Family Search for PF06625 (DUF1151)
PF06625 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
Q9H098 Protein FAM107B from Homo sapiens
Aligns to 12:120 / 131 (83.2%), covers 99.1% of PF06625, 136.9 bits
- The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity.
Carruthers, Scientific reports 2021 - “...subunit, mitochondrial ( SDHA ) 0.45 0.032 1 SDH complex activity, TCA cycle, Oxidative phosphorylation Q9H098 Protein FAM107B ( FAM107B ) 0.39 0.032 0.74 Homologous to cytoskeletal regulators in Rho family P52815 39S ribosomal protein L12, mitochondrial ( MRPL1 ) 0.38 0.032 1 Mitochondrial translation Q9H488...”
- Circulating proteomic signature of early death in heart failure patients with reduced ejection fraction.
Cuvelliez, Scientific reports 2019 - “...0.0011 1 0.001/213 13 Extracellular matrix organization Family with sequence similarity 107 member B (F107B) Q9H098 0.84 (812.421 vs . 972.428.2) 5.54 10 4 1 0.0004/353 * Full name, protein symbol and UniProt ID are provided from the UniProtKB database ( https://www.uniprot.org/ ); **Data are expressed...”
- Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs.
Smith, American journal of ophthalmology 2018 - “...2.18 1.7867E-02 Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) P98194 2.10 3.8855E-02 Protein FAM107B Q9H098 1.97 2.8626E-02 Serine/threonine-protein kinase Nek7 Q8TDX7 1.93 1.5320E-02 HLA class I histocompatibility antigen, A-30 alpha chain P16188 1.89 4.4553E-02 Laminin subunit alpha-5 O15230 1.85 1.9076E-02 Spectrin beta chain, non-erythrocytic 2...”
F107B_MOUSE / Q3TGF2 Protein FAM107B from Mus musculus (Mouse) (see paper)
Aligns to 12:120 / 131 (83.2%), covers 99.1% of PF06625, 136.6 bits
XP_006497581 protein FAM107B isoform X1 from Mus musculus
Aligns to 64:172 / 183 (59.6%), covers 99.1% of PF06625, 134.9 bits
NP_113641 protein FAM107B isoform b from Homo sapiens
Aligns to 187:295 / 306 (35.6%), covers 99.1% of PF06625, 134.4 bits
- FAM107B is regulated by S100A4 and mediates the effect of S100A4 on the proliferation and migration of MGC803 gastric cancer cells.
Guo, Cell biology international 2017 (PubMed)- GeneRIF: Authors first provide experimental evidence suggesting that FAM107B was downregulated by S100A4 in gastric cancer MGC803 cells. And FAM107B at least partially mediates the biological effect of S100A4 in the cells.
- Loss of HITS (FAM107B) expression in cancers of multiple organs: tissue microarray analysis.
Nakajima, International journal of oncology 2012 (PubMed)- GeneRIF: These results show that loss of HITS (FAM107B) expression is a common phenomenon observed in cancers of distinct organs and involved in tumor development and proliferation.
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey, Diabetes care 2010 - GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
- Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud, American journal of human genetics 2009 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe, American journal of human genetics 2006 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose, Molecular medicine (Cambridge, Mass.) - GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
F107A_HUMAN / O95990 Actin-associated protein FAM107A; Down-regulated in renal cell carcinoma 1; Protein TU3A from Homo sapiens (Human) (see 5 papers)
Aligns to 26:133 / 144 (75.0%), covers 99.1% of PF06625, 133.7 bits
- function: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580).
subunit: Interacts with ACTB (PubMed:21969592, PubMed:28604741). Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus (PubMed:28604741). Interacts with MAP1A (PubMed:20543869). Interacts with PRDX1 (PubMed:21969592). Interacts with F-actin (By similarity). - [Fuxinfang improves hypoxia-induced injury of human aortic endothelial cells by regulating c-Fos-NR4A1-p38 pathway].
Xu, Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2021
NP_001269643 actin-associated protein FAM107A isoform c from Homo sapiens
Aligns to 57:164 / 175 (61.7%), covers 99.1% of PF06625, 132.5 bits
- FAM107A as a Tumor Suppressor in Bladder Cancer Inhibits Cell Proliferation, Migration, and Invasion.
Ou, Annals of clinical and laboratory science 2022 (PubMed)- GeneRIF: FAM107A as a Tumor Suppressor in Bladder Cancer Inhibits Cell Proliferation, Migration, and Invasion.
- Transcription factor SP1-induced microRNA-146b-3p facilitates the progression and metastasis of colorectal cancer via regulating FAM107A.
Wang, Life sciences 2021 (PubMed)- GeneRIF: Transcription factor SP1-induced microRNA-146b-3p facilitates the progression and metastasis of colorectal cancer via regulating FAM107A.
- Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria.
Xu, Urologic oncology 2019 (PubMed)- GeneRIF: Both IQGAP3/BMP4 and IQGAP3/FAM107A ratios in ucfDNA were significantly higher in patients with BC than in those with hematuria.
- DRR1 promotes glioblastoma cell invasion and epithelial-mesenchymal transition via regulating AKT activation.
Ma, Cancer letters 2018 (PubMed)- GeneRIF: Results showed that DRR1 is overexpressed in glioblastoma multiforme (GBM) tissues. Its overexpression is associated with tumor progression and poor clinical outcome of GBM patients, which indicates that DRR1 might be a novel prognostic marker of GBM. More results indicated that DRR1 was involved in GBM invasion and progression possibly through the induction of EMT as activated by phosphorylation of AKT.
- A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.
Mu, Oncogene 2017 (PubMed)- GeneRIF: This study has thus revealed a novel nuclear complex of F-actin, DRR1 and COMMD1 that is involved in NF-kappaB degradation and cell cycle suppression in neuroblastoma cells.
- Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors.
Kiwerska, Scientific reports 2017 - GeneRIF: FAM107A gene is down-regulated in laryngeal tumors.
- Decreased FAM107A Expression in Patients with Non-small Cell Lung Cancer.
Pastuszak-Lewandoska, Advances in experimental medicine and biology 2015 (PubMed)- GeneRIF: Importance of FAM107A in lung carcinogenesis, although other than promoter hypermethylation mechanism of the gene decreased expression.
- DRR regulates AKT activation to drive brain cancer invasion.
Dudley, Oncogene 2014 (PubMed)- GeneRIF: Results found that DRR expression leads to elevated AKT activation by recruiting AKT to focal adhesios in a manner dependent on SRC-family kinases (SFKs) and cell adhesion.
- More
F107A_RAT / M0R3K6 Actin-associated protein FAM107A from Rattus norvegicus (Rat) (see paper)
Aligns to 13:120 / 131 (82.4%), covers 99.1% of PF06625, 132.4 bits
- function: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin- dependent manner. May play a role in tumor development (By similarity).
subunit: Interacts with ACTB. Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus. Interacts with MAP1A. Interacts with PRDX1 (By similarity). Interacts with F-actin (By similarity).
XP_038949391 actin-associated protein FAM107A isoform X1 from Rattus norvegicus
Aligns to 54:161 / 172 (62.8%), covers 99.1% of PF06625, 131.6 bits
F107A_MOUSE / Q78TU8 Actin-associated protein FAM107A from Mus musculus (Mouse) (see 2 papers)
Aligns to 26:133 / 144 (75.0%), covers 99.1% of PF06625, 131.1 bits
- function: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics (PubMed:21969592). Mediates polymerization of globular actin to F-actin (PubMed:21969592). Also binds to, stabilizes and bundles F-actin (PubMed:21969592). Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (PubMed:21969592). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity).
subunit: Interacts with ACTB (PubMed:21969592). Interacts with F-actin (PubMed:21969592). Interacts with PRDX1 (PubMed:21969592). Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus (By similarity). Interacts with MAP1A (By similarity).
Or search for genetic data about PF06625 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory