Family Search for PF05255 (UPF0220)

PF05255.11 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

VPS68_YEAST / Q12016 Vacuolar protein sorting-associated protein 68 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
TC 9.B.199.1.7 / Q12016 Vacuolar protein sorting-associated protein 68, Vps68, of 184 aas and 4 TMSs from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
NP_014512 Vps68p from Saccharomyces cerevisiae S288C
YOL129W Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria (RefSeq) from Saccharomyces cerevisiae
Aligns to 5:178 / 184 (94.6%), covers 98.2% of PF05255, 239.1 bits

• function: Involved in vacuolar protein sorting.
• substrates: proteins
  tcdb comment: Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking. Loss of Vps68p disrupts recycling to the trans-Golgi network (TGN) as well as onward trafficking to the vacuole without preventing the formation of lumenal vesicles (Schluter et al. 2008)
• Species Composition and Toxigenic Potential of Fusarium Isolates Causing Fruit Rot of Sweet Pepper in China.
  Wang, Toxins 2019
  • “...Shandong external - Q12013 Shanghai external - Q12014 Shanghai external - Q12015 Shandong external - Q12016 Helongjiang external - Q12017 Zhejiang external - Q12018 Zhejiang internal - Q12019 Zhejiang external - Q12020 Zhejiang external - Q12021 Zhejiang external - Q12022 Zhejiang internal - Q12023 Zhejiang external...”
• Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex.
  Schluter, Molecular biology of the cell 2008
  • GeneRIF: Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking.
• The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans
  Olaisen, FEBS open bio 2018
  • “...DNAdirected RNA polymerase I subunit Rpa49 11, 16 YNR019W Are2 Sterol Oacyltransferase 2 1, 43 YOL129W Vps68 Vacuolar protein sortingassociated protein 68 14, 20 YOR126C Iah1 Isoamyl acetatehydrolyzing esterase 1, 2 YOR176W Hem15 Ferrochelatase 1, 34 YOR255W Osw1 Outer spore wall protein 1 42, 43 YPL125W...”
• The protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity
  Hwang, Scientific reports 2014
  • “...complex 1.14 VPS45 YGL095C Vacuolar protein sorting 1.79 VPS63 YLR261C Vacuolar protein sorting 1.76 VPS68 YOL129W Vacuolar protein sorting 1.25 VTA1 YLR181C Endosomal protein sorting 1.29 Unknown function or BUD22 YMR014W Bud-site selection 1.57 poorly characterised IRS4 YKR019C Silencing of ribosomal DNA 1.27 NNF2 YGR089W Unknown...”
• Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels
  Helbig, BMC genomics 2010
  • “...40 MNSEY 1 -6.2 YIL076W SEC28 33 MDYFN 1 -5.9 YNL313C 45 METLL 1 -5.8 YOL129W VPS68 58 MEADD 1 -5.3 YJL041W NSP1 42 MNFNT 1 -5.3 YOL086W-A 34 MNDDE 1 -5.1 YIL088C AVT7 46 MEATS 1 -4.6 YPL262W FUM1 41 MNSSF 24 -4.5 YLR178C TFS1...”
• Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae
  Bonangelino, Molecular biology of the cell 2002
  • “...VPS65 (YLR322W), VPS66 (YPR139C), VPS67 (YKR020W), VPS68 (YOL129W), VPS69 (YPR087W), VPS70 (YJR126C), VPS71 (YML041C), VPS72 (YDR485C), VPS73 (YGL104C), VPS74...”
• Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve
  Zhang, Nucleic acids research 2000
  • “...YLR404w YOL118c YAR064w YDR115w YGL104c YJL170c YLR414c YOL129w YAR068w YDR119w YGL160w YJL193w YLR416c YOL160w YAR070c YDR126w YGL186c YJL215c YLR463c YOL162w...”
• Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster
  Reboul, Genome research 1999 (secret)

SPBC8D2.02c vacuolar sorting protein Vps68 (RefSeq) from Schizosaccharomyces pombe
Aligns to 4:164 / 170 (94.7%), covers 98.2% of PF05255, 190.8 bits

• Genome-wide screen reveals important roles for ESCRT proteins in drug/ion resistance of fission yeast
  Yang, PloS one 2018
  • “...SPAC1142.07c vps32 ESCRT III complex subunit Vps32 +++ SPAC17G6.05c bro1 BRO1 domain protein Bro1 +++ SPBC8D2.02c vps68 vacuolar sorting protein Vps68 ++ SPAC17A2.06c vps8 CORVET complex WD repeat/ ubiquitin-protein ligase E3 subunit Vps8 + Regulation of transcription and translation SPBC25B2.03 a NA zf-C3HC4 type zinc finger...”

CNAG_06792 hypothetical protein from Cryptococcus neoformans var. grubii H99
Aligns to 9:181 / 187 (92.5%), covers 98.8% of PF05255, 178.7 bits

• Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta
  Do, Mycobiology 2019
  • “...CNAG_06568 SKS1 RAN protein kinase CNAG_06631 Myosin heavy chain CNAG_06672 Formate dehydrogenase CNAG_06731 Hypothetical protein CNAG_06792 Hypothetical protein CNAG_06910 Beta-lactamase CNAG_07334 FRE4 Ferric-chelate reductase CNAG_07362 Nucleolin CNAG_07373 Carbamoyl-phosphate synthase, large subunit CNAG_07414 PAN6 Pantoate-beta-alanine ligase CNAG_07600 Beta-glucosidase CNAG_07636 CSR2 Putative chitin synthase regulator CNAG_07643 Hypothetical protein...”

XP_020926594 transmembrane protein 50B from Sus scrofa
Aligns to 4:157 / 158 (97.5%), covers 98.8% of PF05255, 171.7 bits

• Sequence analysis of the porcine IFNAR1 and IFNGR2 genes.
  Leeb, Cytogenetic and genome research 2006 (PubMed)
  • GeneRIF: The complete 168,835 bp insert sequence of a porcine BAC clone harboring the IFNGR2 gene was determined; the analyzed BAC clone also contained parts of an orphan gene encoding a putative transmembrane protein (TMEM50B).

TM50B_MOUSE / Q9D1X9 Transmembrane protein 50B from Mus musculus (Mouse) (see paper)
NP_084294 transmembrane protein 50B from Mus musculus
XP_017453514 transmembrane protein 50B isoform X1 from Rattus norvegicus
Aligns to 4:157 / 158 (97.5%), covers 98.8% of PF05255, 170.2 bits

• subunit: May form homotrimers or homodimers.
• Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain.
  Moldrich, Neuroscience 2008 (PubMed)
  • GeneRIF: Tmem50b is a developmentally-regulated intracellular ER and Golgi apparatus membrane protein that may prove important for correct brain development through functions associated with precursor cells and glia.
• Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain.
  Moldrich, Neuroscience 2008 (PubMed)
  • GeneRIF: Tmem50b is a developmentally-regulated intracellular ER and Golgi apparatus membrane protein that may prove important for correct brain development through functions associated with precursor cells and glia.

Q9CXL1 Transmembrane protein 50A from Mus musculus
Aligns to 5:156 / 157 (96.8%), covers 96.4% of PF05255, 158.9 bits

• A salmonid EST genomic study: genes, duplications, phylogeny and microarrays.
  Koop, BMC genomics 2008
  • “...serine proteinase 30 10 355 - S/C yes Unknown 31 15 486 - - yes Q9CXL1 8.0E-78 Transmembrane protein 50A 32 11 332 - - yes Q62636 2.0E-90 Ras-related protein Rap-1b precursor 33 22 291 Om/Sf - yes Q3T0Q6 3.0E-71 Cellular nucleic acid-binding protein 34 10...”

O95807 Transmembrane protein 50A from Homo sapiens
Aligns to 5:156 / 157 (96.8%), covers 96.4% of PF05255, 157.4 bits

• Linear epitope prediction in HPV type 16 E7 antigen and their docked interaction with human TMEM 50A structural model.
  Srivastava, Bioinformation 2017
  • “...(TMEM) protein sequence was downloaded from the protein sequence database of NCBI (Swiss Prot ID O95807). Searching the Protein Data Bank (PDB) using BLASTP [ 9 ] identified the structural homolog of the TMEM 50A protein. Analysis of TMEM 50A TMHMM 2.0 (http://www.cbs.dtu.dk/services/TMHMM-2.0/) and Target-P 1.1...”
• Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome
  Attwood, BMC genomics 2016
  • “...either conserved domains or hits through BLASTP searches are also shown TMEM50A and TMEM50B [SwissProt: O95807 and P56557] both contain the UPF0220 Pfam domain (PF05255) and are the sole members of the TMEM50 protein family. TMEM50A is located on chromosome 1p36.11 in the RH gene locus,...”
• Gonadal transcriptomics elucidate patterns of adaptive evolution within marine rockfishes (Sebastes).
  Heras, BMC genomics 2015
  • “...0.019 0.011 1.817 360 Q1LWC2 1.23E-18 Q1LWC2 1.28E-25 transmembrane protein 50a 0.053 0.035 1.518 279 O95807 1.58E-65 O95807 3.27E-37 trna guanosine-2 -o-methyltransferase trm11 homolog 0.036 0.021 1.704 285 Q05B63 2.25E-57 Q7TNK6 7.43E-34 tumor necrosis factor ligand superfamily member 10 0.151 0.127 1.186 309 P50591 2.46E-15 P50591...”
• Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
  Myklebust, Human molecular genetics 2015
  • “...DAD1 (DAD1) NatA M SEGDS NI NI O15258 Protein RER1 (RER1) NatA M SGFLE NI O95807 Transmembrane protein 50A (TM50A) NatA M TAQGG NI Q5J8M3 Transmembrane protein 85 (TMM85) NatA M TKAGS NI Q96AG4 Leucine-rich repeat-containing protein 59 (LRC59) NatA M TKVAE NI NI Q13206 Probable...”
• Quantitative Proteomic Analysis of Enriched Nuclear Fractions from BK Polyomavirus-Infected Primary Renal Proximal Tubule Epithelial Cells.
  Justice, Journal of proteome research 2015
  • “...1, ATPase, H+ transporting, lysosomal V0 subunit A3 -3.515 0.170 Plasma Membrane Enzyme TMEM50 A O95807 Transmembrane protein 50A -2.194 0.346 Plasma Membrane Other Table 2 Comparison of differentially regulated proteins identified in this study to the previous microarray study. Gene names Accession Number Protein Name...”
  • “...T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -3.515 0.170 N/A TMEM50A O95807 Transmembrane protein 50A -2.194 0.346 N/A...”
• Anterior segment alterations and comparative aqueous humor proteomics in the buphthalmic rabbit (an American Ophthalmological Society thesis).
  Edward, Transactions of the American Ophthalmological Society 2011

CG15012 uncharacterized protein from Drosophila melanogaster
Aligns to 4:150 / 152 (96.7%), covers 92.2% of PF05255, 120.4 bits

• Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex
  Arbeitman, G3 (Bethesda, Md.) 2016
  • “...Female Opposing effects 1 1 rost 2L Female Opposing effects/ 1 1 Male specific repressor CG15012 3L Male Female specific repressor 0 0 mav 4 Male Female specific repressor 0 0 CG12158 2R Male Female specific repressor 0 0 Cyp4d21 2L Male Female specific repressor 0...”
• New components of Drosophila leg development identified through genome wide association studies
  Grubbs, PloS one 2013
  • “...No effect Femur CG10947 No effect No effect Femur CG13707 No effect No effect Tarsus CG15012 No effect No effect Tarsus CG18317 No effect No effect Femur CG30371 No effect Antenna-to-leg Tibia CG32333 No effect Antenna-to-leg Tibia CG3961 No effect No effect Femur CG43444 No effect...”
  • “...No effect No effect Tarsus sick No effect Lethal Femur FlyBase IDs: CG10947 , FBgn0032857; CG15012 , FBgn0035528; GlcT-1 , FBgn0067102. We observed altered leg morphology with six candidate genes. At room temperature, Dll -RNAi with COP9 complex homolog subunit 1b ( CSN1b ) resulted in...”

AT1G36980 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 4:135 / 135 (97.8%), covers 80.1% of PF05255, 85.1 bits

• Transcriptome Profiling of Beach Morning Glory (Ipomoea imperati) under Salinity and Its Comparative Analysis with Sweetpotato
  Solis, PloS one 2016
  • “...of UN93566 identified from the sweetpotato root transcriptome (S_PBL_c6736) (3) is annotated with homology to At1g36980 from Arabidopsis and TaSC , a an ortholog of At1g36980, was identified in a salt-tolerant wheat line that accumulated in the plasma membrane [ 60 ]. In the same study,...”
• Identification of immunity-related genes in Arabidopsis and cassava using genomic data
  Leal, Genomics, proteomics & bioinformatics 2013
  • “...responses to P. syringae and necrotrophic fungal pathogens AT1G52100, AT1G19370, AT1G77090, AT1G76070, DegP13, ATRER1A, AT1G57570, AT1G36980, AT5G58790, AT5G47435 FLS2 AT5G46330 LRR receptor-like serine/threonine-protein kinase, recognizes peptide from flagellin AT5G61520, AT1G47710, AT5G65960 CERK1 AT3G21630 LysM receptor-like kinase; essential in the sensing and transduction of the chitin oligosaccharide...”

C6T022 Uncharacterized protein from Glycine max
Aligns to 6:135 / 135 (96.3%), covers 80.7% of PF05255, 82.1 bits

• NanoUPLC-MSE proteomic data assessment of soybean seeds using the Uniprot database
  Murad, BMC biotechnology 2012
  • “...C6T079 C6SYR9 C6T2N3 C6T0R6 C6SYJ1 C6SXB8 C6T013 9 C6T0T6 C6T0X6 C6SZK8 C6T4B2 C6T0S2 C6SYR8 C6SXL1 C6T022 10 C6T0U0 C6T113 C6SZV3 C6T5Y8 C6T0S5 C6SYW9 C6SY37 C6T0H4 11 C6T0U6 C6T128 C6T0P3 C6T604 C6T0T0 C6SZA0 C6SY76 C6T0W0 12 C6T0U8 C6T145 C6T0P7 C6T695 C6T0T6 C6SZK8 C6SYE8 C6T0Y8 13 C6T0V0 C6T149...”

Or search for genetic data about PF05255 in the Fitness Browser