Family Search for PF05600 (CDK5RAP3)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF05600 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

F1RWH6 CDK5 regulatory subunit associated protein 3 from Sus scrofa
Aligns to 4:502 / 505 (98.8%), covers 99.8% of PF05600, 654.8 bits

• Lipopolysaccharide challenge significantly influences lipid metabolism and proteome of white adipose tissue in growing pigs
  Guo, Lipids in health and disease 2015
  • “...protein down 8 F1RUN2;P08835;CON__P02768-1 ALB Serum albumin down 9 F1RVZ1 ACOX1 Uncharacterized protein down 10 F1RWH6 CDK5RAP3 Uncharacterized protein down 11 F1RX84 PROSC Uncharacterized protein down 12 F1RYS5 SEPT11 Uncharacterized protein down 13 F1S0A2 LOC100737887 Peptidyl-prolyl cis-trans isomerase down 14 F1S1X9 TXNL1 Uncharacterized protein down 15...”

CK5P3_MOUSE / Q99LM2 CDK5 regulatory subunit-associated protein 3 from Mus musculus (Mouse) (see 2 papers)
Aligns to 4:500 / 503 (98.8%), covers 99.8% of PF05600, 644.0 bits

• function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (By similarity). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (By similarity). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (By similarity). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (By similarity). May also play a role in the rupture of the nuclear envelope during apoptosis (By similarity). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (PubMed:30635284).
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (By similarity). Interacts with RELA (By similarity). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (By similarity). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:21494687, PubMed:30635284). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Interacts with DDRGK1 (By similarity). Interacts with MAPK14 (By similarity). Interacts with CCNB1 (By similarity). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity).
  disruption phenotype: Prenatal lethality, probably caused by severe liver hypoplasia (PubMed:30635284). 16.5 dpc mutant embryos also show defects in definitive erythropoiesis (PubMed:30635284). Conditional knockout mice lacking Cdk5rap3 in hepatocytes causes lethality after weaning -specific Cdk5rap3 display liver hypoplasia and die after weaning (PubMed:30635284).
• LncRNA RUS shapes the gene expression program towards neurogenesis
  Schneider, Life science alliance 2022
  • “...Q8R149 Bud13 3.20 1.61 No O35658 C1qbp 3.66 2.06 No Q9JJ89 Ccdc86 4.79 1.55 No Q99LM2 Cdk5rap3 2.73 1.51 No Q8K327 Champ1 4.35 1.52 No Q921N6 Ddx27 5.15 2.14 No Nucleolus O08749 Dld 6.00 2.13 No Q9D2G2 Dlst 3.57 2.49 No O08579 Emd 4.27 2.69 No...”
• Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.
  Feng, Frontiers in neurology 2022
• Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.
  Lemaire, PloS one 2011
  • “...5.2 E1 enzyme of UFM1 (Komatsu et al, 2004) CDK5RAP3; CDK5 regulatory subunit-associated protein 3 Q99LM2 57 4 3 6.4 tumor suppressor (Wang et al, 2007); substrate of Ufm1 (this paper) 7 HSPA5/BiP; 78 kDa glucose-regulated protein precursor P20029 72 3 3 4.7 ER stress, chaperone...”

Q3U506 CDK5 regulatory subunit-associated protein 3 from Mus musculus
Aligns to 4:500 / 503 (98.8%), covers 99.8% of PF05600, 642.7 bits

• Assessing the Effects of Redox Modifier MnTnBuOE-2-PyP 5+ on Cognition and Hippocampal Physiology Following Doxorubicin, Cyclophosphamide, and Paclitaxel Treatment
  McElroy, International journal of molecular sciences 2020
  • “...Q8BHC4 Dephospho-CoA kinase domain-containing protein Mitochondrion Enzyme 5.26 Q3U2K2 Uncharacterized protein (Fragment) Membrane Transmembrane 5.27 Q3U506 Uncharacterized protein NA NA 5.80 ijms-21-01867-t003_Table 3 Table 3 Top five IPA protein networks associated with AC-T treatment. Network Rank Network Description Network 1 Associated network functions: neurological disease, cell...”

Q642E3 CDK5 regulatory subunit associated protein 3, isoform CRA_b from Rattus norvegicus
Aligns to 4:501 / 504 (98.8%), covers 99.8% of PF05600, 639.8 bits

• iTRAQ-Based Protein Profiling in CUMS Rats Provides Insights into Hippocampal Ribosome Lesion and Ras Protein Changes Underlying Synaptic Plasticity in Depression.
  Zhang, Neural plasticity 2019
  • “...Calcium uptake protein 1, mitochondrial Micu1 1.22 0.02 Q3KRD0 Aspartate-tRNA ligase, mitochondrial Dars2 1.20 0.03 Q642E3 CDK5 regulatory subunit associated protein 3, isoform CRA_b Cdk5rap3 Undetected in CUMS group / D4A1R8 Copine-1 Cpne1 0.83 0.01 D3ZYT2 Mitochondrial ribosomal protein S5 (predicted) Mrps5 0.82 0.01 D4AEG7 Protein...”

CK5P3_HUMAN / Q96JB5 CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein; Protein HSF-27 from Homo sapiens (Human) (see 15 papers)
Aligns to 4:503 / 506 (98.8%), covers 99.8% of PF05600, 636.9 bits

• function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:23152784, PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). Required for liver development (By similarity).
  function: (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:12737517). Interacts with RELA (PubMed:17785205). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (PubMed:19223857). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Interacts with DDRGK1 (PubMed:20228063). Interacts with MAPK14 (PubMed:21283629). Interacts with CCNB1 (PubMed:15790566). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (PubMed:21465471).
  subunit: (Microbial infection) Interacts with hepatitis B virus large envelope protein mutant pre-s2; promotes mitotic entry.
• LIRcentral: a manually curated online database of experimentally validated functional LIR motifs
  Chatzichristofi, Autophagy 2023
  • “...atypical LIRs in human CDK5 regulatory subunit-associated protein 3 and its Arabidopsis thaliana homolog (UniProt: Q96JB5, Q9FG23 respectively [ 30 ];): such motifs are required for the binding of another functional LIR motif, even though they cannot independently maintain the interaction. Accessory LIR motifs, which function...”
• Blood Proteome Profiling Reveals Biomarkers and Pathway Alterations in Fragile X PM at Risk for Developing FXTAS.
  Zafarullah, International journal of molecular sciences 2023
  • “...ubiquitin carboxyl-terminal hydrolase FAF-X 121 Q8WXF1 PSPC1 0.43 13.62 0.0011414 0.02040483 Paraspeckle component 1 122 Q96JB5 CDK5RAP3 1.49 13.69 0.0011493 0.02040483 CDK5 regulatory subunit-associated protein 3 123 Q6DD87 ZNF787 0.45 12.84 0.00116082 0.02044178 Zinc finger protein 787 124 Q7Z6Z7 HUWE1 0.24 12.95 0.00117746 0.02056758 E3 ubiquitin-protein...”
  • “...protein LAMTOR1 142 Q9Y3B7 MRPL11 0.74 13.36 0.002183 0.033305 39S ribosomal protein L11, mitochondrial 143 Q96JB5 CDK5RAP3 1.37 13.69 0.002288 0.034652 CDK5 regulatory subunit-associated protein 3 144 P18583 SON 1.1 13.47 0.00231 0.034748 Protein SON 145 Q9Y2T2 AP3M1 0.36 13.23 0.002378 0.035172 AP-3 complex subunit mu-1...”
• Chronic Occupational Exposure to Ionizing Radiation Induces Alterations in the Structure and Metabolism of the Heart: A Proteomic Analysis of Human Formalin-Fixed Paraffin-Embedded (FFPE) Cardiac Tissue.
  Azimzadeh, International journal of molecular sciences 2020
  • “...N-acetylmuramoyl-L-alanine amidase 7.7 9.62 10 3 P04745 AMY1B Amylase, alpha 1B 7.3 4 10 2 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 6.3 3.31 10 4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 6.0 2.99 10 2 Q9BQE5 APOL2 Apolipoprotein L2 5.8 3.82 10 5 P20700 LMNB1 Lamin-B1...”
• Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer
  Bouchal, Molecular & cellular proteomics : MCP 2015
  • “...N1-2/N0 Q96JY6 G1: N1-2/N0 G1: N1-2/N0 G3: N1-2/N0 P63313 Q96JB5 G1: N1-2/N0 Q04206 Q9NZT2 G1: N1-2/N0 G1: N1-2/N0 Q9Y592 G1: N1-2/N0 G1: N1-2/N0 P31947 Q96BH1...”
• A proteomic study of potential VEGF-C-associated proteins in bladder cancer T24 cells.
  Zhang, Medical science monitor : international medical journal of experimental and clinical research 2012
  • “...No. Protein Accession * Protein MW(Da) PI Sequence coverage (%) Score Ratio ** Functions 662 Q96JB5 Isoform 2 of CDK5 regulatory subunit-associated protein 3 46664 4.56 5 71 1.62 Involved in cell proliferation 683 P02545 Isoform ADelta 10 of Lamin-A/C 70903 8.55 32 188 1.69 Structural...”

XP_011523599 CDK5 regulatory subunit-associated protein 3 isoform X1 from Homo sapiens
Aligns to 29:528 / 531 (94.2%), covers 99.8% of PF05600, 636.7 bits

• CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.
  Wang, Cancer gene therapy 2023
  • GeneRIF: CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.
• CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling.
  Feng, Toxicology and applied pharmacology 2022 (PubMed)
  • GeneRIF: CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3beta/Wnt/beta-catenin signaling.
• CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer.
  Lin, British journal of cancer 2020
  • GeneRIF: CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer.
• Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.
  Lin, Oncology reports 2019
  • GeneRIF: Study demonstrated that CDK5RAP3/C53 isoform d (IC53d) was upregulated in gastric cancer tissues and was associated with tumor Tstage. Furthermore, overexpression of IC53d promoted the proliferation, colony formation and G1/S phase transition of gastric cancer cells, leading to enhancement of tumorigenesis in vitro and in vivo.
• C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.
  Chen, Journal of molecular and cellular cardiology 2019
  • GeneRIF: The current findings advance innovation in drug discovery and highlight C53 as a novel pGC-B activator with sustained in vivo activity and anti-fibrotic actions in vitro.
• CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer.
  Li, Disease markers 2019
  • GeneRIF: CDK5RAP3 is associated with autophagy and down-regulated in renal cancer.
• CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer.
  Zheng, Journal of experimental & clinical cancer research : CR 2018
  • GeneRIF: Our results demonstrated that CDK5RAP3 negatively regulates the Wnt/beta-catenin signaling pathway by repressing AKT phosphorylation, which leads to better survival of patients with gastric cancer.
• Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.
  Lin, World journal of gastroenterology 2018
  • GeneRIF: Prognostic analysis showed that the co-expression of CDK5RAP3 and DDRGK1 was an independent prognostic factor correlating with the overall survival of gastric cancer patients.
• More

CK5P3_RAT / Q9JLH7 CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53 from Rattus norvegicus (Rat) (see 3 papers)
Aligns to 4:501 / 504 (98.8%), covers 99.8% of PF05600, 634.7 bits

• function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (By similarity). Negatively regulates NF- kappa-B-mediated gene transcription through the control of RELA phosphorylation. Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (By similarity).
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:10721722). Interacts with RELA (By similarity). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (By similarity). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:20531390). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (PubMed:20531390). Interacts with DDRGK1 (By similarity). Interacts with MAPK14 (By similarity). Interacts with CCNB1 (By similarity). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity).
• Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses.
  Song, Bioinorganic chemistry and applications 2022
  • “...HRas Hras 0.08 Decrease Q32PX2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Aimp2 0.46 Decrease Q9JLH7 CDK5 regulatory subunit-associated protein 3 Cdk5rap3 0.41 Decrease P35213-2 14-3-3 protein beta/alpha Ywhab 0.42 Decrease Q07014-2 Tyrosine-protein kinase Lyn Lyn 0.45 Decrease P49950 a Apoptosis regulator Bcl-2 Bcl2 0.06 Decrease...”
• Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study.
  Yang, CNS neuroscience & therapeutics 2018

NP_001002105 CDK5 regulatory subunit-associated protein 3 from Danio rerio
Aligns to 4:504 / 507 (98.8%), covers 99.8% of PF05600, 629.8 bits

• Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly
  Liu, Developmental dynamics : an official publication of the American Association of Anatomists 2011
  • “...al., 1995 ). Cloning of Zebrafish lzap cDNA and Sequence Analysis A zebrafish Lzap ortholog (NP_001002105) was identified by NCBI Blink search using the sequence of the mouse Lzap ortholog (NP_084524.1). Total RNA was isolated from 1-cell to 120 hours post fertilization (hpf) wild-type embryos in...”
  • “...the Clustal W algorithm. Hs, Homo sapiens (NP_788276.1); Mm, Mus musculus (NP_084524.1); Dr, Danio rerio (NP_001002105.1). () identical; () conserved; (:) semi-conserved. C: Pairwise comparison of amino acid conservation between human (H. sapiens), mouse (M. musculus), and zebrafish (D. rerio) Lzap. Fig. 2 lzap is Expressed...”

AT5G06830 hypothetical protein from Arabidopsis thaliana
Q9FG23 CDK5RAP3-like protein from Arabidopsis thaliana
Aligns to 7:537 / 549 (96.7%), covers 99.8% of PF05600, 569.0 bits

• Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy
  Picchianti, The EMBO journal 2023
  • “...reinhardtii) Li etal ( 2019 ) Cre08.g371052 c53 (Arabidopsis thaliana) Stephani etal ( 2020 ) At5g06830 pUbi::C53mCherry GFPATG8A/ c53 (Arabidopsis thaliana) This study N/A pUbi::C53 sAIM(W276A, W287A, Y304A, W335A) mCherry GFPATG8A/ c53 (Arabidopsis thaliana) This study N/A pUbi::C53 cAIM(IDWD274WDDI, IDWD285WDDI, IDWD333WDDI) mCherry GFPATG8A/ c53 (Arabidopsis thaliana)...”
• A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress
  Stephani, eLife 2020
  • “...) HEK293T Fumiyo Ikeda See Affiliations Genetic reagent ( Arabidopsis thaliana ) c53 this study At5g06830 See Methods, CRISPR/Cas9 construct design. Available on request to the corresponding authors. Genetic reagent ( Arabidopsis thaliana ) ddrgk1 this study At4g27120 See Methods, CRISPR/Cas9 construct design. Available on request...”
• Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy
  Picchianti, The EMBO journal 2023
  • “...alignment were then used in an analysis using ConSurf to examine sequence conservation (query sequence: Q9FG23, model: WAG). Likewise, both the C53 and RPL26 alignments were used to assess sequence conservation and divergence between species with and without UFM1 using TwinCons (using the LG substitution model...”
• LIRcentral: a manually curated online database of experimentally validated functional LIR motifs
  Chatzichristofi, Autophagy 2023
  • “...LIRs in human CDK5 regulatory subunit-associated protein 3 and its Arabidopsis thaliana homolog (UniProt: Q96JB5, Q9FG23 respectively [ 30 ];): such motifs are required for the binding of another functional LIR motif, even though they cannot independently maintain the interaction. Accessory LIR motifs, which function complementary...”

8ohdB / Q96JB5 8ohdB
3 alignments in 4:400 / 403 (98.5%), covering up to 34.1% of PF05600, 497.4 bits

• Ligand: rna (8ohdB)

NP_001295112 CDK5 regulatory subunit-associated protein 3 isoform 2 from Mus musculus
Aligns to 1:389 / 392 (99.2%), covers 78.3% of PF05600, 431.5 bits

• CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth.
  Yan, Cell proliferation 2022
  • GeneRIF: CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth.
• Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
  Quintero, Cell death & disease 2021
  • GeneRIF: Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
• CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress.
  Yang, The American journal of pathology 2020 (PubMed)
  • GeneRIF: CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress.
• CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
  Shen, International journal of molecular sciences 2020
  • GeneRIF: CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
• CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
  Yang, Development (Cambridge, England) 2019 (PubMed)
  • GeneRIF: a crucial role of CDK5RAP3 in liver development and hepatic functions, is reported.
• Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53.
  Yin, International journal of molecular medicine 2005 (PubMed)
  • GeneRIF: Results suggest that C53 might play a role in regulating neuronal proliferation, migration and/or differentiation in embryonic development.

Smp_127510 putative myosin XV from Schistosoma mansoni
Aligns to 2040:2325 / 2339 (12.2%), covers 42.8% of PF05600, 67.8 bits

• Identification and characterization of a Mef2 transcriptional activator in schistosome parasites
  Milligan, PLoS neglected tropical diseases 2012
  • “...ctttttatag 230, 600 8343690 gsx family homeobox protein * Smp_138140 ctatttataa 1382 8347764 myosin XV Smp_127510 ctattattaa 1785 8353008 netrin # Smp_146840 CTAAATATAG , ctaatatta 1403, 4948 8348295 netrin Smp_151310 ctaatattag , ctaattttaa 1782, 2823 8340778 semaphorin 5-related # Smp_158550 CTAAATATAG 3459 8343948 TGF beta family...”

cgd3_3650 centrin like EF hand protein from Cryptosporidium parvum Iowa II
Aligns to 1:252 / 471 (53.5%), covers 37.6% of PF05600, 47.9 bits

• Cryptosporidium hominis Phylogenomic Analysis Reveals Separate Lineages With Continental Segregation
  Cabarcas, Frontiers in genetics 2021
  • “...+ cgd7_3550,TPM3 + F + G4:cgd3_2600 + cgd5_3600 + cgd6_2100,HKY + F + I:cgd3_3070 + cgd3_3650 + cgd4_2210 + cgd5_2730,TPM3 + F + G4:cgd3_3310 + cgd5_2700,HKY + F + G4:cgd4_2180 + cgd4_370 + cgd5_1860,TPM2 + F + G4:cgd8_140 We built a haplotype network using the minimum...”

Or search for genetic data about PF05600 in the Fitness Browser