Family Search for PF04430 (DUF498)

PF04430.14 hits 19 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BCAL1928 hypothetical protein (RefSeq) from Burkholderia cenocepacia J2315
Aligns to 14:121 / 124 (87.1%), covers 100.0% of PF04430, 116.3 bits

• Candidate Essential Genes in Burkholderia cenocepacia J2315 Identified by Genome-Wide TraDIS
  Wong, Frontiers in microbiology 2016
  • “...Ortega et al., 2007 ). Conditional lethal mutants of arnT and arnB but not the BCAL1928 mutant, exhibited severe growth defects when grown under a non-permissive condition ( Ortega et al., 2007 ). Our TraDIS data supports the essentiality of these genes, as transposon insertions are...”
• A Burkholderia cenocepacia MurJ (MviN) homolog is essential for cell wall peptidoglycan synthesis and bacterial viability
  Mohamed, Glycobiology 2014
  • “...with 0.2% rhamnose or 0.2% glucose. XOA10 (Prha:: BCAL1928) and XOA11 (Prha::arnT) are rhamnose-independent and -dependent control mutants (Ortega et al. 2007)....”
  • “...ceftazidime and imipenem as the XOA10 (Prha:: BCAL1928) control strain (Table II). However, the Prha:: murJBc bacteria grown under rhamnose-limiting conditions...”
• A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability
  Ortega, Journal of bacteriology 2007
  • “...each target gene consistently failed. In contrast, the genes BCAL1928 and BCAL1936 that flank each end of the putative arn cluster were readily mutated. We...”
  • “...mutant in which this plasmid interrupts the gene locus BCAL1928 (strain XOA10) and which served as a negative control (Fig. 1A). Also, as a positive control for...”

NDUF3_MOUSE / Q9JKL4 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Protein 2P1 from Mus musculus (Mouse) (see paper)
NP_075736 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 from Mus musculus
Aligns to 61:169 / 185 (58.9%), covers 100.0% of PF04430, 114.1 bits

• function: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
  subunit: Interacts with NDUFAF4, NDUFS2 and NDUFS3.
• Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus
  Parente, Molecular genetics and metabolism 2016
  • “...1810035L17 gene Q9ERG2 Strn3 striatin, calmodulin binding protein 3 Q9ERU9 Ranbp2 RAN binding protein 2 Q9JKL4 Ndufaf3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3 Q9JL26 Fmnl1 formin-like 1 Q9QWY8 Asap1 similar to Development and differentiation enhancing; ArfGAP with SH# domain, ankyrin repeat and PH...”
• Tissue expression patterns identify mouse cilia genes.
  McClintock, Physiological genomics 2008 (PubMed)
  • GeneRIF: 4733401H18Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.

TR70_0856 Xcc1710-like domain-containing protein from Burkholderia pseudomallei
Aligns to 26:133 / 136 (79.4%), covers 100.0% of PF04430, 113.6 bits

• Combating biothreat pathogens: ongoing efforts for countermeasure development and unique challenges
  Duplantier, Drug Discovery Targeting Drug-Resistant Bacteria 2020
  • “...l -methionine-dependent methyltransferase, amrR [186] , [187] Lactams penA a , nlpD1, dacC, FlgN, sch, TR70_0856, TR70_1911, ftsI, amrR , bpeR , bpeT , spoT , tRNA, rRNA, proteins with unknown function, SerS seryl-tRNA synthetase, and RND efflux pump AmrAB-OprA, and BpeEF-OprC [186] , [188] ,...”

NDUF3_RAT / O08776 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Nuclear protein E3-3 from Rattus norvegicus (Rat) (see paper)
Aligns to 61:169 / 185 (58.9%), covers 100.0% of PF04430, 113.1 bits

• function: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
  subunit: Interacts with NDUFAF4, NDUFS2 and NDUFS3.

NP_951056 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform b from Homo sapiens
Aligns to 3:111 / 127 (85.8%), covers 100.0% of PF04430, 112.8 bits

• Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  Hendrickson, PloS one 2010
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
• Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease.
  Saada, American journal of human genetics 2009
  • GeneRIF: Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease.
• 2P1, a novel male mouse cDNA specifically expressed during meiosis.
  Hammami-Hamza, The International journal of developmental biology 2003 (PubMed)
  • GeneRIF: Describes a similar transcript in mouse.
• Molecular cloning of a novel alternatively spliced nuclear protein.
  Hartmann, Biochimica et biophysica acta 1997 (PubMed)
  • GeneRIF: Describes a similar transcript in rat, and compares it to human and mouse transcripts.

NDUF3_HUMAN / Q9BU61 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 from Homo sapiens (Human) (see 2 papers)
Aligns to 60:168 / 184 (59.2%), covers 100.0% of PF04430, 111.4 bits

• function: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
  subunit: Interacts with NDUFAF4, NDUFS2 and NDUFS3.
• Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases.
  Giachin, Frontiers in molecular biosciences 2016
  • “...Calvo et al., 2010 ; Herzer et al., 2010 ; Ghaloul-Gonzalez et al., 2016 NDUFAF3 Q9BU61 M1T, G77R, R122P FLA Saada et al., 2009 NDUFAF4 Q9P032 L65P LS, L Saada et al., 2009 NDUFAF5 Q5TEU4 L159F, L229P LS Sugiana et al., 2008 ; Gerards et al.,...”

Q7VV99 Uncharacterized protein from Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Aligns to 14:145 / 150 (88.0%), covers 100.0% of PF04430, 108.0 bits

• A community resource of experimental data for NMR / X-ray crystal structure pairs.
  Everett, Protein science : a publication of the Protein Society 2016 (no snippet)

AT3G60150 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 56:164 / 170 (64.1%), covers 98.2% of PF04430, 105.6 bits

• Selection of reference genes for qPCR- and ddPCR-based analyses of gene expression in Senescing Barley leaves
  Zmienko, PloS one 2015
  • “...A_13_P223939 Contig2551_s_at AT3G52990 Pyruvate kinase family protein, cytosolic Ref B AK252899 Hv.20290 (13) A_13_P073561 Contig14457_s_at AT3G60150 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3, mitochondrial Ref C AK373172 Hv.9031 (15) A_13_P149150 Contig9163_at AT3G15360 Thioredoxin M-type, chloroplastic Ref D AK356259 Hv.10475 (27) A_13_P220544 Contig8615_at AT3G15070 RING/U-box...”
• Natural variation of H3K27me3 distribution between two Arabidopsis accessions and its association with flanking transposable elements
  Dong, Genome biology 2012
  • “...diagram of H3K27me3 targets identified in Col and L er . (b) GBrowse view of AT3G60150 as an example for a L er -specific H3K27me3 target. The red frame indicates the location of AT3G60150 and the differential H3K27me3 signal in Col and L er . (c)...”
  • “...showed only occasional absence of expression among the remaining 17 accessions. For two Exp_Col genes, AT3G60150 and AT2G34840, H3K27me3 invasion from flanking regions could explain the gene-specific H3K27me3 enrichment in L er . For most Rep_Col genes, H3K9me2 seems to be the derived state based on...”

RL2056 hypothetical protein (NCBI) from Rhizobium leguminosarum bv. viciae 3841
Aligns to 18:126 / 128 (85.2%), covers 100.0% of PF04430, 101.6 bits

• The Use of Transposon Insertion Sequencing to Interrogate the Core Functional Genome of the Legume Symbiont Rhizobium leguminosarum
  Perry, Frontiers in microbiology 2016
  • “...protein RL2042 GI 29 0.28 8.5 ES 29 0.17 5.4 GD 0.0.2 Conserved hypothetical protein RL2056 GI 5 0.2 1 GD 5 0.2 2 GD 0.0.2 Conserved hypothetical protein RL2207 GI 6 0.17 1 ES 6 0.17 2 GD 0.0.2 Conserved hypothetical protein RL2232 GI 11...”

RPA2829 conserved hypothetical protein (NCBI) from Rhodopseudomonas palustris CGA009
Aligns to 16:124 / 127 (85.8%), covers 100.0% of PF04430, 95.9 bits

• Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease
  Saada, American journal of human genetics 2009
  • “...performed with the use of the NMR structure of Rpa2829 protein from Rhodopseudomonas palustris as a template (Protein Data Bank [PDB] file 2FVT, 30% sequence...”

NP_001023328 NADH:Ubiquinone oxidoreductase Assembly Factor from Caenorhabditis elegans
Aligns to 72:183 / 270 (41.5%), covers 96.3% of PF04430, 90.7 bits

• Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans.
  van, Mitochondrion 2012 (PubMed)
  • GeneRIF: We demonstrate that two candidates (C50B8.3/NUAF-1, homologue of NDUFAF1 and R07H5.3/NUAF-3, homologue of NDUFAF3) clearly affect complex I function.

ECH_0516 hypothetical protein (NCBI) from Ehrlichia chaffeensis str. Arkansas
Aligns to 14:118 / 120 (87.5%), covers 100.0% of PF04430, 87.4 bits

• Ehrlichia chaffeensis transcriptome in mammalian and arthropod hosts reveals differential gene expression and post transcriptional regulation
  Kuriakose, PloS one 2011
  • “...and ISE6) cells. Gene Function SEQ_ID Length (Amino Acids) Predicted Cellular Location Conserved hypothetical protein ECH_0516 120 Cytoplasmic Conserved hypothetical protein ECH_0767 621 Cytoplasmic Conserved hypothetical protein ECH_0988 208 Cytoplasmic Conserved hypothetical protein ECH_1154 135 Cytoplasmic Conserved domain protein ECH_0526 495 Outer Membrane Hypothetical protein ECH_0059...”

XC_2521 hypothetical protein (NCBI) from Xanthomonas campestris pv. campestris str. 8004
Aligns to 15:121 / 124 (86.3%), covers 94.5% of PF04430, 84.8 bits

• Peptidoglycan hydrolysis mediated by the amidase AmiC and its LytM activator NlpD is critical for cell separation and virulence in the phytopathogen Xanthomonas campestris
  Yang, Molecular plant pathology 2018
  • “...pv. campestris ( Xcc ) strain 8004. The genetic positions and orientations of the genes XC_2521 , XC_2523 , XC_2524 and XC_2525 are shown: arrows indicate the length, location and orientation of the genes; lines between arrows indicate intergenic sequences. The transcriptional start site of nlpD...”

NGO_0780 Mth938-like domain-containing protein from Neisseria gonorrhoeae FA 1090
Aligns to 15:122 / 123 (87.8%), covers 97.2% of PF04430, 79.4 bits

• Discovery of a New Neisseria gonorrhoeae Type IV Pilus Assembly Factor, TfpC
  Hu, mBio 2020
  • “...surrounding genes in the operon as determined by quantitative RT-PCR Locus Fold change NGO_0779 1.1 NGO_0780 2.4 NGO_0781 2 NGO_0782 2.7 NGO_0784 2.2 NGO_0785 2.4 FIG2 Analysis of pilus-dependent colony morphology. (A) Stereo-micrograph pictures of 22-h N. gonorrhoeae colonies grown with or without 0.1mM IPTG in...”

FTN_0426 hypothetical protein (NCBI) from Francisella tularensis subsp. novicida U112
FTT_0900 hypothetical protein (RefSeq) from Francisella tularensis subsp. tularensis SCHU S4
Aligns to 15:123 / 123 (88.6%), covers 99.1% of PF04430, 79.2 bits

• Genome-wide screen in Francisella novicida for genes required for pulmonary and systemic infection in mice
  Kraemer, Infection and immunity 2009
  • “...hypothetical membrane protein Heme O synthase putP FTN_0426 FTN_0430 FTN_0437 FTN_0438 Function class cyoE FTN_0299 FTN_0302 FTN_0326 FTN_0340 FTN_0344 rrmJ...”
  • “...screens with unknown function based on sequence analysis: FTN_0426, FTN_0868, and FTN_1133. The depositions for the FTN_0426 and FTN_1133 mutants were 19,489...”
• Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development
  Pechous, Microbiology and molecular biology reviews : MMBR 2009
  • “...SAICAR synthetase/phosphoribosylamine-glycine ligase Tp FTN_0422 FTN_0426 FTN_0427 FTN_0429 FTN_0430 FTN_0431 FTN_0436 FTN_0437 FTN_0438 FTN_0443 FTN_0444...”
  • “...FTN_0480 FTN_0488 FTN_0493 FTN_0494 FTN_0494 FTN_0503 purE FTN_0426 tul4 FTN_0429 lpnB FTN0431 FTN_0436 FTN_0437 rrmJ maeA FTT0918 fevR cspC mtn FTN_0494...”
• Global Analysis of Genes Essential for Francisella tularensis Schu S4 Growth In Vitro and for Fitness during Competitive Infection of Fischer 344 Rats
  Ireland, Journal of bacteriology 2019
  • “...FTT_0743 FTT_0743 766572 767387 816 Conserved hypothetical protein FTT_0859c FTT_0859c 870754 871077 324 Hypothetical protein FTT_0900 FTT_0900 909502 909873 372 Conserved hypothetical membrane protein FTT_0913 FTT_0913 920784 921251 468 Hypothetical protein FTT_0924 FTT_0924 935772 936170 399 Hypothetical membrane protein FTT_1051c FTT_1051c 1061830 1061994 165 Hypothetical protein...”

Q9JZ97 Uncharacterized protein from Neisseria meningitidis serogroup B (strain MC58)
Aligns to 23:130 / 131 (82.4%), covers 97.2% of PF04430, 78.5 bits

• Towards New Drug Targets? Function Prediction of Putative Proteins of Neisseria meningitidis MC58 and Their Virulence Characterization
  Shahbaaz, Omics : a journal of integrative biology 2015
  • “...128. 129. 130. 131. 132. 133. Q9K0W7 Q9K0N5 Q7DDK1 Q9JZ97 Q7DDA9 Q9JXK9 134. 135. 136. 137. 138. 139. Q9JXT9 Q9K028 Q9K084 Q9K0S1 Q9K167 Q9K0B6 140. 141. 142....”

AAMDC_MOUSE / Q8R0P4 Mth938 domain-containing protein; LI2 from Mus musculus (Mouse) (see 2 papers)
Aligns to 6:119 / 122 (93.4%), covers 100.0% of PF04430, 75.1 bits

• function: May play a role in preadipocyte differentiation and adipogenesis.

Q9H7C9 Mth938 domain-containing protein from Homo sapiens
Aligns to 6:119 / 122 (93.4%), covers 100.0% of PF04430, 74.4 bits

• Bicuspid Aortic Valve Alters Aortic Protein Expression Profile in Neonatal Coarctation Patients
  Skeffington, Journal of clinical medicine 2019
  • “...0.032 0.82 1.49 F2Z2V0 CPNE1 Copine-1 (Fragment) 0.86 1.45 0.11 0.25 0.59 0.038 0.75 1.42 Q9H7C9 AAMDC Mth938 domain-containing protein 1.39 2.31 0.25 0.16 0.60 0.020 0.73 1.71 O95865 DDAH2 N(G), N(G)-dimethylarginine dimethylaminohydrolase 2 1.57 2.60 0.32 0.29 0.61 0.047 0.72 1.33 Q5T6V5 C9orf64 UPF0553 protein...”
• Identification of Candidate Protein Markers in Skeletal Muscle of Laminin-211-Deficient CMD Type 1A-Patients
  Kölbel, Frontiers in neurology 2019
  • “...misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome Q9H7C9 4/4 0.02 Mth938 domain-containing protein ( AAMDC ) Cytoplasm 0.36 1.47 Plays a role in preadipocyte differentiation and adipogenesis Q8N8N7 5/5 0.02 Prostaglandin reductase 2 ( PTGR2 ) Cytoplasm 0.29...”
• The human olfactory cleft mucus proteome and its age-related changes.
  Yoshikawa, Scientific reports 2018
  • “...Q9NR19 79613 Acetyl-coenzyme A synthetase, cytoplasmic 0.41 0.0443 0.0 0.0 0.1 0.0 0.0 0.0 46 Q9H7C9 13438 UPF0366 protein C11orf67 0.41 0.0443 0.0 0.0 0.5 0.1 0.3 0.0 47 P41218 46092 Myeloid cell nuclear differentiation antigen 0.41 0.0453 0.9 0.1 1.7 0.1 1.3 0.1 48 P53609...”
• In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature.
  Pesciotta, PloS one 2015
  • “...protein 2 OSBP2 12 3E-05 -3.7 Q8TDZ6 Glia maturation factor gamma GMFG 2 4E-05 -28436 Q9H7C9 Mth938 domain-containing protein AAMDC 2 0.0006 -4913.5 O43488 Aflatoxin B1 aldehyde reductase member 2 AKR7A2 2 0.0056 -1321.7 Ingenuity Pathway Analysis (IPA) software was used to investigate common pathways and...”
• Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2.
  Tanaka, Monoclonal antibodies in immunodiagnosis and immunotherapy 2014

PAB1927 hypothetical protein (NCBI ptt file) from Pyrococcus abyssi GE5
Aligns to 3:115 / 118 (95.8%), covers 92.7% of PF04430, 36.9 bits

• Phylogenomic analysis of proteins that are distinctive of Archaea and its main subgroups and the origin of methanogenesis
  Gao, BMC genomics 2007
  • “...methanogenic archaea, Archaeoglobus and Thermococci. The first 5 proteins in Table 7(a) (PAB0076, PAB0138, PAB0965, PAB1927 and PAB1994) are present in all of the Thermococci and most of the methanogens. Four of these proteins are also present in A. fulgidus . The next 13 proteins in...”
  • “...CDD15620 PAB1291 [NP_127284] CDD41906 PAB0138 [NP_125896] CDD9576 PAB1584 [NP_126876] COG4072 PAB0965 [NP_127127] CDD15705 PAB1860 [NP_126440] PAB1927 1 [NP_126347] CDD29323 PAB0813 [NP_126902] COG1630 PAB1994 [NP_126245] CDD9568 PAB0853 [NP_126970] PAB0036 [NP_125764] PAB1251 [NP_127332] endonuclease COG3780 PAB0054 [NP_125787] CDD41919 PAB1779 [NP_126559] CDD43950 PAB0176 [NP_125948] CDD43579 PAB1806 2 [NP_126515] CDD43599...”

Or search for genetic data about PF04430 in the Fitness Browser