Family Search for PF04489 (DUF570)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF04489 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

YP_081490 protein UL31 from Human betaherpesvirus 5
Aligns to 122:550 / 595 (72.1%), covers 96.7% of PF04489, 815.2 bits

• Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion.
  Huang, Cell host & microbe 2018 (PubMed)
  • GeneRIF: this study identified the human cytomegalovirus (HCMV) protein UL31 as an inhibitor of cGAS.
• Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection.
  Westdorp, Journal of virology 2017
  • GeneRIF: These studies demonstrate that cytomegalovirus pUL31 functions in regulating nucleolar biology and contributes to the reorganization of nucleoli during infection.

UL31_HCMVA / P16848 Protein UL31 from Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) (see paper)
Aligns to 122:550 / 595 (72.1%), covers 96.7% of PF04489, 813.8 bits

• function: Plays a role in the inhibition of host innate immune system by targeting host CGAS and promoting dissociation of DNA from CGAS, thereby inhibiting the enzymatic activity of CGAS.
  subunit: Interacts with host CGAS.

A8T797 UL31 from Human cytomegalovirus
Aligns to 198:626 / 671 (63.9%), covers 96.7% of PF04489, 813.2 bits

• Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection
  Carter, Proteomics 2015
  • “...UL27 Protein UL27 2 2 4.6 1.8E-13 E7DVH9 UL29 Protein UL29 9 20 31.8 0.0E+00 A8T797 UL31 UL31 3 3 7.9 1.4E-49 A8T798 UL32 Tegument protein pp150 17 17 19.1 0.0E+00 A8T7A3 UL35 Tegument protein UL35 6 6 14.5 1.5E-59 A8T7A4 UL36 Tegument protein vICA 14...”

Or search for genetic data about PF04489 in the Fitness Browser