Family Search for PF04634 (YezG-like)

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PF04634 hits 28 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YEZG_BACSU / C0H3X4 Immunity protein YezG from Bacillus subtilis (strain 168) (see 2 papers)
Aligns to 1:146 / 151 (96.7%), covers 99.3% of PF04634, 184.7 bits

• function: Immunity component of one of 6 LXG toxin-immunity modules in this strain. They promote kin selection, mediate competition in biofilms, and drive spatial segregation of different strains, indicating that LXG toxins may help avoid warfare between strains in biofilms. Mediates intercellular competition during biofilm formation; disruption of the operon disadvantages the bacteria, but overexpression of the cognate immunity protein restores growth in competition with wild-type. In situ neutralizes the toxic effect of cognate toxin YeeF (PubMed:34280190). Probably neutralizes the ability to inhibit growth of cognate toxin YeeF. Probably does not have immunity protein activity on other LXG toxins (Probable).
  subunit: Interacts with cognate toxin YeeF but not with non-cognate toxin YobL. The interaction probably inhibits the toxic activity of YeeF (PubMed:22200572). May bind with a stoichiometry of 2:2 to YeeF (By similarity).
  disruption phenotype: Deletion of the yeeF-yezG operon has no visible growth phenotype, however it is out-competed by wild-type cells.

YEZG_BACSH / E0TU95 Immunity protein YezG from Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) (Bacillus subtilis subsp. spizizenii) (see paper)
Aligns to 6:151 / 161 (90.7%), covers 99.3% of PF04634, 184.5 bits

• function: Immunity component of an LXG toxin-immunity module. These modules promote kin selection, mediate competition in biofilms, and drive spatial segregation of different strains, indicating that LXG toxins may help avoid warfare between strains in biofilms. Neutralizes the toxic abilities of cognate toxin YeeF upon expression in E.coli and in vitro.
  subunit: Monomer (PubMed:32117125). Interacts with the C-terminus of cognate toxin YeeF, probably with 2:2 stoichiometry. The second YezG molecules binds with lower affinity (Probable).

ESSG_STAA8 / Q2G178 Type VII secretion system protein EsaG from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
Aligns to 7:152 / 163 (89.6%), covers 99.3% of PF04634, 174.0 bits

• function: Component of the type VII secretion system (Ess). Acts also as part of toxin-antitoxin system. Counteracts the toxic effect of EssD via direct interaction.
  subunit: Interacts with EssD (via C-terminus) (PubMed:27723728). Interacts with EssE (PubMed:27723728).

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