Family Search for PF05057 (DUF676)

PF05057 hits 82 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YD109_YEAST / Q12103 Putative lipase YDL109C; EC 3.1.-.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
Aligns to 189:389 / 647 (31.1%), covers 97.3% of PF05057, 217.1 bits

• function: Involved in lipid metabolism.

YD444_YEAST / Q04093 Putative lipase YDR444W; EC 3.1.-.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
Aligns to 192:417 / 687 (32.9%), covers 97.3% of PF05057, 213.9 bits

LPL1_YEAST / Q08448 Lipid droplet phospholipase 1; EC 3.1.-.-; EC 3.1.1.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
Aligns to 1:214 / 450 (47.6%), covers 97.7% of PF05057, 210.3 bits

• function: Phospholipase involved in maintaining the lipid droplet morphology (PubMed:25014274). Has phospholipase activity with broad substrate specificity, acting on glycerophospholipids phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidycholine (PC) and phosphatidylserine (PS), primarily at sn-2 position (PubMed:25014274). It can later remove fatty acids from the sn-1 position of the produced lysophospholipids such as lysophosphatidylethanolamine (LPE) (PubMed:25014274). Shows also activity toward phosphatidylglycerol, but, in contrast to what was observed with the other phospholipids tested, prefers the sn-1 position (PubMed:25014274).
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1- acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) (RHEA:44604)
  catalytic activity: a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine (RHEA:32967)
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn- glycero-3-phosphate + a fatty acid + H(+) (RHEA:44420)
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+) (RHEA:15801)
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl- sn-glycero-3-phospho-L-serine + a fatty acid + H(+) (RHEA:44672)
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 2-acyl-sn- glycero-3-phosphoglycerol + a fatty acid + H(+) (RHEA:62032)
  catalytic activity: a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) (RHEA:62036)
  catalytic activity: a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+) (RHEA:62044)
  catalytic activity: an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate (RHEA:62048)
  catalytic activity: a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1- (9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) (RHEA:62052)
  catalytic activity: 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate (RHEA:62100)
  disruption phenotype: Leads to an altered morphology of lipid droplets with a smaller size.

F135A_HUMAN / Q9P2D6 Protein FAM135A from Homo sapiens (Human) (see paper)
Aligns to 1244:1440 / 1515 (13.0%), covers 99.1% of PF05057, 207.2 bits

LIP_PSEPS / P0DUB9 Triacylglycerol lipase; Extracellular lipase; Triacylglycerol ester hydrolase; EC 3.1.1.3 from Pseudarthrobacter phenanthrenivorans (Arthrobacter phenanthrenivorans) (see 2 papers)
Aligns to 9:127 / 319 (37.3%), covers 55.3% of PF05057, 33.0 bits

• function: Catalyzes the hydrolysis of triacylglycerol.
  catalytic activity: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) (RHEA:12044)
  cofactor: Ca(2+) (Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:8683577, ECO:0000305|Ref.)3}
  subunit: Monomer (Probable). Interacts with lipase-specific foldase Lif (By similarity).

GB|BAA00960.1 triacylglycerol lipase; EC 3.1.1.3 from Pseudomonas sp. KWI-56 (see paper)
Aligns to 54:173 / 364 (33.0%), covers 43.4% of PF05057, 33.0 bits

1tahB / P0DUB8 The crystal structure of triacylglycerol lipase from pseudomonas glumae reveals a partially redundant catalytic aspartate (see paper)
Aligns to 8:126 / 318 (37.4%), covers 55.3% of PF05057, 33.0 bits

• Ligand: calcium ion (1tahB)

LIP_BURPL / P0DUB8 Triacylglycerol lipase; Extracellular lipase; Triacylglycerol ester hydrolase; EC 3.1.1.3 from Burkholderia plantarii (see 6 papers)
Q05489 triacylglycerol lipase (EC 3.1.1.3) from Burkholderia glumae (see paper)
lipA / GB|CAA49812.1 Triacylglycerol lipase; EC 3.1.1.3 from Burkholderia glumae (see 4 papers)
Aligns to 48:166 / 358 (33.2%), covers 55.3% of PF05057, 32.6 bits

• function: Catalyzes the hydrolysis of triacylglycerol.
  catalytic activity: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) (RHEA:12044)
  cofactor: Ca(2+) (Binds 1 Ca(2+) ion per subunit.)
  subunit: Monomer (Probable). Interacts with lipase-specific foldase Lif (PubMed:16518399).
  disruption phenotype: Loss of extracellular active lipase. Not required for growth on oleic acid as a carbon source.

7cofA / A0A1Y1BQV9 Cholesterol esterase from burkholderia stabilis (orthorhombic crystal form)
Aligns to 9:136 / 320 (40.0%), covers 55.3% of PF05057, 32.0 bits

• Ligand: calcium ion (7cofA)

Q75NT4 sterol esterase (EC 3.1.1.13) from Burkholderia cepacia (see paper)
Aligns to 53:173 / 364 (33.2%), covers 43.4% of PF05057, 30.3 bits

PPT2_DROME / Q9VKH6 Lysosomal thioesterase PPT2 homolog; PPT-2; EC 3.1.2.- from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 22:198 / 288 (61.5%), covers 57.5% of PF05057, 28.8 bits

• function: Probable thioesterase removing fatty acyl groups from various substrates such as S-palmitoyl-CoA. Because of structural constraints, may be unable to remove palmitate from peptides or proteins (By similarity).

LIP_BURCE / P22088 Triacylglycerol lipase; Extracellular lipase; Triacylglycerol ester hydrolase; EC 3.1.1.3 from Burkholderia cepacia (Pseudomonas cepacia) (see 8 papers)
P22088 triacylglycerol lipase (EC 3.1.1.3) from Burkholderia cepacia (see 3 papers)
lipA / GI|557867 triacylglycerol lipase; EC 3.1.1.3 from Burkholderia cepacia (see 5 papers)
Aligns to 54:172 / 364 (32.7%), covers 43.4% of PF05057, 28.7 bits

• function: Catalyzes the hydrolysis of triacylglycerol. It shows a preference for triacylglycerols with a chain length between 6 and 12 carbons.
  catalytic activity: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) (RHEA:12044)
  cofactor: Ca(2+) (Binds 1 Ca(2+) ion per subunit.)
  subunit: Monomer.

TGL2_YEAST / P54857 Triacylglycerol lipase 2; Lipase 2; Neutral lipid hydrolase; EC 3.1.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
Aligns to 105:230 / 326 (38.7%), covers 39.7% of PF05057, 26.0 bits

• function: Mitochondrial triacylglycerol (TAG) lipase with activity toward long-chain diacylglycerols (DAGs) and triacylglycerols (TAGs) (PubMed:9544243, PubMed:19959834). Involved in mitochondrial lipid metabolism (PubMed:31483742).
  catalytic activity: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) (RHEA:12044)
  catalytic activity: 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) (RHEA:38575)
  catalytic activity: 1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+) (RHEA:40475)
  catalytic activity: 1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate (RHEA:47864)
  catalytic activity: di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z- octadecenoyl)-glycerol + H(+) (RHEA:47868)
  catalytic activity: dioctanoylglycerol + H2O = H(+) + octanoate + octanoylglycerol (RHEA:47880)
  subunit: Interacts with MIA40; forms mixed disulfide intermediates with MIA40.

LCAT3_ARATH / Q93V61 Phospholipase A(1) LCAT3; Lecithin-cholesterol acyltransferase-like 3; EC 3.1.1.32 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
LCAT3 / Q93V61 phospholipase A1 LCAT3 (EC 3.1.1.32) from Arabidopsis thaliana (see paper)
Aligns to 152:276 / 447 (28.0%), covers 37.4% of PF05057, 25.3 bits

• function: Hydrolyzes the sn-1 acylester bond of phospholipids. Phosphatidylcholine, phosphatidylethanolamine and phosphatidic acid can be used as substrates. Weak activity with lysophosphatidylcholine and no activity with tripalmitoylglycerol and cholesteryl oleate. Seems to have a preference for unsaturated fatty acids at the sn-1 position.
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+) (RHEA:18689)

A0A1C9U7K7 feruloyl esterase (EC 3.1.1.73) from Lactobacillus amylovorus (see paper)
Aligns to 25:131 / 247 (43.3%), covers 42.0% of PF05057, 24.1 bits

A9QXC9 triacylglycerol lipase (EC 3.1.1.3) from Burkholderia cepacia (see paper)
Aligns to 54:172 / 364 (32.7%), covers 43.4% of PF05057, 23.5 bits

Q8RJP5 triacylglycerol lipase (EC 3.1.1.3) from Bacillus megaterium (see paper)
Aligns to 29:131 / 210 (49.0%), covers 42.5% of PF05057, 23.2 bits

ESTB_BACSU / Q79F14 Extracellular esterase EstB; Extracellular esterase LipB; Lipase B; Triacylglycerol lipase; EC 3.1.1.3 from Bacillus subtilis (strain 168) (see 2 papers)
Q79F14 acylglycerol lipase (EC 3.1.1.23) from Bacillus subtilis (see paper)
Aligns to 29:131 / 210 (49.0%), covers 42.5% of PF05057, 23.1 bits

• function: An esterase which preferentially hydrolyzes triacylglyceride substrates with short chain fatty acids (C3-C10) with the maximum activity towards tricaprylin (C8:0); essentially inactive on C18:1 or C18:4 substrates. Active against p-nitrophenylesters with fatty acid chain lengths from C6 to C18.
  catalytic activity: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) (RHEA:12044)

7r1kA / W8FKE7 Phosphorylated bacillus pumilus lipase a
Aligns to 2:100 / 181 (54.7%), covers 41.6% of PF05057, 22.6 bits

• Ligand: oxaloacetate ion (7r1kA)

PLA11_ARATH / Q948R1 Phospholipase A(1) DAD1, chloroplastic; Phospholipase A1-Ibeta1; Protein DEFECTIVE IN ANTHER DEHISCENCE 1; AtDAD1; EC 3.1.1.32 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
Q948R1 phospholipase A1 (EC 3.1.1.32) from Arabidopsis thaliana (see paper)
DAD1 / Q948R1 DAD1 (EC 3.1.1.32) from Arabidopsis thaliana (see paper)
Aligns to 219:377 / 447 (35.6%), covers 45.7% of PF05057, 21.8 bits

• function: Sn-1-specific phospholipase that releases free fatty acids from phospholipids. Low activity on galactolipids and triacylglycerols. Catalyzes the initial step of jasmonic acid biosynthesis. Not essential for jasmonate biosynthesis after wounding or upon pathogen infection.
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+) (RHEA:18689)
  catalytic activity: 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphocholine + H(+) + hexadecanoate (RHEA:40971)
  disruption phenotype: Defective in anther dehiscence and pollen maturation. Delayed flower buds opening.

7c4dA / A0A2S1GUX0 Marine microorganism esterase (see paper)
Aligns to 13:121 / 261 (41.8%), covers 43.4% of PF05057, 21.3 bits

• Ligand: acetate ion (7c4dA)

YbfF / b0686 esterase from Escherichia coli K-12 substr. MG1655 (see 4 papers)
YBFF_ECOLI / P75736 Esterase YbfF; EC 3.1.-.- from Escherichia coli (strain K12) (see paper)
P75736 palmitoyl-CoA hydrolase (EC 3.1.2.2) from Escherichia coli (see paper)
ybfF / GB|ABB60819.1 esterase ybfF; EC 3.1.-.- from Escherichia coli K12 (see 5 papers)
Aligns to 12:121 / 254 (43.3%), covers 43.8% of PF05057, 21.3 bits

• function: Displays esterase activity toward palmitoyl-CoA, malonyl-CoA and pNP-butyrate.

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