Family Search for PF04418 (DUF543)

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PF04418 hits 16 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

MIC10_YEAST / Q96VH5 MICOS complex subunit MIC10; Mitochondrial contact site complex 10 kDa subunit; Mitochondrial inner membrane organization component of 10 kDa; Mitochondrial organizing structure protein 1; MitOS1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
Aligns to 4:87 / 97 (86.6%), covers 93.3% of PF04418, 109.9 bits

• function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
  subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex. Interacts with OM45 and POR1.
  disruption phenotype: Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 60-70% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.

MIC10_HUMAN / Q5TGZ0 MICOS complex subunit MIC10; Mitochondrial inner membrane organizing system protein 1 from Homo sapiens (Human) (see 4 papers)
Aligns to 1:63 / 78 (80.8%), covers 81.3% of PF04418, 90.3 bits

• function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
  subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with IMMT/MIC60 and MICOS13/MIC13. Interacts with APOO/MIC23/MIC26 and APOOL/MIC27. Interacts with ARMC1 (PubMed:31644573).

MIC10_ARATH / Q8LAJ9 MICOS complex subunit MIC10; AtMic10 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 1:73 / 99 (73.7%), covers 89.3% of PF04418, 82.4 bits

• function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
  subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex (By similarity). The MICOS complex associates with mitochondrial outer membrane proteins (By similarity). Present in a large lipid-enriched complex called mitochondrial transmembrane lipoprotein (MTL) complex made of proteins located in the two mitochondrial membranes, including the TOM complex and the core components of the MICOS complex and containing at least digalactosyldiacylglycerol (DGDG) (PubMed:26898467).

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