Family Search for PF05267 (DUF725)

PF05267 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CG10911 uncharacterized protein from Drosophila melanogaster
Aligns to 48:168 / 359 (33.7%), covers 99.2% of PF05267, 123.5 bits

• A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes
  Bozler, PLoS genetics 2017
  • “...analysis. In this network, after Try the genes with the greatest number of interactions are CG10911 (17 edges), CG3868 (15 edges), and Try (14 edges) ( Fig 2D ). The most connected genes in the signal peptide cluster are Amy-d , Try , Tsp2A with 12...”
• Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila
  Kemp, Journal of immunology (Baltimore, Md. : 1950) 2013
  • “..., Obp99b , Mal-B1 , Nmda1 , CG8147 , CG1572 , l(2)gd1 , CG14906 , CG10911 and Tsp42EI appear to be only induced in response to viral infections, and may represent the core of an inducible antiviral gene expression program. The case of Obp99b is particularly...”
• Physical and Linkage Maps for Drosophila serrata, a Model Species for Studies of Clinal Adaptation and Sexual Selection
  Stocker, G3 (Bethesda, Md.) 2012
  • “...Dmel\eIF-4a FBgn0001942 0.36 0.213 s58 2 2L CG31811 Dmel\cenG1A FBgn0028509 0.47 0.000 s59 2 2R CG10911 Dmel\CG10911 FBgn0034295 0.43 0.000 s60 3 3R CG6439 Dmel\CG6439 FBgn0038922 0.32 0.807 s61 2 2L CG3763 Dmel\Fbp2 FBgn0000640 0.37 0.279 Included are D. melanogaster gene names corresponding to the top...”

CG7567 uncharacterized protein from Drosophila melanogaster
Aligns to 56:176 / 211 (57.3%), covers 98.3% of PF05267, 119.4 bits

• Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila
  Mossman, Genetics 2016
  • “...3R: 27,020,238..27,021,378 () CG6283 CG6283 FBgn0037936 3R: 11,688,381..11,690,051 () CG6908 CG6908 FBgn0039670 3R: 29,587,237..29,588,104 () CG7567 CG7567 FBgn0039687 3R: 29,724,159..29,724,950 () CG7593 CG7593 BCD intersection PGRP-SC2 FBgn0043575 2R: 8,716,950..8,717,695 (+) PGRP-SC2 CG14745 PGRP-SC1a FBgn0043576 2R: 8,709,733..8,710,320 (+) PGRP-SC1a CG14746 Mitochondrial NADH-ubiquinone oxidoreductase chain 3 FBgn0013681 mitochondrion_genome:...”
• Antagonistic pleiotropy for life-history traits at the gene expression level
  Bochdanovits, Proceedings. Biological sciences 2004
  • “...name low weight, high survival CG15308 CG17738 CAH1 CG7567 CG10622 CG14454 CG10311 CG15353 CG11300 CG2233 CG7834 CG8661 CG8145 Smt3 CG1249 CG14957 BcDNA:GH02250...”

CG5770 uncharacterized protein from Drosophila melanogaster
Aligns to 46:166 / 213 (56.8%), covers 98.3% of PF05267, 118.7 bits

• Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels
  Chen, G3 (Bethesda, Md.) 2020
  • “...hand, among the 40 genes down-regulated by para Shu , only 2 ( CG5966 and CG5770 ) were up-regulated by GstS1 M26 . Although CG5770 is an uncharacterized gene, CG5966 encodes proteins that are highly expressed in the larval and adult fat bodies and predicted to...”
• Drosophila Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis
  Zhu, RNA biology 2019
  • “...CG13215 CG32023 CR45371 CG6277 CG14957 CG12115 Jon65Aii CG5770 Sgs5 CG14300 Listericin CG10725 CR43771 Jon66Ci Peritrophin-15a Fold-change (-/- vs +/+) 54.6...”
• Changes in Neuronal Signaling and Cell Stress Response Pathways are Associated with a Multigenic Response of Drosophila melanogaster to DDT Selection
  Seong, Genome biology and evolution 2017
  • “...1.10E-09 CG18787 Nucleoporin-like protein 2 3.52 1.23E-07 Mal-B1 Maltase-B1 3.44 7.64E-03 CG13658 Alpha-amylase 3.28 2.37E-06 CG5770 Peptidase_C11 3.04 3.71E-06 CG3819 Endonuclease_NS 2.96 4.55E-09 Npc2e Niemann-Pick type C-2e 2.93 6.73E-03 CG33301 EcKinase 2.91 4.48E-17 CG43055 C-lectin domains-containing 2.86 1.61E-09 CG31703 RNA polymerase-associated protein RTF1 2.74 3.03E-03 Spn43Aa...”
  • “...phenotypes that resulted in alteration of wing development and flight capacity through the knockdown of CG5770 , CG6277 , CG6834 , Cyp6g1 , CG6908 , CG14191 , and CG18787 . In addition, bristle morphology or development was impacted in eight different cases when seven different transcripts...”
• MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators
  Kim, Proceedings of the National Academy of Sciences of the United States of America 2004
  • “...activity by an NF-B homologue (24, 25). However, AttA, CG5770, and CG32302 were reduced 2-fold when DIF was depleted, indicating that these three genes are...”

CG5767 uncharacterized protein from Drosophila melanogaster
Aligns to 48:168 / 253 (47.8%), covers 98.3% of PF05267, 118.6 bits

• I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells
  Buddika, Development (Cambridge, England) 2021 (secret)
• Similar effects of high-fructose and high-glucose feeding in a Drosophila model of obesity and diabetes
  Musselman, PloS one 2019
  • “...FDR CGD/CFD InRi FC- HS InRCA FC CG33128 CG33128 putative aspartic-type endopeptidase 2.24E-05 0.04163 -9.2678 CG5767 CG5767 DUF725 family 3.43E-05 0.04163 -4.66179 CG18087 Sgs7 Salivary gland secretion 7 7.33E-06 0.022108 -4.40159 -104.13091 5.842893 CG15404 CG15404 5.66E-06 0.022108 -4.07992 CG7606 CG7606 2.98E-05 0.04163 -3.83348 CG42798 CG42798 3.8E-05...”
• Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila
  Boomgarden, BMC genomics 2019
  • “...1.09E-02 unknown --Upregulated with CCM; Downregulated with Aging-- CG5804 0.51 7.70E-03 0.36 1.68E-01 fatty-acyl-CoA binding CG5767 0.45 4.87E-02 0.65 6.97E-03 unknown CG34330 0.41 3.14E-02 0.22 2.57E-01 unknown AsnS 0.37 7.58E-02 0.36 8.08E-02 asparagine synthase (glutamine-hydrolyzing) activity; protein homodimerization activity log2FC determined by DEseq2 using shrinkage estimation....”
• Gene expression in a Drosophila model of mitochondrial disease
  Fernández-Ayala, PloS one 2010
  • “...2.6 47F4 CG30104 nucleotide phosphatase 2.6 2.7 54B17 Peritrophin-15a gut-specific, chitin metabolism 2.2 3.0 29C1 CG5767 unknown function 1.8 3.3 55B155B2 CG3285 sugar transport 2.8 2.2 23E4 CG8942 tenascin, Wnt-signalling receptor-related 2.1 2.9 34E5 Cyp28a5 cytochrome P450, xenobiotic metabolism 2.6 2.4 34E5 Arc1 cofactor for tRNA...”
  • “...an internally repetitive structure and is practically impossible to parse for similar reasons. CG12057 and CG5767 (upregulated) and CG10659 (downregulated) are all midgut-specific. The first two have homologues only in the Drosophilids, and their function is completely unknown, but CG10569, with homologus in diverse taxa, has...”

CG16762 uncharacterized protein from Drosophila melanogaster
Aligns to 60:180 / 254 (47.6%), covers 99.2% of PF05267, 114.0 bits

• Hawaiian picture-winged Drosophila exhibit adaptive population divergence along a narrow climatic gradient on Hawaii Island
  Eldon, Ecology and evolution 2019
  • “...aay, Cyp4ac2, CG2254, CG3244, CG5023, CG5804, CG5966, CG6426, CG7916, CG8774, CG9259, CG10383, CG10513, CG10514, CG10680, CG16762, CG16898, CG16985, CG17124, CG18585, Eip71CD , GstD2 , GstD4, GstD5 , hgo, HSP23, HSP83 , ImpL3, Pepck, Thor (two paralogs), Trxr1 Population Srensen et al. ( 2005 ), Table 4...”
• Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes
  Hundertmark, PloS one 2019
  • “...CG13428 Peb Muc30E Muc11A AstCC Sfp24Bb CG2772 CG7542 CG12990 Sox21b CG43401 Mur18B Elo68alpha PebII Dh31-R CG16762 CG10764 Obp56g CG9259 CG8028 CG43320 Sfp60F CG42370 CG3285 Uro CG17572 CG6293 CG18095 CG18180 CG14304 CG12017 CG34426 CG12268 CG3868 CG12009 CG32023 Acp24A4 ppk19 CG43707 CG45072 CG34113 CG30427 dpr7 CG14292 Eip63F-1 Hsp70Aa...”
• p53 activity is selectively licensed in the Drosophila stem cell compartment
  Wylie, eLife 2014
  • “...CG5156 8.0 CG31810 5.6 3 LysX 7.9 CG2177 5.2 4 CG31901 7.6 CG7106 5.1 5 CG16762 7.5 CG1504 4.5 6 CG32277 7.3 CG15614 4.3 7 CG17239 7.2 unpg 4.2 8 CG17012 7.1 CG7329 4.2 9 CG9897 7.1 CG15236 4.1 10 Ser12 6.8 CG9294 4.1 11 CG2191...”
• Functional correlates of positional and gender-specific renal asymmetry in Drosophila
  Chintapalli, PloS one 2012
  • “...male-enriched genes. Probeset ID Gene Title P -value Fold-Change Anterior-enriched 1638974_at CG14963 1.9E-19 1940.9 1640881_at CG16762 1.7E-10 239.7 1634031_at Bestrophin 2 1.4E-10 63.6 1631218_at Dorsocross 5.0E-12 52.4 1627384_at CG6225 2.8E-08 18.5 1629459_at Dorsocross3 3.8E-12 16.7 1635591_at ninjurin A 2.7E-10 15.2 1625266_at antigen 5-related 1.1E-05 12.5 1628302_at...”
  • “...typically in the range 510% of the signal. A similar defensive role is implied for CG16762 , another gene strongly (240x) up-regulated in right-hand tubules ( Fig. 2 ), and with tubule-restricted expression. BLASTP searching reveals similarity to TsetseEP, a mucin implicated in tsetse susceptibility to...”
• Function-informed transcriptome analysis of Drosophila renal tubule
  Wang, Genome biology 2004
  • “...29.1 CG10006 29.0 CG15155 28.9 CG10226 ATP-binding cassette transporter 28.3 CG2196 Sodium iodide symporter 27.7 CG16762 27.6 CG14195 27.4 CG8125 Aryldialkylphosphatase 27.4 CG7881 Sodium phosphate cotransporter 27.1 CG8934 Sodium iodide symporter-like 27.1 CG7402 N -acetylgalactosamine-4-sulfatase-like 26.9 NaPi-T Na phosphate cotransporter 26.8 CG8791 Sodium phosphate cotransporter 26.8...”

CG10912 uncharacterized protein from Drosophila melanogaster
Aligns to 48:168 / 271 (44.6%), covers 99.2% of PF05267, 91.0 bits

• Drosophila Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis
  Zhu, RNA biology 2019
  • “...early pupae. Gene CG12057 CG12951 CG31789 CG16727 CG10912 CG7953 Est-P CG7290 CG11865 CG8997 CG7017 CR46031 CG11854 CG31205 CG34282 CG13215 CG32023 CR45371...”
  • “...5 upregulated genes (CG12057, CG12951, CG31789, CG16727, CG10912), whose mRNA levels were significantly increased in regnase-1-/- early pupae than in control...”
• Canalization of gene expression is a major signature of regulatory cold adaptation in temperate Drosophila melanogaster
  von, BMC genomics 2016
  • “...eight genes ( Frost , Hsp23 , brinker , smp30 , TotA , TotC , CG10912 , CG12164 ) we performed qRT-PCR experiments in one European (SU08) and one African (ZI418) strain on a finer timescale: before the cold shock, 3.5h into the cold shock, right...”
  • “...of recovery status. Data for the three most informative genes Frost , Hsp23 , and CG10912 is depicted in the (Additional file 3 : Figure S1). Global expression differences between conditions In order to identify the common properties of the cold shock response, we compared the...”
• Do the genes of the innate immune response contribute to neuroprotection in Drosophila?
  Cantera, Journal of innate immunity 2015 (secret)
• Induced antiviral innate immunity in Drosophila
  Lamiable, Current opinion in microbiology 2014
  • “...both the replicon and SINV infection in vivo ( Vago , Frost , CG11671 , CG10912 ) are induced by other viruses (DCV, FHV, SIGMAV), and that one of them ( Vag o) encodes a protein associated with antiviral activity (see below). In the case of...”
• Expression of defense genes in Drosophila evolves under a different selective regime from expression of other genes
  Wayne, Evolution; international journal of organic evolution 2011
  • “...positive directional selection). Five genes had an NI for D. melanogaster greater than 1 (GCA: CG10912, CG15784, CG17575, hsf ; SCA: fst ), consistent with positive directional selection. Five genes in addition to mys had a positive DoS for D. melanogaster (GCA: cat, CG10680, CG18067, gstd1,...”
• The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae)
  Carpenter, PloS one 2009
  • “...regulator that is important in immune defense ( Thor ) and five other genes (CG13323, CG10912, CG16743, CG9928, CG15293). Seventeen genes were down-regulated in both studies including four Jonah proteases ( Jonah 25Bii, Jonah 25Biii, Jonah 65Ai and Jonah 25Bi ), two related calcium binding proteins...”

TSEP_GLOMM / Q95P09 Protein TsetseEP; EP-repeat protein from Glossina morsitans morsitans (Savannah tsetse fly) (see paper)
Aligns to 52:172 / 320 (37.8%), covers 97.5% of PF05267, 48.3 bits

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