Family Search for PF05667 (CCDC22_CC)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF05667 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
CCD22_HUMAN / O60826 Coiled-coil domain-containing protein 22 from Homo sapiens (Human) (see 6 papers)
NP_054727 coiled-coil domain-containing protein 22 from Homo sapiens
Aligns to 128:597 / 627 (75.0%), covers 100.0% of PF05667, 572.9 bits
- function: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).
function: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.
subunit: Interacts with CPNE1 and CPNE4 (By similarity). Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10 (PubMed:25355947). Interacts with CUL1, CUL2, CUL3, SKP1, BTRC (PubMed:23563313). Interacts with CCDC93; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22 and CCDC93; in the complex interacts directly with CCDC93 (PubMed:25355947). Interacts with VPS35L; associates with the retriever complex (PubMed:25355947, PubMed:28892079). Interacts with SNX17 and SNX31 (PubMed:28892079). - Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome
Healy, Cell 2023 - “...protein sequence NCBI Q9P000 Commd10 human protein sequence NCBI Q9Y6G5 CCDC22 human protein sequence NCBI O60826 CCDC93 human protein sequence NCBI Q567U6 VPS35L human protein sequence NCBI Q7Z3J2 VPS26C human protein sequence NCBI O14972 VPS29 human protein sequence NCBI Q9UBQ0 DENND10/FAM45A human protein sequence NCBI Q8TCE6...”
- Proteomic Analysis in Valvular Cardiomyopathy: Aortic Regurgitation vs. Aortic Stenosis.
Holst, Cells 2023 - “...p -Value * Q9UBV8 PEF1 Peflin 0.028 Q9NVD7 PARVA Alpha-parvin 0.052 P46976 GYG1 Glycogenin-1 0.020 O60826 CCDC22 Coiled-coil domain-containing protein 22 0.032 O43324 EEF1E1 Eukaryotic translation elongation factor 1 epsilon-1 0.019 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0.051 P25686 DNAJB2...”
- BAG3 Proteomic Signature under Proteostasis Stress.
Hiebel, Cells 2020 - “...4 4.69 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1.19 10 2 4.61 O60826 CCDC22 Coiled-coil domain-containing protein 22 1.47 10 2 3.26 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1.08 10 2 2.88 O75147 OBSL1 Obscurin-like protein 1 1.44 10 2 2.58 Q9BTY7 HGH1...”
- Auramine O, an incense smoke ingredient, promotes lung cancer malignancy.
Tung, Environmental toxicology 2017 - “...kinase ARaf ARAF 1 4.1 67.93 3.78E03 O75787 Renin receptor ATP6AP2 5 19.7 39.01 1.93E12 O60826 Coiledcoil domaincontaining protein 22 CCDC22 4 10.4 70.76 6.81E56 Q9UFE4 Coiledcoil domaincontaining protein 39 CCDC39 2 2.7 109.90 9.11E04 Q8WVB6 Chromosome transmission fidelity protein 18 homolog CHTF18 3 3.6 129.40...”
- Expanding the pre- and postnatal phenotype of WASHC5 and CCDC22 -related Ritscher-Schinzel syndromes.
Neri, European journal of medical genetics 2022 (PubMed)- GeneRIF: Expanding the pre- and postnatal phenotype of WASHC5 and CCDC22 -related Ritscher-Schinzel syndromes.
- Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus.
D'Amico, Immunology letters 2017 - GeneRIF: Our results suggest that rs2294020 is associated with the risk of several autoimmune diseases in European populations, specifically with diseases that present themselves, among else, in the skin.
- CCDC22 gene polymorphism is associated with advanced stages of endometriosis in a sample of Brazilian women.
de, Journal of assisted reproduction and genetics 2017 - GeneRIF: SNPs within the CCDC22 gene are associated with increased susceptibility to endometriosis in Brazilian women.
- CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Bartuzi, Nature communications 2016 - GeneRIF: CCDC22 mutation is associated with hypercholesterolemia.
- Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome.
Kolanczyk, European journal of human genetics : EJHG 2015 - GeneRIF: Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome
- CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.
Starokadomskyy, The Journal of clinical investigation 2013 - GeneRIF: CCDC22 participates in NF-kappaB activation and its deficiency leads to decreased IkappaB turnover
- CCDC22: a novel candidate gene for syndromic X-linked intellectual disability.
Voineagu, Molecular psychiatry 2012 - GeneRIF: This study demonistrated that CCDC22 is a novel candidate gene for syndromic X-linked intellectual disability.
- New genetic associations detected in a host response study to hepatitis B vaccine.
Davila, Genes and immunity 2010 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- More
CCD22_MOUSE / Q9JIG7 Coiled-coil domain-containing protein 22 from Mus musculus (Mouse) (see paper)
NP_613069 coiled-coil domain-containing protein 22 from Mus musculus
Aligns to 128:597 / 627 (75.0%), covers 100.0% of PF05667, 565.5 bits
- function: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.
subunit: Interacts with CPNE1 and CPNE4 (PubMed:12522145). Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10. Interacts with CUL1, CUL2, CUL3, SKP1, BTRC. Interacts with CCDC93; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22 and CCDC93; in the complex interacts directly with CCDC93. Interacts with VPS35L; associates with the retriever complex. Interacts with SNX17 and SNX31 (By similarity). - Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.
Tomsig, The Journal of biological chemistry 2003 (PubMed)- GeneRIF: Identifies this protein as a copine-binding protein.
P86182 Coiled-coil domain-containing protein 22 from Rattus norvegicus
Aligns to 128:597 / 627 (75.0%), covers 100.0% of PF05667, 559.4 bits
H0WDS3 Coiled-coil domain-containing protein 22 from Cavia porcellus
2 alignments in 128:536 / 566 (72.3%), covering up to 48.8% of PF05667, 503.0 bits
AT1G55830 hypothetical protein from Arabidopsis thaliana
Aligns to 47:389 / 412 (83.3%), covers 50.9% of PF05667, 116.2 bits
- CCDC22 and CCDC93, two potential retriever-interacting proteins, are required for root and root hair growth in Arabidopsis
Lewis, Frontiers in plant science 2022 - “...CCDC93, two additional proteins required for retriever function in humans. Phylogenetic analysis indicates that CCDC22 (AT1G55830) and CCDC93 (AT4G32560) are single copy genes in plants that are present across the angiosperms, but like VPS26C , are absent from the grasses. Both CCDC22 and CCDC93 are required...”
- “...retriever that are essential for the recycling of plasma membrane proteins. Two of these, CCDC22 (AT1G55830) and CCDC93 (AT4G32560) have orthologs in Arabidopsis. In this paper we characterize the role(s) of these proteins in seedlings and show that they are essential for both root and root...”
Or search for genetic data about PF05667 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory