Family Search for PF04577 (DUF563)

PaperBLAST – Find papers about a protein or its homologs

Family Search for PF04577 (DUF563)

PF04577.14 hits 65 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

EOGT_DROME / Q9VQB7 EGF domain-specific O-linked N-acetylglucosamine transferase; Extracellular O-linked N-acetylglucosamine transferase; EC 2.4.1.255 from Drosophila melanogaster (Fruit fly) (see paper)
Q9VQB7 protein O-GlcNAc transferase (EC 2.4.1.255) from Drosophila melanogaster (see paper)
AAF51259.1 [protein] EGF20 O-β-N-acetylglucosaminyltransferase (Eogt;EOGT;CG9867) (EC 2.4.1.255) (see protein)
Aligns to 232:458 / 520 (43.7%), covers 98.6% of PF04577, 114.9 bits

function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Involved in epithelial cell adhesion/interaction with the extracellular matrix by mediating glycosylation of proteins in the secretory pathway, such as Dumpy (Dp).
catalytic activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP (RHEA:48904)
catalytic activity: L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP (RHEA:48908)
cofactor: a divalent metal cation
disruption phenotype: Defects in apical extracellular matrix. Embryos show defects in the formation of the innermost layer of the apical extracellular matrix and its attachment to the epidermis. Most larvae die during second-instar or second/third-instar interface, but some survive until early third-instar. Surviving larvae display cuticle defect and irregular tracheal morphology. Ultrastructural analysis of larval epidermis reveals disruption of the deposition zone of the endocuticle, leading to separation of the epidermis from the chitin layers.

EOGT_MOUSE / Q8BYW9 EGF domain-specific O-linked N-acetylglucosamine transferase; Extracellular O-linked N-acetylglucosamine transferase; EC 2.4.1.255 from Mus musculus (Mouse) (see 2 papers)
Aligns to 245:472 / 527 (43.3%), covers 99.0% of PF04577, 99.3 bits

function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
catalytic activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP (RHEA:48904)
catalytic activity: L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP (RHEA:48908)

EOGT_HUMAN / Q5NDL2 EGF domain-specific O-linked N-acetylglucosamine transferase; Extracellular O-linked N-acetylglucosamine transferase; EC 2.4.1.255 from Homo sapiens (Human) (see 2 papers)
Q5NDL2 protein O-GlcNAc transferase (EC 2.4.1.255) from Homo sapiens (see paper)
Aligns to 245:472 / 527 (43.3%), covers 99.0% of PF04577, 96.6 bits

function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
catalytic activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N- acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP (RHEA:48904)
catalytic activity: L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O- (N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP (RHEA:48908)

XAX1_ORYSJ / Q6Z7I3 Beta-1,2-xylosyltransferease XAX1; Protein XYLOSYL ARABINOSYL SUBSTITUTION OF XYLAN 1; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
Aligns to 280:507 / 566 (40.3%), covers 91.9% of PF04577, 84.2 bits

function: Glycosyltransferase involved in the xylosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:23027943). Possesses beta-1,2- xylosyltransferase activity, transferring xylose from UDP-xylose to the xylan backbone (PubMed:23027943).
disruption phenotype: Dwarf phenotype, decreased levels of xylose, ferulic acid and coumaric acid in leaves, and increased saccharification efficiency.

AAQ73546.1 β-1,2-xylosyltransferase (EC 2.4.2.38) (see protein)
Aligns to 235:490 / 511 (50.1%), covers 97.1% of PF04577, 82.6 bits

XYLT_ARATH / Q9LDH0 Beta-1,2-xylosyltransferase; AtXYLT; EC 2.4.2.38 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
Q9LDH0 glycoprotein 2-beta-D-xylosyltransferase (EC 2.4.2.38) from Arabidopsis thaliana (see 4 papers)
XYLT / Q9LDH0 glycoprotein 2-β-D-xylosyltransferase (EC 2.4.2.38) from Arabidopsis thaliana (see 3 papers)
CAB90610.1 core β-1,2-xylosyltransferase (XylT;AtXYLT;At5g55500) (EC 2.4.2.38) (see protein)
Aligns to 247:513 / 534 (50.0%), covers 98.1% of PF04577, 81.4 bits

function: Glycosyltransferase involved in the xylosylation of N-glycans (PubMed:10781814, PubMed:12943552, PubMed:15013764, PubMed:15686448). Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the core beta-linked mannose of N-glycans (PubMed:10781814, PubMed:12943552, PubMed:15013764, PubMed:15686448). Involved in the biosynthesis of glycoprotein bound N-glycans (PubMed:15686448, PubMed:22024534). Does not require metal ions for its activity (PubMed:15686448).
catalytic activity: N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc- (1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)- beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)- alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D- GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP (RHEA:10612)

CAI11448.1 β-1,2-xylosyltransferase (Xt1) (EC 2.4.2.38) (see protein)
Aligns to 238:494 / 515 (49.9%), covers 97.1% of PF04577, 80.6 bits

PMGT2_HUMAN / Q8NAT1 Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; POMGnT2; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; EC 2.4.1.312 from Homo sapiens (Human) (see 3 papers)
Q8NAT1 protein O-mannose beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.312) from Homo sapiens (see paper)
POMGNT2 / Q8NAT1 protein O-linked-mannose β-1,4-N-acetylglucosaminyltransferase 2 (EC 2.4.1.312) from Homo sapiens (see 2 papers)
Aligns to 162:395 / 580 (40.3%), covers 96.7% of PF04577, 80.5 bits

function: O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
catalytic activity: 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha- D-mannosyl)-L-threonyl-[protein] + H(+) + UDP (RHEA:37663)

CAI70375.1 β-1,2-xylosyltransferase (PoXYL1) (EC 2.4.2.38) (see protein)
Aligns to 191:447 / 468 (54.9%), covers 97.1% of PF04577, 80.3 bits

PMGT2_MOUSE / Q8BW41 Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; POMGnT2; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; EC 2.4.1.312 from Mus musculus (Mouse) (see 2 papers)
Aligns to 162:395 / 605 (38.7%), covers 97.1% of PF04577, 80.1 bits

function: O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein (By similarity). Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:24256719).
catalytic activity: 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha- D-mannosyl)-L-threonyl-[protein] + H(+) + UDP (RHEA:37663)
disruption phenotype: Newborn are slightly smaller and die within the first day of birth due to abnormal basal lamina formation and neuronal migration defects. Defects are due to a lack of laminin-binding glycans.

RCN11_ORYSJ / Q6ZFH6 Beta-1,2-xylosyltransferase RCN11; OsXylT; Protein REDUCED CULM NUMBER 11; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
Q6ZFH6 glycoprotein 2-beta-D-xylosyltransferase (EC 2.4.2.38) from Oryza sativa (see paper)
BAD09279.1 [N-glycan] β-1,2-xylosyltransferase (RCN11;Xt;Os08g0503800) (EC 2.4.2.38) (see protein)
Aligns to 259:512 / 533 (47.7%), covers 97.1% of PF04577, 78.9 bits

function: Glycosyltransferase involved in the xylosylation of N-glycans (PubMed:26025522). Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the core beta-linked mannose of N-glycans (PubMed:26025522). Beta-1,2-linked xylose residues on N- glycans are critical for seed germination and plant development and growth under conditions of abiotic stress (PubMed:26025522).
disruption phenotype: Reduced number of tillers and reduced biomass.

XAT3_ORYSJ / Q10I20 Alpha-1,3-arabinosyltransferase XAT3; Xylan arabinosyltransferase 3; OsXAT3; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
AAK50581.1 xylan α-1,3-arabinofuranosyltransferase (OsXAT3; Os03g0567600 or Os03g37010) (EC 2.4.2.-) (see protein)
Aligns to 289:513 / 576 (39.1%), covers 96.2% of PF04577, 77.9 bits

function: Glycosyltransferase involved in the arabinosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:22215597). Possesses alpha-1,3- arabinosyltransferase activity, transferring an arabinofuranose residue to the xylan backbone (PubMed:22215597).

CCA61105.1 xylan α-1,3-arabinofuranosyltransferase (TaGT61_1) (EC 2.4.2.-) (see protein)
Aligns to 209:435 / 506 (44.9%), covers 89.5% of PF04577, 77.0 bits

XAT2_ORYSJ / Q6ZFR0 Alpha-1,3-arabinosyltransferase XAT2; Xylan arabinosyltransferase 2; OsXAT2; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
BAD15592.1 xylan α-1,3-arabinofuranosyltransferase (OsXAT2; Os02g22480 or Os02g0330200) (EC 2.4.2.-) (see protein)
Aligns to 296:520 / 583 (38.6%), covers 96.2% of PF04577, 76.4 bits

function: Glycosyltransferase involved in the arabinosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:22215597). Possesses alpha-1,3- arabinosyltransferase activity, transferring an arabinofuranose residue to the xylan backbone (PubMed:22215597).

CCC14964.1 xylan α-1,3-arabinofuranosyltransferase (TaGT61_2) (EC 2.4.2.-) (see protein)
Aligns to 292:516 / 578 (38.9%), covers 95.2% of PF04577, 72.8 bits

PMGT2_DANRE / Q5NDE5 Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; POMGnT2; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; EC 2.4.1.312 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 161:394 / 578 (40.5%), covers 97.1% of PF04577, 72.1 bits

function: O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity).
catalytic activity: 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha- D-mannosyl)-L-threonyl-[protein] + H(+) + UDP (RHEA:37663)

Q2UVB3 glycoprotein 2-beta-D-xylosyltransferase (EC 2.4.2.38) from Zea mays (see paper)
CAJ47425.1 β-1,2-xylosyltransferase (Xt1;XylT) (EC 2.4.2.38) (see protein)
Aligns to 238:491 / 512 (49.6%), covers 97.6% of PF04577, 71.1 bits

MUC21_ARATH / Q9SS43 Xylan glycosyltransferase MUCI21; Protein MUCILAGE-MODIFIED 5; Protein MUCILAGE-RELATED 21; Putative xylan xylosyltransgerase MUCI21; EC 2.4.-.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Aligns to 197:431 / 494 (47.6%), covers 96.7% of PF04577, 68.1 bits

function: Glycosyletransferase required for the proper composition and structural properties of released seed coat mucilage (PubMed:11706181, PubMed:26482889, PubMed:26979331). Required for the production of highly branched xylan polymers in seed coat mucilage (PubMed:26482889). Facilitates the addition of xylose residues directly to the xylan backbone (PubMed:26482889, PubMed:26979331). Xylan with xylose side chains seems to be necessary for pectin attachment to the seed surface (PubMed:26482889, PubMed:26979331). Essential for xylan synthesis in seed coat epidermal (SCE) cells (PubMed:26482889).
disruption phenotype: Reduced amount and altered composition of seed coat mucilage.

XYXT1_ORYSJ / Q5Z8T8 Beta-1,2-xylosyltransferase XYXT1; Xylan xylosyltransferase 1; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
Aligns to 180:384 / 465 (44.1%), covers 88.5% of PF04577, 68.0 bits

function: Glycosyltransferase involved in the xylosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:29325159). Possesses beta-1,2- xylosyltransferase activity, transferring xylose from UDP-xylose to the xylan backbone (PubMed:29325159). Catalyzes the addition of 2-O-xylosyl side chains to the xylan backbone (PubMed:29325159).

Or search for genetic data about PF04577 in the Fitness Browser

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory