Family Search for PF04634 (YezG-like)
Running HMMer for PF04634
PF04634 hits 28 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
SLGD_01962 Repetitive hypothetical protein from Staphylococcus lugdunensis HKU09-01
2 alignments in 7:321 / 338 (86.4%), covering up to 98.6% of PF04634, 220.6 bits
YEZG_BACSU / C0H3X4 Immunity protein YezG from Bacillus subtilis (strain 168) (see 2 papers)
Aligns to 1:146 / 151 (96.7%), covers 99.3% of PF04634, 184.7 bits
- function: Immunity component of one of 6 LXG toxin-immunity modules in this strain. They promote kin selection, mediate competition in biofilms, and drive spatial segregation of different strains, indicating that LXG toxins may help avoid warfare between strains in biofilms. Mediates intercellular competition during biofilm formation; disruption of the operon disadvantages the bacteria, but overexpression of the cognate immunity protein restores growth in competition with wild-type. In situ neutralizes the toxic effect of cognate toxin YeeF (PubMed:34280190). Probably neutralizes the ability to inhibit growth of cognate toxin YeeF. Probably does not have immunity protein activity on other LXG toxins (Probable).
subunit: Interacts with cognate toxin YeeF but not with non-cognate toxin YobL. The interaction probably inhibits the toxic activity of YeeF (PubMed:22200572). May bind with a stoichiometry of 2:2 to YeeF (By similarity).
disruption phenotype: Deletion of the yeeF-yezG operon has no visible growth phenotype, however it is out-competed by wild-type cells.
YEZG_BACSH / E0TU95 Immunity protein YezG from Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) (Bacillus subtilis subsp. spizizenii) (see paper)
Aligns to 6:151 / 161 (90.7%), covers 99.3% of PF04634, 184.5 bits
- function: Immunity component of an LXG toxin-immunity module. These modules promote kin selection, mediate competition in biofilms, and drive spatial segregation of different strains, indicating that LXG toxins may help avoid warfare between strains in biofilms. Neutralizes the toxic abilities of cognate toxin YeeF upon expression in E.coli and in vitro.
subunit: Monomer (PubMed:32117125). Interacts with the C-terminus of cognate toxin YeeF, probably with 2:2 stoichiometry. The second YezG molecules binds with lower affinity (Probable).
SAOUHSC_00275 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
KMZ21_01300 TIGR01741 family protein from Staphylococcus aureus subsp. aureus RN4220
Aligns to 7:152 / 166 (88.0%), covers 100.0% of PF04634, 182.0 bits
- Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing
Bæk, PloS one 2013 - “...read coverage, collectively indicating mis-mapped reads. Three genes annotated in NCTC8325 as hypothetical proteins (SAOUHSC_00274, SAOUHSC_00275 and SAOUHSC_00276) are located in this region, and using the RAST server [ 18 ] they were re-annotated as repetitive hypothetical proteins near ESAT cluster, Sa0282 homologs, of which NCTC8325...”
- Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain
Nair, Journal of bacteriology 2011 - “...frameshift mutations in SAOUHSC_00269, SAOUHSC_00270, SAOUHSC_00274, SAOUHSC_00275, and SAOUHSC_00276, all hypothetical proteins. Among the indels, one of the...”
- Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220
Panthee, Heliyon 2022 - “...166 TIGR01741 family protein 295034..295534 + 10 KMZ21_01295 166 antitoxin YezG family 296056..296556 + 11 KMZ21_01300 166 TIGR01741 family protein 296567..297067 + 12 KMZ21_01855 518 restriction-modification system subunit M 403369..404925 - 13 KMZ21_02625 283 sdrC 559794..560643 - 14 KMZ21_02630 1383 sdrD 561010..565159 - 15 KMZ21_04460 461...”
SA0282 hypothetical protein from Staphylococcus aureus subsp. aureus N315
Aligns to 7:152 / 163 (89.6%), covers 100.0% of PF04634, 181.5 bits
Q2G2Q9 TIGR01741 family protein from Staphylococcus aureus (strain NCTC 8325 / PS 47)
SAOUHSC_00274 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
Aligns to 7:152 / 166 (88.0%), covers 100.0% of PF04634, 179.8 bits
- Antibacterial Activity of Juglone against Staphylococcus aureus: From Apparent to Proteomic
Wang, International journal of molecular sciences 2016 - “...2 2 8.20 0.809 0.000 Q2FV28 uncharacterized conserved protein SAOUHSC_02911 2 2 27.80 0.827 0.023 Q2G2Q9 conserved hypothetical family protein SAOUHSC_00274 1 2 20.10 0.586 0.001 Q2G297 metal-dependent phosphohydrolase SAOUHSC_01696 5 5 22.40 0.807 0.002 All accession numbers indicate entries in the UniProt database. M w,...”
- Antibacterial Activity of Juglone against Staphylococcus aureus: From Apparent to Proteomic
Wang, International journal of molecular sciences 2016 - “...Q2FV28 uncharacterized conserved protein SAOUHSC_02911 2 2 27.80 0.827 0.023 Q2G2Q9 conserved hypothetical family protein SAOUHSC_00274 1 2 20.10 0.586 0.001 Q2G297 metal-dependent phosphohydrolase SAOUHSC_01696 5 5 22.40 0.807 0.002 All accession numbers indicate entries in the UniProt database. M w, molecular weight. ijms-17-00965-t002_Table 2 Table...”
- Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing
Bæk, PloS one 2013 - “...average read coverage, collectively indicating mis-mapped reads. Three genes annotated in NCTC8325 as hypothetical proteins (SAOUHSC_00274, SAOUHSC_00275 and SAOUHSC_00276) are located in this region, and using the RAST server [ 18 ] they were re-annotated as repetitive hypothetical proteins near ESAT cluster, Sa0282 homologs, of which...”
- Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain
Nair, Journal of bacteriology 2011 - “...changea Locus tag W197* W52* SAOUHSC_00162 SAOUHSC_00262 SAOUHSC_00274 P134S Frameshift E449V S815L T164S E53K E220K S286* P331S G42S A106T SAOUHSC_00383...”
- “...causing frameshift mutations in SAOUHSC_00269, SAOUHSC_00270, SAOUHSC_00274, SAOUHSC_00275, and SAOUHSC_00276, all hypothetical proteins. Among the indels, one...”
SA0287 hypothetical protein from Staphylococcus aureus subsp. aureus N315
Aligns to 7:152 / 166 (88.0%), covers 100.0% of PF04634, 178.1 bits
KMZ21_01295 antitoxin YezG family protein from Staphylococcus aureus subsp. aureus RN4220
Aligns to 7:152 / 166 (88.0%), covers 100.0% of PF04634, 177.1 bits
SACOL0297 hypothetical protein from Staphylococcus aureus subsp. aureus COL
SAOUHSC_00278 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_0302 hypothetical protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
Aligns to 7:152 / 162 (90.1%), covers 99.3% of PF04634, 176.5 bits
- Inhibition of Staphylococcus aureus biofilm formation by gurmarin, a plant-derived cyclic peptide
Chang, Frontiers in cellular and infection microbiology 2022 - “...Hypothetical protein 0.02 SAV1913 -3.17 Nicotinate phosphoribosultransferase 0.01 SACOL0549 -3.11 Tetrapyrrole methylase family protein 0.04 SACOL0297 -3.1 Conserved hypothetical protein 0.04 MW0509 -3.01 Branched-chain amino acid aminotransferase ilvE 0.01 SACOL1230 -2.97 Conserved hypothetical protein 0.03 SAV1896 -2.85 Hypothetical protein 0.05 SAV0756 -2.85 Probable HD superfamily hydrolase...”
- Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing
Bæk, PloS one 2013 - “...8325-4 contains nine novel SA0282 homologs in addition to three identical to SAOUHSC_00269, SAOUHSC_00277 and SAOUHSC_00278 found in 8325. None of the hypothetical proteins encoded by the total of 12 SA0282 homologs present in our sequenced 8325-4 have identical sequences, although they contain segments of highly...”
- Identification of Key Determinants of Staphylococcus aureus Vaginal Colonization
Deng, mBio 2019 - “...6 SAUSA300_0298 essI5 3 4 3 SAUSA300_0299 b essI6 2 SAUSA300_0300 b essI7 2 2 SAUSA300_0302 essI9 3 5 5 SAUSA300_0303 b DUF4467 domain-containing protein 2 3 a Genes which encode transcriptional regulators, toxins, secreted enzymes, extracellular matrix (ECM) binding, immune modulation, and T7SS factors and...”
- EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway
Ohr, Journal of bacteriology 2017 - “...the last five contiguous DUF600-encoding genes, SAUSA300_0298 to SAUSA300_0302, using USA300 chromosomal DNA as the template. Inserts were cloned into the NheI...”
ESSG_STAA8 / Q2G178 Type VII secretion system protein EsaG from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
SAUSA300_0289 hypothetical protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
SAOUHSC_00269 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
SACOL0282 hypothetical protein from Staphylococcus aureus subsp. aureus COL
KMZ21_01235 TIGR01741 family protein from Staphylococcus aureus subsp. aureus RN4220
Aligns to 7:152 / 163 (89.6%), covers 99.3% of PF04634, 174.0 bits
- function: Component of the type VII secretion system (Ess). Acts also as part of toxin-antitoxin system. Counteracts the toxic effect of EssD via direct interaction.
subunit: Interacts with EssD (via C-terminus) (PubMed:27723728). Interacts with EssE (PubMed:27723728). - Oxidative stress is intrinsic to staphylococcal adaptation to fatty acid synthesis antibiotics
Wongdontree, iScience 2024 - “...FigureS3 ). Highest expression of several Type 7 secretion system proteins (comprised between SAUSA300_0278 and SAUSA300_0289) occurred in FA conditions, as reported. 19 The FarE FA efflux pump was also upregulated, presumably to avoid accumulation and toxicity of free FAs; 20 as we reported, induction was...”
- Bacterial Membrane-Derived Vesicles Attenuate Vancomycin Activity against Methicillin-Resistant Staphylococcus aureus
Kumaraswamy, Microorganisms 2021 - “...Uncharacterized protein dmpI Tautomerase mtlD Mannitol-1-phosphate 5-dehydrogenase SAUSA300_0003 Uncharacterized protein SAUSA300_1690 Putative thioredoxin HMPREF0776_2533 Alpha-amylase SAUSA300_0289 Uncharacterized protein lysS LysinetRNA ligase pyrG CTP synthase SAUSA300_0706 Putative osmoprotectant ABC transporter, ATP-binding protein SA0224 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein recA Protein RecA HMPREF0776_0345 Accessory regulator family SAUSA300_2132...”
- Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision
Jensen, Scientific reports 2019 - “...type VII secretion system (T7SS) also referred to as the ESAT-6-like secretion systems (ESS) (SAUSA300_0278- SAUSA300_0289) 30 , and a predicted three-cistronic operon (SAUSA300_0767 - SAUSA300_0769) encoding three proteins of unknown function. The finding that ClpX, but not ClpXP, impacts transcription of the cell wall synthesis...”
- EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway
Ohr, Journal of bacteriology 2017 - “...the selection for mutational lesions. Of note, the essI1 (SAUSA300_0289) product is a member of the DUF600 protein family (domain of unknown function 600); nine...”
- “...were used to amplify by PCR the gene SAUSA300_0289 or the last five contiguous DUF600-encoding genes, SAUSA300_0298 to SAUSA300_0302, using USA300 chromosomal...”
- Cigarette Smoke Extract-Exposed Methicillin-Resistant Staphylococcus aureus Regulates Leukocyte Function for Pulmonary Persistence
Kulkarni, American journal of respiratory cell and molecular biology 2016 - “...SAUSA300_0939 SAUSA300_1953 SAUSA300_0101 SAUSA300_1391 SAUSA300_0289 SAUSA300_1928 SAUSA300_1480 SAUSA300_1927 SAUSA300_0153 SAUSA300_1803 SAUSA300_1230...”
- Genomic analysis of group A Streptococcus isolated during a correctional facility outbreak of MRSA in 2004
Lynch, Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada 2022 (secret) - Genome-wide CRISPRi screens reveal the essentialome and determinants for susceptibility to dalbavancin inStaphylococcus aureus
Liu, 2023 - Three small partner proteins facilitate the type VII-dependent secretion export of an antibacterial nuclease
Yang, 2023 - Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression
Panchal, PLoS pathogens 2020 - “...lysA ::p mecA (SJF5002) and lysA ::p mecA (SJF5006) had amino acid substitutions in the SAOUHSC_00269 and SAOUHSC_00270 , which likely code for components of a Type VII secretion system ([ 29 ]; S2 Table ). Four out of seven highly resistant strains had a base...”
- Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains
Kneuper, Molecular microbiology 2014 - “...the NCTC8325 genome sequence. The region from the start of esxA to the end of SAOUHSC_00269 covers approximately 14kb and is almost 100% identical between the RN6390, Newman, COL and USA300 strains (only two nucleotide differences over this region). Genes encoding secreted substrates are coloured in...”
- “...esaE , 1bp; esaE - esxD , 1bp; esxD - essD , 9bp; essD - SAOUHSC_00269 , 10bp; SAOUHSC_00269-SAOUHSC_00270 , 207bp. B. Schematic representation of subcellular location and predicted topologies of the proteins encoded at the ess locus (not to scale). Shading as in part A....”
- Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing
Bæk, PloS one 2013 - “...contigs shows that 8325-4 contains nine novel SA0282 homologs in addition to three identical to SAOUHSC_00269, SAOUHSC_00277 and SAOUHSC_00278 found in 8325. None of the hypothetical proteins encoded by the total of 12 SA0282 homologs present in our sequenced 8325-4 have identical sequences, although they contain...”
- Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain
Nair, Journal of bacteriology 2011 - “...regions, causing frameshift mutations in SAOUHSC_00269, SAOUHSC_00270, SAOUHSC_00274, SAOUHSC_00275, and SAOUHSC_00276, all hypothetical proteins. Among the...”
- Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains
Kneuper, Molecular microbiology 2014 - “...esxB esxB deletion This work COL ess Complete deletion from Sacol0271 ( esxA ) - Sacol0282 This work SA113 ess Complete deletion from esxA SAOUHSC_00269 This work E. coli JM110 rpsL thr leu thi lacY galK galT ara tonA tsx dam dcm glnV44 ( lac-proAB )...”
- Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220
Panthee, Heliyon 2022 - “...KMZ21_00505 161 tnpA: IS200/IS605 family transposase 115089..115573 - 4 KMZ21_01125 117 transposase 263883..264233 - 5 KMZ21_01235 163 TIGR01741 family protein 288910..289401 + 6 KMZ21_01240 227 DUF5079 family protein 289609..290292 + 7 KMZ21_01265 165 TIGR01741 family protein 292558..293053 + 8 KMZ21_01275 227 DUF5079 family protein 293765..294448 +...”
SAOUHSC_00276 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
Aligns to 7:152 / 166 (88.0%), covers 97.9% of PF04634, 173.7 bits
- Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing
Bæk, PloS one 2013 - “...collectively indicating mis-mapped reads. Three genes annotated in NCTC8325 as hypothetical proteins (SAOUHSC_00274, SAOUHSC_00275 and SAOUHSC_00276) are located in this region, and using the RAST server [ 18 ] they were re-annotated as repetitive hypothetical proteins near ESAT cluster, Sa0282 homologs, of which NCTC8325 contains six....”
- Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain
Nair, Journal of bacteriology 2011 - “...in SAOUHSC_00269, SAOUHSC_00270, SAOUHSC_00274, SAOUHSC_00275, and SAOUHSC_00276, all hypothetical proteins. Among the indels, one of the insertions is...”
BaGK_04195 immunity protein YezG family protein from Bacillus atrophaeus
Aligns to 6:151 / 156 (93.6%), covers 99.3% of PF04634, 172.0 bits
SAR0294 conserved hypothetical protein from Staphylococcus aureus subsp. aureus MRSA252
Aligns to 7:152 / 166 (88.0%), covers 97.9% of PF04634, 172.0 bits
- Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus
Overton, BMC systems biology 2011 - “...been characterised, and these all represent ESAT-6 system components; otherwise locus identifiers are given (e.g. SAR0294). Network edges are shown as blue lines. Novel virulence roles were inferred for the SAR0292-0294 module and the seven uncharacterised genes in the ESAT-6 module (see main text). These network-based...”
- “...( p 0.028, 3/3 nodes RanaDown) was composed of relatively uncharacterised, 'hypothetical' genes (SAR0292, SAR0293, SAR0294). Interestingly, the only edge from this module into the rest of the network connected with the ESAT-6 virulence module described above (Figure 3 ). Consistent with the network-based inference of...”
BJL64_01345 TIGR01741 family protein from Staphylococcus aureus
SA0289 hypothetical protein from Staphylococcus aureus subsp. aureus N315
SAV0301 hypothetical protein from Staphylococcus aureus subsp. aureus Mu50
Aligns to 7:152 / 166 (88.0%), covers 100.0% of PF04634, 170.6 bits
- Joint Genomic and Proteomic Analysis Identifies Meta-Trait Characteristics of Virulent and Non-virulent Staphylococcus aureus Strains
Bonar, Frontiers in cellular and infection microbiology 2018 - “...loci Protein lengths Differences 1. 188 Hypothetical protein (associated with type VII secretion system operon) BJL64_01345 BJL64_01350 BJL65_01345 166 161 161 Merge between two coding sequences of CH21. 2. 438 Serine-aspartate repeat protein D SdrD BJL64_02690 BJL65_02680 1,385 1,385 Eight sense mutations, one point mutation upstream...”
- Short term evolution of a highly transmissible methicillin-resistant Staphylococcus aureus clone (ST228) in a tertiary care hospital
Vogel, PloS one 2012 - “...in coa 3 320106 320180 x insertion of 222 bp C in pathogenicity island SAPIn2 (SA0289) 4 528194 528198 x deletion of 5 bp NC between SArRNA05 and SArRNA06 5 528467 528560 x x insertion of 93 bp NC between SArRNA05 and SArRNA06 6 528704 528753...”
- Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus
Cameron, The Journal of infectious diseases 2012 - “...protein 2.9 2.15 SA0287 Hypothetical protein 2.09 SA0289 SAR0592 Hypothetical protein Hypothetical protein 1.96 1.58 SA0336 Hypothetical protein 1.56 Unknown...”
- Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus
Donat, Journal of bacteriology 2009 - “...hypothetical proteins SA0269 Hypothetical protein SA0289 Conserved hypothetical SA0290 Conserved hypothetical SA0291 Hypothetical protein SA0467 Hypothetical...”
- Staphylococcal Superantigen-Like Protein 1 and 5 (SSL1 & SSL5) Limit Neutrophil Chemotaxis and Migration through MMP-Inhibition
Koymans, International journal of molecular sciences 2016 - “...SA0182, SA0357, SA0570, SA0710, SA0719, SA0745, SA0908, SA1633, SA1737, SA1743, SA1774, SA1818, SAOUHSC_00704, SAR0846, SAR1886, SAV0301, SAV0302, SCIN-A (SA1754), SCIN-B (SA1004), SCIN-C (SAR1131), Snase (SA0746), Sortase A (SAOUCHSC_02834), SSL2 (SAOUHSC_00384), SSL3 (SAOUHSC_00386), SSL4 (SAOUHSC_00389), SSL6 (SAOUHSC_00391), SSL7 (SAOUHSC_00392), SSL8 (SAOUHSC_00393), SSL9 (SAOUHSC_00394), SSL10 (SAOUHSC_00395), SSL11 (SAOUHSC_00399),...”
SAOUHSC_00277 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
Aligns to 7:152 / 166 (88.0%), covers 100.0% of PF04634, 170.5 bits
MW0269 hypothetical protein from Staphylococcus aureus subsp. aureus MW2
Aligns to 7:152 / 164 (89.0%), covers 100.0% of PF04634, 169.7 bits
SAUSA300_0299 hypothetical protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
Aligns to 7:152 / 166 (88.0%), covers 97.9% of PF04634, 168.0 bits
NWMN_0233 hypothetical protein from Staphylococcus aureus subsp. aureus str. Newman
Aligns to 7:152 / 166 (88.0%), covers 99.3% of PF04634, 163.1 bits
SAV0302 hypothetical protein from Staphylococcus aureus subsp. aureus Mu50
SA0290 hypothetical protein from Staphylococcus aureus subsp. aureus N315
BJL64_01350 TIGR01741 family protein from Staphylococcus aureus
Aligns to 7:151 / 161 (90.1%), covers 99.3% of PF04634, 162.7 bits
- Staphylococcal Superantigen-Like Protein 1 and 5 (SSL1 & SSL5) Limit Neutrophil Chemotaxis and Migration through MMP-Inhibition
Koymans, International journal of molecular sciences 2016 - “...SA0357, SA0570, SA0710, SA0719, SA0745, SA0908, SA1633, SA1737, SA1743, SA1774, SA1818, SAOUHSC_00704, SAR0846, SAR1886, SAV0301, SAV0302, SCIN-A (SA1754), SCIN-B (SA1004), SCIN-C (SAR1131), Snase (SA0746), Sortase A (SAOUCHSC_02834), SSL2 (SAOUHSC_00384), SSL3 (SAOUHSC_00386), SSL4 (SAOUHSC_00389), SSL6 (SAOUHSC_00391), SSL7 (SAOUHSC_00392), SSL8 (SAOUHSC_00393), SSL9 (SAOUHSC_00394), SSL10 (SAOUHSC_00395), SSL11 (SAOUHSC_00399), and...”
- Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus
Donat, Journal of bacteriology 2009 - “...SA0269 Hypothetical protein SA0289 Conserved hypothetical SA0290 Conserved hypothetical SA0291 Hypothetical protein SA0467 Hypothetical protein SA0725 Conserved...”
- Genome-wide analysis of ruminant Staphylococcus aureus reveals diversification of the core genome
Ben, Journal of bacteriology 2008 - “...SA1751 SP SA1973 Membrane SA2447 SA0089 SA0290 SA0333 SA0477 SAR0590 Classification by functionb Hypothetical protein; similar to deoxyribodipyrimidine...”
- Joint Genomic and Proteomic Analysis Identifies Meta-Trait Characteristics of Virulent and Non-virulent Staphylococcus aureus Strains
Bonar, Frontiers in cellular and infection microbiology 2018 - “...Protein lengths Differences 1. 188 Hypothetical protein (associated with type VII secretion system operon) BJL64_01345 BJL64_01350 BJL65_01345 166 161 161 Merge between two coding sequences of CH21. 2. 438 Serine-aspartate repeat protein D SdrD BJL64_02690 BJL65_02680 1,385 1,385 Eight sense mutations, one point mutation upstream of...”
SAR0293 conserved hypothetical protein from Staphylococcus aureus subsp. aureus MRSA252
Aligns to 7:152 / 166 (88.0%), covers 100.0% of PF04634, 162.6 bits
SAUSA300_0298 hypothetical protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
KMZ21_01285 TIGR01741 family protein from Staphylococcus aureus subsp. aureus RN4220
Aligns to 7:152 / 166 (88.0%), covers 99.3% of PF04634, 159.9 bits
BJL65_01345 TIGR01741 family protein from Staphylococcus aureus
Aligns to 7:151 / 161 (90.1%), covers 99.3% of PF04634, 157.7 bits
SA0288 hypothetical protein from Staphylococcus aureus subsp. aureus N315
Aligns to 7:152 / 153 (95.4%), covers 97.9% of PF04634, 157.2 bits
SACOL0289 hypothetical protein from Staphylococcus aureus subsp. aureus COL
Aligns to 7:152 / 163 (89.6%), covers 99.3% of PF04634, 151.1 bits
- Characterization of a community-acquired-MRSA USA300 isolate from a river sample in Austria and whole genome sequence based comparison to a diverse collection of USA300 isolates
Lepuschitz, Scientific reports 2018 - “...SACOL1708 (type III leader peptidase, YP_186547.1, C218T) in the core genome and the targets (n=2) SACOL0289 (hypothetical protein, YP_185183.1, G56T, C57T, G84A, A105C) and SACOL0651 (hypothetical protein, YP_185536.1, C524A) in the accessory genome. Figure 1 Minimum spanning tree for 165 MRSA isolates based on the cgMLST...”
BH3703 hypothetical protein from Bacillus halodurans C-125
Aligns to 5:148 / 169 (85.2%), covers 99.3% of PF04634, 143.1 bits
- A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria
Wang, Nature communications 2022 - “...protein structures using the Dali server 25 indicated a significant homology with the structure of BH3703 (PDB code 3I0T), with a Z-score of 18.9 and aroot-mean-square deviation (RMSD) of 1.9 (Supplementary Fig. 2 ). BH3703 is also a putative antitoxin produced by the Gram-positive bacterium Alkalihalobacillus...”
- “...on the C-terminus), electron densities were observed for all the other residues of EsaG. Similarly, BH3703 is also well structured with only three residues in the C-terminus missing. This suggests the absence of IDRs in EsaG-like antitoxins and, therefore, a distinct toxin inhibition mechanism in Gram-positive...”
SLGD_01963 Repetitive hypothetical protein from Staphylococcus lugdunensis HKU09-01
Aligns to 7:152 / 164 (89.0%), covers 96.6% of PF04634, 129.3 bits
SAUSA300_0295 hypothetical protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
Aligns to 2:114 / 128 (88.3%), covers 69.9% of PF04634, 108.3 bits
- Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria
Garrett, Microbial genomics 2022 - “...showed almost complete sequence identity, other than in a region spanning from the middle of SAUSA300_0295 to the middle of SAUSA300_0299 ( Fig. 3a ) which was absent from BKV_2. When the nucleotide sequences of SAUSA300_0295 and SAUSA300_0299 were aligned with esaG4 of BKV_2, esaG4 was...”
- “...SAUSA300_0299 ( Fig. 3b ). This is consistent with recombination between homology block 2 of SAUSA300_0295 and SAUSA300_0299 , with loss of the intervening DNA. Fig. 3. A recombination event in an epidemic lineage of USA300 results in loss of part of an esaG cluster and...”
- Homologous recombination between tandem paralogues drives evolution of a subset of Type VII secretion system immunity genes in firmicute bacteria
Garrett, 2022 - Contribution of the EssC ATPase to the assembly of the type 7b secretion system in Staphylococcus aureus
Bobrovskyy, The Journal of biological chemistry 2022 - “...( Table1 ). A few peptides also mapped to EsxA, EsaB, and DUF5079 (encoded by SAUSA300_0295 ) ( Table1 ). Owing to their small sizes, EsxA and EsaB digests yielded fewer peptides. DUF5079 is encoded in ESS clusters, but its function is not known; the gene...”
- “...57.89 1 29 EssA 17.38 0 24 EsaB 9.11 0 3 EsxA 11.03 0 2 SAUSA300_0295 15.64 0 1 SDS-PAGE analysis of Strep-Tactin eluates revealed discrete bands that stained with Coomassie brilliant blue for the EssC TS extract but not the untagged EssC control ( Fig.1...”
BC3287 hypothetical protein from Bacillus cereus ATCC 14579
Aligns to 5:149 / 151 (96.0%), covers 67.1% of PF04634, 32.9 bits
Or search for genetic data about PF04634 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory