Family Search for PF05600 (CDK5RAP3)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF05600 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

CK5P3_MOUSE / Q99LM2 CDK5 regulatory subunit-associated protein 3 from Mus musculus (Mouse) (see 2 papers)
Aligns to 4:500 / 503 (98.8%), covers 99.8% of PF05600, 644.0 bits

• function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (By similarity). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (By similarity). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (By similarity). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (By similarity). May also play a role in the rupture of the nuclear envelope during apoptosis (By similarity). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (PubMed:30635284).
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (By similarity). Interacts with RELA (By similarity). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (By similarity). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:21494687, PubMed:30635284). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Interacts with DDRGK1 (By similarity). Interacts with MAPK14 (By similarity). Interacts with CCNB1 (By similarity). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity).
  disruption phenotype: Prenatal lethality, probably caused by severe liver hypoplasia (PubMed:30635284). 16.5 dpc mutant embryos also show defects in definitive erythropoiesis (PubMed:30635284). Conditional knockout mice lacking Cdk5rap3 in hepatocytes causes lethality after weaning -specific Cdk5rap3 display liver hypoplasia and die after weaning (PubMed:30635284).

CK5P3_HUMAN / Q96JB5 CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein; Protein HSF-27 from Homo sapiens (Human) (see 15 papers)
Aligns to 4:503 / 506 (98.8%), covers 99.8% of PF05600, 636.9 bits

• function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:23152784, PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). Required for liver development (By similarity).
  function: (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:12737517). Interacts with RELA (PubMed:17785205). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (PubMed:19223857). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Interacts with DDRGK1 (PubMed:20228063). Interacts with MAPK14 (PubMed:21283629). Interacts with CCNB1 (PubMed:15790566). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (PubMed:21465471).
  subunit: (Microbial infection) Interacts with hepatitis B virus large envelope protein mutant pre-s2; promotes mitotic entry.

CK5P3_RAT / Q9JLH7 CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53 from Rattus norvegicus (Rat) (see 3 papers)
Aligns to 4:501 / 504 (98.8%), covers 99.8% of PF05600, 634.7 bits

• function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (By similarity). Negatively regulates NF- kappa-B-mediated gene transcription through the control of RELA phosphorylation. Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (By similarity).
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:10721722). Interacts with RELA (By similarity). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (By similarity). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:20531390). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (PubMed:20531390). Interacts with DDRGK1 (By similarity). Interacts with MAPK14 (By similarity). Interacts with CCNB1 (By similarity). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity).

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