Family Search for PF05254 (UPF0203)

PF05254.12 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

MDM35_YEAST / O60200 Mitochondrial distribution and morphology protein 35 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 10 papers)
NP_012870 Mdm35p from Saccharomyces cerevisiae S288C
YKL053C-A Mdm35p (RefSeq) from Saccharomyces cerevisiae
Aligns to 7:75 / 86 (80.2%), covers 97.1% of PF05254, 95.9 bits

• function: Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071602, PubMed:26071601, PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602).
  subunit: Interacts with UPS1, UPS2 and UPS3.
• Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex.
  Yu, EMBO reports 2015
  • GeneRIF: crystal structure of Ups1-Mdm35 bound with a phosphatidic acid (PA) molecule at 2.0 A resolution; study reveals molecular basis of Ups1-Mdm35-mediated PA binding and transfer and sheds new light on mechanism of intramitochondrial lipid transport by MSF1/PRELI family proteins
• Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria.
  Watanabe, Nature communications 2015
  • GeneRIF: The Ups1-Mdm35 complex constitutes a single domain that has a deep pocket and flexible Omega-loop lid. A basic residue at the pocket bottom and the Omega-loop lid are important for phosphatidic acid extraction from the membrane following Ups1 binding.
• Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
  Tamura, The EMBO journal 2010
  • GeneRIF: The authors show that Ups1, Ups2 and Ups3 protein import is mediated by another mitochondrial intermembrane space protein, Mdm35p.
• Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35.
  Potting, The EMBO journal 2010
  • GeneRIF: The authors identified Mdm35, a member of the twin Cx9C protein family, as a novel interaction partner of Ups1 and Ups2.
• Systematic analysis of the twin cx(9)c protein family.
  Longen, Journal of molecular biology 2009 (PubMed)
  • GeneRIF: Loss of Mdm35, Emi1, and Mrp10 leads to abnormal mitochondrial morphology
• Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1
  Hoke, Current genetics 2010
  • “...4.0 Unknown YHR215W PHO12 3.7 Acid phosphatase YML123C PHO84 3.1 Inorganic phosphate and manganese transporter YKL053C-A MDM35 3.1 Mitochondrial intermembrane space YBR147W RTC2 2.9 Similarity to G-protein coupled receptor YDL098C SNU23 2.8 Component of U4/U6.U5 snRNP YKL120W OAC1 2.7 Mitochondrial inner membrane transporter YBR050C REG2 2.7...”
• The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria
  Osman, The Journal of cell biology 2009
  • “...b YHR194w IM GD MDM32 b YOR147w IM SL MDM34 b YGL219c OM SL MDM35 YKL053c-A IMS SL UPS1 b YLR193c IMS SL Unknown GEP1 YLR168c IMS SL GEP3 YOR205c M GD GEP4 YHR100c M SL GEP5 YLR091w M GD GEP6 YMR293c M SL GEP7 YGL057c...”
• Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae
  Kastenmayer, Genome research 2006
  • “...YFR032C-A YBR089C-A YPR052C YEL020W-A YLR325C YJR135W-A YKL053C-A YHR143W-A YCL057C-A YLR287C-A YOR182C YLR388W YFL017W-A YBL026W YHR072W-A YHR005C-A YLL018C-A...”
• Functional genomics reveals relationships between the retrovirus-like Ty1 element and its host Saccharomyces cerevisiae
  Griffith, Genetics 2003 (secret)
• Transitive functional annotation by shortest-path analysis of gene expression data
  Zhou, Proceedings of the National Academy of Sciences of the United States of America 2002
  • “...C], TOS5 [2, 1, C] (16), YDR165W [114, 113, C] (23), YKL053C-A [16, 62, M], YKL195W* [25, 37, M] (16), YLR356W [46, 45, C], YLR434C [119, 124, C] YBR089W [2, 1,...”
  • “...YDR324C* [3, 1, N], YML093W* [3, 2, C] LSG1 [3, 2, C] YKL053C-A [3, 3, M] RNQ1 [9, 8, M] (16), YGL069C* [24, 44, M] (26), YGL102C* [4, 4, C] (27) RNQ1 [3, 2, M]...”

TRIA1_HUMAN / O43715 TP53-regulated inhibitor of apoptosis 1; Protein 15E1.1; WF-1; p53-inducible cell-survival factor; p53CSV from Homo sapiens (Human) (see 3 papers)
TC 3.A.9.1.1 / O43715 TP53-regulated inhibitor of apoptosis 1, component of Chloroplast envelope protein translocase (CEPT); outer membrane complex. The Tic20-like protein (acc # AUO68237.1; 413 aas, 6 TMSs in a 1 TMS (N-terminal) + 5 TMSs (C-terminal)), of the lower brown alga, Saccharina japonica, has been characterized from Homo sapiens
NP_057483 TP53-regulated inhibitor of apoptosis 1 from Homo sapiens
Aligns to 2:65 / 76 (84.2%), covers 82.6% of PF05254, 88.8 bits

• function: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn- glycero-3-phosphate(out) (RHEA:36435)
  subunit: Monomer (PubMed:26071602). Interacts with APAF1 and HSP70 (PubMed:15735003). Forms a complex with PRELID1 in the mitochondrion intermembrane space (PubMed:23931759). Interacts with PRELID3A (PubMed:26071602).
• substrates: proteins
• Predicting Apoptosis Protein Subcellular Locations based on the Protein Overlapping Property Matrix and Tri-Gram Encoding.
  Yang, International journal of molecular sciences 2019
  • “...illustrate this point, the longest sequence (ID: Q68749, length: 3037) and the shortest sequence (ID: O43715, length: 76) of the datasets were selected to test the time required of this method. Remarkably, in our laboratory environment (Intel Xeon CPU E5620 @ 2.40GHz, 16 4-core processors, 16G...”
  • “...seconds and 471 seconds to generate the PSSM profiles of two proteins (i.e., Q68749 and O43715) respectively. This result also indicates that the longer a sequence is, the more time it will take to process it. However, the required time for obtaining POPMs of two proteins...”
• Effect of ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells.
  Perla, PloS one 2018
  • “...4 I3L276 HMOX2 Heme oxygenase 2 64.98 110.82 208.33 144.13 -3.21 0.031 UR, protein 5 O43715 TRIAP1 TP53-regulated inhibitor of apoptosis 1 49.04 19.75 1.00 0.00 49.04 0.052 Protein 6 P04040 CAT Catalase 37.92 55.59 236.27 118.47 -6.23 0.043 Protein 7 P06681 C2 Complement C2 1.00...”
  • “...pathways in ghost pepper treated cells [ 35 ]. As TP53-regulated inhibitor of apoptosis 1 (O43715; TRIAP1 ) was decreased in treated cells, its role in inhibiting activation of caspase-9 and prevention of apoptosis induction [ 36 ] was probably negatively affected by Ghost pepper at...”
• miR-1301/TRIAP1 Axis Participates in Epirubicin-Mediated Anti-Proliferation and Pro-Apoptosis in Osteosarcoma.
  Yu, Yonsei medical journal 2019
  • GeneRIF: miR-1301 was implicated in the chemosensitivity of osteosarcoma to epirubicin by modulating TRIAP1.
• TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1) stable silencing increases late apoptosis by upregulation of caspase 9 and APAF1 in RPMI8226 multiple myeloma cell line.
  Fook-Alves, Biochimica et biophysica acta 2016 (PubMed)
  • GeneRIF: Inhibition of TRIAP1 in RPMI8226 cells increased the percentage of apoptotic cells, accompanied by increased expression of APAF1 and Caspase 9, and Caspase 9 and Caspase 3/7 activity.
• Overexpression of Mitochondria Mediator Gene TRIAP1 by miR-320b Loss Is Associated with Progression in Nasopharyngeal Carcinoma.
  Li, PLoS genetics 2016
  • GeneRIF: TRIAP1 is regulated by miR-320b and has a role in progression in nasopharyngeal carcinoma
• Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance.
  Adams, Oncology reports 2015 (PubMed)
  • GeneRIF: Results describe the upregulation of TRIAP1 in drugresistant breast cancer cells. Its experimental modulation changed breast tumor cells sensitivity to doxorubicin, thus confirming its role in drug resistance.
• Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.
  Miliara, EMBO reports 2015
  • GeneRIF: crystal structures of free TRIAP1 and TRIAP1-SLMO1 complex reveal how the PRELI domain is chaperoned during import into the intermembrane mitochondrial space; structural resemblance of PRELI-like domain of SLMO1 with that of mammalian phoshatidylinositol transfer proteins suggest they share similar lipid transfer mechanisms
• A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation.
  Andrysik, Cell reports 2013
  • GeneRIF: TRIAP1 is Conserved Specific Coregulators of the p21:PUMA Expression Ratio.
• TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid.
  Potting, Cell metabolism 2013 (PubMed)
  • GeneRIF: Loss of TRIAP1 or PRELI impairs the accumulation of Cardiolipin, facilitates the release of cytochrome c, and renders cells vulnerable to apoptosis upon intrinsic and extrinsic stimulation.
• Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  Hendrickson, PloS one 2010
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
• More

TRIA1_XENTR / A9ULB4 TP53-regulated inhibitor of apoptosis 1; p53-inducible cell-survival factor; p53csv from Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) (see paper)
Aligns to 2:64 / 78 (80.8%), covers 82.6% of PF05254, 85.5 bits

• function: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The triap1:prelid1 complex probably functions as a phosphatidic acid (PA) transporter across the mitochondrion intermembrane space to provide PA for cardiolipin CL synthesis in the inner membrane. Likewise, the triap1:prelid3a complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (By similarity). Required for pronephros development; probably involved at an early stage in the formation of pronephric components derived from the somatic layer (PubMed:18472403).
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn- glycero-3-phosphate(out) (RHEA:36435)
  subunit: Monomer. Forms a complex with prelid1 in the mitochondrion intermembrane space. Interacts with prelid3a.

Q9SMZ9 Uncharacterized protein At4g33100 from Arabidopsis thaliana
AT4G33100 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 13:81 / 92 (75.0%), covers 92.8% of PF05254, 84.6 bits

• Gene3D: modelling protein structure, function and evolution
  Yeats, Nucleic acids research 2006
  • “...took the first three non-viral proteins with the name hypothetical protein returned by UniProt-O43716 (human), Q9SMZ9 ( Arabidopsis thaliana ) and O30176 ( Archaeoglobus fulgidis ). By examining the functional terms and structural predictions associated with these proteins and the protein families they belong to, we...”
  • “...us to justify this transfer of information. O43716 is a Glu-tRNAGln amidotransferase C subunit (Pfam:PF02686). Q9SMZ9 is possibly involved in mitochondrial distribution and morphology (GO process:0007005). O30176 contains a MazG nucleotide pyrophosphohydrolase domain (Pfam:PF03819). Identifying structural targets Another current task for Gene3D is in identifying good...”
• Glycerolipid synthesis and lipid trafficking in plant mitochondria
  Michaud, The FEBS journal 2017
  • “...At1g72100 Ups1 Yeast/mammals IMS [ 59 ] PA transfer between OM IM At5g13070 Mdm35 IMS At4g33100 Ups2 Yeast IMS [ 58 ] PL transfer between OMIM At5g13070 NDPK-D Mammals IMS [ 60 ] OMIM CL transfer between OMIM NDPK3 (At4g11010) mtCK Mammals IMS [ 84 ]...”

CG30108 uncharacterized protein from Drosophila melanogaster
Aligns to 2:64 / 88 (71.6%), covers 87.0% of PF05254, 84.0 bits

• Transcriptional profiling of Drosophila S2 cells in early response to Drosophila C virus
  Zhu, Virology journal 2013
  • “...CG15097, CG15308, CG15543, CG15673, CG1600, CG16717, CG16718, CG16833, CG17599, CG17660, CG17681, CG18528, CG18557, CG18643, CG18769, CG30108, CG30115, CG30281, CG30421, CG30466, CG30502, CG31012, CG31323, CG31324, CG31431, CG31522, CG31523, CG3168, CG31778, CG32048, CG32066, CG32170, CG32206, CG32207, CG32313, CG32512, CG32982, CG33099, CG3348, CG34330, CG34349, CG34360, CG34383, CG34404, CG3788, CG3884,...”

LOC103505407 TP53-regulated inhibitor of apoptosis 1-like from Diaphorina citri
Aligns to 27:93 / 102 (65.7%), covers 82.6% of PF05254, 79.9 bits

• Annotation of the Asian Citrus Psyllid Genome Reveals a Reduced Innate Immune System
  Arp, Frontiers in physiology 2016
  • “...LOC103520736 XM_017448611.1 NW_007381407.1 5 Zootermopsis nevadensis KDR14692.1 97 6.00E-161 49 TP53-regulated inhibitor of apoptosis 1-like LOC103505407 XM_008469737.2 NW_007377609.1 3 Microplitis demolitor XP_008548768.1 23 5.00E-29 61 TNF receptor-associated factor 4 LOC103507530 XM_008472010.2 NW_007377755.1 7 + Cimex lectularius XP_014244337.1 72 0 62 TNF receptor-associated factor 6-like LOC103510016 XM_017444539.1...”

CG30109 uncharacterized protein from Drosophila melanogaster
Aligns to 2:68 / 88 (76.1%), covers 87.0% of PF05254, 79.7 bits

• Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster
  Valanne, PLoS pathogens 2019
  • “...(genomic loci 2R:17,671,068..17,671,295 [+]) and it is located between two protein coding genes; P32 and CG30109 . Therefore, CR44404 is classified as a long non-coding intergenic RNA (lincRNA) molecule. Although CR44404 is very close to the protein-coding gene P32, the genes do not overlap. To confirm...”
  • “...expression levels of the adjacent genes were examined in the transcriptome analysis. Neither P32 nor CG30109 were affected by infection in the same way as CR44404 , the expression of which was ~1300-fold upon a M . luteus infection. Instead, P32 (1.17-fold) and CG30109 (1.27-fold) were...”

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