Family Search for PF05728 (UPF0227)

PF05728 hits 41 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

VC2432 conserved hypothetical protein from Vibrio cholerae O1 biovar eltor str. N16961
Aligns to 7:194 / 195 (96.4%), covers 98.9% of PF05728, 263.6 bits

• Metabolic Reprogramming of Vibrio cholerae Impaired in Respiratory NADH Oxidation Is Accompanied by Increased Copper Sensitivity
  Toulouse, Journal of bacteriology 2018
  • “...A0A0H3AJP0 A0A0H3ADK1 A0A0H3ALE9 A0A0H3AI44 A0A0H3AIT2 VCA0645 VC2432 VC1966 VC1249 VCA0858 VCA0032 VC0300 VCA0487 VCA0738 VC1031 VCA0900 VC0038 VC0873...”

YzzI / b3031 esterase YqiA from Escherichia coli K-12 substr. MG1655 (see 4 papers)
YQIA_ECOLI / P0A8Z7 Esterase YqiA; EC 3.1.-.- from Escherichia coli (strain K12) (see paper)
P0A8Z7 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) from Escherichia coli (see paper)
b3031 predicted esterase from Escherichia coli str. K-12 substr. MG1655
c3777 Hypothetical protein yqiA from Escherichia coli CFT073
Aligns to 3:189 / 193 (96.9%), covers 98.9% of PF05728, 256.4 bits

• function: Displays esterase activity toward palmitoyl-CoA and pNP- butyrate.
• The Gene Expression Profile of Uropathogenic Escherichia coli in Women with Uncomplicated Urinary Tract Infections Is Recapitulated in the Mouse Model
  Frick-Cheng, mBio 2020
  • “...protein YqcC 2.5 b2792 yqgF Ribonuclease H-like domain-containing nuclease 2.3 b2949 yqiA Esterase YqiA 2.3 b3031 a FC, fold change. TABLE2 Top 30 genes differentially downregulated in human patients and mice Gene Annotation Log 2 FC Locus tag allB Allantoinase 7.0 b0512 allD Ureidoglycolate dehydrogenase 6.0...”
• Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis
  Reinhardt, mBio 2022
  • “...and ClpP processing assays. For the ClpC1-mediated degradation of fluorescein isothiocyanate-casein (FITC-casein; Sigma; catalog no. c3777), 4M ClpC1 and a total ClpP protein concentration of 8M (4M each in mixed samples) were resuspended in activity buffer. Proteins were preincubated for 10min at 30C before the reaction...”

t3103 conserved hypothetical protein from Salmonella enterica subsp. enterica serovar Typhi Ty2
Aligns to 3:189 / 193 (96.9%), covers 98.9% of PF05728, 249.6 bits

• A whole-genome screen identifies Salmonella enterica serovar Typhi genes involved in fluoroquinolone susceptibility
  Turner, The Journal of antimicrobial chemotherapy 2020
  • “...d -alanine carboxypeptidase 1.47 1.3 10 72 metL aspartokinase II 1.45 2.31 10 57 Others t3103 conserved hypothetical protein 2.76 9.4 10 161 guaA GMP synthase 2.29 2.51 10 14 yabC conserved hypothetical protein 2.22 2.04 10 13 yojL thiamine biosynthesis protein 1.87 1.99 10 68...”
  • “...this location is immediately outside of the parC gene. (e) Increased transposon insertions within the t3103 gene with ciprofloxacin treatment may lead to altered expression of the parE gene coding for a subunit of topoisomerase IV, which is the secondary target of ciprofloxacin. (f) Transposon insertions...”

WP_021000185 alpha/beta hydrolase YcfP from Salmonella enterica
Aligns to 1:178 / 180 (98.9%), covers 99.5% of PF05728, 248.8 bits

• Protective Immunity Elicited by Oral Immunization of Mice with Salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) Mutants
  Erova, Frontiers in cellular and infection microbiology 2016
  • “...protein 2 precursor CAD05326 2.0 to 2.5 Flagellar-associated GTP-binding protein AAU07126 2.5 to 3.0 Esterase WP_021000185 2.5 to 4.1 Superoxide dismutase AAV77363 2.1 to 2.2 # Based on the normalized volumes (NVs), and () sign denotes decreased production in the mutants . In contrast, the level...”

YcfP / b1108 UPF0227 protein YcfP from Escherichia coli K-12 substr. MG1655 (see 3 papers)
P0A8E1 UPF0227 protein YcfP from Escherichia coli (strain K12)
b1108 orf, hypothetical protein from Escherichia coli str. K-12 substr. MG1655
SF1112 hypothetical protein from Shigella flexneri 2a str. 301
S1192 hypothetical protein from Shigella flexneri 2a str. 2457T
Aligns to 1:178 / 180 (98.9%), covers 99.5% of PF05728, 248.7 bits

• The Escherichia coli proteome: past, present, and future prospects
  Han, Microbiology and molecular biology reviews : MMBR 2006
  • “...protein Protein YcfH YcfP YcgK P0AFQ7 P0A8E1 P76002 Putative DNase Hypothetical UPF0227 protein Protein 5.19/29,808.78 6.13/21,226.18 9.01/12,518.82 Putative...”
• Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12
  Smulski, Journal of bacteriology 2001
  • “...b0966 b1003 b1045 b1050 b1060 b1103 b1104 b1105 b1107 b1108 b1111 b1112 b1128 b1145 b1168 b1178 b1195 b1205 b1256 b1257 b1273 b1285 b1321 b1333 b1376 b1378...”
• A Novel Small RNA Regulates Tolerance and Virulence in Shigella flexneri by Responding to Acidic Environmental Changes
  Wang, Frontiers in cellular and infection microbiology 2016
  • “...gi|24115223 Ribonuclease activity regulator protein RraA 2.76987 4.07 17,464 109 Cytoplasmic B57 gi|56479823 Hypothetical protein SF1112 (UPF0227 protein YcfP) 2.99923 6.13 21,441 302 Cytoplasmic B58 gi|24113666 Hypothetical protein SF2370(UPF0304 protein YfbU) 2.19077 5.95 19,649 255 Cytoplasmic B61 gi|31983576 IpgC, cytoplasmic chaperone for IpaB and IpaC 5.56608...”
• Addendum
  , Open forum infectious diseases 2019
• Genomic and Phenotypic Analyses Reveal the Emergence of an Atypical Salmonella enterica Serovar Senftenberg Variant in China
  Abd, Journal of clinical microbiology 2016
  • “...that the SPI-1-negative isolates (all SC1 isolates except S1192) uniquely share 30 SNPs that distinguish them from the other Salmonella Senftenberg isolates....”

B7NKH1 UPF0227 protein YcfP from Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Aligns to 1:178 / 180 (98.9%), covers 99.5% of PF05728, 247.6 bits

• Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment
  Kosgodage, Frontiers in cellular and infection microbiology 2019
  • “...Abbreviation MS2 Intensity Score ( p < 0.05) a B7MQF2 Trigger factor tig 81193 192.72 B7NKH1 UPF0227 protein YcfP ycfP 11941 166.86 B7MSJ0 RNA-binding protein Hfq hfq 256917 132.47 Q1R638 50S ribosomal protein L17 rplQ 126430 128.85 Q1R602 50S ribosomal protein L3 rplC 69461 254.77 Q1R619...”

YPO1616 conserved hypothetical protein from Yersinia pestis CO92
Aligns to 1:178 / 180 (98.9%), covers 99.5% of PF05728, 247.4 bits

• High-throughput, signature-tagged mutagenic approach to identify novel virulence factors of Yersinia pestis CO92 in a mouse model of infection
  Ponnusamy, Infection and immunity 2015
  • “...Unconfirmed YPO3164 PMT1 Caf1R YPO1484 YPO3248 Intergenic, YPO0093-YPO0094 YPO1616 YPO1995 YPO0815 Intergenic, YPO1119-YPO1120 40 100 100 60 80 60 100 100 80 80...”
  • “...ypo1717 ypmt1.80c rbsA (ypo2500) ypo0498 vasK (ypo3603) ypo3164 hxuB (ypo3248) ypo1616 ypo1119-ypo1120 15 85 80 100 85 100 60 100 100 85 100 0 85 60 40 70 85...”

ESA_00377 hypothetical protein from Enterobacter sakazakii ATCC BAA-894
ESA_00377 esterase YqiA from Cronobacter sakazakii ATCC BAA-894
Aligns to 3:189 / 191 (97.9%), covers 98.9% of PF05728, 245.9 bits

• Sialic acid utilization by Cronobacter sakazakii
  Joseph, Microbial informatics and experimentation 2013
  • “...by the activity of various -galactosidases (ESA_01827, ESA_02977 & ESA_03417), -acetyl-hexosaminidases (ESA_02237 and ESA_02655), esterases (ESA_00377 & ESA_00776) and lipases (ESA_02127 & ESA_02202), and therefore able to grow on this substrate. The %GC content of the nanC gene was found to be 47%, considerably less than...”

STM3182 putative esterase from Salmonella typhimurium LT2
Aligns to 3:189 / 193 (96.9%), covers 98.9% of PF05728, 245.1 bits

• Conserved intergenic sequences revealed by CTAG-profiling in Salmonella: thermodynamic modeling for function prediction
  Tang, Scientific reports 2017
  • “...STM2692 & STM2693 intergenic region between STM2692 and STM2693 3221860 STM3060 putative cytoplasmic protein 3346112 STM3182 putative esterase 3414851 STM3245 & STM3246 intergenic region between tdcA and rnpB 3494593 STM3330 glutamate synthase, large subunit 3585835 STM3418 & STM3419 intergenic region between rpsM and rpmJ 3589847 STM3427...”

PMI0874 hypothetical protein from Proteus mirabilis HI4320
Aligns to 1:177 / 181 (97.8%), covers 99.5% of PF05728, 222.4 bits

• Outer membrane antigens of the uropathogen Proteus mirabilis recognized by the humoral response during experimental murine urinary tract infection
  Nielubowicz, Infection and immunity 2008
  • “...in: Protein LB PMI0047 PMI0103* PMI0631 PMI0776* PMI0874 PMI1150 PMI1449 PMI1451 PMI1488* PMI1506 PMI1905* PMI3062 PMI3210 PMI3377 a Putative secreted...”

Q88DB1 Esterase from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Aligns to 4:188 / 202 (91.6%), covers 99.5% of PF05728, 219.1 bits

• When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α,ω-diols in Pseudomonas putida KT2440
  Lu, Biotechnology for biofuels 2021
  • “...Q88F80 PP_4218 957 Est8 AAN69916.1 Q88EW5 PP_4337 1113 Est9 AAN70088.2 Q88EF1 PP_4514 2187 Est10 AAN70483.2 Q88DB1 PP_4916 609 Est11 AAN67697.1 Q88L52 PP_2083 1029 Est12/K AAN69406.1 Q88GB2 PP_3812 1020 Est13 AAN70423.1 Q88DH1 PP_4854 891 Est14 AAN66966.1 Q88N71 PP_1343 912 Est15 AAN69866.1 Q88F13 PP_4286 927 Est16 AAN68665.1 Q88IE2...”

PP_4916 conserved hypothetical protein from Pseudomonas putida KT2440
Aligns to 49:233 / 247 (74.9%), covers 99.5% of PF05728, 218.1 bits

• When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α,ω-diols in Pseudomonas putida KT2440
  Lu, Biotechnology for biofuels 2021
  • “...PP_4218 957 Est8 AAN69916.1 Q88EW5 PP_4337 1113 Est9 AAN70088.2 Q88EF1 PP_4514 2187 Est10 AAN70483.2 Q88DB1 PP_4916 609 Est11 AAN67697.1 Q88L52 PP_2083 1029 Est12/K AAN69406.1 Q88GB2 PP_3812 1020 Est13 AAN70423.1 Q88DH1 PP_4854 891 Est14 AAN66966.1 Q88N71 PP_1343 912 Est15 AAN69866.1 Q88F13 PP_4286 927 Est16 AAN68665.1 Q88IE2 PP_3057...”

Pf6N2E2_3637 yqiA-like hydrolase, affects the cell envelope from Pseudomonas fluorescens FW300-N2E2
Aligns to 4:188 / 202 (91.6%), covers 99.5% of PF05728, 214.4 bits

• mutant phenotype: PFam PF05728.8 (UPF0227). conserved phenotypes: important for resisting doxycycline and for octanoate utilization (also a putative stress)

Psest_0482 yqiA-like hydrolase, affects the cell envelope from Pseudomonas stutzeri RCH2
Aligns to 7:191 / 201 (92.0%), covers 99.5% of PF05728, 211.5 bits

• mutant phenotype: PFam PF05728.8 (UPF0227). Conserved phenotypes: important for resisting carbenicillin and doxycycline

SO3900 yqiA-like hydrolase, affects the cell envelope from Shewanella oneidensis MR-1
SO3900 conserved hypothetical protein from Shewanella oneidensis MR-1
Aligns to 1:189 / 191 (99.0%), covers 99.5% of PF05728, 198.5 bits

• mutant phenotype: PFam PF05728.8 (UPF0227). conserved phenotypes: important for resisting fusidic acid and carbenicillin
• Transcriptome profiling of Shewanella oneidensis gene expression following exposure to acidic and alkaline pH
  Leaphart, Journal of bacteriology 2006
  • “...characterized proteins (e.g., so1053, so3047, so3719, so3720, so3900, so4126, so4355, so4362, and so4621) constituted part of a general transcriptome response...”

Shew_0548 yqiA-like hydrolase, affects the cell envelope from Shewanella loihica PV-4
Aligns to 1:189 / 192 (98.4%), covers 99.5% of PF05728, 185.1 bits

• mutant phenotype: PFam PF05728.8 (UPF0227). conserved phenotypes: important in most defined media conditions

Sama_3044 yqiA-like hydrolase, affects the cell envelope from Shewanella amazonensis SB2B
Aligns to 1:189 / 191 (99.0%), covers 99.5% of PF05728, 174.3 bits

• mutant phenotype: PFam PF05728.8 (UPF0227). conserved phenotypes: important in most defined media conditions

Pnuc_0959 hypothetical protein from Polynucleobacter sp. QLW-P1DMWA-1
Aligns to 5:194 / 196 (96.9%), covers 98.9% of PF05728, 162.0 bits

• Combined Methylome, Transcriptome and Proteome Analyses Document Rapid Acclimatization of a Bacterium to Environmental Changes
  Srivastava, Frontiers in microbiology 2020
  • “...5 and +7.56 fold; p = 8 10 6 , respectively. Intracellular predicted esterases (Pnuc_0531, Pnuc_0959) were also overexpressed: +1.21 fold; p = 0.002 and +0.78 fold; p = 0.04, respectively. Lipases and esterases can directly modulate the turnover of lipids and long/short chain triacylglycerols (...”

ACIAD3545 conserved hypothetical protein; putative esterase from Acinetobacter sp. ADP1
Aligns to 5:193 / 197 (95.9%), covers 98.9% of PF05728, 144.1 bits

• Prophage induction and differential RecA and UmuDAb transcriptome regulation in the DNA damage responses of Acinetobacter baumannii and Acinetobacter baylyi
  Hare, PloS one 2014
  • “...to H 2 O 2 , ferritin-like Neither 2.8 ACIAD2479 Conserved hypothetical protein Neither 2.8 ACIAD3545 Putative esterase Neither 2.5 ACIAD2295 Putative oxidoreductase Neither 2.5 ACIAD3566 Hypothetical protein Neither 2.5 ACIAD2652 gyrA DNA gyrase, subunit A, type II topoisomerase Neither 2.4 ACIAD0151 guaA Glutamine aminotransferase Neither...”

KZA74_00625 YqiA/YcfP family alpha/beta fold hydrolase from Acinetobacter baumannii
Aligns to 2:189 / 193 (97.4%), covers 98.9% of PF05728, 139.9 bits

• DNA damage response coregulator <i>ddrR</i> affects many cellular pathways and processes in <i>Acinetobacter baumannii</i> 17978
  Cook, Frontiers in cellular and infection microbiology 2023
  • “...NSD ddrR KZA74_18810* A1S_3511 upreg NSD ddrR repM ** NA NSD NSD ddrR and umuDAb KZA74_00625 A1S_3360 NSD upreg ddrR and umuDAb uvrA A1S_3295 NSD NSD ddrR and umuDAb ssb A1S_3287 NSD NSD ddrR and umuDAb KZA74_01905 A1S_3116 NSD upreg ddrR and umuDAb KZA74_01910 A1S_3115 NSD...”

BUM88_18980 YqiA/YcfP family alpha/beta fold hydrolase from Acinetobacter calcoaceticus
Aligns to 2:189 / 193 (97.4%), covers 98.9% of PF05728, 139.7 bits

• Complete Genome Sequence of Acinetobacter calcoaceticus CA16, a Bacterium Capable of Degrading Diesel and Lignin
  Ho, Genome announcements 2017
  • “...including alkane monooxygenase (BUM88_05740, BUM88_08900), rubredoxin (BUM88_04810), esterase (BUM88_04820, BUM88_05375, BUM88_06405, BUM88_11675, BUM88_14825, BUM88_15860, BUM88_18905, BUM88_18980, BUM88_19775), and WeeF (BUM88_00230), a protein involved in biosurfactant production ( 12 , 17 19 ). The assembled genome sequence presented here will contribute to the elucidation of regulatory pathways...”

ABTJ_00120 YqiA/YcfP family alpha/beta fold hydrolase from Acinetobacter baumannii MDR-TJ
Aligns to 2:189 / 193 (97.4%), covers 98.9% of PF05728, 134.2 bits

• Complete sequence of pABTJ2, a plasmid from Acinetobacter baumannii MDR-TJ, carrying many phage-like elements
  Huang, Genomics, proteomics & bioinformatics 2014
  • “...tail 231 46.81 ABTJ_00118 Cell wall-associated hydrolases 249 36.80 ABTJ_00119 Phage tail component 192 34.83 ABTJ_00120 Phage tail component 3727 18.27 ABTJ_00126 Phage-related lysozyme 212 42.40 Note: Length of protein is indicated by number of amino acid residues comprised; amino acid similarity (%) of individual ORFs...”

SULAZ_0137 hypothetical protein from Sulfurihydrogenibium azorense Az-Fu1
Aligns to 2:186 / 188 (98.4%), covers 98.4% of PF05728, 118.6 bits

• Microbial diversity and biochemical potential encoded by thermal spring metagenomes derived from the Kamchatka Peninsula
  Wemheuer, Archaea (Vancouver, B.C.) 2013
  • “...protein, ZP_03857090 Thermobaculum terrenum ATCC BAA-798 4 e 61 2251 (47%) EstBW2 191 Hypothetical protein SULAZ_0137, YP_ 002728134 Sulfurihydrogenibium azorense Az-Fu1 2 e 91 1188 (85%) PepBW1 411 Subtilisin-like serine protease, YP_002428837.1 Desulfurococcus kamchatkensis 0 1411 (98%) Table 4 Relative activities of recombinant esterases in the...”

A1S_3360 putative esterase from Acinetobacter baumannii ATCC 17978
Aligns to 1:158 / 162 (97.5%), covers 81.8% of PF05728, 106.6 bits

• DNA damage response coregulator <i>ddrR</i> affects many cellular pathways and processes in <i>Acinetobacter baumannii</i> 17978
  Cook, Frontiers in cellular and infection microbiology 2023
  • “...ddrR KZA74_18810* A1S_3511 upreg NSD ddrR repM ** NA NSD NSD ddrR and umuDAb KZA74_00625 A1S_3360 NSD upreg ddrR and umuDAb uvrA A1S_3295 NSD NSD ddrR and umuDAb ssb A1S_3287 NSD NSD ddrR and umuDAb KZA74_01905 A1S_3116 NSD upreg ddrR and umuDAb KZA74_01910 A1S_3115 NSD NSD...”
• Acinetobacter baumannii OxyR Regulates the Transcriptional Response to Hydrogen Peroxide
  Juttukonda, Infection and immunity 2019
  • “...A1S_3326 A1S_1438 A1S_3375 A1S_1539 A1S_1767 A1S_1503 A1S_3360 A1S_2319 A1S_0565 A1S_1197 Hypothetical A1S_0517 A1S_3813 A1S_3666 A1S_3906 A1S_1718 A1S_2272...”

ABZJ_01101, HMPREF0010_01533 YqiA/YcfP family alpha/beta fold hydrolase from Acinetobacter baumannii MDR-ZJ06
ABBFA_002613 Uncharacterized protein family (UPF0227) family protein from Acinetobacter baumannii AB307-0294
Aligns to 2:112 / 162 (68.5%), covers 50.3% of PF05728, 48.6 bits

• Colistin Resistance in Acinetobacter baumannii MDR-ZJ06 Revealed by a Multiomics Approach
  Hua, Frontiers in cellular and infection microbiology 2017
  • “...5.88E-06 ABZJ_01873 hypothetical protein 1.01999 5.846082 1.89E-05 0.000128 ABZJ_03812 hypothetical protein 1.02082 4.567471 0.001409 0.005227 ABZJ_01101 hypothetical protein 1.03046 5.533349 0.001752 0.006282 ABZJ_01908 Zn-dependent hydrolase, including glyoxylase 1.03588 9.460654 2.53E-10 4.12E-09 ABZJ_03819 hypothetical protein 1.05745 9.905586 6.08E-11 1.11E-09 ABZJ_03796 putative acyltransferase 1.06273 6.680253 2.34E-07 2.42E-06 ABZJ_00947...”
• Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens
  Cheah, Scientific reports 2016
  • “...2.28 1.71 5.54E-08 ABBFA_001549 HMPREF0010_00427 57.7% 2,4-dienoyl-CoA reductase [NADPH](2,4-dienoyl coenzymeA reductase) 1.03 2.25 7.05E-06 ABBFA_002613 HMPREF0010_01533 54.3% Hypothetical protein 0.87 1.66 7.02E-07 ABBFA_000601 HMPREF0010_02763 52.0% MFS transporter, metabolite:H+ symporter (MHS) family protein 0.59 0.69 5.28E-05 ABBFA_000867 HMPREF0010_02122 52.0% Hypothetical protein 0.43 0.71 3.25E-05 ABBFA_000206 HMPREF0010_02442 51.7%...”
• Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens
  Cheah, Scientific reports 2016
  • “...protein 2.28 1.71 5.54E-08 ABBFA_001549 HMPREF0010_00427 57.7% 2,4-dienoyl-CoA reductase [NADPH](2,4-dienoyl coenzymeA reductase) 1.03 2.25 7.05E-06 ABBFA_002613 HMPREF0010_01533 54.3% Hypothetical protein 0.87 1.66 7.02E-07 ABBFA_000601 HMPREF0010_02763 52.0% MFS transporter, metabolite:H+ symporter (MHS) family protein 0.59 0.69 5.28E-05 ABBFA_000867 HMPREF0010_02122 52.0% Hypothetical protein 0.43 0.71 3.25E-05 ABBFA_000206 HMPREF0010_02442...”

BUM88_04820 YqiA/YcfP family alpha/beta fold hydrolase from Acinetobacter calcoaceticus
Aligns to 2:112 / 162 (68.5%), covers 50.3% of PF05728, 44.5 bits

• Complete Genome Sequence of Acinetobacter calcoaceticus CA16, a Bacterium Capable of Degrading Diesel and Lignin
  Ho, Genome announcements 2017
  • “...hydrocarbon degradation are located on the chromosome, including alkane monooxygenase (BUM88_05740, BUM88_08900), rubredoxin (BUM88_04810), esterase (BUM88_04820, BUM88_05375, BUM88_06405, BUM88_11675, BUM88_14825, BUM88_15860, BUM88_18905, BUM88_18980, BUM88_19775), and WeeF (BUM88_00230), a protein involved in biosurfactant production ( 12 , 17 19 ). The assembled genome sequence presented here will...”

A1S_0997 hypothetical protein from Acinetobacter baumannii ATCC 17978
Aligns to 1:55 / 107 (51.4%), covers 17.1% of PF05728, 34.6 bits

• Molecular mechanisms of ethanol-induced pathogenesis revealed by RNA-sequencing
  Camarena, PLoS pathogens 2010
  • “...A1S_0970 3.8 Transketolase, C-terminal subunit, COG3958 A1S_1291 2.3 Hypothetical protein, pfam03781:DUF323 A1S_0043 2.5 Phospholipase C A1S_0997 2.4 Predicted esterase, COG3150 A1S_2020 2.2 RNA binding protein, HicA family A1S_3543 2.2 Hypothetical protein 1 A1S_2195 2.6 Hypothetical protein 6 A1S_3024 2.4 Hypothetical protein A1S_3231 4.3 Acetyl-CoA hydrolase/transferase domain...”

Afu4g13070 alpha/beta hydrolase, putative from Aspergillus fumigatus Af293
Aligns to 55:190 / 279 (48.7%), covers 50.3% of PF05728, 30.0 bits

• HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus
  Feng, PLoS pathogens 2011
  • “...Afu1g06150 L-serine dehydratase, putative * 1.0856 0.9025 Afu7g06540 Threonine aldolase, putative 0.8491 0.6323 Lipid metabolism Afu4g13070 Alpha/beta hydrolase, putative 1.7477 0.7507 Unclassified Afu6g00690 Conserved hypothetical protein * * 1.7940 1.8562 Afu6g00680 Hypothetical protein 1.1532 1.1835 Afu6g04410 DUF1183 domain protein * * 0.7494 0.7362 Afu7g00370 Hypothetical protein...”

GALLO_0140 putative cinnamoyl ester hydrolase from Streptococcus gallolyticus UCN34
SGGBAA2069_c01580, SGGB_0137 S9 family peptidase from Streptococcus gallolyticus subsp. gallolyticus ATCC 43143
Aligns to 65:237 / 244 (70.9%), covers 67.4% of PF05728, 28.0 bits

• Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex
  Papadimitriou, BMC genomics 2014
  • “...- Beta-1,4-endoglucanase V (cellulase) - GALLO_0330 SGGB_0358 SGGBAA2069_c03180 - - - Cinnamoyl ester hydrolase cinA GALLO_0140 SGGB_0137 SGGBAA2069_c01580 - - - Mannanase - GALLO_0162 SGGB_0206 SGGBAA2069_c01800 - - Sinf_0174 (p) Endo-beta-1,4-galactanase - GALLO_0189 SGGB_0233 SGGBAA2069_c02070 SGPB_0176 SMA_0214 (p) Sinf_0197 (p) Pectate lyase - GALLO_1577 SGGB_1576 SGGBAA2069_c16050...”
• Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex
  Papadimitriou, BMC genomics 2014
  • “...V (cellulase) - GALLO_0330 SGGB_0358 SGGBAA2069_c03180 - - - Cinnamoyl ester hydrolase cinA GALLO_0140 SGGB_0137 SGGBAA2069_c01580 - - - Mannanase - GALLO_0162 SGGB_0206 SGGBAA2069_c01800 - - Sinf_0174 (p) Endo-beta-1,4-galactanase - GALLO_0189 SGGB_0233 SGGBAA2069_c02070 SGPB_0176 SMA_0214 (p) Sinf_0197 (p) Pectate lyase - GALLO_1577 SGGB_1576 SGGBAA2069_c16050 - -...”
  • “...Beta-1,4-endoglucanase V (cellulase) - GALLO_0330 SGGB_0358 SGGBAA2069_c03180 - - - Cinnamoyl ester hydrolase cinA GALLO_0140 SGGB_0137 SGGBAA2069_c01580 - - - Mannanase - GALLO_0162 SGGB_0206 SGGBAA2069_c01800 - - Sinf_0174 (p) Endo-beta-1,4-galactanase - GALLO_0189 SGGB_0233 SGGBAA2069_c02070 SGPB_0176 SMA_0214 (p) Sinf_0197 (p) Pectate lyase - GALLO_1577 SGGB_1576 SGGBAA2069_c16050 -...”
• Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence
  Lin, PloS one 2011
  • “...ATCC 43143 may be more efficient in degrading complex carbohydrates. The presence of cinA gene (SGGB_0137) encoding the cinnamoyl ester hydrolase in ATCC 43143 that can release cinnamic acids from various plant materials (such as esterified arabinoxilan). This gene is known to be present in rumen...”

8b9sA / A0A1G7VV58 Native form, thermostable lipase from thermoanaerobacter thermohydrosulfuricus (see paper)
Aligns to 72:252 / 259 (69.9%), covers 75.4% of PF05728, 27.2 bits

• Ligand: glycerol (8b9sA)

LIP1 / AAA95964.1 lipase-esterase from Mycoplasma mycoides (see paper)
Aligns to 20:256 / 264 (89.8%), covers 52.4% of PF05728, 27.1 bits

APH_0179 hypothetical protein from Anaplasma phagocytophilum HZ
Aligns to 2:211 / 227 (92.5%), covers 92.5% of PF05728, 27.0 bits

• Whole genome transcription profiling of Anaplasma phagocytophilum in human and tick host cells by tiling array analysis
  Nelson, BMC genomics 2008
  • “...carrier protein APH_0929 Cytoplasmic 2.2 55 Es1 family protein APH_0006 Cytoplasmic 2.2 56 hypothetical protein APH_0179 Cytoplasmic 2.2 57 iron-sulfur cluster assembly accessory protein APH_0676 Cytoplasmic 2.2 58 putative ATP synthase F0 B' subunit APH_1190 Cytoplasmic 2.1 59 hypothetical protein APH_0719 Cytoplasmic 2.1 60 hypothetical protein...”

PA2168 hypothetical protein from Pseudomonas aeruginosa PAO1
Aligns to 70:227 / 258 (61.2%), covers 71.1% of PF05728, 26.7 bits

• Transcriptional Responses of Pseudomonas aeruginosa to Inhibition of Lipoprotein Transport by a Small Molecule Inhibitor
  Lorenz, Journal of bacteriology 2020
  • “...Alginate O -acetyltransferase AlgF PA3544 algE 23.4 19.5 Alginate production outer membrane protein AlgE precursor PA2168 21.4 29.0 Hypothetical protein PA3549 algJ 19.4 15.9 Alginate O -acetyltransferase AlgJ PA3691 18.2 31.5 Hypothetical protein PA3542 alg44 17.7 14.2 Alginate biosynthesis protein Alg44 PA1471 17.7 22.0 Hypothetical protein...”
• Analysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN
  Damron, Journal of bacteriology 2012
  • “...PA2158 PA2159 PA2160 PA2161 PA2162 PA2163 PA2164 PA2165 PA2167 PA2168 PA2169 algW algC algB lptF yhxC glgP katE glgB ybhN ybhO ybhP glgX glgA (Continued on...”
• A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence
  Goldová, BMC genomics 2011
  • “...synthase (Energy metabolism) 10.3 5.5 8.3 5.3 PA2167 2.72 0.049 HP 6.5 3.0 5.1 2.5 PA2168 2.78 0.049 HP 8.0 4.6 6.5 4.3 PA2178 3.55 0.004 HP 6.6 3.3 4.8 3.9 PA2179 3.16 0.023 HP 5.7 2.5 4.1 2.7 PA2180 3.05 0.032 HP 8.3 4.2 6.6...”
• Transcriptome analysis of Pseudomonas aeruginosa growth: comparison of gene expression in planktonic cultures and developing and mature biofilms
  Waite, Journal of bacteriology 2005
  • “...www.tigr.org) for seven of these genes (PA0290, PA0557, PA2168, PA2179, PA2181, PA3461, and PA4870) (see Table S2 in the supplemental material). Three of the...”
  • “...PA1932 PA1933 PA2021 PA2107 PA2136 PA2140 PA2149 PA2155 PA2168 PA2179 PA2181 PA2184 PA2186 PA2188 PA2718 PA3460 PA3461 PA3540 PA4570 PA4870 PA4877 PA5460...”
• Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector
  Rasmussen, Journal of bacteriology 2005
  • “...PA2153 PA2158 PA2159 PA2162 PA2163 PA2165 PA2166 PA2167 PA2168 PA2169 PA2170 PA2171 PA2172 PA2174 PA2175 PA2176 PA2184 PA2187 PA2190 PA2191 PA2198 PA2225 PA2226...”
• MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa
  Wu, Journal of bacteriology 2004
  • “...PA1245 PA1323 #PA1471 #PA1784 PA1852 PA2159 PA2161 #PA2167 PA2168 #PA2172 PA2176 PA2403 PA2404 #PA2405 PA2406 PA2412 PA2485 PA2486 PA2562 PA3274 PA4154 #PA4469...”

IR196_00850 S9 family peptidase from Brucella anthropi
Aligns to 66:229 / 242 (67.8%), covers 64.7% of PF05728, 26.4 bits

• Characterization of Potential Plastic-Degradation Enzymes from Marine Bacteria
  Jin, ACS omega 2024
  • “...Exiguobacterium sp. / hydrolase PD9 QPI66066.1 IR195_10375 Halomonas venusta response regulator transcription factor PD10 QPA26456.1 IR196_00850 Brucella anthropi / fold hydrolase Materials and Methods Stains, Plasmids, and Mutagenesis The candidate enzymes in this work are listed in Table 1 . Plasmid cloning and mutagenesis were conducted...”

lmo0857 similar to carboxylesterase from Listeria monocytogenes EGD-e
Aligns to 3:211 / 237 (88.2%), covers 49.7% of PF05728, 26.2 bits

• Whole-Genome Sequencing of Recent Listeria monocytogenes Isolates from Germany Reveals Population Structure and Disease Clusters
  Halbedel, Journal of clinical microbiology 2018
  • “...SNP calling in one case or by one different allele (lmo0857) in the other (data not shown). Because the low mutation rates contrast with the high number of...”

WP_024569139 alpha/beta fold hydrolase from Cupriavidus metallidurans
Aligns to 87:192 / 322 (32.9%), covers 42.8% of PF05728, 26.0 bits

• A novel esterase from a marine mud metagenomic library for biocatalytic synthesis of short-chain flavor esters
  Gao, Microbial cell factories 2016
  • “...beta-lactamase class C (AAZ48934) Uncultured bacterium WWRS-2005 77/86 642 0.0 est4 52.9 316 Alpha/beta hydrolase (WP_024569139) Cupriavidus metallidurans 48/65 304 3e98 est5 51.8 302 Hypothetical protein GM46_7005 (KGA09147) Actinobacterium acAcidi 76/88 486 4e170 a Length of predicted ORF in amino acids b Bit score of alignment...”

A1S_1078 hypothetical protein from Acinetobacter baumannii ATCC 17978
Aligns to 15:129 / 190 (60.5%), covers 24.6% of PF05728, 25.5 bits

• A1S_2811, a CheA/Y-like hybrid two-component regulator from Acinetobacter baumannii ATCC17978, is involved in surface motility and biofilm formation in this bacterium
  Chen, MicrobiologyOpen 2017
  • “...A1S_3447 26.5 149.7 2.5 5.80E21 RND efflux transporter A1S_3273 13 70.7 2.4 4.00E10 Peptide signal A1S_1078 5.6 24.8 2.2 1.10E03 Hypothetical protein A1S_1387 59.3 277.4 2.2 2.20E33 Oxidoreductase A1S_2074 22.5 106.9 2.2 1.60E13 Hypothetical protein a q value, corrected p value; smaller q values represent a...”

TTE1809 Hydrolases of the alpha/beta superfamily from Thermoanaerobacter tengcongensis MB4
Aligns to 72:252 / 258 (70.2%), covers 75.9% of PF05728, 24.6 bits

• Thermostable feruloyl esterase for the bioproduction of ferulic acid from triticale bran
  Abokitse, Applied microbiology and biotechnology 2010 (PubMed)
  • “...A putative / hydrolase fold-encoding gene (locus tag TTE1809) from the genome of Thermoanaerobacter tengcongensis was cloned and expressed in Escherichia coli...”
  • “...in the thermophilic T. tengcongensis strain MB4T (locus tag TTE1809; NP_623397; Bao et al. 2002) showing 26% sequence identity was chosen for this study. The T....”
• Carboxylic ester hydrolases from hyperthermophiles
  Levisson, Extremophiles : life under extreme conditions 2009
  • “...Lysophospholipase 314 GHSFG TTE0552 AAM23828 Predicted hydrolase 279 GVSMG TTE0556 AAM23832 Predicted hydrolase 298 GWSMG TTE1809 AAM25001 Alpha/beta hydrolase 258 GLSMG TTE2321 AAM25462 Alpha/beta hydrolase 414 CHSMG TTE2547 AAM25672 Alpha/beta hydrolase 285 AHSFG Thermococcus kodakaraensis TK0522 BAD84711 Carbohydrate esterase 449 GSSLG Thermotoga maritima TM1022 AAD36099 Esterase...”

MSMEG_0625 hypothetical protein from Mycobacterium smegmatis str. MC2 155
Aligns to 230:393 / 399 (41.1%), covers 63.6% of PF05728, 24.0 bits

• Association of Mycobacterium Proteins with Lipid Droplets
  Armstrong, Journal of bacteriology 2018
  • “...rpsQ MSMEG_4533 MSMEG_1028 MSMEG_0946 dxs MSMEG_0625 MSMEG_5430 MSMEG_3204 MSMEG_1981 MSMEG_4632 MSMEG_6753 MSMEG_0220 cwsA MSMEG_0424 MSMEG_6291 asnB...”
• Mycobacterial Esx-3 requires multiple components for iron acquisition
  Siegrist, mBio 2014
  • “...M.tuberculosis region from espJ to espB ( 5 , 8 ); , there is no MSMEG_0625 , mycP 3ms is MSMEG_0624 , and eccE 3ms is MSMEG_0626 . We use the nomenclature proposed by Bitter et al. ( 29 ). Briefly, the terms ecc and esp...”

6yuqA / O68216 Capsule o-acetyltransferase of neisseria meningitidis serogroup a in complex with polysaccharide (see paper)
Aligns to 48:166 / 245 (48.6%), covers 53.5% of PF05728, 24.0 bits

• Ligand: 2-acetamido-2-deoxy-6-o-phosphono-alpha-d-mannopyranose (6yuqA)

LIC_11183 carboxylesterase from Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
Aligns to 75:186 / 335 (33.4%), covers 48.7% of PF05728, 23.1 bits

• A comprehensive in silico analysis of putative outer membrane and secretory hydrolases from the pathogenic Leptospira: Possible implications in pathogenesis
  Shankar, Biotechnology and applied biochemistry 2024 (PubMed)
  • “...exported proteins to generate a deeper understanding. Our analysis yielded four putative outer/secretory hydrolases, LIC_10995, LIC_11183, LIC_11463, and LIC_12988, containing / hydrolase fold and displayed similarity with lipase motif. Moreover, their conservation analysis of the predicted hydrolases across the spectrum of different Leptospira species showed high...”

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