mio10 cells display a phenotype similar to atp20 and fcj1 cells. Therefore we refer to YCL057C-A as Mio10 for mitochondrial inner membrane organization complex constituent. DISCUSSION The mitochondrial inner membrane is highly organized with respect to its morphology. This organization also affects the distribution of mitochondrial...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...0.967935658 782587 + chr03 YCL064C 0.957150698 0.95270514 16880 chr03 YCL058W-A 0.969895345 0.992394829 23584 + chr03 YCL057C-A 0.990886192 0.987170576 24325 chr03 YCL057W 0.963062357 0.961804623 24768 + chr03 YCL038C 0.978210537 0.957633548 56527 chr03 YCL035C 0.981360705 0.973568151 61173 chr03 YCL019W 0.953241664 0.978688459 85102 + chr03 YCR026C 0.96886665 0.97932414 166335...”
- “...YGL055W AFUA_7G05920 0.583471232 YER094C AFUA_4G07420 0.580111415 YER026C AFUA_4G13680 0.579632053 YKR031C AFUA_3G05630 0.578947614 YJR041C AFUA_1G13200 0.577042969 YCL057C-A AFUA_1G13195 0.56703028 YKL167C AFUA_6G12620 0.566497151 YDR334W AFUA_7G02370 0.556810391 YDL085W AFUA_1G11960 0.555058025 YIR038C AFUA_8G02500 0.553657653 YGL056C AFUA_1G06660 0.550891198 YLR133W AFUA_1G15930 0.547961885 YLR137W AFUA_2G09930 0.542448721 YER095W AFUA_1G10410 0.540102076 YCR090C AFUA_2G15510 0.540015424 YIR022W...”
- The mitochondrial contact site complex, a determinant of mitochondrial architecture
Harner, The EMBO journal 2011 - “...Mcs19 (Yfr011c, AIM13), Mcs12 (Ybr262c, AIM5), Mcs10 (Ycl057c-a) and Fcj1 (Ykr016w, AIM28). The MICOS complex Co-isolation of Mcs proteins. To investigate...”
- A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria
Hoppins, The Journal of cell biology 2011 - “...In addition to Fcj1, Aim5, Aim13, and Aim37, the above-described purifications contained significant peptides/coverage of Ycl057c-a (hereafter Ycl057c) and Ygr235c, two poorly characterized proteins that localize to mitochondria based on proteomic analyses ( Fig. 3 A ; Sickmann et al., 2003 ). To test whether Ycl057c...”
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Q6AVR1 Expressed protein from Oryza sativa subsp. japonica
Aligns to 2:103 / 126 (81.0%), covers 93.3% of PF04418, 112.0 bits
- Proteomic response of hybrid wild rice to cold stress at the seedling stage
Wang, PloS one 2018 - “...Os09g0517000 protein 1.54 Q84M68 Os03g0856500 protein 1.53 Q0DFD6 Os05g0597100 protein 1.53 A0A0P0XA87 Os07g0673500 protein 1.51 Q6AVR1 Expressed protein 0.65 Q650Y5 Os09g0564000 protein 0.65 Q943W1 Os01g0501800 protein 0.64 Q7G649 Expressed protein 0.64 A0A0P0V7A3 Os01g0711400 protein (Fragment) 0.64 Q10N30 Os03g0284400 protein 0.63 Q67IZ7 Os09g0461800 protein 0.63 B9FCM4 Os04g0626400...”
- “...Os12g0189400 protein 0.46 Q75LD8 Os03g0843400 protein 0.46 Q0JCX3 Os04g0445200 protein 0.42 Q2RAK8 Os11g0147800 protein 0.39 Q6AVR1 Expressed protein 0.23 Q0E032 Os02g0581100 protein 0.14 A0A0P0XC80 Os08g0169300 protein 0.04 a: the protein ID come from UniProt databse. b: T3 represents hybrid wild rice DC907; C3 represents cultivar rice...”
Q7RYI0 MICOS complex subunit mic10 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Aligns to 8:83 / 93 (81.7%), covers 89.3% of PF04418, 104.4 bits
AFUA_1G13195 DUF543 domain protein from Aspergillus fumigatus Af293
Aligns to 3:79 / 91 (84.6%), covers 96.0% of PF04418, 102.9 bits
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...AFUA_7G05920 0.583471232 YER094C AFUA_4G07420 0.580111415 YER026C AFUA_4G13680 0.579632053 YKR031C AFUA_3G05630 0.578947614 YJR041C AFUA_1G13200 0.577042969 YCL057C-A AFUA_1G13195 0.56703028 YKL167C AFUA_6G12620 0.566497151 YDR334W AFUA_7G02370 0.556810391 YDL085W AFUA_1G11960 0.555058025 YIR038C AFUA_8G02500 0.553657653 YGL056C AFUA_1G06660 0.550891198 YLR133W AFUA_1G15930 0.547961885 YLR137W AFUA_2G09930 0.542448721 YER095W AFUA_1G10410 0.540102076 YCR090C AFUA_2G15510 0.540015424 YIR022W AFUA_3G12840...”
AT1G72170 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 1:74 / 102 (72.5%), covers 93.3% of PF04418, 98.3 bits
- 3D Gel Map of Arabidopsis Complex I
Peters, Frontiers in plant science 2013 - “...et al., 2010 ; Klodmann and Braun, 2011 ), At1g68680 (Meyer et al., 2008 ), At1g72170, At3g10110 and At2g28430 (Klodmann et al., 2011 ), and At1g72750 (Wang et al., 2012b ) (Table 2 ). However, detection of these proteins is not consistent. It currently cannot be...”
- “...et al. ( 2008 ) At3g10110 Klodmann et al. ( 2011 ) Similar to TIM22 At1g72170 Klodmann et al. ( 2011 ) At2g28430 Klodmann et al. ( 2011 ) At1g72750 Wang et al. ( 2012b ) Similar to TIM23 1 At5g14105 was suggested to be named...”
- A molecular link between mitochondrial preprotein transporters and respiratory chain complexes
Murcha, Plant signaling & behavior 2012 - “...Tim17-3 At3g25120 OEP16.1 Complex I subunits At1g68680 At1g72170 At2g27730 At2g27730 CAL2 At4g34700 The locations of import components, Preprotein and Amino...”
- “...I subunits encoded by At1g68680, At2g27730, At4g34700 and At1g72170 also migrate with TIM17:23 complex at 160 and 110 kilodaltons (kD) (Table1). Functional...”
- Proteomic investigations of complex I composition: how to define a subunit?
Meyer, Frontiers in plant science 2012 - “...X X X X X X X At5g14105 P3 X X X X At1g68680 X At1g72170 X At3g10110, At1g18320 TIM22 X At3g47930 GLDH X $ BOVINE SUBUNITS NOT FOUND IN MATURE ARABIDOPSIS COMPLEX I At1g72040 42kDa subunit At2g46540 B9 subunit At5g08050 B14.5a subunit At4g34700 B22 subunit...”
- “...role of TIM22 in the assembly of complex I is plausible. Another protein, encoded by At1g72170, has also been identified by Klodmann et al. ( 2011 ) as a putative new complex I subunit. This protein had previously been found in the Arabidopsis mitochondrial proteome (Heazlewood...”
LOC106779628 MICOS complex subunit Mic10 from Vigna radiata var. radiata
Aligns to 2:73 / 93 (77.4%), covers 88.0% of PF04418, 96.6 bits
MIC10_ARATH / Q8LAJ9 MICOS complex subunit MIC10; AtMic10 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 1:73 / 99 (73.7%), covers 88.0% of PF04418, 92.4 bits
- function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex (By similarity). The MICOS complex associates with mitochondrial outer membrane proteins (By similarity). Present in a large lipid-enriched complex called mitochondrial transmembrane lipoprotein (MTL) complex made of proteins located in the two mitochondrial membranes, including the TOM complex and the core components of the MICOS complex and containing at least digalactosyldiacylglycerol (DGDG) (PubMed:26898467).
AT1G22520 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 1:73 / 179 (40.8%), covers 88.0% of PF04418, 89.9 bits
SPAPJ691.03 DUF543 family protein (RefSeq) from Schizosaccharomyces pombe
Aligns to 1:68 / 86 (79.1%), covers 85.3% of PF04418, 86.5 bits
- Dataset describing the genome wide effects on transcription resulting from alterations in the relative levels of the bZIP transcription factors Atf1 and Pcr1 in Schizosaccharomyces pombe
Basu, Data in brief 2022 - “...protein, uncharacterized SPBC4B4.05 smg1 Sm snRNP core protein Smg1 SPAC922.04 SPAC922.04 Schizosaccharomyces specific protein, uncharacterized SPAPJ691.03 mic10 MICOS complex subunit Mic10 SPBC3B9.13c rpp102 ribosomal protein P1 Rpp102 SPBC405.04c ypt7 GTPase Ypt7 SPAC2F3.05c SPAC2F3.05c xylose and arabinose reductase SPNCRNA.844 SPNCRNA.844 intergenic RNA (predicted) SPAC4D7.02c pgc1 phosphatidylglycerol phospholipase...”
- Proteomic analysis of the secretory response of Aspergillus niger to D-maltose and D-xylose
de, PloS one 2011 - “...Yhm1 (4.2/6.7), Sc Hsp60 (4.0/4.7) Sc Qcr8 (15.4), Nc nuo-12.3 (6.8), Nc nuo-19.3 (6.2), Sp SPAPJ691.03 (5.3), Sc Atp3 (4.2), Sc Pic2-like (3.9) Sc Mcr1 (7.5), Sc Yhm2 (6.7), Nc CYT-1 (6.2), Sp rip1 (5.7), Sc Atp7 (5.5), Yl :YALI0F25135p (5.4), Nc nuo-78 (4.8), Hs NAA16...”
Q7TNS2 MICOS complex subunit Mic10 from Mus musculus
Aligns to 1:63 / 76 (82.9%), covers 80.0% of PF04418, 86.2 bits
MIC10_HUMAN / Q5TGZ0 MICOS complex subunit MIC10; Mitochondrial inner membrane organizing system protein 1 from Homo sapiens (Human) (see 4 papers)
Aligns to 1:63 / 78 (80.8%), covers 80.0% of PF04418, 85.4 bits
- function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with IMMT/MIC60 and MICOS13/MIC13. Interacts with APOO/MIC23/MIC26 and APOOL/MIC27. Interacts with ARMC1 (PubMed:31644573). - Inhibition of MAPKs, Myc/Max, NFκB, and hypoxia pathways by Phyllanthus prevents proliferation, metastasis and angiogenesis in human melanoma (MeWo) cancer cell line.
Tang, International journal of medical sciences 2014 - “...Q5VTE0 Putative elongation factor 1-alpha-like 3 -1.48 -1.64 -1.64 -1.57 -1.57 -1.64 -1.58 -1.85 44 Q5TGZ0 Mitochondrial inner membrane organizing system protein 1 -1.53 -1.63 -1.74 -1.56 -1.67 -1.68 -1.64 -1.75 45 P07339 Cathepsin D -1.54 -1.54 -1.65 -1.46 -1.68 -1.68 -1.47 -1.58 46 Q9Y587 AP-4...”
- Phyllanthus Suppresses Prostate Cancer Cell, PC-3, Proliferation and Induces Apoptosis through Multiple Signalling Pathways (MAPKs, PI3K/Akt, NFκB, and Hypoxia).
Tang, Evidence-based complementary and alternative medicine : eCAM 2013 - “...60 P49411 Elongation factor Tu, mitochondrial 1.48 1.45 1.57 1.33 1.38 1.54 1.68 1.47 61 Q5TGZ0 Mitochondrial inner membrane organizing system protein 1 1.47 1.46 1.47 1.49 1.57 1.47 1.67 1.65 62 P19404 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 1.21 1.32 1.33 1.43 1.57 1.57 1.57...”
- Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Zhao, Molecular & cellular proteomics : MCP 2011
C1orf151 MICOS complex subunit MIC10 from Gallus gallus
Aligns to 1:64 / 77 (83.1%), covers 80.0% of PF04418, 85.1 bits
NP_001191012 MICOS complex subunit MIC10 isoform c from Homo sapiens
Aligns to 1:63 / 140 (45.0%), covers 80.0% of PF04418, 83.4 bits
CG41128 uncharacterized protein from Drosophila melanogaster
Aligns to 2:69 / 72 (94.4%), covers 78.7% of PF04418, 69.8 bits
- The Organization of Pericentromeric Heterochromatin in Polytene Chromosome 3 of the Drosophilamelanogaster Line with the Rif11; SuURES Su(var)3-906 Mutations Suppressing Underreplication.
Zykova, Cells 2021 - “...16 Parp 1 4 16 8 Aq 17 Alg-2 2 13 12 2 Aq 18 CG41128 2 12 9 6 Aq 19 CG41099 1 1 8 17 2 Aq 20 scro 1 4 9 5 10 Mlch 21 eIF4B 13 16 Aq 22 Me18S-C419 1 9...”
- Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system
Robles-Murguia, NPJ aging and mechanisms of disease 2019 - “...data, qPCR analysis confirms that the expression of mitochondrial genes ( CG10924 , CG30493 , CG41128 , Hsp60 , Las , and mRpS5 ) declines in response to RU486 treatment in a dose-dependent manner. Conversely, RU486 induces the expression of the cytoplasmic chaperones Hsp26 and Hsp83...”
- “...mRpS5 : 5-GCTTCTTTAACAAATTACCTGCTGA-3 and 5-TATGCGACCGCATTTTCCGA-3 Las : 5-TTAAGGCGCGCAACTCAAAC-3 and 5-TTGGCGATCGTCTTCACACA-3 CG30493 : 5-GAGTTCCTCAAGAGCCGCAT-3 and 5-CGAGAATATTACGCGCCGTG-3 CG41128 : 5-TTAAAGGATGTGGAGGCGTAA-3 and 5-CGTCCTATAAGCGATGCCCA-3 CG10924 : 5-GGCCCAACAAAGCGCAATAA-3 and 5-TGGTGAGACCAATCCGCATC-3 AlphaTub84B : 5-GTTTGTCAAGCCTCATAGCCG-3 and 5-GGAAGTGTTTCACACGCGAC-3 SDH assays For each sample, 15 thoraces were homogenized in a bullet blender (NextAdvance) with 100L...”
- The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.
Landskron, eLife 2018 - “...Su(var)2-HP2 (TCCTTGGGATTCGGGAAATG, GAGGCTGCTACTGAGCTAATG), tai (ACTACGGTGGCTTCAACTTC, TGGATTGCTACTGCTGCTATT), CG32479 (GCAAGTCCCACAGCAACTAT, CTGCGGATTGGCTGATGAA), Su(Tpl) (GGTACTCATCGTAGTCGCTTTC, CGCTACGACTTCAGCCAATA), Taf12L (ACAGCGATAAATCGTCGGATAA, GGACAGACTGGCTCTCAATTAC), CG41128 (TTAAAGGATGTGGAGGCGTAAT, TCCTATAAGCGATGCCCATTC), Hsp67Ba (GCCAGCAATCTCCCACTATT, AATAATCTGCACGGGTAGGC), CG2021 (CATGAGCGCGTCTTCTCTAC, AGTCGATGGTCTCGTCTATCA), CG11882 (ACTAACAGCGTCAGCTTCTC, GAGCCTGATGAAGGGCTATT). Gene expression was normalized to Act5C (AGTGGTGGAAGTTTGGAGTG, GATAATGATGATGGTGTGCAGG). Primers used for RIP-qPCR were: RpL32 (GCCGCTTCAAGGGACAGTAT, TTCTGCATGAGCAGGACCTC), cherub - all...”
- A proteomics approach to identify targets of the ubiquitin-like molecule Urm1 in Drosophila melanogaster
Khoshnood, PloS one 2017 - “...Trxr-1 CG15697 RpS30 CG32346 E(bx) CG1594 hop CG3564 CHOp24 CG16757 Spn CG3931 Rrp4 CG17051 dod CG41128 CG41128 CG1721 Pglym78 CG4463 Hsp23 CG17320 ScpX CG5933 Ime4 CG2559 Lsp1alpha CG6523 CG6523 CG2843 Cwc25 CG6677 ash2 CG31793 CG31793 CG7010 l(1)G0334 CG3717 bcn92 CG8479 Opa1 CG4178 Lsp1beta CG8983 ERp60 CG5502...”
Or search for genetic data about PF04418 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory