Family Search for PF05346 (DUF747)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF05346 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
HCBG_06018 DUF747 domain-containing protein from Histoplasma capsulatum G186AR
Aligns to 511:937 / 1057 (40.4%), covers 99.4% of PF05346, 426.8 bits
- Extracellular Vesicle-Mediated RNA Release in Histoplasma capsulatum
Alves, mSphere 2019 - “...protein 1 subunit beta HCBG_05763 3R 3F Conserved hypothetical protein HCBG_05878 3F Hypothetical protein HCBG_05878 HCBG_06018 5F Cytomegalovirus GH-receptor family HCBG_06054 MR Phosphotransferase family protein Ion binding, kinase activity HCBG_06071 MF MF Protein HCBG_06082 MR Conserved hypothetical protein HCBG_06114 3F Protein HCBG_06176 3F KH domain protein...”
TSTA_065560 cytomegalovirus gH-receptor family protein, putative from Talaromyces stipitatus ATCC 10500
Aligns to 464:891 / 1008 (42.5%), covers 99.7% of PF05346, 419.8 bits
- Intracellular growth is dependent on tyrosine catabolism in the dimorphic fungal pathogen Penicillium marneffei
Boyce, PLoS pathogens 2015 - “...fahA ; green, maiA ; pink and hmgR ; orange. Flanking genes (PMAA_031940, PMAA_032030, TSTA_065640, TSTA_065560, AN1900, AN1892, AFUA_2G04190, AFUA_2G04270, PADG_08469, PADG_08463, CIMG_01309, CIMG_01315, HCEG_08529, HCEG_08533, HCEG_03254, HCEG_03257, BDDG_05746, BDDG_05738, BDDG_08624 and BDDG_12986) with no characterized role in tyrosine catabolism are shown in grey (same shade...”
TAPT1_SCHPO / O60067 Endoplasmic reticulum membrane protein 65 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 218:585 / 649 (56.7%), covers 99.0% of PF05346, 386.2 bits
- function: May be involved in membrane protein folding.
subunit: Interacts with slp1.
TAPT1_MOUSE / Q4VBD2 Transmembrane anterior posterior transformation protein 1 from Mus musculus (Mouse) (see paper)
Aligns to 152:456 / 564 (54.1%), covers 99.4% of PF05346, 385.0 bits
- function: Plays a role in primary cilia formation (By similarity). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity).
disruption phenotype: Mice die during perinatal development and are the cause of the L5Jcs1 phenotype. They exhibit posterior-to-anterior transformations of the vertebral column midsection, similar to mice deficient for Hoxc8 and Hoxc9. - Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics.
Ma, Molecules (Basel, Switzerland) 2022 - “...Major urinary protein 1 Mup22 0.779 0.009 down Q8BQ99 Uncharacterized protein Mrps2 0.795 0.011 down Q4VBD2 Transmembrane anterior posterior transformation protein 1 Tapt1 0.736 0.012 down P02802 Metallothionein-1 Mt1 0.723 0.014 down H3BKQ2 Intraflagellar transport-associated protein (Fragment) Iftap 0.817 0.016 down B2RUG7 Zinc finger RNA binding...”
- Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
Walsh, Journal of proteomics 2014 - “...0.70 0.049 Q64FW2 All-trans-retinol 13,14-reductase 8 0.69 0.041 0.55 0.004 P48678 Prelamin-A/C 18 0.68 0.002 Q4VBD2 Transmembrane anterior posterior transformation protein 1 1 0.68 0.012 0.61 0.002 P25688 Uricase 36 0.67 0.027 Q8VEH5 EPM2A-interacting protein 1 2 0.67 0.019 P08032 Spectrin alpha chain, erythrocyte 7 0.66...”
TAPT1_HUMAN / Q6NXT6 Transmembrane anterior posterior transformation protein 1 homolog; Cytomegalovirus partial fusion receptor from Homo sapiens (Human) (see 2 papers)
NP_699196 transmembrane anterior posterior transformation protein 1 homolog from Homo sapiens
Aligns to 155:459 / 567 (53.8%), covers 99.4% of PF05346, 384.8 bits
- function: Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity).
function: (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. - A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI-NET sequencing.
Nabavizadeh, EMBO molecular medicine 2023 - GeneRIF: A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI-NET sequencing.
- TAPT1-at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta.
Etich, EMBO molecular medicine 2023 - GeneRIF: TAPT1-at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta.
- Transmembrane anterior posterior transformation 1 regulates BMP signaling and modulates the protein stability of SMAD1/5.
Wang, The Journal of biological chemistry 2022 - GeneRIF: Transmembrane anterior posterior transformation 1 regulates BMP signaling and modulates the protein stability of SMAD1/5.
- Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations.
Howell, Genetics 2007 - GeneRIF: A perinatal lethal mutation in mouse Tapt1 results in homeotic, posterior-to-anterior transformations of the axial skeleton.
- TAPT1-at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta.
Etich, EMBO molecular medicine 2023 - “...mutation were visualized employing ChimeraX and the AlphaFold 2 model of human TAPT1 (UniProt entry Q6NXT6). Leu108 is located within an Nterminal alpha helix protruding into the membrane bilayer and projects into a cavity surrounded by several transmembrane helices (upper panel). Glu285, Asp306, Asp353, Lys356, His357...”
TAPT1_DANRE / A2BIE7 Transmembrane anterior posterior transformation protein 1 homolog from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
NP_001116722 transmembrane anterior posterior transformation protein 1 homolog from Danio rerio
Aligns to 152:456 / 567 (53.8%), covers 99.4% of PF05346, 378.6 bits
TAPT1_YEAST / P40085 Endoplasmic reticulum membrane protein 65; 65 kDa endoplasmic reticulum membrane protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YER140W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies from Saccharomyces cerevisiae
NP_011067 Emp65p from Saccharomyces cerevisiae S288C
Aligns to 143:457 / 556 (56.7%), covers 99.0% of PF05346, 334.0 bits
- function: May be involved in membrane protein folding.
subunit: Interacts with SLP1. - Inner-nuclear-membrane-associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity
Flagg, Molecular biology of the cell 2021 - “...to the cytosol and plasma membrane, while a GFP fusion protein localizes to the nucleus YER140W EMP65 Yes 0.01037 Integral membrane protein of the ER; forms an ER-membraneassociated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the UPR; proposed...”
- Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
LaMonte, Nature communications 2020 - “...), and 217.912.5M ( sur2 ) respectively). We found that the homozygous deletion strain for yer140w (which encodes the PfCARL homolog EMP65 38 ) showed low-level resistance to IZPs (152.210.5M), and a homozygous deletion of sec72 , another nonessential subunit of the complex for importing proteins...”
- “...deletion of sur2 Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine 217.912.5 1.8 emp65 YER140W Haploid deletion of emp65 Integral membrane protein of the ER 152.210.5 1.3 atg15 YCR068W Haploid deletion of atg15 Phospholipase 137.5412.9 1.1 Strain name, systematic name, 18h IC 50 against GNF179...”
- Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1
Friederichs, G3 (Bethesda, Md.) 2012 - “...mutants, pointing to a role for Mps3 in nuclear membrane organization. Deletion of SLP1 or YER140W / EMP65 (for ER membrane protein of 65 kDa) aggravated growth of mps3 SUN domain mutants. Slp1 and Emp65 form an ER-membrane associated protein complex that is not required directly...”
- “...the gene encoding the SUN-like protein, SLP1 , and an uncharacterized open reading frame (ORF) YER140W , which we have named EMP65 (for E R m embrane p rotein of 65 kDa). We show that Slp1 and Emp65 form an ER-associated membrane complex. Slp1 and Emp65...”
- Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control
Copic, Genetics 2009 - “...YML013W YAL007C YML013C-A YIR033W YJR075W YNL107W YJR117W YER140W YBL051C YNL087W YDR300C YLR111W YDR485C YAL011W YOR085W YDL095W YDR372C YJR118C Ambiguous...”
- “...SGA YNL107W Yaf9 N/D PCR YJR117W Ste24 cross/SGA SGA YER140W ORF cross/SGA SGA YBL051C Pin4 cross/SGA SGA YNL087W Tcb2 cross/SGA SGA YDR300C Pro1 cross N/D...”
- Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations
Howell, Genetics 2007 - “...for their Tapt1 ortholog (an uncharacterized ORF called YER140W) are viable, although C. elegans RNA interference (RNAi) screens (summarized in WormBase) report...”
- “...the worm ortholog cause 24-100% embryonic lethality. The YER140W gene product was found to interact, in two-hybrid screens, with Mch1p, Dhh1p, and Tma19p (Ito...”
- Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action
Baetz, Proceedings of the National Academy of Sciences of the United States of America 2004 - “...YJR007W* YML092C* SYG1 TSC10* LCB1* SUI2* PRE8* YER140W YER188W YGR205W YLR294C YER140W YER188W YGR205W YLR294C Biological process Actin filament organization...”
- Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve
Zhang, Nucleic acids research 2000 - “...YCR085w YER135c YIL054w YLR124w YNL269w YPR170w-a YCR087c-a YER140w YIL058w YLR145w YNL303w YPR195c YCR102w-a YER172c-a YIL088c YLR151c YNL305c YPR203w YCR103c...”
- Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation.
Zhang, Cell 2017 (PubMed)- GeneRIF: Study shows that a conserved endoplasmic reticulum (ER) membrane protein complex, consisting of Slp1 and Emp65 proteins, performs this function in the ER lumen. The complex binds unfolded proteins and protects them from degradation during folding.
POD1_ARATH / F4HVJ3 Protein POLLEN DEFECTIVE IN GUIDANCE 1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT1G67960 hypothetical protein from Arabidopsis thaliana
NP_176963 POLLEN DEFECTIVE IN GUIDANCE-like protein from Arabidopsis thaliana
Aligns to 303:611 / 624 (49.5%), covers 99.0% of PF05346, 322.9 bits
- function: Probable component of the calreticulin 3 (CRT3) complex, acting probably as a co-chaperone involved in protein retention in the endoplasmic reticulum lumen. Required for micropylar pollen tube guidance. Plays an essential role in cell plate orientation or positioning in early embryo patterning.
subunit: Interacts with CRT3, but not with CRT1 or CNX.
disruption phenotype: Defective in micropylar pollen tube guidance leading to zygotic lethality. - Maize WRKY Transcription Factor ZmWRKY79 Positively Regulates Drought Tolerance through Elevating ABA Biosynthesis
Gulzar, International journal of molecular sciences 2021 - “...(AT5G25610) and RD29A (AT5G52310) and several antioxidant enzyme-related genes such as AtCAT3 (AT1G20620) and AtPOD1 (AT1G67960) were also identified ( Supplementary Dataset 1 ). All these genes showed up-regulation in ZmWRKY79 -OE plants under drought stress, which explains the higher sugar content and higher antioxidant enzyme...”
- The Role of Endoplasmic Reticulum Stress Response in Pollen Development and Heat Stress Tolerance
Singh, Frontiers in plant science 2021 - “...double mutant Normal viable pollen Completely lost exine reticulation POD1; POLLEN DEFECTIVE in GUIDANCE 1 AT1G67960 ER lumen pod1 Pollen tubes fail to target the female gametophyte, defective in micropylar pollen tube guidance leading to zygotic lethality Li et al., 2011 UTR1, UDP-GALACTOSE TRANSPORTER 1 AT2G02810...”
- Genomic analyses of diverse wild and cultivated accessions provide insights into the evolutionary history of jujube
Guo, Plant biotechnology journal 2021 - “...C and F ST values (Figure 4a,b and Table S8 ). In Arabidopsis , POD1 (AT1G67960) regulates pollen tube guidance and early embryo patterning (Li et al ., 2011 ). Thus, we focused on ZjPOD1 and looked at other genetic variations including indel. Finally, we found...”
- Cytosolic Glucose-6-Phosphate Dehydrogenase Is Involved in Seed Germination and Root Growth Under Salinity in Arabidopsis
Yang, Frontiers in plant science 2019 - “...G6PD2 (AT5G13110), G6PD3 (AT1G24280), G6PD4 (AT1G09420), AtrbohD (AT5G47910), AtrbohF (AT1G64060), APX1 (At1G07890), SOD1 (At1G08830), POD1 (At1G67960), CAT1 (At1G20630), GR2 (At3G54660). Generation of the G6PD5 and G6PD6 Overexpressing Lines Arabidopsis full-length G6PD5 or G6PD6 cDNA was obtained using reverse transcription PCR, cloned into the pENTR-TOPO cloning vector...”
- Common and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells
Wang, BMC genomics 2011 - “...AT3G23580 RNR2 RIBONUCLEOTIDE REDUCTASE 2A 6.0E-09 6.1 AT4G17420 similar to unknown protein AT5G47420.1 7.6E-09 3.8 AT1G67960 similar to unnamed protein product GB:CAO42391.1 8.2E-09 2.2 AT5G45920 carboxylesterase 1.3E-08 5.9 AT5G16990 NADP-dependent oxidoreductase, putative 1.5E-08 2.8 AT2G35700 ERF38 ERF FAMILY PROTEIN 38; transcription factor 1.6E-08 2.5 AT4G11370 RHA1A...”
- POD1 regulates pollen tube guidance in response to micropylar female signaling and acts in early embryo patterning in Arabidopsis.
Li, The Plant cell 2011 - GeneRIF: POD1 is a novel ER luminal protein involved in ER protein retention and interacts with CALRETICULIN3. It plays a specific role in the micropylar response and is also essential for cell patterning during early embryogenesis.
LOC106765735 protein POLLEN DEFECTIVE IN GUIDANCE 1 from Vigna radiata var. radiata
Aligns to 231:541 / 553 (56.2%), covers 98.7% of PF05346, 310.0 bits
S8FBJ7 Membrane protein, putative from Toxoplasma gondii (strain ATCC 50611 / Me49)
2 alignments in 3103:3796 / 3811 (10.5%), covering up to 76.5% of PF05346, 291.1 bits
- Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins
Li, Parasites & vectors 2022 - “...corresponding proteins Entry Protein name Peptide Position Length S8EQX7 Carrier protein superfamily DAPSDGEGSGPRQGDREVTT 520539 20 S8FBJ7 Membrane protein, putative GGRQIENGGEDAAVND 936951 16 Q6GV23 Rhomboid-like protease 5 EQPPTGDYKRRALASP 5166 16 S8GSS4 Vacuolar transporter chaperone (VTC) domain-containing protein VGSQESGQARERDDREATE 136154 19 S8GRC2 Uncharacterized protein [Basic Local Alignment Search...”
PF3D7_0321900 cyclic amine resistance locus protein from Plasmodium falciparum 3D7
Aligns to 785:1268 / 1283 (37.7%), covers 98.7% of PF05346, 277.4 bits
- Antimalarial drug discovery: progress and approaches
Siqueira-Neto, Nature reviews. Drug discovery 2023 - “...GNF179 can be mediated by mutations in the P. falciparum cyclic amine resistance locus (CARL; PF3D7_0321900) or via mutations or stop codons in the endoplasmic reticulum-localized acetyl-CoA transporter (ACT) or UDP-galactose transporter (UGT) 149 . PfCARL encodes a relatively uncharacterized transmembrane protein expressed in the cis...”
- Updated List of Transport Proteins in Plasmodium falciparum
Wunderlich, Frontiers in cellular and infection microbiology 2022 - “...putative metabolite/vitamin transporter ( Ginsburg and Tilley, 2011 ) 9.B.14 unknown b - yes no Pf3D7_0321900 CARL unknown 9.B.314 e - cis-Golgi ( LaMonte etal., 2016 ) b - no yes PF3D7_0824700 LMF1 putative transporter 9.B.365.5.1 c - ER ( Blake etal., 2015 ) b -...”
- Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology
Okombo, Trends in parasitology 2021 - “...imidazolopiperazines KAF156 and GNF179 also associated resistance with SNPs in the cyclic amine resistance locus (PF3D7_0321900), acetyl-CoA transporter (PF3D7_1036800), and UDP-galactose transporter (PF3D7_1113300) [ 21 ]. Other reports have demonstrated PfK13-independent resistance phenotypes arising from ART selections in vitro [ 64 ], increased copy number and...”
- “...Endoplasmic Reticulum/Golgi apparatus Endoplasmic Reticulum-dependent protein processing 3D7, Dd2 Cyclic amine resistance locus ( pfcarl, Pf3D7_0321900); UDP-galactose transporter ( pfugt , PF3D7_1113300); acetyl-CoA transporter ( pfact , PF3D7_1036800) [ 20 ] MB14 4-cyano-3-methylisoquinoline Pre-clinical Na + efflux pump (PfATP4) Parasite plasma membrane ATP4-regulated Na + homeostasis...”
- Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials
Duffey, Trends in parasitology 2021 - “...3 9 15 [ 72 ] Unknown Ganaplacide (KAF156) Patient exploratory ABS, transmission, prophylaxis pfcarl (Pf3D7_0321900) pfugt (Pf3D7_1113300) pfact (Pf3D7_1036800) 3 8 10 [ 56 ] MIR: in vitro logarithmic value of the minimum inoculum for resistance obtained in Pf Dd2 with a drug pressure corresponding...”
- Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
LaMonte, Nature communications 2020 - “...mediated by mutations in three different genes including pfcarl , the cyclic amine resistance transporter (PF3D7_0321900); 11 , 12 pfact , the Acetyl-CoA transporter (PF3D7_1036800); and pfugt , the UDP-galactose transporter (PF3D7_1113300) 18 . GFP-tagging and localization experiments have shown that these three transmembrane transporters are...”
- Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs
Foguim, Malaria journal 2019 - “...of pfact , pfugt and pfcarl The three genes, pfact (PF3D7_1036800), pfugt (PF3D7_1113300) and pfcarl (PF3D7_0321900), were amplified by polymerase chain reaction using the oligonucleotide primer pairs described in Table 1 . Table1 Forward and reverse primers, hybridization temperature (Tm) and MgCl 2 concentration used for...”
- “...TGA TAA GGA ATT TTG-3 Pfact-2R 5-TTC GTT CTC CAA TCT TCT AAA-3 48C pfcarl (PF3D7_0321900) Pfcarl-F 5-TTG CCA TGA TTT GAA GTA CA-3 Pfcarl-R 5-AAC CAT TTT CGT ATT CAT GTT-3 50C Two primer pairs were used to amplify the pfact fragments (1042 and 407...”
- Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum
Ross, Cell host & microbe 2019 - “...KAI407, MMV390048 pfpi4k (PF3D7_0509800) Endoplasmic Reticulum and Golgi apparatus Unknown Unknown KAF156 and analogues pfcarl (PF3D7_0321900) pfugt (PF3D7_1113300) pfact (PF3D7_1036800) Apicoplast Protein synthesis Apicoplast rRNA Azithromycin pfRpl4 (PF3D7_API00100) Apicoplast isoleucyl-tRNA synthetase Mupirocin pfapi-IRS (PF3D7_1225100) Isoprenoid synthesis 1-Deoxy-D-xylulose 5-phosphate reductoisomerase Fosmidomycin pfdxr (PF3D7_1467300) Proteasome Ubiquitin-regulated protein degradation...”
- Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Cowell, Science (New York, N.Y.) 2018 - “...acquired mutations resulting in coding changes in the cyclic amine resistance locus ( pfcarl ; PF3D7_0321900). Furthermore, amplification of the pfmdr1 region was observed in all 3D7 clones that acquired resistance to three closely related carbazoles: MMV009063, MMV019017, and MMV665882 (table S10 and Fig. 2 )....”
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B4DR99 cDNA FLJ59140 from Homo sapiens
2 alignments in 1:196 / 200 (98.0%), covering up to 42.9% of PF05346, 257.1 bits
Or search for genetic data about PF05346 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory