Family Search for PF05255 (UPF0220)
PF05255 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
VPS68_YEAST / Q12016 Vacuolar protein sorting-associated protein 68 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
TC 9.B.199.1.7 / Q12016 Vacuolar protein sorting-associated protein 68, Vps68, of 184 aas and 4 TMSs from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
NP_014512 Vps68p from Saccharomyces cerevisiae S288C
YOL129W Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria (RefSeq) from Saccharomyces cerevisiae
Aligns to 5:178 / 184 (94.6%), covers 98.2% of PF05255, 238.4 bits
- function: Involved in vacuolar protein sorting.
- substrates: proteins
tcdb comment: Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking. Loss of Vps68p disrupts recycling to the trans-Golgi network (TGN) as well as onward trafficking to the vacuole without preventing the formation of lumenal vesicles (Schluter et al. 2008) - Species Composition and Toxigenic Potential of Fusarium Isolates Causing Fruit Rot of Sweet Pepper in China.
Wang, Toxins 2019 - “...Shandong external - Q12013 Shanghai external - Q12014 Shanghai external - Q12015 Shandong external - Q12016 Helongjiang external - Q12017 Zhejiang external - Q12018 Zhejiang internal - Q12019 Zhejiang external - Q12020 Zhejiang external - Q12021 Zhejiang external - Q12022 Zhejiang internal - Q12023 Zhejiang external...”
- Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex.
Schluter, Molecular biology of the cell 2008 - GeneRIF: Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking.
- VID22 counteracts G-quadruplex-induced genome instability
Galati, Nucleic acids research 2021 - “...0.00623 0.23168 0.1252 0.0925 Subunit of E3 ubiquitin ligase complex involved in replication repair VPS68 YOL129W 0.02521 0.23802 0.10864 0.1240 0.0876 Vacuolar membrane protein of unknown function THR4 YCR053W 0.12709 0.11031 0.12391 0.1204 0.0073 Threonine synthase DBP7 YKR024C 0.08875 0.16635 0.10059 0.1186 0.0341 Putative ATP-dependent RNA...”
- The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans
Olaisen, FEBS open bio 2018 - “...DNAdirected RNA polymerase I subunit Rpa49 11, 16 YNR019W Are2 Sterol Oacyltransferase 2 1, 43 YOL129W Vps68 Vacuolar protein sortingassociated protein 68 14, 20 YOR126C Iah1 Isoamyl acetatehydrolyzing esterase 1, 2 YOR176W Hem15 Ferrochelatase 1, 34 YOR255W Osw1 Outer spore wall protein 1 42, 43 YPL125W...”
- The protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity
Hwang, Scientific reports 2014 - “...complex 1.14 VPS45 YGL095C Vacuolar protein sorting 1.79 VPS63 YLR261C Vacuolar protein sorting 1.76 VPS68 YOL129W Vacuolar protein sorting 1.25 VTA1 YLR181C Endosomal protein sorting 1.29 Unknown function or BUD22 YMR014W Bud-site selection 1.57 poorly characterised IRS4 YKR019C Silencing of ribosomal DNA 1.27 NNF2 YGR089W Unknown...”
- Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels
Helbig, BMC genomics 2010 - “...40 MNSEY 1 -6.2 YIL076W SEC28 33 MDYFN 1 -5.9 YNL313C 45 METLL 1 -5.8 YOL129W VPS68 58 MEADD 1 -5.3 YJL041W NSP1 42 MNFNT 1 -5.3 YOL086W-A 34 MNDDE 1 -5.1 YIL088C AVT7 46 MEATS 1 -4.6 YPL262W FUM1 41 MNSSF 24 -4.5 YLR178C TFS1...”
- Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae
Bonangelino, Molecular biology of the cell 2002 - “...VPS65 (YLR322W), VPS66 (YPR139C), VPS67 (YKR020W), VPS68 (YOL129W), VPS69 (YPR087W), VPS70 (YJR126C), VPS71 (YML041C), VPS72 (YDR485C), VPS73 (YGL104C), VPS74...”
- Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve
Zhang, Nucleic acids research 2000 - “...YLR404w YOL118c YAR064w YDR115w YGL104c YJL170c YLR414c YOL129w YAR068w YDR119w YGL160w YJL193w YLR416c YOL160w YAR070c YDR126w YGL186c YJL215c YLR463c YOL162w...”
- Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster
Reboul, Genome research 1999 (secret)
SPBC8D2.02c vacuolar sorting protein Vps68 (RefSeq) from Schizosaccharomyces pombe
Aligns to 4:164 / 170 (94.7%), covers 98.2% of PF05255, 190.5 bits
CNAG_06792 hypothetical protein from Cryptococcus neoformans var. grubii H99
Aligns to 9:181 / 187 (92.5%), covers 98.8% of PF05255, 178.0 bits
- Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta
Do, Mycobiology 2019 - “...CNAG_06568 SKS1 RAN protein kinase CNAG_06631 Myosin heavy chain CNAG_06672 Formate dehydrogenase CNAG_06731 Hypothetical protein CNAG_06792 Hypothetical protein CNAG_06910 Beta-lactamase CNAG_07334 FRE4 Ferric-chelate reductase CNAG_07362 Nucleolin CNAG_07373 Carbamoyl-phosphate synthase, large subunit CNAG_07414 PAN6 Pantoate-beta-alanine ligase CNAG_07600 Beta-glucosidase CNAG_07636 CSR2 Putative chitin synthase regulator CNAG_07643 Hypothetical protein...”
P56557 Transmembrane protein 50B from Homo sapiens
XP_020926594 transmembrane protein 50B from Sus scrofa
Aligns to 4:157 / 158 (97.5%), covers 98.8% of PF05255, 173.9 bits
- Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids.
Notaras, Molecular psychiatry 2021 - “...NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex Assembly Factor 2 Q8N183 0.000481025 TMEM50B Transmembrane Protein 50B P56557 0.000548505 IMPA1 Inositol Monophosphatase 1 P29218 0.001902383 ARMCX1 Armadillo Repeat-Containing X-Linked Protein 1 Q9P291 0.002196252 GBF1 Golgi-Specific Brefeldin A-Resistance Guanine Nucleotide Exchange Factor 1 Q92538-3 0.002520107 HDHD5 Haloacid Dehalogenase-Like Hydrolase...”
- “...Protein name Uniprot accession WIN IL17a CORT Nicotine Ethanol Endomorphin ADD1 P35611 POLR3C Q9BUI4 TMEM50B P56557 NELFCD Q8IXH7 KPNA6 O60684 MTX2 Q75431 CLPTM1 Q96005 APP P05067 FXR2 P51116 TFCP2 Q12800 SUPT6H Q7KZ85 APLP2 Q06481 USP7 Q93009 TIMM21 Q9BVV7 APMAP Q9HDC9 SRP19 P09132 RPS27L Q71UM5 LSM3 P62310...”
- Sequence analysis of the porcine IFNAR1 and IFNGR2 genes.
Leeb, Cytogenetic and genome research 2006 (PubMed)- GeneRIF: The complete 168,835 bp insert sequence of a porcine BAC clone harboring the IFNGR2 gene was determined; the analyzed BAC clone also contained parts of an orphan gene encoding a putative transmembrane protein (TMEM50B).
TM50B_MOUSE / Q9D1X9 Transmembrane protein 50B from Mus musculus (Mouse) (see paper)
NP_084294 transmembrane protein 50B from Mus musculus
XP_017453514 transmembrane protein 50B isoform X1 from Rattus norvegicus
Aligns to 4:157 / 158 (97.5%), covers 98.8% of PF05255, 172.3 bits
Q9CXL1 Transmembrane protein 50A from Mus musculus
Aligns to 5:156 / 157 (96.8%), covers 96.4% of PF05255, 161.2 bits
O95807 Transmembrane protein 50A from Homo sapiens
Aligns to 5:156 / 157 (96.8%), covers 96.4% of PF05255, 159.7 bits
- Linear epitope prediction in HPV type 16 E7 antigen and their docked interaction with human TMEM 50A structural model.
Srivastava, Bioinformation 2017 - “...(TMEM) protein sequence was downloaded from the protein sequence database of NCBI (Swiss Prot ID O95807). Searching the Protein Data Bank (PDB) using BLASTP [ 9 ] identified the structural homolog of the TMEM 50A protein. Analysis of TMEM 50A TMHMM 2.0 (http://www.cbs.dtu.dk/services/TMHMM-2.0/) and Target-P 1.1...”
- Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome
Attwood, BMC genomics 2016 - “...either conserved domains or hits through BLASTP searches are also shown TMEM50A and TMEM50B [SwissProt: O95807 and P56557] both contain the UPF0220 Pfam domain (PF05255) and are the sole members of the TMEM50 protein family. TMEM50A is located on chromosome 1p36.11 in the RH gene locus,...”
- Gonadal transcriptomics elucidate patterns of adaptive evolution within marine rockfishes (Sebastes).
Heras, BMC genomics 2015 - “...0.019 0.011 1.817 360 Q1LWC2 1.23E-18 Q1LWC2 1.28E-25 transmembrane protein 50a 0.053 0.035 1.518 279 O95807 1.58E-65 O95807 3.27E-37 trna guanosine-2 -o-methyltransferase trm11 homolog 0.036 0.021 1.704 285 Q05B63 2.25E-57 Q7TNK6 7.43E-34 tumor necrosis factor ligand superfamily member 10 0.151 0.127 1.186 309 P50591 2.46E-15 P50591...”
- Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
Myklebust, Human molecular genetics 2015 - “...DAD1 (DAD1) NatA M SEGDS NI NI O15258 Protein RER1 (RER1) NatA M SGFLE NI O95807 Transmembrane protein 50A (TM50A) NatA M TAQGG NI Q5J8M3 Transmembrane protein 85 (TMM85) NatA M TKAGS NI Q96AG4 Leucine-rich repeat-containing protein 59 (LRC59) NatA M TKVAE NI NI Q13206 Probable...”
- Quantitative Proteomic Analysis of Enriched Nuclear Fractions from BK Polyomavirus-Infected Primary Renal Proximal Tubule Epithelial Cells.
Justice, Journal of proteome research 2015 - “...1, ATPase, H+ transporting, lysosomal V0 subunit A3 -3.515 0.170 Plasma Membrane Enzyme TMEM50 A O95807 Transmembrane protein 50A -2.194 0.346 Plasma Membrane Other Table 2 Comparison of differentially regulated proteins identified in this study to the previous microarray study. Gene names Accession Number Protein Name...”
- “...T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -3.515 0.170 N/A TMEM50A O95807 Transmembrane protein 50A -2.194 0.346 N/A...”
- Anterior segment alterations and comparative aqueous humor proteomics in the buphthalmic rabbit (an American Ophthalmological Society thesis).
Edward, Transactions of the American Ophthalmological Society 2011
CG15012 uncharacterized protein from Drosophila melanogaster
Aligns to 4:150 / 152 (96.7%), covers 92.2% of PF05255, 121.7 bits
- Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids
Cinege, Journal of innate immunity 2022 - “...Bet1, Bet3, Bet5, BicD, Blos1, boca, BORCS5, CanB2, car, CASK, Ccz1, Cdc42, CG10103, CG10435, CG13531, CG15012, CG16865, CG18659, CG30423, CG32069, CG32576, CG33635, CG43322, CG4645, CG5021, CG5104, CG5510, CG7956, CG8134, CG8155, CG9067, Chc, Chmp1, CHMP2B, Clc, cni, comm, Dab, DCTN2-p50, Dlc90F, epsilonCOP, Esyt2, Exo70, Exo84, fab1, Flo1,...”
- Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex
Arbeitman, G3 (Bethesda, Md.) 2016 - “...Female Opposing effects 1 1 rost 2L Female Opposing effects/ 1 1 Male specific repressor CG15012 3L Male Female specific repressor 0 0 mav 4 Male Female specific repressor 0 0 CG12158 2R Male Female specific repressor 0 0 Cyp4d21 2L Male Female specific repressor 0...”
- New components of Drosophila leg development identified through genome wide association studies
Grubbs, PloS one 2013 - “...No effect Femur CG10947 No effect No effect Femur CG13707 No effect No effect Tarsus CG15012 No effect No effect Tarsus CG18317 No effect No effect Femur CG30371 No effect Antenna-to-leg Tibia CG32333 No effect Antenna-to-leg Tibia CG3961 No effect No effect Femur CG43444 No effect...”
- “...No effect No effect Tarsus sick No effect Lethal Femur FlyBase IDs: CG10947 , FBgn0032857; CG15012 , FBgn0035528; GlcT-1 , FBgn0067102. We observed altered leg morphology with six candidate genes. At room temperature, Dll -RNAi with COP9 complex homolog subunit 1b ( CSN1b ) resulted in...”
XP_044389037 transmembrane protein 50 homolog from Triticum aestivum
Aligns to 8:141 / 141 (95.0%), covers 83.1% of PF05255, 96.1 bits
AT1G36980 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 4:135 / 135 (97.8%), covers 80.1% of PF05255, 85.3 bits
- Unraveling Reticulate Evolution in Opuntia (Cactaceae) From Southern Mexico
Granados-Aguilar, Frontiers in plant science 2020 - “...genomes. Five candidate genes were recovered, AT3G05090 , AT4G24040 , AT3G48380 , AT1G18270 , and AT1G36980 (names based on the A. thaliana annotation). Additional Cactaceae species coding sequences from these five genes were mined from oneKP 2 using BLAST in Geneious v.11.1.5 with the transcriptome databases...”
- “...genes ( Table 1 ) due to the risk of sequences not overlapping in gene AT1G36980 because its intron size of more than 1,200 bp for Cactaceae species. We designed up to three pairs of primers per candidate gene to span introns from 800 to 1,200...”
- Transcriptome Profiling of Beach Morning Glory (Ipomoea imperati) under Salinity and Its Comparative Analysis with Sweetpotato
Solis, PloS one 2016 - “...of UN93566 identified from the sweetpotato root transcriptome (S_PBL_c6736) (3) is annotated with homology to At1g36980 from Arabidopsis and TaSC , a an ortholog of At1g36980, was identified in a salt-tolerant wheat line that accumulated in the plasma membrane [ 60 ]. In the same study,...”
- Identification of immunity-related genes in Arabidopsis and cassava using genomic data
Leal, Genomics, proteomics & bioinformatics 2013 - “...responses to P. syringae and necrotrophic fungal pathogens AT1G52100, AT1G19370, AT1G77090, AT1G76070, DegP13, ATRER1A, AT1G57570, AT1G36980, AT5G58790, AT5G47435 FLS2 AT5G46330 LRR receptor-like serine/threonine-protein kinase, recognizes peptide from flagellin AT5G61520, AT1G47710, AT5G65960 CERK1 AT3G21630 LysM receptor-like kinase; essential in the sensing and transduction of the chitin oligosaccharide...”
C6T022 Transmembrane protein 50 homolog from Glycine max
Aligns to 6:135 / 135 (96.3%), covers 80.7% of PF05255, 82.3 bits
Or search for genetic data about PF05255 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory