Family Search for PF05277 (DUF726)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF05277 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

MIL1_YEAST / P43564 Probable lipase MIL1; Medium adaptin-interacting ligand 1; EC 3.1.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
NP_116583 Mil1p from Saccharomyces cerevisiae S288C
Aligns to 536:875 / 1073 (31.7%), covers 99.7% of PF05277, 491.2 bits

• function: Probable lipase that recruits the AP-1-related (AP-1R) complex to membranes via interaction with APM2 (PubMed:26658609). The AP-1R complex is an adapter protein complex that mediates of cargo protein SNC1 sorting in clathrin-coated vesicles (PubMed:26658609).
  subunit: Interacts with RPP0 (PubMed:15286401). Interacts with APM2 (PubMed:26658609).
• The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting.
  Whitfield, Molecular biology of the cell 2016
  • GeneRIF: Mil1 is a predicted lipase that binds Apm2 but not Apm1 and contributes to its membrane recruitment.

YFL034W Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk from Saccharomyces cerevisiae
Aligns to 536:875 / 1073 (31.7%), covers 99.7% of PF05277, 491.0 bits

• The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting
  Whitfield, Molecular biology of the cell 2016 (no snippet)
• Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop
  Vazquez, PLoS genetics 2016
  • “...high correlations of a deletion in the acyltransferase paralog YDR018c or in the lipase paralog YFL034w with deletions in amino acid permeases suggest that these ORFs may disturb amino acid transport or signaling mediated through such transporters, possibly by disturbing the lipid composition of membranes. Furthermore,...”
• Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins
  Sauerwald, Molecular and cellular biology 2015
  • “...fmp33 strain hit1 strain jlp2 strain ngr1 strain yfl034w strain ypl067c strain SGA crd1 GFP-OM14 strain SGA fmp32 GFP-OM14 strain SGA fmp33 GFP-OM14 strain...”
  • “...SGA jlp2 GFP-OM14 strain SGA ngr1 GFP-OM14 strain SGA yfl034w GFP-OM14 strain SGA ypl067c GFP-OM14 strain MATa MATa MATa MATa MATa MATa MATa MATa MATa MATa...”
• RNA polymerase II contributes to preventing transcription-mediated replication fork stalls
  Felipe-Abrio, The EMBO journal 2015
  • “...gene. This reduction in the speed was also observed at YFL034W, located near a late replication origin (Fig 5A). We could detect The EMBO Journal Vol 34 | No...”
  • “...500 500 0 0 0 20 30 40 0 0 20 30 40 Time after G1 (min) YFL034W ARS603 IP-BrdU (AU) - HU 15 15 15 10 10 10 5 5 5 0 0 0 20 30 0 0 40 20 30 40 Time after G1 (min)...”
• Different nucleosomal architectures at early and late replicating origins in Saccharomyces cerevisiae
  Soriano, BMC genomics 2014
  • “...along S phase. (A) , ARS603 is represented by a red rectangle and flanking genes, YFL034W and YFL033C, by blue ones. Vertical bars indicate sites for digestion with restriction enzymes PvuII and HindIII. Green rectangle represents the end-terminal probe. The nucleosomal profile from the G1 sample...”
• Mutation rates across budding yeast chromosome VI are correlated with replication timing
  Lang, Genome biology and evolution 2011
  • “...GL35 b YFR019W FAB1 184490 GL11 b YFL036W RPO41 58781 GL36 YFR021W ATG18 194800 GL12 YFL034W Uncharacterized 65475 GL37 YFR023W PES4 199862 GL13 YFL032W Hypothetical 74870 GL38 YFR026C Hypothetical 205736 GL14 YFL027C GYP8 80417 GL39 YFR030W MET10 213300 GL15 YFL025C BST1 84143 GL40 YFR032C Hypothetical 222078...”
• Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae
  Protchenko, Eukaryotic cell 2008
  • “...YMR052C-A YOR092W YOR292C YOR291W YDR107C YOL075C YBR235W YFL034W YPR114W YLR241W YLR426W YDL222C YBR241C YDR387C YDL133W YGR045C YDL199C YNL115C YKR106W Q0010...”
• Integrative investigation of metabolic and transcriptomic data
  Pir, BMC bioinformatics 2006
  • “...3.4E-02 LV4+ MSC2, PRX1, AMS1, PHM8, YMR034C, HXT1, MTH1, YPL099C, TRS23, CYC7, ZRG17, YLR431C, GPG1, YFL034W, PKH1, HXT3, YER028C monosaccharide transport 1.2E-05 hexose transport 1.2E-05 carbohydrate transport 5.5E-05 transport 6.5E-04 establishment of localization 7.4E-04 LV4- CNM67, MRK1, MKC7, YDL157C, YDR119W, QCR8, QCR9, INH1, COX8, COX4, HAP4,...”
• More

YELD_SCHPO / O14244 Uncharacterized membrane protein C6F6.13c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPAC6F6.13c DUF726 family protein from Schizosaccharomyces pombe
Aligns to 351:692 / 778 (44.0%), covers 99.7% of PF05277, 490.0 bits

• The Natural Product Resveratrol Inhibits Yeast Cell Separation by Extensively Modulating the Transcriptional Landscape and Reprogramming the Intracellular Metabolome
  Wang, PloS one 2016
  • “...right): wild-type, SPAC24B11.12c, rho4, hht3,pof3, isp6, pmc1, SPBC21B10.13c, mfm2, SPBC19G7.04, ste7, spd1, SPBC3B8.06, SPBC1773.02c, SPBC800.11, SPAC6F6.13c, dak2, plr1, SPBC119.03, cdm1, chs2, SPBC25B2.08, SPBC27.05, gpx1, klp6, SPBC839.02, pho1, gal1, SPBPB2B2.18, SPCPB1C11.02, SPCC1183.11, SPAC9E9.04, bgs4, SPAPB24D3.07c, SPBC2A9.13, SPBC31F10.17c, cys11, SPCC757.12, SPAC24H6.13, SPCC965.06, SPBC28F2.11, ctr4, ace2, top1, rnc1, ski3,...”

CBG13461 Protein CBG13461 from Caenorhabditis briggsae
Aligns to 211:551 / 624 (54.6%), covers 99.7% of PF05277, 479.5 bits

• Population-specific gene expression in the plant pathogenic nematode Heterodera glycines exists prior to infection and during the onset of a resistant or susceptible reaction in the roots of the Glycine max genotype Peking
  Klink, BMC genomics 2009
  • “...Hypothetical protein CBG13418 -2.52 0.00454 1.268364923 HgAffx.15681.1.S1_at CB281313 XP_001678446 1.00E-21 Caenorhabditis briggsae AF16 Hypothetical protein CBG13461 -2.19 0.00417 4.791600821 HgAffx.23342.1.S1_at BF014507 CAC83611 7.00E-61 Globodera rostochiensis EXPB1 protein -2.16 0.00882 9.06375819 Probe set lists that are induced in pi-L2 NL1-RHg that ultimately undergo a resistant reaction. FC-...”

YK68_SCHPO / Q9US10 Uncharacterized membrane protein C6F6.13c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 167:512 / 579 (59.8%), covers 98.8% of PF05277, 457.3 bits

A0A6J8D250 Uncharacterized membrane protein F35D11.3,Transmembrane and coiled-coil domain-containing protein 4 from Mytilus coruscus
Aligns to 171:515 / 753 (45.8%), covers 99.4% of PF05277, 421.7 bits

• Morphological change and differential proteomics analysis of gill in Mytilus coruscus under starvation
  Liang, Frontiers in physiology 2023
  • “...12 43.668 A0A6J8BQR5 Uncharacterized protein 26.981 77.2 18 97.935 A0A6J8C029 COL22A 107.58 21.4 17 54.385 A0A6J8D250 Uncharacterized protein 82.28 2.8 2 2.467 A0A6J8AGJ9 SDCBP 24.681 23.8 5 11.627 A0A6J8EAW444 MMP17 24.148 22.1 6 14.365 A0A6J8EA38 Uncharacterized protein 83.546 8.9 5 19.476 A0A6J8CA19 CTSL 35.765 19.9 5...”

NCU02065 DUF726 domain-containing protein from Neurospora crassa OR74A
Aligns to 285:627 / 949 (36.1%), covers 98.5% of PF05277, 389.3 bits

• Experimental Evolution of Multidrug Resistance in Neurospora crassa under Antifungal Azole Stress
  Zhou, Journal of fungi (Basel, Switzerland) 2022
  • “...RIP defective protein ( NCU02034 ), 3-hydroxyacyl-CoA dehydrogenase ( NCU16336 ), DUF726 domain-containing protein ( NCU02065 ), mitochondrial intermediate peptidase ( NCU02063 ), zinc metallopeptidase ( NCU02060 ), uridine nucleosidase Urh1 ( NCU02055 ), transcription initiation factor ( NCU02052 ), GTP-binding protein ( NCU02044 ), sterol-4alpha-carboxylate...”
  • “...). To be noted, 30thK2 and 30thK1 shared 10 commonly mutated genes. These genes include NCU02065 , NCU02063 , NCU02051 , NCU02026 , NCU02024 , NCU02012, and NCU01993 , whose mutants were tested above, and three hypothetical protein encoding genes without available mutants ( NCU16667 ,...”

TGME49_203300 hypothetical protein from Toxoplasma gondii ME49
Aligns to 1060:1400 / 1401 (24.3%), covers 99.4% of PF05277, 381.5 bits

• A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma
  Farhat, eLife 2021
  • “...resulting in chimeric RNAs. Figure 8figure supplement 2. Read-through events and chimeric RNAs detected near TGME49_203300 locus following CPSF4 and METTL3 post-translational knock-down. ( A ) and ( B ) A representative analysis of the read-through from the TGME49_203300 into the TGME49_203290 locus. ( A )...”

AT4G36210 hypothetical protein from Arabidopsis thaliana
Aligns to 312:662 / 672 (52.2%), covers 99.4% of PF05277, 329.5 bits

• Overexpression of a developing xylem cDNA library in transgenic poplar generates high mutation rate specific to wood formation
  Rauschendorfer, Plant biotechnology journal 2020
  • “...KEEP ON GOING (KEG) 1F39 0 Potri.016G086400 AT2G37090 IRREGULAR XYLEM 9 (IRX9) 1F433 0 Potri.007G016100 AT4G36210 DUF726 1F474.1 1E133 Potri.013G013000 AT1G56230 DUF1399 1F474.2 2.4E102 Potri.005G101400 AT1G20693 HIGH MOBILITY GROUP B2 (HMGB2) 2F11 0 Potri.014G045100 AT4G16780 HOMEOBOX LEUCINE ZIPPER PROTEIN 4 (HAT4) 2F65.1 1.3E113 Potri.003G132000 AT1G63910 MYB...”

AT2G18100 hypothetical protein from Arabidopsis thaliana
Aligns to 296:646 / 656 (53.5%), covers 99.4% of PF05277, 324.9 bits

• DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation
  Dubin, eLife 2015
  • “...THIOREDOXIN REDUCTASE 2 (NTR2) 9.96E-04 2_7666059 AT2G17430 MILDEW RESISTANCE LOCUS O 7 (MLO7) 7.56E-04 2_7915712 AT2G18100 Protein of unknown function (DUF726) 1.73E-06 2_7915712 AT2G17980 ATSLY member of SLY1 Gene Family 1.33E-05 2_7915712 AT2G18400 Ribosomal protein L6 family protein 1.26E-04 2_7915712 AT2G18150 Haem peroxidase 8.05E-04 2_7915712 AT2G18050...”

DDB_G0275413 DUF726 family protein from Dictyostelium discoideum AX4
Aligns to 726:1050 / 1268 (25.6%), covers 91.3% of PF05277, 233.7 bits

• The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA
  Li, Cell host & microbe 2009
  • “...3.00 4.57 2.27 DDB_G0288203 HEAT repeat 2.84 4.20 1.21 DDB_G0267440 LimpC, CD36 2.19 2.70 1.21 DDB_G0275413 Vacuolar sorting protein 9 (VPS9) 3.64 4.08 0.79 DDB_G0289485 Vacuolin A1 2.51 5.45 1.52 Lipid metabolism Reduced Expression DDB_G0275125 B-like phospholipase (2 genes) 0.160.19 0.340.36 1.121.52 DDB_G0286651 Saposin-like type B...”

XP_567060 hypothetical protein from Cryptococcus neoformans var. neoformans JEC21
2 alignments in 187:682 / 683 (58.7%), covering up to 66.2% of PF05277, 209.5 bits

• Genomic sequencing and analyses of Lymantria xylina multiple nucleopolyhedrovirus
  Nai, BMC genomics 2010
  • “...hit. Lyxy130 had a 32% identity match to 20 aa of a hypothetical protein [GenBank: XP_567060 ] of the fungal species Cryptococcus neoformans (the e-value is 25). Interestingly, Lyxy131 had a 31% identity match to 62 aa of Drosophila melanogaster GAG protein [GenBank: AAT12844 ] (the...”

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