Family Search for PF06658 (DUF1168)

PF06658 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Q17N70 AAEL000785-PA from Aedes aegypti
Aligns to 39:175 / 256 (53.5%), covers 96.4% of PF06658, 159.1 bits

• Towards a Proteomic Catalogue and Differential Annotation of Salivary Gland Proteins in Blood Fed Malaria Vector Anopheles culicifacies by Mass Spectrometry
  Rawal, PloS one 2016
  • “...Band 27 T1EB87 Uncharacterized protein An . aquasalis 10.46 2 NCD * / Band 13 Q17N70 AAEL000785-PA Aedes aegypti 4.69 1 DUF1168/ Band 2 *NCD- No conserved domain Comparison of salivary gland proteins between Sugar Fed (SF) and Blood Fed (BF) An . culicifacies mosquitoes by...”

PKRI1_MOUSE / Q9CWV6 PRKR-interacting protein 1; Protein C114 from Mus musculus (Mouse) (see paper)
NP_080050 PRKR-interacting protein 1 from Mus musculus
Aligns to 42:180 / 186 (74.7%), covers 98.5% of PF06658, 157.4 bits

• function: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity.
  subunit: Component of the pre-catalytic and post-catalytic spliceosome complexes (By similarity). Interacts with EIF2AK2.
• Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease.
  Butte, Molecular & cellular proteomics : MCP 2011
  • GeneRIF: Significant elevations in the titer of novel auto-Ab were noted against angiotensinogen and PRKRIP1 in renal insufficiency.
• C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding protein that inhibits protein kinase R.
  Yin, The Journal of biological chemistry 2003 (PubMed)
  • GeneRIF: C114 binds to protein kinase R (PKR), via dsRNA-binding domains of PKR and the N-terminal region of the C114 protein

PKRI1_HUMAN / Q9H875 PRKR-interacting protein 1 from Homo sapiens (Human) (see 2 papers)
NP_078929 PRKR-interacting protein 1 from Homo sapiens
Aligns to 42:178 / 184 (74.5%), covers 97.8% of PF06658, 155.8 bits

• function: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:30705154). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).
  subunit: Component of the pre-catalytic and post-catalytic spliceosome complexes (PubMed:28502770, PubMed:30705154). Interacts with EIF2AK2 (By similarity).
• PRKRIP1, A Splicing Complex Factor, Is a Marker of Poor Prognosis in Colorectal Cancer.
  Ozato, Anticancer research 2022 (PubMed)
  • GeneRIF: PRKRIP1, A Splicing Complex Factor, Is a Marker of Poor Prognosis in Colorectal Cancer.
• Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.
  Coltri, PloS one 2011
  • “...33 4 14 Q9UKM9 RALY 32 1 P26599 PTBP1 57 15 Q86U42 PABP2 32 1 Q9H875 PKRI1 21 1 Q96PU8 QKI 37 17 P43243 MATR3 94 17 Q9Y580 RBM7 30 2 Q15717 ELAV1 36 1 LC-MS/MS analysis of urea and maltose eluate of lariat-intron tagged C...”

8c6jD / Q9H875 8c6jD (see paper)
Aligns to 23:123 / 123 (82.1%), covers 70.8% of PF06658, 148.9 bits

• Ligand: rna (8c6jD)

LOC100283616 uncharacterized protein LOC100283616 from Zea mays
Aligns to 45:177 / 177 (75.1%), covers 88.3% of PF06658, 98.9 bits

• Identification of Genomic Regions Associated with Agronomic and Disease Resistance Traits in a Large Set of Multiple DH Populations
  Sadessa, Genes 2022
  • “...6 0.08 0.37 - uncharacterized LOC100383423 S1_77141315 1 5.83 10 6 0.14 0.37 GRMZM2G425736 uncharacterized LOC100283616 S1_85991848 1 9.18 10 6 0.44 0.22 GRMZM2G040743 putative calcium-dependent protein kinase family protein S2_164888999 2 3.56 10 106 0.06 0.51 GRMZM2G151549 eukaryotic translation initiation factor 3 subunit 6 S2_24033162...”

AT2G15270 hypothetical protein from Arabidopsis thaliana
Aligns to 44:178 / 194 (69.6%), covers 86.9% of PF06658, 96.9 bits

• Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase
  Cromer, Proceedings of the National Academy of Sciences of the United States of America 2019
  • “...2 3 5 AT5G23900 Ribosomal protein 2 3 5 AT3G07090 Thiol peptidase 2 2 4 AT2G15270 PRKRIP1 2 2 Fig. 9. Conservation of securin organization in eukaryotes. Sequence consensus of securin homologs obtained from the multiple sequence alignments of A. thaliana PANS1 (PANS1_ARATH), Oryza sativa RSS1...”

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