Family Search for PF06722 (EryCIII-like_C)
PF06722 hits 521 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
ERYC3_SACEN / A4F7P3 3-alpha-mycarosylerythronolide B desosaminyl transferase; Desosaminyl transferase EryCIII; Erythromycin biosynthesis protein CIII; EC 2.4.1.278 from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 3 papers)
CAA74710.1 TDP-desosamine: α-mycarosyl erythronolide B desosaminyltransferase (EryCIII;SACE_0726) (EC 2.4.1.-) (see protein)
YP_001102993 glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B from Saccharopolyspora erythraea NRRL 2338
Aligns to 269:413 / 421 (34.4%), covers 99.3% of PF06722, 217.2 bits
- function: Catalyzes the conversion of alpha-L-mycarosylerythronolide B into erythromycin D in the erythromycin biosynthesis pathway.
catalytic activity: 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+) (RHEA:32091)
subunit: Heterotetramer composed of EryCII and EryCIII. - Structural studies of the spinosyn forosaminyltransferase, SpnP
Isiorho, Biochemistry 2014 - “...substituted with other residues. The secondary structure is from SpnP. Accession numbers: SpnP, AAG23277; EryCIII, YP_001102993; MegCIII, CAC37820; DesVII, AAC68677; TylMII, CAA57472; CosG, ABC00729; DnrS, AAD15267; SnogD, AAF01811; SpnG, AAG23268; UrdGT2, AAF00209; CalG3, AAM94798; OleD, ABA42119; GtfA, AAB49292. (B) Stereodiagram of the three-helix motif showing the...”
- Elucidation of the di-c-glycosylation steps during biosynthesis of the antitumor antibiotic, kidamycin.
Heo, Frontiers in bioengineering and biotechnology 2022 - “...[AknK (AAF70102), AknS (AAF73455), AraGT (ABL09968), Asm25 (AAM54103), DesVII (Q9ZGH7), ElaGT (ADP68587), EryBV (AAB84072), EryCIII (A4F7P3), GilGT (AAP69578), Gra-ORF14 (CAA09635), HedJ (AA85354), HedL (AAP85354), LanGT (AAD13562), LanGT2 (AAD13553), Med8 (BAC79040), SsfS6 (ADE34512), SunS (KIX81208), UrdGT2 (AAF00209) and VlnC (BAJ52701)] were aligned using the Clustal W method....”
- “...AknK (AAF70102), AknS (AAF73455), AraGT (ABL09968), Asm25 (AAM54103), DesVII (Q9ZGH7), ElaGT (ADP68587), EryBV (AAB84072), EryCIII (A4F7P3), GilGT (AAP69578), Gra-ORF14 (CAA09635), HedJ (AA85354), HedL (AAP85354), LanGT (AAD13562), LanGT2 (AAD13553), Med8 (BAC79040), SsfS6 (ADE34512), SunS (KIX81208), UrdGT2 (AAF00209), and VlnC (BAJ52701). Amino acid sequences were aligned using the...”
eryBV / A4F7N6 dTDP-L-mycarosyl: erythronolide B mycarosyltransferase (EC 2.4.1.328) from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 2 papers)
ERYBV_SACER / O33939 Erythronolide mycarosyltransferase; EC 2.4.1.328 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see paper)
SACE_0719 6-DEB TDP-mycarosyl glycosyltransferase from Saccharopolyspora erythraea NRRL 2338
Aligns to 268:409 / 415 (34.2%), covers 99.3% of PF06722, 209.3 bits
- function: Involved in the biosynthesis of the macrolide antibiotic erythromycin. Catalyzes the reversible transfer of mycarosyl from dTDP- beta-L-mycarose to erythronolide B to yield 3-alpha-L- mycarosylerythronolide B. It can also use TDP-beta-L-cladinose.
catalytic activity: dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L- mycarosylerythronolide B + dTDP + H(+) (RHEA:41576) - CRISPR/Cas9-Mediated Multi-Locus Promoter Engineering in ery Cluster to Improve Erythromycin Production in Saccharopolyspora erythraea
Zhang, Microorganisms 2023 - “...producer and six genes representing extremely low transcription levels, SACE_0716 , SACE_0717 , SACE_0718 , SACE_0719 , SACE_0720 , and SACE_0731 , encoding EryCIV, EryBVI, EryCVI, EryBV, EryBIV, and EryBIII, respectively, were characterized to play important roles in limiting erythromycin biosynthesis in S. erythraea NRRL 23338...”
- “...Limiting Genes In our previous study, six ery genes, SACE_0716 , SACE_0717 , SACE_0718 , SACE_0719 , SACE_0720 , and SACE_0731 , were demonstrated to play important roles in erythromycin biosynthesis, and overexpression of any one of the six genes led to improved erythromycin production in...”
- Droplet-Microfluidic-Based Promoter Engineering and Expression Fine-Tuning for Improved Erythromycin Production in Saccharopolyspora erythraea NRRL 23338
Yun, Frontiers in bioengineering and biotechnology 2022 - “...pSET152-hyg- p SACE_2101_s32 -SACE_0716, pSET152-hyg- p SACE_2101_s32 -SACE_0717, pSET152-hyg- p SACE_2101_s32 -SACE_0718, pSET152-hyg- p SACE_2101_s32 -SACE_0719, pSET152-hyg- p SACE_2101_s32 -SACE_0720, pSET152-hyg- p SACE_2101_s32 -SACE_0731, pSET152-hyg- p ermE*_s23 -SACE_0716, pSET152-hyg- p ermE*_s23 -SACE_0717, pSET152-hyg- p ermE*_s23 -SACE_0718, pSET152-hyg- p ermE*_s23 -SACE_0719, pSET152-hyg- p ermE*_s23 -SACE_0720, pSET152-hyg- p...”
- “.../pSET152-hyg- p SACE_2101_s32 -SACE_0717, S. erythraea /pSET152-hyg- p SACE_2101_s32 -SACE_0718, S. erythraea /pSET152-hyg- p SACE_2101_s32 -SACE_0719, S. erythraea /pSET152-hyg- p SACE_2101_s32 -SACE_0720, S. erythraea /pSET152-hyg- p SACE_2101_s32 -SACE_0731, S. erythraea /pSET152-hyg- p ermE*_s23 -SACE_0716, S. erythraea /pSET152-hyg- p ermE*_s23 -SACE_0717, S. erythraea /pSET152-hyg- p ermE*_s23 -SACE_0718,...”
cloM / Q8GHC2 L-demethylnoviosyl:clorobiocic acid transferase (EC 2.4.1.302) from Streptomyces roseochromogenus subsp. oscitans (see paper)
Aligns to 229:372 / 390 (36.9%), covers 99.3% of PF06722, 204.5 bits
CAC37820.1 dTDP-D-desosamine: 3-α-mycarosylerythronolide B desosaminyltransferase (MegCIII) (EC 2.4.1.-) (see protein)
Aligns to 270:414 / 422 (34.4%), covers 97.2% of PF06722, 204.3 bits
STM2773 putative glycosyl transferase, related to UDP-glucuronosyltransferase from Salmonella typhimurium LT2
Aligns to 227:367 / 371 (38.0%), covers 100.0% of PF06722, 197.7 bits
- Comparative genomics between Colombian clinical isolates of Monophasic VariantSalmonellaTyphimurium and international clonal lineages
Paloma, 2023 - Evidence of international transmission of mobile colistin resistant monophasic Salmonella Typhimurium ST34
Supa-Amornkul, Scientific reports 2023 - “...was accompanied by an inversion of a 150,626-bp-long segment (position 2,916,0403,066,666), including 152 genes from STM2773 ( iroB ) to STM2924 ( rpoS ) and the last 111bp of STM2925c ( nlpD ). The inverted segment was flanked on both sides by IS 26 . There...”
- Identification of a Recently Dominant Sublineage in Salmonella 4,[5],12:i:- Sequence Type 34 Isolated From Food Animals in Japan
Arai, Frontiers in microbiology 2021 - “...and Pairwise Alignment of the DNA Sequences Nucleotide sequences of the genes from STM2743 to STM2773 in the Salmonella Typhimurium LT2 strain were used as query sequences. The detection thresholds were as follows: minimum coverage length 80% and nucleotide sequence identity 85%. Pairwise alignment of the...”
- Sequence Analyses and Phenotypic Characterization Revealed Multidrug Resistant Gene Insertions in the Genomic Region Encompassing Phase 2 Flagellin Encoding fljAB Genes in Monophasic Variant Salmonella enterica Serovar 4,5,12:i:- Isolates From Various Sources in Thailand
Win, Frontiers in microbiology 2021 - “...five target regions (131L, tniA , tetC , MAK, and 131R) spanning from STM2759 to STM2773 ( iroB ) among 108 Thai S . 4,5,12:i:- isolates and four non-Thai isolates (two Spanish and two U.S. strains) was performed. We identified nine patterns of presence or absence...”
- Population structure, case clusters, and genetic lesions associated with Canadian Salmonella 4,[5],12:i:- isolates
Clark, PloS one 2021 - “...of adjacent DNA, including fljAB hin , between homologs of S. Typhimurium homologs STM2692 and STM2773. A small number of isolates with this element are also found in other clades in which they do not predominate, raising questions about whether this prophage fragment is, in fact,...”
- Genotyping Study of Salmonella 4,[5],12:i:- Monophasic Variant of Serovar Typhimurium and Characterization of the Second-Phase Flagellar Deletion by Whole Genome Sequencing
Arrieta-Gisasola, Microorganisms 2020 - “...A1 ) fljAB 2 fljAB 2-A 1 1201 bp of STM2746 334 bp upstream from STM2773 ( iroB ) 820 bp (one IS26) fljAB 2-B 1 1263 bp of STM2746 fljAB 3 fljAB 3-A 1 177 of STM2753 334 bp upstream from STM2773 ( iroB )...”
- “...353 bp of STM2753 fljAB 4 3 222 bp downstream of STM2757 571 bp of STM2773 ( iroB ) 820 bp (one IS26) fljAB 5 1 222 bp downstream of STM2757 848 bp of the STM2784 820 bp (one IS26) fljAB 6 fljAB 6-A 1 1079...”
- Horizontal Acquisition of a Multidrug-Resistance Module (R-type ASSuT) Is Responsible for the Monophasic Phenotype in a Widespread Clone of Salmonella Serovar 4,[5],12:i:
García, Frontiers in microbiology 2016 - “...is inserted between two chromosomal loci, named STM2759 (encoding a putative phosphotransferase) and iro B (STM2773, a putative glycosyl transferase), causing the deletion of the genomic fragment located in between (15,716 bp). The latter comprises the genes STM2760STM2769 (encoding different putative proteins), the fljAB operon (encoding...”
- “...unknown function. The module is inserted between two chromosomal loci, named STM2759 and iro B (STM2773), causing the deletion of the genomic fragment located in between. Regarding the flanking chromosomal DNA of RR3, it shows high-level sequence identity to the corresponding regions of the biphasic S...”
- Characterization of Salmonella enterica serovar Typhimurium and Salmonella enterica serovar 4,[5],12:i:- isolates from pigs presenting with diarrhea in Korea
Lee, The Journal of veterinary medical science 2015 - “...25922 was used as a control strain. The expression of flagellar genes (STM1053-1997, STM2740, STM2757, STM2773, fljA , fljB and hin ) was assessed by PCR ( Table 1 ) as described previously [ 27 ]. DNA fragments were separated on a 1.5% agarose gel. Fragments...”
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t2668 putative glycosyl transferase from Salmonella enterica subsp. enterica serovar Typhi Ty2
Aligns to 227:367 / 371 (38.0%), covers 100.0% of PF06722, 193.9 bits
CAC37814.1 mycarosyltransferase (MegBV) (EC 2.4.1.-) (see protein)
Aligns to 268:409 / 417 (34.1%), covers 98.6% of PF06722, 183.5 bits
RJF2_RS26160 salmochelin biosynthesis C-glycosyltransferase IroB from Klebsiella pneumoniae subsp. pneumoniae
Aligns to 227:367 / 371 (38.0%), covers 99.3% of PF06722, 181.9 bits
NRG857_30008 salmochelin biosynthesis C-glycosyltransferase IroB from Escherichia coli O83:H1 str. NRG 857C
Aligns to 227:367 / 371 (38.0%), covers 99.3% of PF06722, 181.4 bits
iroB / A0A0H2V630 enterobactin C-glucosyltransferase (EC 2.4.1.369) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see 3 papers)
IROB_ECOL6 / A0A0H2V630 Enterobactin C-glucosyltransferase; Ent C-glucosyltransferase; EC 2.4.1.369 from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see 3 papers)
A0A0H2V630 enterobactin C-glucosyltransferase (EC 2.4.1.369) from Escherichia coli O6:H1 (see 2 papers)
Aligns to 227:367 / 371 (38.0%), covers 99.3% of PF06722, 181.4 bits
- function: Catalyzes the successive monoglucosylation, diglucosylation and triglucosylation of enterobactin (Ent) (PubMed:15598734, PubMed:24960592). Transfers glucosyl groups from uridine-5'- diphosphoglucose (UDP-Glc) to C5 of one, two or three of the 2,3- dihydroxybenzoyl (DHB) units of Ent to yield monoglucosyl-C-Ent (MGE), diglucosyl-C-Ent (DGE) and triglucosyl-C-Ent (TGE) (PubMed:15598734, PubMed:24960592). Glucosylation decreases the membrane affinity of Ent and increases the iron acquisition rate (PubMed:17163637).
catalytic activity: enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP (RHEA:24448)
catalytic activity: monoglucosyl-enterobactin + UDP-alpha-D-glucose = diglucosyl- enterobactin + H(+) + UDP (RHEA:59096)
catalytic activity: diglucosyl-enterobactin + UDP-alpha-D-glucose = H(+) + triglucosyl-enterobactin + UDP (RHEA:59100)
c1254 Putative glucosyltransferase from Escherichia coli CFT073
Aligns to 243:383 / 387 (36.4%), covers 99.3% of PF06722, 181.3 bits
O2ColV53 IroB from Escherichia coli
UTI89_C1122 putative glucosyltransferase from Escherichia coli UTI89
Aligns to 243:383 / 387 (36.4%), covers 99.3% of PF06722, 181.3 bits
oleG2 / O87831 oleandolide olivosyltransferase from Streptomyces antibioticus (see 3 papers)
Aligns to 267:411 / 426 (34.0%), covers 99.3% of PF06722, 181.1 bits
novM / Q9L9F5 4-O-demethyl-L-noviosyl transferase (EC 2.4.1.302) from Streptomyces niveus (see paper)
NOVM_STRNV / Q9L9F5 L-demethylnoviosyl transferase; Novobiocin biosynthesis protein M; EC 2.4.1.302 from Streptomyces niveus (Streptomyces spheroides) (see 3 papers)
Aligns to 229:371 / 379 (37.7%), covers 97.2% of PF06722, 175.2 bits
- function: Catalyzes the transfer of L-noviose from dTDP-4-O-demethyl- beta-L-noviose to the phenolic oxygen of novobiocic acid, creating the full ABC ring system in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Also shows activity with variant coumarin aglycones, suggesting it may be a promiscuous catalyst for noviosylation of a range of planar scaffolds. Does not show activity with TDP-L-rhamnose.
catalytic activity: dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+) (RHEA:36695)
CAJ42338.1 steffimycin L-rhamnosyltransferase (StfG) (EC 2.4.1.-) (see protein)
stfG / CAJ42338.1 glycosyl transferase from Streptomyces steffisburgensis (see paper)
Aligns to 267:411 / 420 (34.5%), covers 99.3% of PF06722, 171.1 bits
ABB52547.1 TDP-D-chalcose: macrolide chalcosyltransferase / TDP-D-desosamine: macrolide D-desosaminyltransferase (GerTII) (EC 2.4.1.-) (see protein)
Aligns to 273:417 / 425 (34.1%), covers 99.3% of PF06722, 167.1 bits
oleG1 / O87830 L-oleandrosyl-oleandolide desosaminyltransferase from Streptomyces antibioticus (see 2 papers)
Aligns to 268:413 / 426 (34.3%), covers 99.3% of PF06722, 166.5 bits
megDI / Q9F839 dTDP-L-megosamine:erythromycin C L-megosaminyltransferase from Micromonospora megalomicea subsp. nigra (see 2 papers)
CAC37807.1 rhodosaminyltransferase (MegDI) (EC 2.4.1.-) (see protein)
Aligns to 272:415 / 436 (33.0%), covers 99.3% of PF06722, 166.2 bits
Sare_1263 protein of unknown function DUF1205 from Salinispora arenicola CNS205
Aligns to 232:377 / 387 (37.7%), covers 98.6% of PF06722, 163.1 bits
SSHG_05324 activator-dependent family glycosyltransferase from Streptomyces albidoflavus
Aligns to 274:418 / 426 (34.0%), covers 98.6% of PF06722, 160.7 bits
ABL09968.1 TDP-L-Rha: CBS000020 α-L-rhamnosyltransferase (aranciamycin synthase) (AraGT;Orf21) (EC 2.4.1.-) (see protein)
Aligns to 277:421 / 427 (34.0%), covers 97.9% of PF06722, 160.6 bits
Q93GK9 DUF1205 domain-containing protein from Klebsiella pneumoniae
Aligns to 224:364 / 370 (38.1%), covers 98.6% of PF06722, 160.0 bits
Q83ZB1 Putative glycosyltransferase McmL from Escherichia coli
Aligns to 226:365 / 372 (37.6%), covers 97.9% of PF06722, 159.6 bits
Q83ZA2 Glycosyltransferase from Escherichia coli
Aligns to 226:365 / 372 (37.6%), covers 97.9% of PF06722, 159.1 bits
Z1190 putative glucosyltransferase from Escherichia coli O157:H7 EDL933
Aligns to 226:365 / 374 (37.4%), covers 97.9% of PF06722, 158.9 bits
CP966_RS29040 activator-dependent family glycosyltransferase from Streptomyces galilaeus
Aligns to 277:421 / 441 (32.9%), covers 99.3% of PF06722, 158.8 bits
- Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines
Hulst, Frontiers in bioengineering and biotechnology 2024 - “...Glycosyltransferase dnrQ DnrQ 1,317/438 S. peucetius CGZ69_RS24505 Glycosyltransferase auxiliary protein aknS AknS 1,332/443 S. galilaeus CP966_RS29040 Glycosyltransferase aknT AknT 1,332/443 S. galilaeus CP966_RS29045 Glycosyltransferase auxiliary protein dnrP DnrP 885/294 S. peucetius CGZ69_RS24510 15-Methylesterase rdmC RdmC 894/297 S. purpurascens LYO46_16725 15-Methylesterase dnrK DnrK 1,071/356 S. peucetius CGZ69_RS24515...”
aknS / Q9L4U6 L-rhodosaminyltransferase (EC 2.4.1.326) from Streptomyces galilaeus (see 4 papers)
AKNS_STRGJ / Q9L4U6 Aklavinone 7-beta-L-rhodosaminyltransferase; EC 2.4.1.326 from Streptomyces galilaeus (see 2 papers)
AAF73455.1 dTDP-L-rhodosamine:aklavinone α-L-rhodosaminyltransferase (AknS) (EC 2.4.1.-) (see protein)
Aligns to 279:423 / 443 (32.7%), covers 99.3% of PF06722, 158.0 bits
- function: Involved in the biosynthesis of the anthracycline antitumor agent aclacinomycin A. Catalyzes the transfer of the proximal deoxyhexose, L-rhodosamine, from dTDP-beta-L-rhodosamine to the C7-OH of aklavinone aglycone to yield aclacinomycin T (rhodosaminyl- aklavinone). It can also use dTDP-2-deoxy-beta-L-fucose, TDP-2- deoxyfucose, dTDP-4-amino-2-deoxyrhamnose, TDP-L-rhodosamine as sugar donor and epsilon-rhodomycinone as sugar acceptor.
catalytic activity: aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+) (RHEA:41564)
mchA / CAG25570.1 MchA protein from Escherichia coli (see 5 papers)
Aligns to 226:365 / 372 (37.6%), covers 97.9% of PF06722, 157.8 bits
ABC00729.1 cosmomycin α-L-rhodosaminyltransferase (CosG) (EC 2.4.1.-) (see protein)
Aligns to 271:415 / 426 (34.0%), covers 98.6% of PF06722, 156.7 bits
DES7_STRVZ / Q9ZGH7 10-deoxymethynolide desosaminyltransferase; EC 2.4.1.277 from Streptomyces venezuelae (see 5 papers)
Q9ZGH7 10-deoxymethynolide desosaminyltransferase (EC 2.4.1.277); 3-alpha-mycarosylerythronolide B desosaminyl transferase (EC 2.4.1.278); erythronolide mycarosyltransferase (EC 2.4.1.328) from Streptomyces venezuelae (see 8 papers)
AAC68677.1 TDP-D-desosamine: 10-deoxymethynolide/narbonolide desosaminyltransferase (DesVII) (EC 2.4.1.-) (see protein)
Aligns to 269:413 / 426 (34.0%), covers 98.6% of PF06722, 153.7 bits
- function: Involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin. Catalyzes the attachment of dTDP-D-desosamine onto 12- and 14-membered macrolactone rings 10-deoxymethynolide and narbonolide to produce 10-deoxymethymycin (YC-17) and narbomycin. DesVII is unique among glycosyltransferases in that it requires an additional protein component, DesVIII, for its activity. DesVII can recognize and process not only cyclic substrates of different ring size, but also a variety of linear substrates albeit with reduced, but measurable activities (PubMed:18548476). Both L- sugars and D-sugars are recognized as substrates and variant substitutions at C-3 and C-4 are tolerated, but deoxygenation at C-6 is required (PubMed:16538696).
catalytic activity: 10-deoxymethynolide + dTDP-alpha-D-desosamine = 10- deoxymethymycin + dTDP + H(+) (RHEA:31627)
subunit: Forms a complex with DesVIII.
disruption phenotype: Cells lacking this gene are not able to produce glycosylated macrolides. - Elucidation of the di-c-glycosylation steps during biosynthesis of the antitumor antibiotic, kidamycin
Heo, Frontiers in bioengineering and biotechnology 2022 - “...generation of natural products by Streptomyces [AknK (AAF70102), AknS (AAF73455), AraGT (ABL09968), Asm25 (AAM54103), DesVII (Q9ZGH7), ElaGT (ADP68587), EryBV (AAB84072), EryCIII (A4F7P3), GilGT (AAP69578), Gra-ORF14 (CAA09635), HedJ (AA85354), HedL (AAP85354), LanGT (AAD13562), LanGT2 (AAD13553), Med8 (BAC79040), SsfS6 (ADE34512), SunS (KIX81208), UrdGT2 (AAF00209) and VlnC (BAJ52701)] were...”
- “...natural product biosynthesis by Streptomyces : AknK (AAF70102), AknS (AAF73455), AraGT (ABL09968), Asm25 (AAM54103), DesVII (Q9ZGH7), ElaGT (ADP68587), EryBV (AAB84072), EryCIII (A4F7P3), GilGT (AAP69578), Gra-ORF14 (CAA09635), HedJ (AA85354), HedL (AAP85354), LanGT (AAD13562), LanGT2 (AAD13553), Med8 (BAC79040), SsfS6 (ADE34512), SunS (KIX81208), UrdGT2 (AAF00209), and VlnC (BAJ52701). Amino...”
mycB / Q83WE1 protomycinolide IV desosaminyltransferase from Micromonospora griseorubida (see 2 papers)
Aligns to 269:413 / 428 (33.9%), covers 97.9% of PF06722, 151.6 bits
tylM2 / P95747 tylactone mycaminosyltransferase (EC 2.4.1.316) from Streptomyces fradiae (see paper)
TYLM2_STRFR / P95747 Tylactone mycaminosyltransferase; EC 2.4.1.316 from Streptomyces fradiae (Streptomyces roseoflavus) (see paper)
P95747 tylactone mycaminosyltransferase (EC 2.4.1.316) from Streptomyces fradiae (see paper)
CAA57472.2 TDP-D-mycaminose : tylactone mycaminyltransferase (TylMII;Orf2*) (EC 2.4.1.-) (see protein)
Aligns to 293:437 / 452 (32.1%), covers 99.3% of PF06722, 150.3 bits
- function: Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of alpha-D-mycaminosyl from dTDP-alpha-D-mycaminose to the 5- hydroxyl group of tylactone to yield 5-O-mycaminosytylactone. It can also accept 16-membered tylactone and 12-membered ring macrolide.
catalytic activity: dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D- mycaminosyltylactone + dTDP + H(+) (RHEA:21468)
dnmS / Q54824 dTDP-daunosamine transferase from Streptomyces peucetius (see 2 papers)
DNRS_STRPE / Q54824 TDP-daunosamine transferase DnrS; 2,3,6-trideoxy-3-aminohexose transferase; EC 2.4.1.- from Streptomyces peucetius (see 2 papers)
Aligns to 271:417 / 431 (34.1%), covers 99.3% of PF06722, 148.1 bits
- function: Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the addition of the TDP activated glycoside, L-daunosamine-TDP (2,3,6- trideoxy-3-aminohexose-TDP) at position C-7 of epsilon-rhodomycinone to yield rhodomycin D. Glycosylation is a prerequisite for biological activity of anthracyclines and requires DnrQ which seems to act as an activator.
catalytic activity: dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D (RHEA:45760) - Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
Hu, Proceedings of the National Academy of Sciences of the United States of America 2003 - “...GT (daunosamine transferase, Stretomyces peucetius, Q54824); zeaxanthin GluT (zeaxanthin glucosyltransferase, Erwinia ananus, P21686); oleandomycin GT...”
aknK / Q9L555 L-rhodinosyltransferase (EC 2.4.1.327) from Streptomyces galilaeus (see paper)
AKNK_STRGJ / Q9L555 Aclacinomycin-T 2-deoxy-L-fucose transferase; AknK; L-2-deoxyfucosyltransferase; EC 2.4.1.327 from Streptomyces galilaeus (see paper)
Aligns to 277:422 / 440 (33.2%), covers 99.3% of PF06722, 147.9 bits
- function: Involved in the biosynthesis of the trisaccharide moiety characteristic of the antitumor drug aclacinomycins. In the first reaction, AknK catalyzes the transfer of 2-deoxy-beta-L-fucose from the activated donor dTDP-2-deoxy-beta-L-fucose to the mono-glycosylated aclacinomycin T (rhodosaminyl aklavinone), forming the di-glycosylated aclacinomycin S (L-2-deoxyfucosyl-L-rhodosaminyl aklavinone). It can also catalyze the addition of an alternate dTDP-L-sugar, dTDP-L- daunosamine, to aclacinomycin T and the addition of 2-deoxy-beta-L- fucose to the mono-glycosylated aglycones (monoglycosylated anthracyclines) such as daunomycin (daunorubicin), adriamycin (doxorubicin) and idarubicin. In vitro, AknK also catalyzes the addition of a second L-2-deoxyfucosyl moiety from dTDP-2-deoxy-beta-L- fucose, albeit with reduced activity, to the natural disaccharide chain of aclacinomycin S to produce L-deoxyfucosyl-L-deoxyfucosyl-L- rhodosaminyl aklavinone (2-deoxy-alpha-D-fucosyl-aclacinomycin S), a variant of the natural aclacinomycin A.
catalytic activity: aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+) (RHEA:41568)
BAD08357.1 dTDP-vicenisamine: vicenilactam β-vicenisaminyltransferase (VinC) (EC 2.4.1.-) (see protein)
Aligns to 267:412 / 419 (34.8%), covers 96.6% of PF06722, 144.9 bits
3wagB / Q76KZ6 Crystal structure of glycosyltransferase vinc in complex with dtdp
Aligns to 250:395 / 401 (36.4%), covers 96.6% of PF06722, 143.4 bits
- Ligand: thymidine-5'-diphosphate (3wagB)
AAS20331.1 β-olivosyltransferase (LndGT1) (EC 2.4.1.-) (see protein)
Aligns to 239:386 / 389 (38.0%), covers 98.6% of PF06722, 142.3 bits
AAD13555.1 olivosyltransferase (LanGT1) (EC 2.4.1.-) (see protein)
Aligns to 239:386 / 390 (37.9%), covers 99.3% of PF06722, 135.8 bits
AAD13562.1 L-rhodinosyltransferase (LanGT4) (EC 2.4.1.-) (see protein)
Aligns to 266:411 / 417 (35.0%), covers 99.3% of PF06722, 134.9 bits
7yp3F / E5L4T5 Crystal structure of elaiophylin glycosyltransferase in complex with elaiophylin (see paper)
Aligns to 268:413 / 419 (34.8%), covers 98.6% of PF06722, 132.5 bits
- Ligand: elaiophylin (7yp3F)
4rifB / Q9ZGC0 Landomycin glycosyltransferase langt2, carbasugar substrate complex (see paper)
Aligns to 231:372 / 379 (37.5%), covers 97.9% of PF06722, 132.0 bits
- Ligand: 2'-deoxy-5'-o-[(r)-{[(r)-{[(1s,3r,4r,5s)-3,4-dihydroxy-5-methylcyclohexyl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-3,4-dihydrothymidine (4rifB)
ABO27085.1 aquayamycin α-L-rhodinosyltransferase (SaqGT2) (EC 2.4.1.-) (see protein)
Aligns to 274:418 / 443 (32.7%), covers 98.6% of PF06722, 131.5 bits
ABC00725.1 glycosyltransferase (CosK) (EC 2.4.1.-) (see protein)
Aligns to 278:423 / 430 (34.0%), covers 98.6% of PF06722, 130.9 bits
4riiA / Q9RPA7,Q9ZGC0 Chimeric glycosyltransferase langt2s8ac, tdp complex (see paper)
Aligns to 211:352 / 354 (40.1%), covers 97.2% of PF06722, 130.5 bits
- Ligand: thymidine-5'-diphosphate (4riiA)
AAD13553.1 8-O-tetrangulol β-D-olivosyltransferase (LanGT2) (EC 2.4.1.-) (see protein)
Aligns to 231:372 / 373 (38.1%), covers 97.9% of PF06722, 130.2 bits
spnP / Q9ALN7 spinosyn forosaminyltransferase from Saccharopolyspora spinosa (see 2 papers)
Aligns to 294:439 / 455 (32.1%), covers 99.3% of PF06722, 129.8 bits
CAE17548.1 premithramycin A1 / deacteyl-prechromomycin A3 D-olivosyltransferase (CmmGII) (EC 2.4.1.-) (see protein)
Aligns to 233:376 / 396 (36.4%), covers 97.9% of PF06722, 129.6 bits
ABO27084.1 SaqAE1 (L-rhodinose) α-1,4-L-rhodinosyltransferase (SaqGT1) (EC 2.4.1.-) (see protein)
Aligns to 266:411 / 424 (34.4%), covers 99.3% of PF06722, 128.7 bits
Q53881 Glycosyltransferase from Streptomyces sp. (strain C5)
Aligns to 275:419 / 442 (32.8%), covers 99.3% of PF06722, 127.1 bits
AAD13559.1 olivosyltransferase (LanGT3) (EC 2.4.1.-) (see protein)
Aligns to 248:394 / 401 (36.7%), covers 90.3% of PF06722, 126.1 bits
3otiA / Q8KND7 Crystal structure of calg3, calicheamicin glycostyltransferase, tdp and calicheamicin t0 bound form (see paper)
Aligns to 235:377 / 379 (37.7%), covers 97.9% of PF06722, 125.4 bits
- Ligands: thymidine-5'-diphosphate; calicheamicin t0 (3otiA)
AAF01811.1 TDP-nogalamine : 3prime,4prime-demethoxynogalose-1-hydroxynogalamycinone nogalaminyltransferase (SnogD) (EC 2.4.1.-) (see protein)
Aligns to 248:388 / 390 (36.2%), covers 98.6% of PF06722, 125.3 bits
CAE17547.1 D-olivosyltransferase (CmmGIV) (EC 2.4.1.-) (see protein)
Aligns to 254:403 / 421 (35.6%), covers 98.6% of PF06722, 125.0 bits
AAF00214.1 C-12β-L-rhodinosyltransferase (UrdGT1a) (EC 2.4.1.-) (see protein)
Aligns to 274:420 / 426 (34.5%), covers 97.2% of PF06722, 124.5 bits
LRR80_00497 nucleotide disphospho-sugar-binding domain-containing protein from Streptomyces sp. RO-S4
Aligns to 232:375 / 376 (38.3%), covers 95.9% of PF06722, 123.9 bits
AAF00217.1 aquayamycin / urdamycinone B L-rhodinosyltransferase (UrdGT1c) (EC 2.4.1.-) (see protein)
Aligns to 240:384 / 391 (37.1%), covers 91.0% of PF06722, 123.2 bits
AAF00215.1 (12b -derhodinosyl-)urdamycin G D-olivosyltransferase (UrdGT1b) (EC 2.4.1.-) (see protein)
Aligns to 241:385 / 388 (37.4%), covers 92.4% of PF06722, 123.2 bits
CAE17545.1 D-olivosyltransferase (CmmGIII) (EC 2.4.1.-) (see protein)
Aligns to 248:392 / 397 (36.5%), covers 98.6% of PF06722, 122.1 bits
mtmGIII / Q194P9 MtmGIII from Streptomyces argillaceus (see paper)
AAD55583.1 premithramycin A1 D-olivosyltransferase (MtmGIII) (EC 2.4.1.-) (see protein)
Aligns to 245:389 / 396 (36.6%), covers 98.6% of PF06722, 121.5 bits
snogZ / CAB59003.1 SnogZ from Streptomyces nogalater (see 3 papers)
Aligns to 265:408 / 411 (35.0%), covers 96.6% of PF06722, 120.4 bits
ABO27086.1 SaqAE3 (L-rhodinose) β-1,4A-olivosyltransferase (SaqGT3) (EC 2.4.1.-) (see protein)
Aligns to 248:392 / 404 (35.9%), covers 91.7% of PF06722, 120.1 bits
ACP19375.1 SaqAE62 α-1,4-L-2-deoxyfucosyltransferase (SaqGT6) (EC 2.4.1.-) (see protein)
Aligns to 263:407 / 416 (34.9%), covers 99.3% of PF06722, 120.1 bits
3othA / Q8KNF2 Crystal structure of calg1, calicheamicin glycostyltransferase, tdp and calicheamicin alpha3i bound form (see paper)
Aligns to 248:391 / 395 (36.5%), covers 95.2% of PF06722, 119.7 bits
- Ligands: thymidine-5'-diphosphate; calicheamicin alpha3i (3othA)
LRR80_00495 nucleotide disphospho-sugar-binding domain-containing protein from Streptomyces sp. RO-S4
Aligns to 239:385 / 398 (36.9%), covers 91.7% of PF06722, 119.6 bits
- Integrated Metabolomic, Molecular Networking, and Genome Mining Analyses Uncover Novel Angucyclines From Streptomyces sp. RO-S4 Strain Isolated From Bejaia Bay, Algeria
Ouchene, Frontiers in microbiology 2022 - “...of sequence similarity to known enzymes involved in the modification of aromatic polyketides. Three genes (LRR80_00495, LRR80_00496, and LRR80_00498) likely associated with the glycosylation steps showed high similarity to genes coding for glycosyltransferases (GTs) in other angucyclines. All the annotated genes involved in the BGC of...”
- “...(Kawasaki et al., 2016 )], and SchS10 [81.63% (Basnet et al., 2006 )]. The second (LRR80_00495) is closely related to GcnG2 [92.46% (Zhang et al., 2013 )], sprGT2 [83.92% (Kawasaki et al., 2016 )], sqnG2 [81.91% (Salem et al., 2017 )], and schS9 [74.74% (Basnet et...”
ABX71119.1 lactonamycinone glycosyltransferase (Lct36) (EC 2.4.1.-) (see protein)
Aligns to 273:421 / 429 (34.7%), covers 99.3% of PF06722, 118.2 bits
ABX71153.1 lactonamycin glycosyltransferase (Lcz36) (EC 2.4.1.-) (see protein)
Aligns to 273:421 / 427 (34.9%), covers 99.3% of PF06722, 116.4 bits
4leiA / Q9ALN7 Spinosyn forosaminyltransferase spnp (see paper)
Aligns to 234:372 / 375 (37.1%), covers 99.3% of PF06722, 115.0 bits
- Ligand: thymidine-5'-diphosphate (4leiA)
CAE17535.1 dideacetyl-prechromomycin A4 D-olivosyltransferase (CmmGI) (EC 2.4.1.-) (see protein)
Aligns to 237:382 / 393 (37.2%), covers 98.6% of PF06722, 114.0 bits
LOC112052352 uncharacterized protein LOC112052352 from Bicyclus anynana
2 alignments in 493:1144 / 1225 (22.2%), covering up to 90.3% of PF06722, 113.4 bits
- Transcriptional responses of Daphnis nerii larval midgut to oral infection by Daphnis nerii cypovirus-23
Kuang, Virology journal 2021 - “...hypothetical protein B5X24_HaOG201493 [Helicoverpa armigera] RDH12 TRINITY_DN9738_c0_g1_i1_6 438.41149 83.17535239 0.189719828 0.04256225 0.7412925 Down uncharacterized protein LOC112052352 [Bicyclus anynana] UGT TRINITY_DN8673_c0_g1_i3_3 839.7824168 167.2848772 0.199200262 0.00073535 0.0803495 Down PREDICTED: UDP-glucuronosyltransferase 2B19-like isoform X6 [Amyelois transitella] UGT TRINITY_DN17220_c0_g1_i1_4 6379.593263 3.929259199 0.000615911 0.00570705 0.2744919 Down UDP-glycosyltransferase UGT340C1 precursor [Bombyx mori]...”
mtmGI / Q194P5 premithramycin A3:dTDP-D-olivose D-olivosyltransferase from Streptomyces argillaceus (see paper)
AAC64928.1 D-olivosyltransferase (MtmGI) (EC 2.4.1.-) (see protein)
Aligns to 232:378 / 393 (37.4%), covers 97.9% of PF06722, 113.0 bits
AAF00209.1 D-olivosyltransferase (UrdGT2) (EC 2.4.1.-) (see protein)
Aligns to 221:364 / 365 (39.5%), covers 97.2% of PF06722, 110.9 bits
3tsaB / Q9ALM8 Spinosyn rhamnosyltransferase spng (see paper)
Aligns to 227:372 / 372 (39.2%), covers 91.0% of PF06722, 109.2 bits
- Ligand: alpha-d-glucopyranose (3tsaB)
elmGT / Q9F2F9 8-demethyltetracenomycin C rhamnosyltransferase (EC 2.4.1.331) from Streptomyces olivaceus (see 2 papers)
ELMGT_STROV / Q9F2F9 Elloramycin glycosyltransferase ElmGT; EC 2.4.1.331 from Streptomyces olivaceus (see 2 papers)
Q9F2F9 8-demethyltetracenomycin C L-rhamnosyltransferase (EC 2.4.1.331) from Streptomyces olivaceus (see 5 papers)
CAC16413.2 dTDP-L-Rha: 8-demethyl-tetracenomycin C α-L-rhamnosyltransferase / elloramycin glycosyltransferase (ElmGT) (EC 2.4.1.-) (see protein)
elmgt / CAC16413.2 elloramycin glycosyltransferase from Streptomyces olivaceus (see 2 papers)
Aligns to 234:372 / 382 (36.4%), covers 93.8% of PF06722, 108.2 bits
- function: Glycosyltransferase that transfers an L-rhamnose moiety from dTDP-L-rhamnose to the elloramycin aglycone 8-demethyl-tetracenomycin C (8DMTC) in elloramycin biosynthesis, an antitumor polyketide. Possesses donor substrate flexibility: able to transfer at least 11 different sugars to 8DMTC, such as NDP-D-glucose, as well as NDP-L-digitoxose, including both L- and D-isomeric forms of some sugars.
catalytic activity: 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8- demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) (RHEA:42848)
spnG / Q9ALM8 spinosyn rhamnosyltransferase subunit from Saccharopolyspora spinosa (see paper)
AAG23268.1 TDP-β-L-Rha: spinosyn 9-O-α-L-rhamnosyltransferase (SpnG) (EC 2.4.1.-) (see protein)
Aligns to 239:385 / 390 (37.7%), covers 91.0% of PF06722, 107.9 bits
SACE_0652 putative glucosyltransferase from Saccharopolyspora erythraea NRRL 2338
Aligns to 238:377 / 383 (36.6%), covers 97.2% of PF06722, 107.6 bits
jadS / Q939Q6 2,6-dideoxy-α-L-ribohexopyranosyl-O-glycosyltransferase from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see 2 papers)
Aligns to 242:391 / 396 (37.9%), covers 97.9% of PF06722, 105.1 bits
mtmGII / Q194P6 3A-deolivosylpremithramycin B:dTDP-D-olivose D-olivosyltransferase from Streptomyces argillaceus (see paper)
AAC64927.1 3A-Deolivosylpremithramycin B D-olivosyltransferase (premithramycin B synthase) (MtmGII) (EC 2.4.1.-) (see protein)
Aligns to 232:377 / 379 (38.5%), covers 95.2% of PF06722, 104.9 bits
sibH / C0LTM2 sibiromycin sibirosaminetransferase from Streptosporangium sibiricum (see paper)
Aligns to 241:387 / 392 (37.5%), covers 97.9% of PF06722, 101.4 bits
SSHG_05335 glycosyltransferase from Streptomyces albidoflavus
Aligns to 232:374 / 375 (38.1%), covers 97.9% of PF06722, 99.5 bits
LOC100142486 UDP-glycosyltransferase UGT5 from Tribolium castaneum
2 alignments in 305:861 / 929 (28.6%), covering up to 74.5% of PF06722, 95.0 bits
mtmGIV / Q194Q0 MtmGIV from Streptomyces argillaceus (see 2 papers)
AAD55582.1 premithramycinone D-olivosyltransferase (MtmGIV) (EC 2.4.1.-) (see protein)
Aligns to 254:405 / 407 (37.3%), covers 98.6% of PF06722, 94.5 bits
FQZ25_16345 macrolide family glycosyltransferase from Bacillus thuringiensis
Aligns to 248:391 / 402 (35.8%), covers 85.5% of PF06722, 92.3 bits
- A Genome-Centric Approach Reveals a Novel Glycosyltransferase from the GA A07 Strain of Bacillus thuringiensis Responsible for Catalyzing 15-O-Glycosylation of Ganoderic Acid A
Chang, International journal of molecular sciences 2019 - “...glycosyltransferase (GT) family genes were identified from the complete genome, among which three genes ( FQZ25_16345 , FQZ25_19840 , and FQZ25_19010 ) were closely related to BsUGT398 and BsUGT489. Two of the three candidate genes, FQZ25_16345 and FQZ25_19010 , were successfully cloned and expressed in a...”
- “...4 ). Among the 40 GTs, one GT1 ( FQZ25_19010 ) and two GT28 ( FQZ25_16345 , FQZ25_19840 ) family genes were most closely related to the five validated genes (marked by stars in Figure 4 ), and were considered putative gene candidates. 2.4. Cloning, Overexpression,...”
BC2066 Macrolide glycosyltransferase from Bacillus cereus ATCC 14579
Aligns to 248:391 / 402 (35.8%), covers 85.5% of PF06722, 91.6 bits
- Necrotrophism is a quorum-sensing-regulated lifestyle in Bacillus thuringiensis
Dubois, PLoS pathogens 2012 - “...the necrotrophic development of Bt . A putative efflux system (BC1063), two macrolide glycosyl transferases (BC2066 and BC2622) and a N-hydroxyarylamine O-acetyltransferase could be involved in resistance to antimicrobial molecules, and cytochrome P450 (BC2613) may be involved in resistance to reactive oxygen species. The membrane-associated proteins...”
LOC105195675 uncharacterized protein LOC105195675 from Solenopsis invicta
2 alignments in 321:965 / 1041 (23.9%), covering up to 72.4% of PF06722, 90.1 bits
AAS41089.1 UDP-Glc: β-glucosyltransferase (BcGT-1;BCE2168) (EC 2.4.1.-) (see protein)
Aligns to 248:390 / 400 (35.8%), covers 85.5% of PF06722, 89.0 bits
LOC105220158 uncharacterized protein LOC105220158 from Zeugodacus cucurbitae
2 alignments in 314:1012 / 1086 (25.5%), covering up to 85.5% of PF06722, 87.4 bits
- Identification of testis development-related genes by combining Iso-Seq and RNA-Seq in Zeugodacus tau
Liu, Frontiers in cell and developmental biology 2024 - “...genes (2 belonging to SDR16C (LOC105209516 and LOC105213735) and 2 belonging to UGT (LOC105209919 and LOC105220158)) was higher than the remaining 11 genes throughout testis developments (T1T11). With the development of testis (from T1 to T11), only one UGT gene (LOC128919756) was continuously downregulated. Seven genes...”
- “...expression level of 1 DGAT ( Dgat1_0 ) and 6 UGT (LOC105210436, LOC105218581, LOC105219093, LOC105219094, LOC105220158, and LOC105221422) was significantly increased and plateaued ( Table 2 ). Therefore, these retinol metabolism-associated DEGs with specific expression patterns were highly likely to be involved in testis development. TABLE...”
AAS41737.1 flavonoid β-3(7)-O-glucosyltransferase (BcGT-3;BCE2825) (EC 2.4.1.-) (see protein)
Aligns to 249:391 / 397 (36.0%), covers 86.2% of PF06722, 87.3 bits
4g2tA / D6MSX4 Crystal structure of streptomyces sp. Sf2575 glycosyltransferase ssfs6, complexed with thymidine diphosphate (see paper)
Aligns to 225:356 / 356 (37.1%), covers 95.9% of PF06722, 84.3 bits
- Ligand: thymidine-5'-diphosphate (4g2tA)
FQZ25_19840 macrolide family glycosyltransferase from Bacillus thuringiensis
Aligns to 249:392 / 397 (36.3%), covers 84.8% of PF06722, 84.0 bits
- A Genome-Centric Approach Reveals a Novel Glycosyltransferase from the GA A07 Strain of Bacillus thuringiensis Responsible for Catalyzing 15-O-Glycosylation of Ganoderic Acid A
Chang, International journal of molecular sciences 2019 - “...family genes were identified from the complete genome, among which three genes ( FQZ25_16345 , FQZ25_19840 , and FQZ25_19010 ) were closely related to BsUGT398 and BsUGT489. Two of the three candidate genes, FQZ25_16345 and FQZ25_19010 , were successfully cloned and expressed in a soluble form...”
- “...Among the 40 GTs, one GT1 ( FQZ25_19010 ) and two GT28 ( FQZ25_16345 , FQZ25_19840 ) family genes were most closely related to the five validated genes (marked by stars in Figure 4 ), and were considered putative gene candidates. 2.4. Cloning, Overexpression, and Purification...”
J8Y18_13760 macrolide family glycosyltransferase from Bacillus cereus
Aligns to 249:392 / 397 (36.3%), covers 84.8% of PF06722, 83.3 bits
- Investigating the Role of OrbF in Biofilm Biosynthesis and Regulation of Biofilm-Associated Genes in Bacillus cereus BC1
Sun, Foods (Basel, Switzerland) 2024 - “...IV subunit A ( J8Y18_17815 ), phosphoribosylamine-glycine ligase ThiC (J8Y18_25845 ), glycosyltransferase family I ( J8Y18_13760 ), adenosine succinate hydrolase ( J8Y18_01690 ), and UDP-N-acetylglucosamine lipid carrier transferase ( J8Y18_08880 ) ( Table 2 ). The gene encoding adenosine succinate hydrolase, J8Y18_01690 , plays a role...”
- “...NJS-5-10 J8Y18_17815 (2424) DNA topoisomerase IV subunit A NJS-5-26 J8Y18_25845 (1761) phosphomethylpyrimidine synthase ThiC NJS-5-26 J8Y18_13760 (1194) glycosyl transferase family 1 NJS-5-58 J8Y18_01690 (1308) adenylosuccinate lyase NJS-5-73 J8Y18_08880 (804) UDP-galactose-lipid carrier transferase...”
BTH_II1880 rhamnosyltransferase I, subunit B from Burkholderia thailandensis E264
BTH_II1076 rhamnosyltransferase I, subunit B from Burkholderia thailandensis E264
Aligns to 332:461 / 475 (27.4%), covers 73.1% of PF06722, 81.2 bits
rebG / Q8KHE4 RebG N-glycosyl transferase (EC 4.3.3.5) from Lentzea aerocolonigenes (see 2 papers)
REBG_LENAE / Q8KHE4 4'-demethylrebeccamycin synthase; Arcyriaflavin A N-glycosyltransferase; EC 4.3.3.5 from Lentzea aerocolonigenes (Lechevalieria aerocolonigenes) (Saccharothrix aerocolonigenes) (see 3 papers)
Q8KHE4 4'-demethylrebeccamycin synthase (EC 4.3.3.5) from Lentzea aerocolonigenes (see paper)
CAC93713.1 rebeccamycin N-glucosyltransferase (RebG;RbmA) (EC 2.4.1.-) (see protein)
rebG / BAC15749.1 N-glycosyl transferase RebG from Lentzea aerocolonigenes (see 3 papers)
Aligns to 275:420 / 421 (34.7%), covers 88.3% of PF06722, 79.5 bits
- function: Catalyzes the penultimate step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid that inhibits topoisomerase 1. Has a wide substrate range, including staurosporine aglycone, EJG- III-108A, J-104303, 6-N-methyl-arcyriaflavin and indolo-[2,3-a]- carbazole.
catalytic activity: 4'-demethylrebeccamycin + H2O = beta-D-glucose + dichloroarcyriaflavin A (RHEA:27397)
WP_003225398 glycosyltransferase from Bacillus spizizenii
Aligns to 244:389 / 394 (37.1%), covers 96.6% of PF06722, 78.4 bits
- A Genome-Centric Approach Reveals a Novel Glycosyltransferase from the GA A07 Strain of Bacillus thuringiensis Responsible for Catalyzing 15-O-Glycosylation of Ganoderic Acid A
Chang, International journal of molecular sciences 2019 - “...and two GTs, BsUGT398 and BsUGT489, from B. subtilis ATCC 6633 (GenBank Protein accession nos. WP_003225398 and WP_003220489, respectively) [ 4 ]. To classify which genes were responsible for the biotransformation of GAA, GT genes were first annotated from the GA A07 genome. The 40 identified...”
- Uridine Diphosphate-Dependent Glycosyltransferases from Bacillus subtilis ATCC 6633 Catalyze the 15-O-Glycosylation of Ganoderic Acid A
Chang, International journal of molecular sciences 2018 - “...with three validated UGTs (gray background in Figure 2 ). BsUGT398 (GenBank Protein Accession No. WP_003225398), BsGT110 (GenBank Protein Accession No. WP_003220110), BsGT292 (GenBank Protein Accession No. WP_032727292), and BsGT296 (GenBank Protein Accession No. WP_003219296) were closely related to the UGT cluster. Thus, the five candidates...”
KALB_6579 macrolide family glycosyltransferase from Kutzneria albida DSM 43870
Aligns to 254:399 / 416 (35.1%), covers 97.2% of PF06722, 78.1 bits
staG / Q83WG5 K252c N-glycosyltransferase from Streptomyces sp. TP-A0274 (see paper)
Aligns to 288:432 / 446 (32.5%), covers 93.1% of PF06722, 77.7 bits
BAA83130.1 indolocarbazole N-glucosyltransferase (NGT) (EC 2.4.1.-) (see protein)
Aligns to 275:410 / 414 (32.9%), covers 87.6% of PF06722, 77.5 bits
WP_006678995 nucleotide disphospho-sugar-binding domain-containing protein from Paenibacillus dendritiformis
Aligns to 268:412 / 423 (34.3%), covers 94.5% of PF06722, 77.5 bits
3ia7A / Q8KNC3 Crystal structure of calg4, the calicheamicin glycosyltransferase (see paper)
Aligns to 250:391 / 397 (35.8%), covers 81.4% of PF06722, 76.5 bits
- Ligand: calcium ion (3ia7A)
BAA84592.1 TDP-L-oleandrose: avermectin iterative α-L-oleandrosyltransferase (AveBI) (EC 2.4.1.-) (see protein)
Aligns to 260:394 / 412 (32.8%), covers 85.5% of PF06722, 76.3 bits
AAC12648.1 UDP-Glc: oleandomycin β-glucosyltransferase (OleI) (EC 2.4.1.-) (see protein)
Aligns to 274:417 / 424 (34.0%), covers 89.0% of PF06722, 75.6 bits
2iyaA / Q3HTL7 The crystal structure of macrolide glycosyltransferases: a blueprint for antibiotic engineering (see paper)
Aligns to 243:386 / 392 (36.7%), covers 89.0% of PF06722, 75.4 bits
- Ligands: uridine-5'-diphosphate; (3s,5r,6s,7r,8r,11r,12s,13r,14s,15s)-6-hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranoside (2iyaA)
SACE_4644 putative glycosyltransferase from Saccharopolyspora erythraea NRRL 2338
Aligns to 247:391 / 392 (37.0%), covers 97.2% of PF06722, 75.3 bits
FQZ25_19010 macrolide family glycosyltransferase from Bacillus thuringiensis
Aligns to 244:389 / 395 (37.0%), covers 95.2% of PF06722, 75.2 bits
oleI / Q3HTL7 oleandomycin glycosyltransferase from Streptomyces antibioticus (see 3 papers)
ABA42118.2 oleandomycin glycosyltransferase (OleI) (EC 2.4.1.-) (see protein)
Aligns to 274:417 / 424 (34.0%), covers 89.0% of PF06722, 75.2 bits
BC2622 Macrolide glycosyltransferase from Bacillus cereus ATCC 14579
Aligns to 182:327 / 333 (43.8%), covers 95.2% of PF06722, 73.9 bits
- Necrotrophism is a quorum-sensing-regulated lifestyle in Bacillus thuringiensis
Dubois, PLoS pathogens 2012 - “...value (p) smaller than 0.01, were considered for subsequent analysis. The genes matching probes for BC2622, a macrolide glycosyltransferase, and BC3725, an exochitinase, were also investigated due to their functional similarity to the genes fulfilling these criteria. Quantitative RT-PCR confirmed that these 41 genes were at...”
- “...development of Bt . A putative efflux system (BC1063), two macrolide glycosyl transferases (BC2066 and BC2622) and a N-hydroxyarylamine O-acetyltransferase could be involved in resistance to antimicrobial molecules, and cytochrome P450 (BC2613) may be involved in resistance to reactive oxygen species. The membrane-associated proteins are mainly...”
- The bcr1 DNA repeat element is specific to the Bacillus cereus group and exhibits mobile element characteristics
Økstad, Journal of bacteriology 2004 - “...Deoxyribonuclease, TatD family, putative BC2949 BC2622 BC0673 BC0556 Hypothetical membrane-spanning protein Macrolide glycosyltransferase (EC 2.4.1.-)...”
BSU05720 putative glycosyltransferase from Bacillus subtilis subsp. subtilis str. 168
Aligns to 244:389 / 395 (37.0%), covers 97.9% of PF06722, 73.8 bits
PSPA7_1648 rhamnosyltransferase chain B from Pseudomonas aeruginosa PA7
Aligns to 274:412 / 426 (32.6%), covers 72.4% of PF06722, 72.9 bits
rhlB / Q51560 RhlB rhamnosyltransferase from Pseudomonas aeruginosa (see 4 papers)
Q51560 Rhamnosyl transferase from Pseudomonas aeruginosa
Aligns to 274:413 / 426 (32.9%), covers 72.4% of PF06722, 72.2 bits
- Genomic characterization of a polyvalent hydrocarbonoclastic bacterium Pseudomonas sp. strain BUN14
Mahjoubi, Scientific reports 2021 - “...this group of compounds. Blastp searches against 3-(3-hydroxydecanoyloxy) decanoate synthase RhlA (Q51559), rhamnosyl transferase RhlB (Q51560) and Rhamnosyltransferase 2 RhlC (Q9I4K5) of P. aeruginosa did not yield orthologous of these proteins. The BUN14 proteome was subsequently annotated for glycosyltransferase (GT1 and GT2) signatures using dbCAN2 46...”
- “...to be a member of the glycosyltransferase family GT1. This protein shared 22.1% similarity with Q51560 (325 aa) of P. aeruginosa and the domain architecture of both proteins was similar. Seven BUN14 proteins were predicted to be members of the glycosyltransferase family GT2. Of these, two...”
AAG06866.1 rhamnosyltransferase (RhlB;PA3478) (EC 2.4.1.-) (see protein)
PA3478 rhamnosyltransferase chain B from Pseudomonas aeruginosa PAO1
NP_252168 rhamnosyltransferase subunit B from Pseudomonas aeruginosa PAO1
PA14_19110 rhamnosyltransferase chain B from Pseudomonas aeruginosa UCBPP-PA14
BWR11_07885 glycosyltransferase from Pseudomonas aeruginosa
Aligns to 274:413 / 426 (32.9%), covers 72.4% of PF06722, 72.2 bits
- Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump
Kristensen, Antimicrobial agents and chemotherapy 2024 - “...factors ( Table 1 ), such as genes encoding rhamnolipid production, rhlA (PA3479) and rhlB (PA3478), lasA (1871), and lasB (PA3724), which are involved in the production of elastase; the two phenazine operons phzA1-G1 (PA4210-PA4216) and phzA2-G2 (PA1899-PA1905), encoding phenazine biosynthesis proteins; phzM (PA4209), encoding a...”
- “...PA2570 lecA Lectin A Adhesion, cytotoxic 156 4.19E-86 PA3361 lecB Lectin B Adhesion 22 4.41E-75 PA3478 rhlB Rhamnolipid Immune evasion, motility 15 4.00E-77 PA3479 rhlA Rhamnolipid Immune evasion, motility 17 1.34E-58 PA3692 lptF Lipotoxin F Resistance to oxidative stress and adhesion -8 2.20E-21 PA3724 lasB Elastase...”
- Secondary metabolite profiling of Pseudomonas aeruginosa isolates reveals rare genomic traits
Neve, mSystems 2024 - “...described above, the biosynthetic pathway for di-RLs consists of a bicistronic operon of rhlAB ( PA3478 / PA3479 ) and the accessory gene rhlC ( PA1130 ) located separately on the genome ( 64 ). Analogously, the biosynthesis of the phenazine PCN is dependent upon the...”
- Geraniol attenuates virulence factors by inhibiting quorum sensing of Pseudomonas aeruginosa
Li, Frontiers in microbiology 2023 - “...0.785649354 Quorum sensing PA2587 pqsH 0.054480343 0.906288652 Quorum sensing PA3479 rhlA 2.161753902 7.61774E-05 Quorum sensing PA3478 rhlB 1.879839834 4.79516E-05 Quorum sensing PA1130 rhlC 1.42583676 9.6008E-06 Quorum sensing PA1871 lasA 3.16297037 1.3179E-11 Quorum sensing PA3724 lasB 1.94856245 8.18372E-06 Quorum sensing PA2570 lecA 5.189666242 1.70617E-15 Quorum sensing PA3361...”
- A VirB4 ATPase of the mobile accessory genome orchestrates core genome-encoded features of physiology, metabolism, and virulence of Pseudomonas aeruginosa TBCF10839
Wiehlmann, Frontiers in cellular and infection microbiology 2023 - “...Acp3 77.9 PA3476 rhlL, autoinducer synthesis protein RhlL 10.7 PA3477 rhlR, transcriptional regulator RhlR 12.3 PA3478 rhlB, rhamnosyltransferase chain B 11.7 PA3479 rhlA, rhamnosyltransferase chain A 29.7 PA3519 Hypothetical protein 8.2 PA3535 Probable serine protease 9.1 PA3550 algF, alginate O -acetyltransferase AlgF 14.4 PA3690 Probable metal-transporting...”
- Inactivation of Pseudomonas aeruginosa biofilms by thymoquinone in combination with nisin
Chen, Frontiers in microbiology 2022 - “...thioesterase PqsE PA2587 1.40 pqsH quinolone synthase Virulence factors PA3479 5.73 rhlA rhamnosyltransferase subunit A PA3478 5.32 rhlB rhamnosyltransferase subunit B PA1130 3.04 rhlC rhamnosyltransferase PA1871 4.81 lasA protease LasA PA3724 5.38 lasB elastase LasB PA2570 5.88 lecA PA-I galactophilic lectin PA1077 3.14 flgB flagellar biosynthesis...”
- CRISPRi-Mediated Gene Suppression Reveals Putative Reverse Transcriptase Gene PA0715 to Be a Global Regulator of Pseudomonas aeruginosa
Zhou, Infection and drug resistance 2022 - “...biosynthesis outer 1.7047 Up Membrane protein PelC PA3063 pelB Pellicle/biofilm biosynthesis protein PelB 1.4383 Up PA3478 rhlB Rhamnosyltransferase subunit B 2.0555 Up PA3479 rhlA Rhamnosyltransferase subunit A 2.3069 Up PA3542 alg44 Alginate biosynthesis protein Alg44 1.4137 Up PA4969 cpdA cAMP phosphodiesterase 1.0595 Down Antibiotic resistance and...”
- Pf4 Phage Variant Infection Reduces Virulence-Associated Traits in Pseudomonas aeruginosa
Tortuel, Microbiology spectrum 2022 - “...precursor 62.50 PA3724 lasB* Elastase LasB AlgQ 40.00 14.49 Rhamnolipids PA1130 rhlC* Rhamnosyltransferase 2 10.87 PA3478 rhlB* Rhamnosyltransferase chain B AlgR, RhlR 22.22 PA3479 rhlA* Rhamnosyltransferase chain A AlgR, RhlR 15.87 6.25 Lectins PA2570 lecA* LecA RhlR 4.37 2.24 PA3361 lecB* Fucose-binding lectin PA-IIL AlgU, RhlR...”
- Anaerobic biosynthesis of rhamnolipids by Pseudomonas aeruginosa: performance, mechanism and its application potential for enhanced oil recovery
Zhao, Microbial cell factories 2021 - “...5.88 1.56E87 autoinducer synthesis protein RhlI PA3477 rhlR 13664.1 732.3 4.22 1.93E56 transcriptional regulator RhlR PA3478 rhlB 26462.6 243.7 6.76 1.28E91 rhamnosyltransferase chain B PA3479 rhlA 42259.3 370.3 6.83 1.27E69 rhamnosyltransferase chain A PA1130 rhlC 1418.9 16.1 6.46 2.61E86 rhamnosyltransferase 2 PA1432 lasI 1260. 4 196.1...”
- More
- The Pseudomonas aeruginosa rhlG and rhlAB genes are inversely regulated and RhlG is not required for rhamnolipid synthesis.
Bazire, BMC microbiology 2014 - GeneRIF: rhlG was inversely regulated compared to rhlAB and rhlC.
- Evolution of biofilm-adapted gene expression profiles in lasR-deficient clinical Pseudomonas aeruginosa isolates
Jeske, NPJ biofilms and microbiomes 2022 - “...napB PA14_16250 lasB PA14_36820 PA14_49310 PA14_18630 eprS PA14_37745 PA14_51350 phnB PA14_19100 rhlA PA14_37760 PA14_51380 pqsE PA14_19110 rhlB PA14_37770 PA14_51390 pqsD PA14_19120 rhlR PA14_37780 PA14_51410 pqsC PA14_19130 rhlI PA14_38260 PA14_51420 pqsB PA14_19870 ldh PA14_39880 phzG2 PA14_51430 pqsA PA14_19900 PA14_39890 phzF2 PA14_53250 cpbD PA14_19910 pdhB PA14_39910 phzE2 PA14_55080...”
- Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist
Ueda, Microbial biotechnology 2009 - “...genes upon deleting pyrF Quorum sensing PA14_19120 PA3477 rhlR 4.9 1.1 4.9 Transcriptional regulator RhlR PA14_19110 PA3478 rhlB 21.1 1.2 17.1 Rhamnosyltransferase chain B PA14_19100 PA3479 rhlA 19.7 1.4 16 Rhamnosyltransferase chain A PA14_45950 PA1431 rsaL 2.1 1.4 2.6 Regulatory protein RsaL PA14_40290 PA1871 lasA 39.4...”
- Pseudomonas aeruginosa L10: A Hydrocarbon-Degrading, Biosurfactant-Producing, and Plant-Growth-Promoting Endophytic Bacterium Isolated From a Reed (Phragmites australis)
Wu, Frontiers in microbiology 2018 - “...responsible for the biosurfactant synthesis. In the rhamnolipid pathway, the rhlAB genes ( BWR11_07880 and BWR11_07885 ; functioning as one operon) encode rhamnosyltransferase 1, while rhlR ( BWR11_07890 ) and rhlI ( BWR11_07895 ) are arranged in sequence and act as regulators of rhlAB expression (...”
BCAM2338 putative glycosyltransferase from Burkholderia cenocepacia J2315
WQ49_RS07360 nucleotide disphospho-sugar-binding domain-containing protein from Burkholderia cenocepacia
Aligns to 269:407 / 427 (32.6%), covers 70.3% of PF06722, 70.3 bits
- Identification of putative essential protein domains from high-density transposon insertion sequencing
Rahman, Scientific reports 2022 - “...dehydratase MaoC-like dehydratase 46 0 New WQ49_RS04450 BCAM1749 Hypothetical protein Unknown 17 0 New WQ49_RS07360 BCAM2338 Glycosyl transferase family 1 UDP-glycosyltransferase 0 152 Domain (Glyco_transf_28) WQ49_RS07395 QU43_RS66100 Hypothetical protein Unknown 0 58 New WQ49_RS09185 BCAS0417 Cytochrome biogenesis protein CcdA Electron transfer 0 38 New WQ49_RS10495 BCAS0158...”
- Comparative metabolic systems analysis of pathogenic Burkholderia
Bartell, Journal of bacteriology 2014 - “...rhlABC genes in B. ceno- 218 jb.asm.org cepacia are BCAM2340, BCAM2338, and BCAM2336, which have BLASTP E values of 7 1063, 5 1086, and 4 1063 to the...”
- Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction
Fang, BMC systems biology 2011 - “...61 ]. By protein similarity search against the UniProt database, proteins coded by genes BCAM2340, BCAM2338, and BCAM2336 in B. cenocepacia J2315 were identified as highly similar in sequence to rhlA, rhlB, and rhlC in both B. thailandensis (with BLAST E value of 1E-121, 1E-173, and...”
- “...identified from annotation as 93% similarity from Staphylococcus aureus and E value of 1E-33 BCAM2340, BCAM2338, BCAM2336 Putative (R)-3-hydroxydecanoyl-ACP: CoA transacylase, putative glycosyltransferase, putative sugar transferase Rhamnosyltransferase chain A, Rhamnosyltransferase chain B, Rhamnosyltransferase 2 RhlA, RhlB, RhlC - Strong physiological evidence from Dubeau et. al. (2009):...”
- Burkholderia cenocepacia differential gene expression during host-pathogen interactions and adaptation to the host environment
O'Grady, Frontiers in cellular and infection microbiology 2011 - “...Putative acyl-CoA dehydrogenase 2.10 BCAM2237 Putative 2,2-dialkylglycine decarboxylase 2.41 BCAM2260 Major facilitator superfamily protein 1.61 BCAM2338 Putative glycosyltransferase 1.53 BCAM2356 Conserved hypothetical protein 1.63 d BCAM2453 Putative redoxin protein 1.69 BCAM2479 Putative transporter LysE family 1.54 BCAM2488 Putative phosphoglycerate/bisphosphoglycerate 1.56 BCAM2504 Conserved hypothetical protein 1.84 c...”
- Identification of putative essential protein domains from high-density transposon insertion sequencing
Rahman, Scientific reports 2022 - “...family dehydratase MaoC-like dehydratase 46 0 New WQ49_RS04450 BCAM1749 Hypothetical protein Unknown 17 0 New WQ49_RS07360 BCAM2338 Glycosyl transferase family 1 UDP-glycosyltransferase 0 152 Domain (Glyco_transf_28) WQ49_RS07395 QU43_RS66100 Hypothetical protein Unknown 0 58 New WQ49_RS09185 BCAS0417 Cytochrome biogenesis protein CcdA Electron transfer 0 38 New WQ49_RS10495...”
6j31B / A0A514S208 Crystal structure analysis of the glycotransferase of kitacinnamycin (see paper)
Aligns to 242:380 / 387 (35.9%), covers 75.2% of PF06722, 69.5 bits
6kqxA / O34539 Crystal structure of yijc from b. Subtilis in complex with udp (see paper)
Aligns to 188:326 / 327 (42.5%), covers 75.2% of PF06722, 69.2 bits
- Ligand: uridine-5'-diphosphate (6kqxA)
3rscA / Q8KNE0 Crystal structure of calg2, calicheamicin glycosyltransferase, tdp and calicheamicin t0 bound form (see paper)
Aligns to 252:384 / 397 (33.5%), covers 77.9% of PF06722, 69.0 bits
- Ligands: thymidine-5'-diphosphate; calicheamicin t0 (3rscA)
NDPGT_BACSU / O34539 NDP-glycosyltransferase YjiC; UDP-glycosyltransferase YjiC; EC 2.4.1.384 from Bacillus subtilis (strain 168) (see 3 papers)
O34539 NDP-glycosyltransferase (EC 2.4.1.384) from Bacillus subtilis (see 2 papers)
NP_389104 putative glycosyltransferase from Bacillus subtilis subsp. subtilis str. 168
Aligns to 246:384 / 392 (35.5%), covers 75.2% of PF06722, 68.8 bits
- function: Glycosyltransferase that can glycosylate a wide range of substrates, including various flavonoids, phenyl ketones, curcuminoid, lignins, zingerone, triterpenes, stilbene and anthraquinone, using UDP- glucose or ADP-glucose as sugar donor (PubMed:28315700, PubMed:33152360). It also exhibits O-, N- and S-glycosylation activities towards simple aromatics (PubMed:28315700). In vivo, the broad acceptor tolerance of YjiC might function as a detoxification agent against exogenous xenobiotics to make the strain adaptable to the changeable environment (Probable).
catalytic activity: an NDP-glycose + an acceptor = a glycosylated acceptor + NDP.
subunit: Monomer. - Recent Advances in the Metabolic Engineering of Yeasts for Ginsenoside Biosynthesis
Chu, Frontiers in bioengineering and biotechnology 2020 - “...(AKQ76388), UGTPg1 (AIE12479), UGTPg101 (AKQ76389), UGTPg29 (AKA44579), UGTPg74AE2 (AGR44631), UGTPg45 (AKA44586), and B. subtilis YjiC (NP_389104), UGT109A1 (ASY97769). Subsequently, the condensation of IPP and DMAPP was catalyzed by farnesyl diphosphate synthase (FPS/ERG20) to form farnesyl diphosphate (FPP). Next, FPP was converted into 2,3-oxidosqualene through two enzymatic...”
- A Genome-Centric Approach Reveals a Novel Glycosyltransferase from the GA A07 Strain of Bacillus thuringiensis Responsible for Catalyzing 15-O-Glycosylation of Ganoderic Acid A
Chang, International journal of molecular sciences 2019 - “...microbial GTs were validated to have triterpenoid glycosylation activity, including BsYjiC (GenBank Protein accession no. NP_389104) from B. subtilis 168 [ 19 , 20 , 21 , 22 , 23 ], UGT109A1 (GenBank Protein accession no. ASY97769) from B. subtilis CTCG 63501 [ 24 , 28...”
- Uridine Diphosphate-Dependent Glycosyltransferases from Bacillus subtilis ATCC 6633 Catalyze the 15-O-Glycosylation of Ganoderic Acid A
Chang, International journal of molecular sciences 2018 - “...three microbial UGTs were validated with triterpenoid glycosylation activity, including BsYjiC (GenBank Protein Accession No. NP_389104) from B. subtilis 168 [ 19 , 20 ], UGT109A1 (GenBank Protein Accession No. ASY97769) from B. subtilis CTCG 63501 [ 21 ], and BsGT1 (GenBank Protein Accession No. ANP92054)...”
HZ99_RS01145 glycosyltransferase from Pseudomonas fluorescens
Aligns to 270:409 / 423 (33.1%), covers 82.8% of PF06722, 68.5 bits
7xx4A / Q3HTL6 Designed glycosyltransferase (see paper)
Aligns to 258:391 / 395 (33.9%), covers 75.2% of PF06722, 67.8 bits
- Ligand: uridine-5'-diphosphate-glucose (7xx4A)
tylCV / Q9XC67 demethyllactenocin mycarosyltransferase (EC 2.4.1.318) from Streptomyces fradiae (see paper)
TYLCV_STRFR / Q9XC67 Demethyllactenocin mycarosyltransferase; EC 2.4.1.318 from Streptomyces fradiae (Streptomyces roseoflavus) (see paper)
Q9XC67 demethyllactenocin mycarosyltransferase (EC 2.4.1.318) from Streptomyces fradiae (see paper)
AAD41824.1 mycarosyltransferase (TylCV) (EC 2.4.1.-) (see protein)
Aligns to 331:456 / 461 (27.3%), covers 80.0% of PF06722, 67.0 bits
- function: Involved in the biosynthesis of mycarose which is a 6- deoxyhexose sugar required during production of the macrolide antibiotic tylosin. Catalyzes the transfer of L-mycarosyl from dTDP- beta-L-mycarose to demethyllactenocin to yield demethylmacrocin.
catalytic activity: demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+) (RHEA:14649)
disruption phenotype: Cells lacking this gene accumulate desmycosin (tylosin B).
ML0128 putative glycosyl transferase from Mycobacterium leprae TN
Aligns to 274:417 / 435 (33.1%), covers 86.9% of PF06722, 66.9 bits
- Mycobacterium leprae's Infective Capacity Is Associated with Activation of Genes Involved in PGL-I Biosynthesis in a Schwann Cells Infection Model
Chavarro-Portillo, International journal of molecular sciences 2023 - “...( Figure 5 a,b,df). The analysis of the transcriptional behavior of the ML0126, ML0127, and ML0128 genes, located in a different locus in the M. leprae genome ( Figure 5 g), which are involved in the process of methylation and translocation of the rhamnosyl residues of...”
- “...days analyzed, reaching their maximum peak at 3 days post-infection, which decreased over time. The ML0128 gene began with a negative transcription at 2 h post-infection, rising at 3 days and decreasing negatively at 7 days post-infection ( Figure 5 j). Since the function of glycosyltransferases...”
- PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand
Ishizuka, ACS central science 2023 - “...genes, 20 i.e., rhamnosyl 3- O -methyltransferase (ML0126), rhamnosyl 2- O -methyltransferase (ML0127), rhamnosyl transferase (ML0128), two glucosyl methyltransferases (ML2346 and ML2347), and glucosyltransferase (ML2348), M. marinum produced a large amount of PGL-I, as previously reported. 21 When developing the lipid extract of this PGL-I-producing M....”
- “...each enzyme and the Hsp60 promoter, respectively. ML0126, Rha-3- O -methyltransferase; ML0127, Rha-2- O -methyltransferase; ML0128, rhamnosyl transferase; ML2346 and ML2347, Glc-3- and Glc-6- O -methyltransferases; and ML2348, glycosyl transferase. (b) Acetone-soluble lipids were extracted from crude lipids derived from mock and recombinant M. marinum and...”
- Mycobacterium lepromatosis as a Second Agent of Hansen's Disease
Deps, Frontiers in microbiology 2021 - “...al., 2015 ). M. leprae genes encoding laminin-2 binding protein ML1683c and the six enzymes (ML0128, ML2348 ML0126, ML0127, ML23246c, and ML2347) required to produce the terminal trisaccharide moiety of phenolic glycolipid 1 (PGL-1) are highly conserved in M. lepromatosis ( Singh et al., 2015 ),...”
- A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy
Madigan, Cell 2017 - “...by transforming M.marinum with the integrating plasmid pWM122, which encodes the M.leprae genes ML0126, ML0127, ML0128, ML2346c, ML2347, and ML2348 under the M.fortuitum pBlaF promoter ( Tabouret etal., 2010 ). Kanamycin-resistant transformants were confirmed by PCR using primers targeting all six M.leprae genes ( Tabouret etal.,...”
- Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis
Singh, Proceedings of the National Academy of Sciences of the United States of America 2015 - “...are required, namely a rhamnosyl transferase (ML0128), a glucosyltransferase (ML2348), and four methyltransferases (ML0126, ML0127, ML23246c, and ML2347)...”
- Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes
Tabouret, PLoS pathogens 2010 - “...transfer of the two terminal residues and for the methylation of the first rhamnosyl residue: ML0128 and ML2348 encoding proteins with similarities to glycosyltransferases, and ML0126 , ML0127 , ML2346c and ML2347 encoding proteins with similarities to methyltransferases ( Figures 1B and 1C ) [18] ,...”
- “...or 6 M. leprae genes. Next, a DNA fragment encompassing the ML0126 , ML0127 and ML0128 genes was inserted into the mycobacterial vector pMIP12H [24] to yield plasmid pBNF03 ( Figure S1 ). In parallel, a second DNA fragment carrying ML2346c , ML2347 and ML2348 genes...”
- The genome of Mycobacterium leprae: a minimal mycobacterial gene set
Vissa, Genome biology 2001 - “...Clustered with methyltransferases ( ML0127 / Rv2959c ); candidate genes for glycosyltransferases in PGL-I synthesis ML0128 Rv2958c Y 99/99 C-terminal ? See comments for ML0125 Putative mannosyltransferase for glycoproteins (O-linked) ML0192 Rv1002c Y 99/99 Y 85/91 Y 42/59 Some homology to protein mannosyltransferases in yeast Unassigned...”
Rv2958c / P9WFR1 mycoside B rhamnosyltransferase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
GLTR2_MYCTU / P9WFR1 PGL/p-HBAD biosynthesis glycosyltransferase Rv2958c; EC 2.4.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
AAK47360.1 MT3034 (EC 2.4.1.-) (see protein)
CAB05418.1 mono-rhamnosylated phenophthiocerol dimycocerosate glycosyltransferase (Rv2958c) (EC 2.4.1.-) (see protein)
Rv2958c POSSIBLE GLYCOSYL TRANSFERASE from Mycobacterium tuberculosis H37Rv
MT3034 UDP-glucoronosyl and UDP-glucosyltransferase family protein from Mycobacterium tuberculosis CDC1551
Aligns to 283:426 / 428 (33.6%), covers 87.6% of PF06722, 66.8 bits
- function: Involved in glycosylation steps downstream of mono-O-methyl- glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl- rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p- hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
- Contraction and expansion dynamics: deciphering genomic underpinnings of growth rate and pathogenicity in Mycobacterium
Zhu, Frontiers in microbiology 2023 - “...produced through the collaboration of ddrB, drrC, fadD22, lppx, mmpL7, ppsA, ppsE, Rv2949c, Rv2951c, Rv2954c, Rv2958c, Rv2959c and tesA , serves as a vital constituent of the mycobacterial cell wall, aiding in the evasion of host immune detection and counterattack ( Rens et al., 2021 )....”
- Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex
Hailu, Microbial genomics 2023 - “...pks1 ) A1437V Rv2946c ( pks1 ) P1151S Rv2947c ( pks15 ) S228P Rv2952 R184H Rv2958c F409L Rv2962c E132A VirS/MymA Rv3080c (pknK) L237R Rv3083 (mymA) G13S Rv3084 (lipR) S198X Rv3089 (fadD13) A43S Rv3089 (fadD13) K172T Mycolic acid modification Rv0643c (mmaA3) E263X Fig. 2. (a) Gene cluster...”
- Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis
Shee, eLife 2023 - “...Rv0158 binds to several genes involved in methyl-branched lipid biosynthesis ( pks2 , fadD23 , rv2958c , rv2959c , rv2961 ), lipid transporter ( rv0987-rv0988 , mmpL1-mmpS1 , mmpL4-mmpS4 ), biotin synthesis ( bioF2 ), and surface-associated proteins ( esp operon, lpqG , esxQ, rv1501 -r...”
- “...Rv0158 binds to several genes involved in methyl-branched lipid biosynthesis ( pks2 , fadD23 , rv2958c , rv2959c , rv2961 ), lipid transporter ( rv0987-rv0988 , mmpL1-mmpS1 , mmpL4 - mmpS4 ), biotin synthesis ( bioF2 ), and surface-associated proteins ( esp operon, lpqG , esxQ,...”
- Advancements in Vaccine Adjuvants: The Journey from Alum to Nano Formulations
Moni, Vaccines 2023 - “...IL-17A cytokines [ 145 ]. An earlier report suggests that protein antigens Rv0447c, Rv2957, and Rv2958c derived from Mycobacterium tuberculosis can efficiently boost the BCG vaccine either in the presence or absence of glucopyranosyl lipid adjuvant [ 146 ]. Lactic acid bacteria (LAB) express proteins associated...”
- Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis
Singh, 2023 - Sub-Lineage Specific Phenolic Glycolipid Patterns in the Mycobacterium tuberculosis Complex Lineage 1
Gisch, Frontiers in microbiology 2022 - “...members have specific mutation signatures in PGL biosynthesis genes, e.g., pks15/1 or glycosyltransferases Rv2962c and/or Rv2958c. Sub-lineage specific PGL production was studied by NMR-based lipid profiling and strains with a completely abolished phenolphthiocerol dimycoserosate biosynthesis showed in average a more prominent growth in human macrophages. In...”
- “...1.2.1.1 2 No 1 bp insertion in Rv2946c 8316/09 1.2.2.1 3b Mycoside B, PGL-OH, PGL-OMe Rv2958c Tyr182Asp, Rv2962c Leu46Gly 5239/09 1.2.2.1 3b Mycoside B, PGL-OH, PGL-OMe Rv2958c Tyr182Asp, Rv2962c Leu46Gly 6006/03 1.2.2.1 3a PGL-OH, PGL-OMe Rv2962c Leu46Arg 682/08 1.2.2.1 3a PGL-OH, PGL-OMe Rv2962c Leu46Arg 5093/09 1.2.2.2...”
- The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group
Melkie, European respiratory review : an official journal of the European Respiratory Society 2022 - “...target (>98%) [ 24 ] Sp: 96100% Met the optimal value (>98%) IgG against Rv0220, Rv2958c, Rv2994 and Rv3347c Sen: 80.491.3% Slightly comparable to the optimal value (98%) [ 25 ] Sp: 91.798.3% Moderately comparable Anti-TB-LTBI IgG, anti-Tpx IgG and anti-MPT64 IgA. TB-LTBI: (antigen cocktail composed...”
- “...LipC with unknown function. A lipolytic enzyme probably active in cellular metabolism. [ 77 ] Rv2958c Rv2958c Possible glycosyl transferase with unknown function. Probably involved in cellular metabolism and has a role in resistance to killing by human macrophages. [ 77 ] Rv2994 Rv2994 Probable conserved...”
- Label-Free Comparative Proteomics of Differentially Expressed Mycobacterium tuberculosis Protein in Rifampicin-Related Drug-Resistant Strains
Ullah, Pathogens (Basel, Switzerland) 2021 - “...Rv2957 Function unknown; probably involved in cellular metabolism Possible glycosyl transferase Intermediary metabolism and respiration Rv2958c Rv2958c Unknown; probably involved in cellular metabolism.Possibly involved in resistance to killing by human macrophages Possible glycosyl transferase Intermediary metabolism and respiration Rv3228 Rv3228 Unknown Conserved hypothetical protein Conserved hypotheticals...”
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- Detecting the molecular scars of evolution in the Mycobacterium tuberculosis complex by analyzing interrupted coding sequences
Deshayes, BMC evolutionary biology 2008 - “...of this gene has no frameshift in the two strains of M. tuberculosis (Rv2958c and MT3034). Functional complementation of M. bovis BCG with the Rv2958c gene from M. tuberculosis leads to the accumulation of a new metabolite, the diglycosylated phenolglycolipid [ 42 ]. Some frameshift-containing genes...”
- Microsatellite polymorphism across the M. tuberculosis and M. bovis genomes: implications on genome evolution and plasticity
Sreenu, BMC genomics 2006 - “...(236) TG2 1 SseB Rv2291 (284) MT2348 (268) Mb2314 (256) G2 3 UDP-glucosyltransferases *Rv2958c (428) MT3034 (428) Mb2982c (366) G3 2 Cyclase *Rv3377c (501) MT3487 (501) Mb3411c (483) G2 3 Conserve hypothetical *Rv3836 (137) MT3944 (133) Mb3886 (116) V) Inframe mutation (11) CGGCCC1 2 Lipoprotein, s,...”
ML0125 putative glycosyl transferase from Mycobacterium leprae TN
Aligns to 275:418 / 438 (32.9%), covers 86.9% of PF06722, 66.8 bits
- The genome of Mycobacterium leprae: a minimal mycobacterial gene set
Vissa, Genome biology 2001 - “...100/100 Y 61/74 ? plant and microbial glucosyl or 6-deoxyglycosyl transferases; candidate rhamnosyltransferase for PGL-I ML0125 Rv2962c Y 99/99 ? 27/41 ? Clustered with methyltransferases ( ML0127 / Rv2959c ); candidate genes for glycosyltransferases in PGL-I synthesis ML0128 Rv2958c Y 99/99 C-terminal ? See comments for...”
Rv2962c / P9WN09 dimycocerosyl phenolphthiocerol rhamnosyltransferase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
RNTF_MYCTU / P9WN09 PGL/p-HBAD biosynthesis rhamnosyltransferase; EC 2.4.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CAB05415.1 p-hydroxybenzoic acid ethyl ester rhamnosyltransferase (Rv2962c) (EC 2.4.1.-) (see protein)
MT3038 UDP-glucoronosyl andUDP-glucosyltransferase family proteins from Mycobacterium tuberculosis CDC1551
Rv2962c POSSIBLE GLYCOSYL TRANSFERASE from Mycobacterium tuberculosis H37Rv
Aligns to 294:437 / 449 (32.1%), covers 87.6% of PF06722, 66.6 bits
- function: Catalyzes the transfer of the first rhamnosyl residue on p- hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O- methylation at position 2 of the sugar unit, mono-O-methyl-glycosyl-p- hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl- phenolphthiocerol dimycocerosate (also called mycoside B) during p- hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
- Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
Evangelopoulos, Nature communications 2019 - “...was observed with DCS R strains having a mutation at the putative rhamnosyltransferase (Uniprot ID P9WN09), Rv2962c, including the alr repression mutant that was also found to be attenuated in mice (Fig. 2c ). These results indicate that most of the DCS R strains incur significant...”
- Transcriptional Response of Mycobacterium tuberculosis to Cigarette Smoke Condensate
Willemse, Frontiers in microbiology 2021 - “...3.89 4.24E-02 MT2981 Rv2913c Probable D-amino acid hydrolase Av-Gay and Everett, 2000 1.20 3.64E-09 MT3037 MT3038 Hypothetical protein 1.60 7.51E-11 MT3038 Rv2962c Probable glycosyltransferase Perez et al., 2004 1.82 5.28E-03 MT3039 Rv2963 Probable integral membrane protein/permeases of unknown function, copper induced protein Ward et al., 2010...”
- A novel copper-responsive regulon in Mycobacterium tuberculosis
Festa, Molecular microbiology 2011 - “...Rv0849 Probable conserved integral membrane transport protein 27.26 2.35 MT0873 Rv0850 IS1606, transposase 10.58 2.28 MT3038 Rv2962c Rv2962c UDP-glucoronosyl andUDP-glucosyltransferase family proteins 13.34 1.95 MT3039 Rv2963 hypothetical protein 41.00 3.77 MT3041 Rv2964 purU formyltetrahydrofolate deformylase 15.23 5.95 MT3041.1 NA hypothetical protein 5.31 2.63 MT3159 Rv3074 hypothetical...”
- Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex
Hailu, Microbial genomics 2023 - “...), Rv2940c ( mas ), Rv2946c ( pks1 ), Rv2947c ( pks15 ), Rv2952 , Rv2962c and Rv0643c ( mmaA3 ). Table 2. Selected genes of M. tuberculosis L7 with conserved non-synonymous SNPs clustered in three cell wall loci Protein mutations that were predicted by sift...”
- “...A1437V Rv2946c ( pks1 ) P1151S Rv2947c ( pks15 ) S228P Rv2952 R184H Rv2958c F409L Rv2962c E132A VirS/MymA Rv3080c (pknK) L237R Rv3083 (mymA) G13S Rv3084 (lipR) S198X Rv3089 (fadD13) A43S Rv3089 (fadD13) K172T Mycolic acid modification Rv0643c (mmaA3) E263X Fig. 2. (a) Gene cluster Rv0635Rv0647c of...”
- Sub-Lineage Specific Phenolic Glycolipid Patterns in the Mycobacterium tuberculosis Complex Lineage 1
Gisch, Frontiers in microbiology 2022 - “...sub-lineages, whose members have specific mutation signatures in PGL biosynthesis genes, e.g., pks15/1 or glycosyltransferases Rv2962c and/or Rv2958c. Sub-lineage specific PGL production was studied by NMR-based lipid profiling and strains with a completely abolished phenolphthiocerol dimycoserosate biosynthesis showed in average a more prominent growth in human...”
- “...( Stadthagen et al., 2006 ; Bourke et al., 2014 ). Interestingly, a mutation in Rv2962c (Q294Stop), which deletion leads to an abolishment of PGL biosynthesis at the stage of phenolic PDIM ( Prez et al., 2004 ), was described in strains of the L1 lineage...”
- Detection of Mycobacterium tuberculosis multiple strains in sputum samples from patients with pulmonary tuberculosis in south western Uganda using MIRU-VNTR
Micheni, Scientific reports 2022 - “...as previously described 44 using lineage 3 and 4 specific primers (Rv004C for MTB L4-U, Rv2962C for MTB L4-NU and Rv0129C for MTB L3) and their accompanying hybridization probes. Briefly, the assays were performed in 20l reaction mixture containing 3.75l of PCR water, 1.25l (0.5M final...”
- “...95C for 30s, primer annealing (50C for Rv004C or 52C for Rv0129C or 51C for Rv2962C) for 30s and extension at 60C for 30s for 45 cycles. The melting curve analysis consisted of denaturation of the amplicons at 95C for 10s to produce single-stranded DNA, probe...”
- Diversity of Mycobacterium tuberculosis Complex Lineages Associated with Pulmonary Tuberculosis in Southwestern, Uganda
Micheni, Tuberculosis research and treatment 2021 - “...performed by RT-PCR (Bio-Rad CFX96 Touch). Lineage-specific primers were as follows: Rv004C for MTB L4-U, Rv2962C for MTB L4-NU, and Rv0129C for MTB L3 based on a previous study of Wampande et al. [ 37 ] and their accompanying hybridization probes (Supplementary File 2 : Table...”
- “...95C for 30s, primer annealing (50C for Rv004C or 52C for Rv0129C or 51C for Rv2962C) for 30s, and extension at 60C for 30s for 45 cycles. The melting curve analysis consisted of denaturation of the amplicons at 95C for 10s to produce single-stranded DNA, probe...”
- Transcriptional Response of Mycobacterium tuberculosis to Cigarette Smoke Condensate
Willemse, Frontiers in microbiology 2021 - “...acid hydrolase Av-Gay and Everett, 2000 1.20 3.64E-09 MT3037 MT3038 Hypothetical protein 1.60 7.51E-11 MT3038 Rv2962c Probable glycosyltransferase Perez et al., 2004 1.82 5.28E-03 MT3039 Rv2963 Probable integral membrane protein/permeases of unknown function, copper induced protein Ward et al., 2010 2.43 8.89E-05 MT3041 Rv2964 purU Formyltetrahydrofolate...”
- Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
Evangelopoulos, Nature communications 2019 - “...mutation might lead to a high-fitness cost phenotype, and thus either mutations in mas or rv2962c had to be established to provide compensatory effects and survival of these strains prior to promoter changes. DCS R 7, DCS R 9, and DCS R 10 have an additional...”
- “...DCS R 5, bearing the deletion upstream of the alr gene and a SNP on rv2962c gene encoding a rhamnosyltransferase involved in PDIM biosynthesis 42 , was significantly attenuated for growth in human macrophages, compared with the parent strain (Fig. 2b ). Similarly, DCS R 6...”
- Transcriptional Profile of Mycobacterium tuberculosis in an in vitro Model of Intraocular Tuberculosis
Abhishek, Frontiers in cellular and infection microbiology 2018 - “...Metabolism and Respiration Intracellular survival Rv2672 and Rv1755c Cellular metabolism Rv0044c, Rv3712, Rv0197, Rv0561c, Rv3329, Rv2962c, Rv1723 , and Rv0245 Repair enzyme Rv2674 Information Pathways Translation activity Rv2056c, Rv3459c, Rv3456c, Rv3462c, Rv0979A , and Rv1630 Replication of bacteria Rv3721c Cell Wall and Cell Process Regulating the...”
- Lipid metabolism and Type VII secretion systems dominate the genome scale virulence profile of Mycobacterium tuberculosis in human dendritic cells
Mendum, BMC genomics 2015 - “...of PGL also had a fitness cost ( pkS15/1 , Rv2957-2959c [ 57 ] and Rv2962c) at day 3 and day 7 suggesting that PGL, at least in our GC1237 strain, has a role in M. tuberculosis survival in DCs (Additional file 4 ). This is...”
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7vlbB / A0A289QH46 Crystal structure of ugt109a1 from bacillus
Aligns to 206:349 / 353 (40.8%), covers 75.2% of PF06722, 66.5 bits
- Ligand: uridine-5'-diphosphate (7vlbB)
WP_003220489 glycosyltransferase from Bacillus spizizenii
Aligns to 241:384 / 392 (36.7%), covers 75.2% of PF06722, 66.4 bits
7vlbA / A0A289QH46 Crystal structure of ugt109a1 from bacillus
Aligns to 238:381 / 385 (37.4%), covers 75.2% of PF06722, 66.4 bits
- Ligand: uridine-5'-diphosphate (7vlbA)
AAA51867.1 glucuronosyltransferase (UGT1;UGT1*6;UGT1-06;UGT1.6;UGT1A6) (EC 2.4.1.17) (see protein)
Aligns to 320:458 / 531 (26.2%), covers 74.5% of PF06722, 66.1 bits
SS1G_09997 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
Aligns to 301:443 / 456 (31.4%), covers 83.4% of PF06722, 66.0 bits
XNR_4394 macrolide family glycosyltransferase from Streptomyces albidoflavus
Aligns to 262:393 / 397 (33.2%), covers 73.8% of PF06722, 65.5 bits
- Insights into naturally minimised Streptomyces albus J1074 genome
Zaburannyi, BMC genomics 2014 - “...for daunorubicin (XNR_2457-58, XNR_4042-43), camphor (XNR_2486-87), bicyclomycin (XNR_0140), tetracycline (XNR_3352) and one putative macrolide glycosyltransferase (XNR_4394). S. albus contains two genes for tryptophanyl-tRNA synthetase: XNR_3910 and XNR_3513, of which the latter is an ortholog of indolmycin-resistant Trp-synthetase from S. coelicolor [ 37 ]. It is worth...”
ABC02800.1 indolocarbazole N-glucosyltransferase (AtmG;AtG) (EC 2.4.1.-) (see protein)
Aligns to 307:433 / 445 (28.5%), covers 82.1% of PF06722, 65.4 bits
WP_051422100 macrolide family glycosyltransferase from Streptomyces sp. DpondAA-D4
Aligns to 255:388 / 399 (33.6%), covers 73.1% of PF06722, 65.4 bits
LOC660846 UDP-glycosyltransferase UGT5 from Tribolium castaneum
Aligns to 309:441 / 511 (26.0%), covers 76.6% of PF06722, 65.2 bits
AAA51868.1 glucuronosyltransferase (UGT1;UGT1*4;UGT1-04;UGT1.4;UGT1A4) (EC 2.4.1.17) (see protein)
Aligns to 321:459 / 532 (26.1%), covers 74.5% of PF06722, 65.1 bits
FRAAL4787 putative N-glycosyltransferase from Frankia alni ACN14a
Aligns to 264:401 / 462 (29.9%), covers 84.1% of PF06722, 65.1 bits
- Genomic Insights of Alnus-Infective Frankia Strains Reveal Unique Genetic Features and New Evidence on Their Host-Restricted Lifestyle
Kim, Genes 2023 - “...example, recovered from the list of lost genes in Sp+ genomes, such as FRAAL3448 or FRAAL4787 encoding a putative Glycerophosphoryl diester phosphodiesterase (indicated as GlpQ in Table 5 ) and putative N-glycosyltransferase, respectively. GlpQ is a protein able to hydrolyze glycerophosphodiester bonds [ 70 ] of...”
- “...FRAAL1769 Hypothetical protein FRAAL5611 Single copy C Energy production and conversion FRAAL1457 Putative Xanthine dehydrogenase FRAAL4787 Putative N-glycosyltransferase FRAAL3448 glpQ Glycerophosphoryl diester phosphodiesterase SP D Cell cycle control, cell division, chromosome partitioning FRAAL2959 ATP/GTP binding protein TM E Amino acid transport and metabolism FRAAL5354 Hypothetical protein...”
7vm0B / O31853 Crystal structure of yojk from b.Subtilis in complex with udp (see paper)
Aligns to 246:390 / 406 (35.7%), covers 86.9% of PF06722, 65.0 bits
- Ligand: uridine-5'-diphosphate (7vm0B)
BSU19420 putative glycosyltransferase from Bacillus subtilis subsp. subtilis str. 168
Aligns to 250:394 / 405 (35.8%), covers 86.9% of PF06722, 65.0 bits
AAB65795.1 glucuronosyltransferase (UGT1A7) (EC 2.4.1.17) (see protein)
Aligns to 318:456 / 530 (26.2%), covers 73.8% of PF06722, 64.8 bits
GBAA2638 glycosyl transferase, putative from Bacillus anthracis str. 'Ames Ancestor'
Aligns to 239:384 / 387 (37.7%), covers 89.0% of PF06722, 64.8 bits
PputUW4_03146 glycosyltransferase from Pseudomonas sp. UW4
Aligns to 280:423 / 427 (33.7%), covers 89.0% of PF06722, 64.0 bits
K659_RS0103715 nucleotide disphospho-sugar-binding domain-containing protein from Pseudomonas corrugata CFBP 5454
Aligns to 293:411 / 420 (28.3%), covers 66.2% of PF06722, 63.6 bits
BLU14_RS07155 nucleotide disphospho-sugar-binding domain-containing protein from Pseudomonas corrugata
Aligns to 291:411 / 420 (28.8%), covers 66.9% of PF06722, 63.6 bits
KALB_6584 macrolide family glycosyltransferase from Kutzneria albida DSM 43870
Aligns to 253:388 / 399 (34.1%), covers 79.3% of PF06722, 63.4 bits
UGT48_CAEEL / Q18081 Putative UDP-glucuronosyltransferase ugt-48; UDPGT 48; EC 2.4.1.17 from Caenorhabditis elegans (see paper)
Aligns to 315:464 / 526 (28.5%), covers 85.5% of PF06722, 63.1 bits
- catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
subunit: Interacts with cmd-1 in the presence of Ca(2+).
UGTB1_STABO / E9L011 UDP-glucosyltransferase B1; GTII; EC 2.4.1.- from Starmerella bombicola (Yeast) (Candida bombicola) (see 4 papers)
ADT71703.1 UDP-Glc: [sophorolipid] β-glucosyl-17-O-octadecenoic acid β-1,2-glucosyltransferase (GTII;UgtB1) (EC 2.4.1.-) (see protein)
Aligns to 287:420 / 432 (31.0%), covers 78.6% of PF06722, 63.0 bits
- function: Catalyzes the second glycosylation step of sophorolipid biosynthesis, the further glucosylation of the previoulsy formed glucolipid to give rise to an acidic sophorolipid.
catalytic activity: (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP- alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP (RHEA:60964)
XP_001638304 UDP-glucuronosyltransferase 2A3 isoform X2 from Nematostella vectensis
Aligns to 232:376 / 438 (33.1%), covers 84.8% of PF06722, 62.5 bits
- Coral-zooxanthellae meta-transcriptomics reveals integrated response to pollutant stress
Gust, BMC genomics 2014 - “...increased expression of potential detoxification mechanisms (i.e. cytochrome P450, XP_001624662, and UDP glucuronosyltransferase 2 family, XP_001638304, Figure 5 ). Carbohydrate metabolism was the most represented second order KEGG term in the 0.5mg/L treatment. All transcripts involved in carbohydrate metabolism had increased expression (Additional file 2 :...”
GYO_2344 macrolide family glycosyltransferase from Bacillus spizizenii TU-B-10
Aligns to 250:394 / 405 (35.8%), covers 86.2% of PF06722, 62.5 bits
- Disparate Effects of Two Clerodane Diterpenes of Giant Goldenrod (Solidago gigantea Ait.) on Bacillus spizizenii
Bozsó, International journal of molecular sciences 2024 - “...importance of menaquinone dependent respiratory electron transport during diterpene-induced stress response. Finally, a putative glycosyltransferase (GYO_2344, yojK ) was activated in all samples. Glycosyltransferases catalyze the transfer of sugar moieties to an acceptor molecule. B. subtilis has three putative UDP-glycosyltransferases with broad substrate ranges, capable of...”
- “...glycerol-3-phosphate dehydrogenase GYO_1674 2.3 1.8 2.8 1.2 B. subtilis (BSU_13490) htpX , stress-responsive membrane protease GYO_2344 2.4 2.5 2.6 2.9 B. subtilis (BSU_19420) yojK similar to macrolide glycosyltransferase GYO_2953 1.1 1.0 2.1 1.7 B. subtilis (BSU_27160) yrhJ , cytochrome P450, fatty acid metabolism GYO_3335 1.1 2.1...”
YP_003204087 UDP-glucuronosyl/UDP-glucosyltransferase from Nakamurella multipartita DSM 44233
Aligns to 289:423 / 436 (31.0%), covers 82.1% of PF06722, 62.0 bits
WP_003220110 macrolide family glycosyltransferase from Bacillus spizizenii
Aligns to 250:394 / 405 (35.8%), covers 86.2% of PF06722, 61.8 bits
XP_013840053 UDP glucuronosyltransferase 1 family, polypeptide A6 isoform X3 from Sus scrofa
Aligns to 318:456 / 530 (26.2%), covers 73.8% of PF06722, 61.4 bits
UGTA1 / E7CQW6 UDP-glucose:hydroxy fatty acid glucosyltransferase from Starmerella bombicola (see 3 papers)
UGTA1_STABO / E7CQW6 UDP-glucosyltransferase A1; GTI; EC 2.4.1.- from Starmerella bombicola (Yeast) (Candida bombicola) (see 5 papers)
ADT71702.1 UDP-Glc: [sophorolipid] 17-hydroxy-octadecenoic acid O-β-glucosyltransferase I (GTI;UgtA1;SbUGTA1) (EC 2.4.1.-) (see protein)
Aligns to 300:434 / 463 (29.2%), covers 75.9% of PF06722, 60.7 bits
- function: Catalyzes the first glycosylation step of sophorolipid biosynthesis, the coupling of glucose to a hydroxylated fatty acid to give rise to a glucolipid (PubMed:21073653, PubMed:23516968). Can glycosylate all hydroxyl fatty acids generated by cytochrome P450 monooxygenases CYP52M1, CYP52N1 and CYP52E3 into their corresponding glucolipids. Main products are 17-O- and 18-O-(beta-D-glucopyranosyl)- octadecenoic acids (PubMed:24242247, PubMed:26298016).
catalytic activity: 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18- hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP (RHEA:60960)
catalytic activity: 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17- hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP (RHEA:60956)
NP_787040 UDP-glucuronosyltransferase 1A8 precursor from Rattus norvegicus
Aligns to 318:456 / 530 (26.2%), covers 73.8% of PF06722, 60.6 bits
AAL67851.1 Glucuronosyltransferase 1.8 (EC 2.4.1.17) (see protein)
Aligns to 318:456 / 530 (26.2%), covers 73.8% of PF06722, 60.6 bits
BAA24692.1 glucuronosyltransferase (UGT1A1) (EC 2.4.1.17) (see protein)
Aligns to 336:459 / 533 (23.3%), covers 73.1% of PF06722, 60.5 bits
Q64634 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 3 papers)
Aligns to 333:456 / 530 (23.4%), covers 73.8% of PF06722, 60.5 bits
UD11_RAT / Q64550 UDP-glucuronosyltransferase 1A1; UGT1A1; B1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; EC 2.4.1.17 from Rattus norvegicus (Rat) (see paper)
Q64550 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 4 papers)
AAC52219.1 glucuronosyltransferase 1.1 (Ugt1a1;Ugt1.1) (EC 2.4.1.17) (see protein)
NP_036815 UDP-glucuronosyltransferase 1A1 precursor from Rattus norvegicus
Aligns to 322:461 / 535 (26.2%), covers 73.8% of PF06722, 60.4 bits
- function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:8554318). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:8554318). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (By similarity). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (By similarity). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (By similarity). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (By similarity). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53072)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
subunit: Homodimers. Homooligomer. Interacts with UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers. - Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics.
Chen, PloS one 2022 - “...Retinol metabolic process 0.832 0.0024 Sdhd Q6PCT8 Succinate dehydrogenase [ubiquinone] Carbohydrate metabolism 0.797 0.0424 Ugt1a1 Q64550 UDP-glucuronosyltransferase 11 Glycosyltransferase 0.722 0 Ugt1a5 Q64638 UDP-glucuronosyltransferase 15 Glycosyltransferase 0.694 0.0246 Ugt2b7 Q62789 UDP-glucuronosyltransferase 2B7 Lipid metabolism 0.623 0.0038 As shown in Table 1 , all impact values of...”
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...MPL-regulated Phase-II enzymes related to drug/xenobiotic/endogenous substrate metabolism. UProt_ID Gene Name Protein Name Function Regulation Q64550 Ugt1a1 UDP-glucuronosyltransferase 1A1 Drugs = opioids, SN-38 (irinotecan); endogenous substrates = bilirubin, ethinylestradiol; polymorphic enzyme DOWN/UP Q62452 Ugt1a9 UDP-glucuronosyltransferase 1A9 Drugs = R-oxepam, mycophenolic acid, SN-38 (irinotecan); halogenated phenols; polymorphic...”
- Improved detection of quantitative differences using a combination of spectral counting and MS/MS total ion current
Freund, Journal of proteome research 2013 - “...2B15 P36511 0.00022 6.4 1.8 (1.0) 17.0 (0.7) 1.9E+05 (1.7E+05) 7.0E+04 (2.2E+04) UDP-glucuronosyltransferase 11 (UGT1A1) Q64550 0.00086 4.6 11.0 (1.8) 54.1 (4.5) 6.3E+04 (2.0E+04) 6.8E+04 (4.6E+03) Peroxisomal multifunctional enzyme type 2 (HSD17B4) P97852 0.0018 2.0 48.1 (3.6) 96.3 (6.3) 1.8E+06 (2.8E+04) 1.6E+06 (1.6E+04) Dimethylglycine dehydrogenase. mitochondrial...”
- Response of the mitochondrial proteome of rat renal proximal convoluted tubules to chronic metabolic acidosis
Freund, American journal of physiology. Renal physiology 2013 - “...Protein Name Gene Mass, kDa P36511 Ugt2b15 61 Q66HG6 Q64240 Q64550 Ca5b Ambp Ugt1a1 37 39 60 G3V7V6 Q6AXT5 D4A0Y1 Retsat Rab21 Cfb 67 24 141 P13264 Gls Q3MIE0...”
- Differential permeabilization effects of Ca2+ and valinomycin on the inner and outer mitochondrial membranes as revealed by proteomics analysis of proteins released from mitochondria
Yamada, Molecular & cellular proteomics : MCP 2009 - “...IM M Q9JM53 NP_579829e P10860 P63039 P15999 P04762 Q64550 P19643 P07633 Q6P799 Q64565 Q02253 P11884 P22791 P04785 P50554 O35827 P10719 Q6P6R2 P14408 O08816...”
- The phagosome proteome: insight into phagosome functions.
Garin, The Journal of cell biology 2001 - “...54700 4.8 Microtubule proteins. 14% Tubulin -5 P05218 49670.8 4.78 49500 4.5 13/24 38% UDPGT Q64550 59662.7 8.77 27000 ND UDP-glucuronosyltransferase. E.R. protein. 22% VAP33 Q9QY77 27271.5 7.66 83000 ND Vesicle-associated membrane protein, associated protein A. Associated with ER and microtubules. 40% Mol Wt pI Mr...”
- Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats.
Asai, Biopharmaceutics & drug disposition 2018 (PubMed)- GeneRIF: study indicated that Status Epilepticus altered the expression of brain Ugt1a1 and Ugt1a7, which could alter glucuronidation in the brain.
- Disturbance of Mammary UDP-Glucuronosyltransferase Represses Estrogen Metabolism and Exacerbates Experimental Breast Cancer.
Zhou, Journal of pharmaceutical sciences 2017 (PubMed)- GeneRIF: UGT1A1 controls estrogen metabolism.
- Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies.
Wen, Molecular & cellular proteomics : MCP 2013 - GeneRIF: Data indicate that the up-regulation of phase II detoxification in the DR group was confirmed by mRNA and protein expression levels of uridinediphospho-glucuronosyltransferase and glycine-N-acyltransferase in actual liver tissues.
- CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats.
Roques, Toxicological sciences : an official journal of the Society of Toxicology 2012 (PubMed)- GeneRIF: Both fipronil and fipronil sulfone treatments induced a 2.5-fold increase in Ugt1a1 and Sult1b1 messenger RNA (mRNA) expressions.
- Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver.
Kishi, Biochemical and biophysical research communications 2008 (PubMed)- GeneRIF: Developmental stage-specific switching of regulation of the rat UGT1 gene complex was found.
- Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats.
Embola, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002 (PubMed)- GeneRIF: UDP-glucuronosyltransferase (UDP-GT) activities towards p-nitrophenol were markedly increased in rats that consumed tea.Induction of UDP-glucuronosyltransferase activity by tea may involve the UDP-GT1 (UGT1A) gene complex of the UDP-GT multigene family
- Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver.
Haberkorn, Molecular and cellular endocrinology 2002 (PubMed)- GeneRIF: Data suggest that thyroid hormones and vitamin A are co-regulators of UDP-glucuronosyltransferase (UGT) 1 expression, without affecting the UGT2 family
- Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat.
Yokota, Journal of biochemistry 2002 (PubMed)- GeneRIF: These results indicate that the expression of extrahepatic UDP-glucuronosyltransferases UGT1a1 and UGT1a6 is isoform-specific and regulated differentially in tissues by the pituitary gland.
- More
AAL67850.1 Glucuronosyltransferase 1.5 (EC 2.4.1.17) (see protein)
Aligns to 318:457 / 531 (26.4%), covers 73.8% of PF06722, 60.4 bits
B2RT14 UDP-glucuronosyltransferase from Mus musculus
Aligns to 316:455 / 529 (26.5%), covers 73.8% of PF06722, 60.3 bits
Q64638 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see paper)
Aligns to 334:457 / 531 (23.4%), covers 73.8% of PF06722, 60.3 bits
BAA23359.1 UDP-glucuronosyltransferase UGT1A4 (EC 2.4.1.17) (see protein)
Aligns to 307:456 / 529 (28.4%), covers 73.1% of PF06722, 60.2 bits
NP_958826 UDP-glucuronosyltransferase 1-2 precursor from Rattus norvegicus
Aligns to 320:459 / 533 (26.3%), covers 73.8% of PF06722, 60.1 bits
AAH78732.1 Glucuronosyltransferase 1.7 (EC 2.4.1.17) (see protein)
Aligns to 331:469 / 543 (25.6%), covers 73.8% of PF06722, 60.0 bits
P20720 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see paper)
Aligns to 336:459 / 533 (23.3%), covers 73.8% of PF06722, 60.0 bits
- Genetic resources of narrow-leaved lupine (Lupinus angustifolius L.) and their role in its domestication and breeding.
Vishnyakova, Vavilovskii zhurnal genetiki i selektsii 2021 - “...et al., 2012a) classifying accessions according to their domestication status and origin. The designated accessions (P20720, P22872, P26167, P26562, P26603, P26668, P27221, and P28221) were used in enriching BC2 crosses with cv. Mandelup (from Berger et al., 2013). Methods for identifying differentiation in the gene pool...”
- Exploring the genetic and adaptive diversity of a pan-Mediterranean crop wild relative: narrow-leafed lupin.
Mousavi-Derazmahalleh, TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 2018 - “...accessions from Italy and one accession from Greece that fell within the western clusters (Accessions P20720, P20724, P25040, P25051, P25052, P26107, P26109 and P26991). Investigating historic population bottlenecks To explore further how genomic diversity differs between the distinct eastern and western Mediterranean population groups and to...”
AAA42312.1 Glucuronosyltransferase 1A2 (Ugt1a2) (EC 2.4.1.17) (see protein)
Aligns to 334:457 / 531 (23.4%), covers 73.8% of PF06722, 60.0 bits
NP_569091 UDP-glucuronosyltransferase 1A7 precursor from Rattus norvegicus
Aligns to 319:457 / 531 (26.2%), covers 73.8% of PF06722, 60.0 bits
AAL67853.1 Glucuronosyltransferase 1A6 (Ugt1a6) (EC 2.4.1.17) (see protein)
Aligns to 317:456 / 530 (26.4%), covers 73.8% of PF06722, 59.9 bits
Q64633 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 2 papers)
Aligns to 334:457 / 531 (23.4%), covers 73.8% of PF06722, 59.9 bits
NP_001034780 UDP-glucuronosyltransferase 1-6 precursor from Rattus norvegicus
Q6T5E9 UDP-glucuronosyltransferase from Rattus norvegicus
Aligns to 317:456 / 530 (26.4%), covers 73.8% of PF06722, 59.9 bits
- Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation.
Yang, Redox biology 2024 - GeneRIF: Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation.
- Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats.
Asai, Biopharmaceutics & drug disposition 2018 (PubMed)- GeneRIF: study indicated that Status Epilepticus altered the expression of brain Ugt1a1 and Ugt1a7, which could alter glucuronidation in the brain.
- Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain.
Sakakibara, Biological & pharmaceutical bulletin 2016 (PubMed)- GeneRIF: This study clarified that Ugt1a6 and Ugt1a7 mRNA expression and their enzyme activities were altered by beta-naphthoflavone, suggesting that these changes may lead to alteration in the pharmacokinetics of UGT substrate in rat brain.
- Effect of adrenalectomy on expression and induction of UDP-glucuronosyltransferase 1A6 and 1A7 in rats.
Sakakibara, Biological & pharmaceutical bulletin 2014 (PubMed)- GeneRIF: results indicate that adrenal-dependent factors such as glucocorticoids are partially involved in the basal regulation of UGT1A6 and UGT1A7 transcription.
- Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes.
Gradinaru, Toxicology letters 2012 (PubMed)- GeneRIF: Catalytic properties/expression of UGT1A6/7 are influenced by the pro-oxidant environment in astrocytes.
- Drug metabolizing enzyme expression in rat choroid plexus: effects of in vivo xenobiotics treatment.
Gradinaru, Archives of toxicology 2009 (PubMed)- GeneRIF: We present for the first time evidences that the choroids plexus express transcripts for both UGT1A6 and NADPH-cytochrome P450 reductase
- Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver.
Haberkorn, Molecular and cellular endocrinology 2002 (PubMed)- GeneRIF: Data suggest that thyroid hormones and vitamin A are co-regulators of UDP-glucuronosyltransferase (UGT) 1 expression, without affecting the UGT2 family.
- Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat.
Yokota, Journal of biochemistry 2002 (PubMed)- GeneRIF: These results indicate that the expression of extrahepatic UDP-glucuronosyltransferases UGT1a1 and UGT1a6 is isoform-specific and regulated differentially in tissues by the pituitary gland.
- More
- High throughput metabolomics-proteomics investigation on metabolic phenotype changes in rats caused by Radix Scrophulariae using ultra-performance liquid chromatography with mass spectrometry.
Lu, RSC advances 2019 - “...Olr796 Olfactory receptor 1.5880 Up* 0.0484 L70 D3ZMQ0 Mga Protein Mga 1.6374 Up* 0.0312 L71 Q6T5E9 Ugt1a6 UDP-glucuronosyltransferase 1.7279 Up** 0.0003 L72 A1XF83 Ugt2b UDP-glucuronosyltransferase 1.8256 Up** 0.0001 L73 D3ZXC8 Ebpl Emopamil binding protein-like (predicted), isoform CRA_a 1.8324 Up** 0.0018 L74 F1LM22 Ugt2b UDP-glucuronosyltransferase 1.8894 Up**...”
UD19_MOUSE / Q62452 UDP-glucuronosyltransferase 1A9; UGT1A9; UDP-glucuronosyltransferase 1-7; UDPGT; UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UGT1A12; UGTP4; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
NP_964006 UDP-glucuronosyltransferase 1A9 precursor from Mus musculus
Aligns to 315:454 / 528 (26.5%), covers 73.8% of PF06722, 59.8 bits
- function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolic acid, an immunosuppressive agent.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53040)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O- (beta-D-glucuronate) + H(+) + UDP (RHEA:53060)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
subunit: Homodimer. Homooligomer. Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 to form heterodimers. - Tandem mass tag-based proteomics analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease in mice treated with acupuncture
Wang, Bioscience reports 2022 - “...synthase Fasn 0.698 0.00244 down P97311 DNA replication licensing factor MCM6 Mcm6 0.682 0.00278 down Q62452 UDP-glucuronosyltransferase 1-9 Ugt1a9 0.676 0.00134 down P10648 Glutathione S-transferase A2 Gsta2 0.674 0.000537 down P56655 Cytochrome P450 2C38 Cyp2c38 0.669 0.0061 down Q8BUE4 Apoptosis-inducing factor 2 Aifm2 0.669 0.000524 down...”
- Interpreting the Molecular Mechanisms of Yinchenhao Decoction on Hepatocellular Carcinoma through Absorbed Components Based on Network Pharmacology.
Sun, BioMed research international 2021 - “...Q64435 Tar098 UGT1A7 UDP-glucuronosyltransferase 1A7 Q9HAW7 Tar099 UGT1A8 UDP-glucuronosyltransferase 1A8 Q9HAW9 Tar100 UGT1A9 UDP-glucuronosyltransferase 1A9 Q62452 Tar101 UGT2B15 UDP-glucuronosyltransferase 2B15 P54855 Tar102 UGT2B17 UDP-glucuronosyltransferase 2B17 O75795 Tar103 VCAM1 Vascular cell adhesion protein 1 P19320 Tar104 VEGFA Vascular endothelial growth factor A P15692 Tar105 XDH Xanthine dehydrogenase/oxidase...”
- Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice.
Li, Toxicological sciences : an official journal of the Society of Toxicology 2018 - Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.
Ayyar, Journal of proteomics 2017 - “...UDP-glucuronosyltransferase 1A1 Drugs = opioids, SN-38 (irinotecan); endogenous substrates = bilirubin, ethinylestradiol; polymorphic enzyme DOWN/UP Q62452 Ugt1a9 UDP-glucuronosyltransferase 1A9 Drugs = R-oxepam, mycophenolic acid, SN-38 (irinotecan); halogenated phenols; polymorphic enzyme DOWN P09875 Ugt2b1 UDP-glucuronosyltransferase 2B1 Drug = diclofenac ; bisphenol A (environmental chemical) UP P36511 Ugt2b15...”
- The invertebrate Caenorhabditis elegans biosynthesizes ascorbate
Patananan, Archives of biochemistry and biophysics 2015 - “...67% 0 Yes UDP-glucose dehydrogenase * O70475 UDP-glucoseUDP-glucuronate F29F11.1 * 66% 0 Yes UDP-glucuronosyltransferase * Q62452 UDP-glucuronateacceptor-beta-D-glucuronoside C08F11.8 *** 27% 710 56 2 nd -glucuronidase ** P12265 a beta-D-glucuronosideD-glucuronate Y105E8B.9 **** 40% 9310 154 Yes Glucuronate reductase ** Q540D7 D-glucuronateL-gulonate Y39G8B.1 **** 47% 410 97 2...”
- Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.
Kitteringham, Journal of proteomics 2010 - “...0.58 0.80 0.72 0.021 O70475 UDP-glucose 6-dehydrogenase 1.09 0.97 1.23 0.79 0.63 0.99 0.73 0.183 Q62452 UDP-glucuronosyltransferase 1-9 0.99 0.93 1.06 0.73 0.58 0.92 0.74 0.183 Q91VA0 Acyl-coenzyme A synthetase ACSM1, mitochondrial 0.97 0.91 1.04 0.79 0.74 0.84 0.81 0.001 Q64442 Sorbitol dehydrogenase 1.02 0.92 1.13...”
- Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.
Xu, Drug metabolism and disposition: the biological fate of chemicals 2020 (PubMed)- GeneRIF: Circadian Clock Component Rev-erbalpha Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.
- Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.
Shi, Biopharmaceutics & drug disposition 2016 (PubMed)- GeneRIF: Diabetes mellitus caused a decrease in the activity of Cyp3a11-mediated testosterone-6beta-hydroxylation, but no change in the activity of Cyp3a11-mediated midazolam 1-hydroxylation and an increase in the activity of UGT1a9-mediated propofol O-glucuronidation in db/db mice
AAR95632.1 Glucuronosyltransferase 1.3 (EC 2.4.1.17) (see protein)
Aligns to 318:457 / 531 (26.4%), covers 73.8% of PF06722, 59.8 bits
ABA42119.2 UDP-Glc: oleandomycin glycosyltransferase (OleD;UGT102A2) (EC 2.4.1.-) (see protein)
Aligns to 263:396 / 415 (32.3%), covers 75.2% of PF06722, 59.8 bits
AAP48599.1 Glucuronosyltransferase 1.7 (EC 2.4.1.17) (see protein)
Aligns to 315:454 / 528 (26.5%), covers 73.8% of PF06722, 59.8 bits
AAA18021.1 glucuronosyltransferase (EGT12;UGT2B14) (EC 2.4.1.17) (see protein)
Aligns to 323:459 / 530 (25.8%), covers 86.9% of PF06722, 59.7 bits
oleD / Q53685 oleandomycin glycosyltransferase from Streptomyces antibioticus (see 4 papers)
Q53685 Oleandomycin glycosyltransferase from Streptomyces antibioticus
Aligns to 263:396 / 430 (31.2%), covers 75.2% of PF06722, 59.7 bits
P08430 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 2 papers)
Aligns to 332:455 / 529 (23.4%), covers 73.8% of PF06722, 59.7 bits
Q64637 glucuronosyltransferase (EC 2.4.1.17) from Rattus norvegicus (see 2 papers)
Aligns to 334:457 / 531 (23.4%), covers 73.8% of PF06722, 59.7 bits
UD17_MOUSE / Q6ZQM8 UDP-glucuronosyltransferase 1A7; UGT1A7; UDP-glucuronosyltransferase 1-7C; UDPGT 1-7C; UGT1*7C; UGT1-07C; UGT1.7C; UDP-glucuronosyltransferase 1A7C; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Aligns to 319:457 / 531 (26.2%), covers 73.8% of PF06722, 59.6 bits
- function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
subunit: Homodimer. Homooligomer. Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers. - Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.
Shelton, Kidney international 2015 - “...03 Q148B6 N.D. N.D. N.D. N.D. Ugt1a10 446962 NM_201641 0.58 9.04 04 1.45 2.12 02 Q6ZQM8 0.25 6.18 05 1.09 5.50 01...”
- Characterization of the proteome of cytoplasmic lipid droplets in mouse enterocytes after a dietary fat challenge.
D'Aquila, PloS one 2015 - “...46 ] 19.562 Sulfotransferase family cytosolic 1B member 1 Sult1b1 Q9QWG7 21.097 UDP-glucuronosyltransferase 1-7C Ugt1a7c Q6ZQM8 18.177 Transitional endoplasmic reticulum ATPase Vcp Q8BNF8 [ 45 47 ] Thirty seven proteins associated with known lipid metabolism pathways were identified, of which twenty three proteins have been previously...”
AAG21378.1 UDP-Glucuronosyltransferase UGT2B33 (EC 2.4.1.17) (see protein)
Aligns to 321:458 / 529 (26.1%), covers 72.4% of PF06722, 59.5 bits
Q80X89 UDP-glucuronosyltransferase 2A1 from Mus musculus
Aligns to 321:458 / 528 (26.1%), covers 72.4% of PF06722, 59.4 bits
AAG17003.1 Glucuronosyltransferase 2A1 (Ugt2a1) (olfactory) (EC 2.4.1.17) (see protein)
Aligns to 320:457 / 527 (26.2%), covers 72.4% of PF06722, 59.4 bits
NP_995584 UDP-glucuronosyltransferase 1-6 isoform 2 from Homo sapiens
Aligns to 52:192 / 265 (53.2%), covers 73.8% of PF06722, 59.4 bits
- Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy.
Saleh, Gene 2024 (PubMed)- GeneRIF: Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy.
- The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors.
Gündüz, Journal of pediatric hematology/oncology 2024 (PubMed)- GeneRIF: The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors.
- Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma.
Matsumoto, Molecular and cellular biochemistry 2023 (PubMed)- GeneRIF: Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma.
- Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients.
Zheng, Pharmacogenomics 2023 (PubMed)- GeneRIF: Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients.
- Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy.
Song, Clinical laboratory 2022 (PubMed)- GeneRIF: Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy.
- UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy.
Nandith, Indian journal of pediatrics 2021 (PubMed)- GeneRIF: UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy.
- Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children.
Du, Xenobiotica; the fate of foreign compounds in biological systems 2021 (PubMed)- GeneRIF: Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children.
- A meta-analysis of the influence of UGT1A6 genetic polymorphisms on valproic acid pharmacokinetics
.
Kim, International journal of clinical pharmacology and therapeutics 2019 (PubMed)- GeneRIF: concentration-to-dose ratio for valproic acid monotherapy were significantly lower for UGT1A6 homozygous variants 541A>G and 552A>C than for the wild type
- More
UD11_MOUSE / Q63886 UDP-glucuronosyltransferase 1A1; UGT1A1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UGTBR1; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Q63886 glucuronosyltransferase (EC 2.4.1.17) from Mus musculus (see paper)
AAH93516.1 glucuronosyltransferase 1A1 (Ugt1a1) (EC 2.4.1.17) (see protein)
NP_964007 UDP-glucuronosyltransferase 1A1 precursor from Mus musculus
Aligns to 322:461 / 535 (26.2%), covers 73.8% of PF06722, 59.3 bits
- function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (By similarity). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (By similarity). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (By similarity). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (By similarity). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (By similarity). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (By similarity). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53072)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
subunit: Homodimers. Homooligomer. Interacts with UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers. - Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice.
Li, Toxicological sciences : an official journal of the Society of Toxicology 2018 - Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes.
Bruegger, The Journal of biological chemistry 2018 - Re-adaption on Earth after Spaceflights Affects the Mouse Liver Proteome.
Anselm, International journal of molecular sciences 2017 - “...Q3UEP4 - 2.1 0.0167 0.0132 Cytochrome P450 3A13 Q3UW87 - 0.4 0.0121 0.0279 UDP-glucuronosyltransferase 1-1 Q63886 - 1.2 0.0420 0.0185 UDP-glucuronosyltransferase 1-6 Q64435 - 2.0 0.0179 0.0410 Cytochrome P450 2C54 Q6XVG2 * >0.05 0.0476 UDP-glucuronosyltransferase 2A3 Q8BWQ1 - 1.9 0.0109 0.0132 UDP-glucuronosyltransferase Q8K154 - 1.9 0.0172...”
- Gene expression profiling to identify eggshell proteins involved in physical defense of the chicken egg.
Jonchère, BMC genomics 2010 - “...Contains CD80-like C2-set immunoglobulin domain, B302 (SPRY) domain and Ig-like V-type (immunoglobulin-like) domain UDP-glucuronosyltransferase 1-1 (Q63886) UDP-glucoronosyl and UDP-glucosyl transferase family. Involved in detoxication and elimination of toxics Mannose-binding protein C (Q66S61) Binds mannose and N-acetylglucosamine in a calcium-dependent manner. Is capable of host defense. Contains...”
- “...6.5 2.8 6.9 Glioma pathogenesis-related protein 1 P48060 8.7 5.7 2 4.1 6.1 UDP-glucuronosyltransferase 1-1 Q63886 8.87 3.8 5.1 4.3 6.3 Glutamate [NMDA] receptor subunit zeta-1 Q5R1P0 8.92 4.8 6.1 6.1 6.1 Avian Beta defensin-9 Q6QLR1 8.94 4.8 0 7.1 7.1 Glycine receptor subunit beta P48167...”
- Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury.
Jiang, World journal of gastroenterology 2024 - GeneRIF: Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury.
- Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR.
Yang, The Journal of biological chemistry 2023 - GeneRIF: Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR.
- Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease.
Bates, Biomolecules 2023 - GeneRIF: Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease.
- UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder.
Liu, Biochemical pharmacology 2021 (PubMed)- GeneRIF: UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder.
- Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Miyauchi, Biochemical and biophysical research communications 2020 (PubMed)- GeneRIF: Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
- Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases.
De, JCI insight 2019 - GeneRIF: Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases.
- AAV8 Gene Therapy Rescues the Newborn Phenotype of a Mouse Model of Crigler-Najjar.
Greig, Human gene therapy 2018 (PubMed)- GeneRIF: An AAV8 vector was developed expressing a codon-optimized human version of UGT1A1 from a liver-specific promoter. High doses of the vector rescued neonatal lethality in newborn UGT1 knockout (KO) mice, which serve as a model of Crigler-Najjar syndrome, and significantly increased survival from 5 to 270 days.
- UDP-glucuronosyltransferase 1a enzymes are present and active in the mouse blastocyst.
Collier, Drug metabolism and disposition: the biological fate of chemicals 2014 - GeneRIF: data confirm that Ugt1a proteins are present and active in preimplantation murine embryos and point to a potential role for these proteins in implantation and early embryonic and fetal development
- More
UD2A3_CAVPO / Q9R110 UDP-glucuronosyltransferase 2A3; UDPGT 2A3; EC 2.4.1.17 from Cavia porcellus (Guinea pig) (see paper)
AAD51732.1 UDP glucuronosyltransferase UGT2A3 (EC 2.4.1.17) (see protein)
Aligns to 323:462 / 530 (26.4%), covers 73.8% of PF06722, 59.3 bits
- function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
Q95M37 glucuronosyltransferase (EC 2.4.1.17) from Canis lupus familiaris (see paper)
Aligns to 311:454 / 528 (27.3%), covers 73.1% of PF06722, 59.1 bits
AAB49299.1 TDP/UDP-Glc: aglycosyl-vancomycin glucosyltransferase (GtfE';Vcm10) (EC 2.4.1.-) (see protein)
AORI_1487 glycosyltransferase from Amycolatopsis keratiniphila
Aligns to 284:392 / 408 (26.7%), covers 57.9% of PF06722, 59.1 bits
- Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis
Xu, BMC genomics 2014 - “...7 , 8 ], only two glycosyltransferases are encoded in the vcm cluster (AORI_1486 and AORI_1487). On the other hand, the vancomycin-resistance genes vanHAX (AORI_1471-AORI_1473) are only predicted in vcm and not in the other two clusters (Table 2 ). Throughout the A. orientalis genome, we...”
- “...Cytochrome P450 lcl|AJ223998.1_cdsid_CAA11791.1 91.69 AORI_1485 vhal Halogenase lcl|Y16952.3_cdsid_CAA76550.1 93.89 AORI_1486 gtfD Vancosaminyl transferase lcl|Y16952.3_cdsid_CAA76553.1 69.93 AORI_1487 gtfE Glycosyl transferase lcl|Y16952.3_cdsid_CAA76552.1 81.17 AORI_1488 vcaC Methyltransferase family protein lcl|Y16952.3_cdsid_CAC48364.1 93.87 AORI_1489 LmbE family protein lcl|Y16952.3_cdsid_CAC48365.1 75.91 AORI_1490 vmt Methyltransferase lcl|AJ223998.1_cdsid_CAA11779.1 73.21 AORI_1491 hpgT 4-hydroxyphenylglycine aminotransferase lcl|AJ223998.1_cdsid_CAA11790.1 89.7 AORI_1492...”
Celf_3212 glycosyltransferase from Cellulomonas fimi ATCC 484
Aligns to 277:410 / 414 (32.4%), covers 68.3% of PF06722, 59.1 bits
- The genome sequences of Cellulomonas fimi and "Cellvibrio gilvus" reveal the cellulolytic strategies of two facultative anaerobes, transfer of "Cellvibrio gilvus" to the genus Cellulomonas, and proposal of Cellulomonas gilvus sp. nov
Christopherson, PloS one 2013 - “...PL3, and PL11 families in addition to four gene products involved in uronic acid interconversions (Celf_3212, _3268, _3292, and _3346) while C. flavigena had a PL3 and a PL11 pectate lyase and six predicted uronic acid gene products (Cfla_0976, _2984, _3012, _0879, _9878, _3194). In contrast,...”
UD12_MOUSE / P70691 UDP-glucuronosyltransferase 1-2; UDPGT 1-2; UGT1*2; UGT1-02; UGT1.2; Bilirubin-specific UDPGT; UDP-glucuronosyltransferase 1A2; UGT1A2; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
BAA13482.1 Glucuronosyltransferase 1.2 (Ugt1a2) (EC 2.4.1.17) (see protein)
NP_038729 UDP-glucuronosyltransferase 1-2 precursor from Mus musculus
Aligns to 320:459 / 533 (26.3%), covers 73.8% of PF06722, 58.8 bits
UD16_MOUSE / Q64435 UDP-glucuronosyltransferase 1-6; UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; Phenol UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1A6; UGT1A6; UGP1A1; UGT1A7; EC 2.4.1.17 from Mus musculus (Mouse) (see 2 papers)
Q64435 glucuronosyltransferase (EC 2.4.1.17) from Mus musculus (see paper)
AAA65979.1 glucuronosyltransferase 1.6 (Ugt1a6;UGT1*06;UGT1A1) (EC 2.4.1.17) (see protein)
NP_659545 UDP-glucuronosyltransferase 1-6 precursor from Mus musculus
Aligns to 318:457 / 531 (26.4%), covers 73.8% of PF06722, 58.8 bits
- function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4- nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4- hydroxybiphenyl, androgens and estrogens are not substrates. 2- hydroxybiphenyl is an excellent substrate
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032) - Interpreting the Molecular Mechanisms of Yinchenhao Decoction on Hepatocellular Carcinoma through Absorbed Components Based on Network Pharmacology.
Sun, BioMed research international 2021 - “...P22309 Tar095 UGT1A10 UDP-glucuronosyltransferase 1A10 Q9HAW8 Tar096 UGT1A3 UDP-glucuronosyltransferase 1A3 P35503 Tar097 UGT1A6 UDP-glucuronosyltransferase 1-6 Q64435 Tar098 UGT1A7 UDP-glucuronosyltransferase 1A7 Q9HAW7 Tar099 UGT1A8 UDP-glucuronosyltransferase 1A8 Q9HAW9 Tar100 UGT1A9 UDP-glucuronosyltransferase 1A9 Q62452 Tar101 UGT2B15 UDP-glucuronosyltransferase 2B15 P54855 Tar102 UGT2B17 UDP-glucuronosyltransferase 2B17 O75795 Tar103 VCAM1 Vascular cell adhesion...”
- Re-adaption on Earth after Spaceflights Affects the Mouse Liver Proteome.
Anselm, International journal of molecular sciences 2017 - “...3A13 Q3UW87 - 0.4 0.0121 0.0279 UDP-glucuronosyltransferase 1-1 Q63886 - 1.2 0.0420 0.0185 UDP-glucuronosyltransferase 1-6 Q64435 - 2.0 0.0179 0.0410 Cytochrome P450 2C54 Q6XVG2 * >0.05 0.0476 UDP-glucuronosyltransferase 2A3 Q8BWQ1 - 1.9 0.0109 0.0132 UDP-glucuronosyltransferase Q8K154 - 1.9 0.0172 0.0126 UDP-glucuronosyltransferase Q8R084 - 3.5 0.0118 0.0119...”
- Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice.
Lohr, Physiological reports 2016 - Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus.
Kebaabetswe, Virology 2015 - “...Polysaccharides Metabolism Q8C166 Copine I 11 0.67 (0.029) P50405 Surfactant-associated protein B 8 0.37 (<0.001) Q64435 UDP glucuronosyltransferase 16 6 0.78 (0.05) Q80UM7 Mannosyl-oligosaccharide glucosidase 2 * (0.014) Other Metabolism P22437 Prostaglandin-endoperoxide synthase 1 2 0.44 (0.007) Miscellaneous Transmembrane Q9DBS1 Transmembrane protein 43 11 0.77 (0.037)...”
- Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells
Carmean, American journal of physiology. Endocrinology and metabolism 2019 - GeneRIF: This study provides evidence that UGT1A6A, acting on the serotonin pathway, regulates glucose induced insulin secretion under both normal and pathological conditions.
- Comparison of serotonin glucuronidation activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: evidence for the preferential expression of Ugt1a6a in the mouse brain.
Uchihashi, Drug metabolism and pharmacokinetics 2013 (PubMed)- GeneRIF: the difference in expression levels between Ugt1a6a and Ugt1a6b in the hippocampus led us to speculate that Ugt1a6a is likely the predominant catalyst of serotonin glucuronidation in the mouse brain.
XP_011512261 UDP-glucuronosyltransferase 3A1 isoform X4 from Homo sapiens
Aligns to 260:402 / 469 (30.5%), covers 82.1% of PF06722, 58.6 bits
asm25 / Q8KUH5 ansamitocin N-glucosyltransferase from Actinosynnema pretiosum subsp. auranticum (see 4 papers)
AAM54103.1 ansamitocin N-β-glucosyltransferase (Asm25) (EC 2.4.1.-) (see protein)
Aligns to 251:392 / 402 (35.3%), covers 97.2% of PF06722, 58.5 bits
AAB96668.1 glucuronosyltransferase (UGT1A) (EC 2.4.1.17) (see protein)
Aligns to 336:459 / 533 (23.3%), covers 73.1% of PF06722, 58.4 bits
Q6NUS8 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 2 papers)
CAC42674.1 UDP-GlcNAc: ursodeoxycholic acid β-N-acetylglucosaminyltransferase (UGT3A1;LOC133688) (UGT3A1) (EC 2.4.1.-) (see protein)
Aligns to 314:456 / 523 (27.3%), covers 82.1% of PF06722, 58.4 bits
- Similarities in Structure and Function of UDP-Glycosyltransferase Homologs from Human and Plants.
Lethe, International journal of molecular sciences 2024 - “...which shares 25% homology. The AlphaFold2 prediction is also available for UGT3A1 (from UniProtKB; accession Q6NUS8). A structural comparison between UGT71G1 and UGT3A1 shows significant differences in surface loops and helices, but they still align well enough to show a common origin. The listed acceptor substrates...”
- Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.
Barker, PloS one 2020 - “...Solute carrier family 13 member 1 secondary carrier transporter (PC00258) kidney UGT3A1 0.8608 4.52E-26 26625 Q6NUS8 UDP-glucuronosyltransferase 3A1 kidney SLC27A2 0.8535 3.26E-25 10996 O14975 Very long-chain acyl-CoA synthetase secondary carrier transporter (PC00258) kidney TMEM27 0.8526 4.1E-25 29437 Q9HBJ8 Collectrin kidney CLRN3 0.8443 3.36E-24 20795 Q8NCR9 Clarin-3...”
- Massive peptide sharing between viral and human proteomes
Kanduc, Peptides 2008 - “...TSH3_HUMAN; Q6ZNA9; Q5TG33 17 OR5U1_HUMAN; Q9BRW6; FBX2_HUMAN; Q5TAE7; Q5T011; ELOV2_HUMAN; Q8NC43; Q5JR89 18 Q6ZRR8; Q5T435; Q6NUS8; CX033_HUMAN; ALG1_HUMAN; Q6ZUT0; Q86UH7; NCKX5_HUMAN; Q9BRY8; RT34_HUMAN; PODO_HUMAN; Q6ZNI2; Q6UXQ0 19 Q6ZTL0; Q6H9L7; Q96I32; PIPNA_HUMAN; Q9H5L8; Q5W0W3; Q9UMD0; Q5T9C4; Q5VU34; Q8N996; TRI11_HUMAN; Q5T884; Q6VEP3 20 VPS16_HUMAN; GLUC_HUMAN; Q5TI49; DAF_HUMAN; Q4G1H0;...”
AAB96667.1 glucuronosyltransferase (UGT1A) (EC 2.4.1.17) (see protein)
Aligns to 336:459 / 533 (23.3%), covers 73.1% of PF06722, 58.4 bits
EFUA_HORCR / A0A2Z4HPY4 Enfumafungin synthase efuA; Enfumafungin biosynthesis cluster protein A; Terpene cyclase-glycosyl transferase fusion protein efuA; EC 5.4.99.-; EC 2.4.1.- from Hormonema carpetanum (see paper)
Aligns to 983:1131 / 1314 (11.3%), covers 71.7% of PF06722, 58.4 bits
- function: Terpene cyclase-glycosyl transferase fusion protein; part of the gene cluster that mediates the biosynthesis of enfumafungin, a glycosylated fernene-type triterpenoid with potent antifungal activity, mediated by its interaction with beta-1,3-glucan synthase and the fungal cell wall (PubMed:30051576). The pathway begins with the terpene cyclase-glycosyl transferase fusion protein that most likely uses 2,3- oxidosqualene as substrate and catalyzes glycosylation immediately after cyclization (Probable). The fernene glycoside then could be processed by the desaturase efuI which catalyzes isomerization of a double bond established by efuA to form the core structure (Probable). The latter would then undergo a series of hydroxylations in unknown order at C-2, C-19, C-23 and C-25, which would be catalyzed by two of the three cytochrome P450 monooxygenases efuB, efuG or efuH (Probable). The hydroxy-group at C-25 becomes oxidized by the dehydrogenase efuE to enable a spontaneous, non-enzymatic hemiacetal formation with C-23 (Probable). After hydroxylation at C-2, acetylation by the acetyltransferase efuC takes place (Probable). The final steps in enfumafungin biosynthesis require expansion of the 5-membered ring by lactonization via a Baeyer-Villiger reaction mediated by one of the BGC's cytochrome P450 monooxygenases (efuB, efuG or efuH) followed by ring cleavage (Probable). This type of reaction would establish a double bond between C-20 and C-21 which could be reduced by the reductase efuL to form the final product (Probable).
disruption phenotype: Abolishes the production of enfumafungin and loses antifungal activity.
XP_063129642 UDP-glucuronosyltransferase 2A1 isoform X2 from Rattus norvegicus
Aligns to 316:457 / 527 (26.9%), covers 72.4% of PF06722, 58.3 bits
UD2A1_RAT / P36510 UDP-glucuronosyltransferase 2A1; UDPGT 2A1; UGT2A1; UGT-OLF; EC 2.4.1.17 from Rattus norvegicus (Rat) (see paper)
CAA40797.1 Glucuronosyltransferase 2A1 (Ugt2a1) (EC 2.4.1.17) (see protein)
Aligns to 316:457 / 527 (26.9%), covers 72.4% of PF06722, 58.3 bits
- function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterones) and estrogens (estradiol and estriol). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52920)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52872)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP (RHEA:52456)
catalytic activity: epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52568)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl- 3-O-(beta-D-glucuronate) + UDP (RHEA:53028)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52952)
catalytic activity: deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52948)
catalytic activity: hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP (RHEA:52964)
catalytic activity: hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta- D-glucuronate) + UDP (RHEA:52960) - Diviner uncovers hundreds of novel human (and other) exons though comparative analysis of proteins.
Nord, bioRxiv : the preprint server for biology 2024 - “...for the pictured Diviner search result, [C] the sole rat UGT2A1 isoform in SwissProt (accession: P36510), and [D] the protein sequence produced by incorporating the novel rat exon predicted by Diviner into the rat UGT2A1 isoform pictured in [C]. The rat exon predicted by Diviner and...”
- Detection of new pathways involved in the acceptance and the utilisation of a plant-based diet in isogenic lines of rainbow trout fry.
Callet, PloS one 2018 - “...to perception. Swiss Prot Description Genotype effect Diet effect R23h AB1h A22h Perception of smell/taste P36510 UDP-glucuronosyltransferase 2A1 (Ugt2a1) R23h <A22h ns ns ns P56373 P2X purinoceptor 3 (P2RX3) R23h <A22h ns ns up Q3V3I2 Guanine nucleotide-binding protein G(t) subunit -3 (GNAT3) R23h <A22h ns ns...”
UGT1A8 / Q9HAW9 UDP-glucuronosyltransferase 1-8 (EC 2.4.1.17) from Homo sapiens (see 4 papers)
UD18_HUMAN / Q9HAW9 UDP-glucuronosyltransferase 1A8; UGT1A8; UDP-glucuronosyltransferase 1-8; UDPGT 1-8; UGT1*8; UGT1-08; UGT1.8; UDP-glucuronosyltransferase 1-H; UGT-1H; UGT1H; EC 2.4.1.17 from Homo sapiens (Human) (see 12 papers)
Q9HAW9 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 20 papers)
NP_061949 UDP-glucuronosyltransferase 1A8 precursor from Homo sapiens
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.2 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15472229, PubMed:16595710, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens (PubMed:15472229, PubMed:16595710, PubMed:18719240, PubMed:23288867). Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps (PubMed:16595710). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D- glucuronate) + H(+) + UDP (RHEA:52476)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52924)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53032)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53036)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53040)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53052)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O- (beta-D-glucuronate) + H(+) + UDP (RHEA:53060)
catalytic activity: 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53072)
catalytic activity: 2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53064)
catalytic activity: 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53080)
catalytic activity: 4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53068)
catalytic activity: 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D- glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53000)
catalytic activity: 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP- alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D- glucuronosyl-(1->2)-glucuronate] + H(+) + UDP (RHEA:53388)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10 (PubMed:20610558). - Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families.
Yang, International journal of molecular sciences 2022 - “...an input of the human UGT1A7, UGT1A8, UGT1A9, UGT1A10 and UGT2A1 sequence (UniProt, Identifiers: Q9HAW7, Q9HAW9, O60656, Q9HAW8 and P0DTE4), respectively. The crystal structure of sterol 3-beta-glucosyltransferase in complex with its cofactor UDP-glucose (PDB code: 5GL5 [ 45 ]) was chosen as the template, for all...”
- Interpreting the Molecular Mechanisms of Yinchenhao Decoction on Hepatocellular Carcinoma through Absorbed Components Based on Network Pharmacology
Sun, BioMed research international 2021 - “...P35503 Tar097 UGT1A6 UDP-glucuronosyltransferase 1-6 Q64435 Tar098 UGT1A7 UDP-glucuronosyltransferase 1A7 Q9HAW7 Tar099 UGT1A8 UDP-glucuronosyltransferase 1A8 Q9HAW9 Tar100 UGT1A9 UDP-glucuronosyltransferase 1A9 Q62452 Tar101 UGT2B15 UDP-glucuronosyltransferase 2B15 P54855 Tar102 UGT2B17 UDP-glucuronosyltransferase 2B17 O75795 Tar103 VCAM1 Vascular cell adhesion protein 1 P19320 Tar104 VEGFA Vascular endothelial growth factor A...”
- Proteome biology of primary colorectal carcinoma and corresponding liver metastases.
Fahrner, Neoplasia (New York, N.Y.) 2021 - “...0.645 1.79E-03 3.00E-02 TRA2A Transformer-2 protein homolog alpha Q3LXA3 0.784 1.64E-03 2.88E-02 TKFC Triokinase/FMN cyclase Q9HAW9 1.288 4.08E-05 2.57E-03 UGT1A8 UDP-glucuronosyltransferase 1A8 P02774 0.79 3.06E-05 2.02E-03 GC Vitamin D-binding protein P04004 0.76 2.59E-03 3.97E-02 VTN Vitronectin Significantly depleted proteins in liver metastases P62736 -1.065 6.90E-06 6.60E-04...”
- Exploring active ingredients and function mechanisms of Ephedra-bitter almond for prevention and treatment of Corona virus disease 2019 (COVID-19) based on network pharmacology
Gao, BioData mining 2020 - “...P05177 CYP1A2 113 P08581 MET 173 P14679 TYR 54 Q16678 CYP1B1 114 O43451 MGAM 174 Q9HAW9 UGT1A8 55 P08684 CYP3A4 115 P03956 MMP1 175 P19320 VCAM1 56 Q96PD7 DGAT2 116 P08253 MMP2 176 P15692 VEGFA 57 P27487 DPP4 117 P08254 MMP3 177 P47989 XDH 58 P21728...”
- Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy
Ye, BMC complementary medicine and therapies 2020 - “...P08700 IL3 interleukin 3 None 67 P19320 VCAM1 vascular cell adhesion molecule 1 None 68 Q9HAW9 UGT1A8 UDP glucuronosyl transferase family 1member A8 None 69 P29474 NOS3 nitric oxide synthase 3 None 70 Q16790 CA9 carbonic anhydrase 9 None 71 P83111 LACTB lactamase beta None 72...”
- Molecular Insight into Stereoselective ADME Characteristics of C20-24 Epimeric Epoxides of Protopanaxadiol by Docking Analysis.
Guo, Biomolecules 2020 - “...cytochrome P450 (CYP) isoform 3A4 (PDB ID: 1W0F) and UDP-glucuronosyltransferase (UGT) isoform 1A8 (accession ID: Q9HAW9). According to the available results from both in vitro and in vivo experiments [ 14 , 17 , 18 ], the three target proteins are mainly involved in disposition of...”
- “...sequence was retrieved as a target from the NCBI database with an accession number of Q9HAW9 and downloaded as a FAST ALL format file. Then BLAST (the program Basic Local Alignment Search Tool) was performed to find the best homologous sequence with known 3-D structure as...”
- Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis
Zhu, Medical science monitor : international medical journal of experimental and clinical research 2019 - “...Drugbank Q9HAW8 UGT1A10 UDP-glucuronosyltransferase 1-10 Homo sapiens Drugbank P35503 UGT1A3 UDP-glucuronosyltransferase 1-3 Homo sapiens Drugbank Q9HAW9 UGT1A8 UDP-glucuronosyltransferase 1-8 Homo sapiens Drugbank O60656 UGT1A9 UDP-glucuronosyltransferase 1-9 Homo sapiens Drugbank P06133 UGT2B4 UDP-glucuronosyltransferase 2B4 Homo sapiens Drugbank P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 Homo sapiens Drugbank P02768 ALB Serum...”
- Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen, Molecular pharmaceutics 2018 - “...(UniProt Consortium, 2015). The accession codes for the retrieved UGT1As were: Q9HAW8 (1A10), O60656 (1A9), Q9HAW9 (1A8), Q9HAW7 (1A7), P19224 (1A6), P35504 (1A5), P22310 (1A4), P35503 (1A3), and P22039 (1A1). To identify template protein structures for homology modeling purposes, the retrieved UGT sequences were used in...”
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- The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation.
Zhao, Hormones (Athens, Greece) 2020 (PubMed)- GeneRIF: The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation.
- In Vitro Study on Influences of UGT1A8 Gene Polymorphisms on Mycophenolate Mofetil Metabolism.
Zhou, Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2018 (PubMed)- GeneRIF: UGT1A8 gene polymorphisms can affect the activity of UDP glucuronosyltransferase enzyme, which may influence the elimination of mycophenolate mofetil in different patients.
- Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.
Mubarokah, Molecular pharmacology 2018 (PubMed)- GeneRIF: studies lead to a model for the developmental patterning of UGT1A8, UGT1A9, and UGT1A10 in hepatic and/or extrahepatic tissues involving discrete regulatory modules that may function (independently and cooperatively) in a context-dependent manner
- Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study.
Falkowski, BMC cancer 2017 - GeneRIF: Polymorphism of UGT1A8 rs1042597-G variant allele is associated with colorectal cancer.
- Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9.
Kishi, Xenobiotica; the fate of foreign compounds in biological systems 2016 (PubMed)- GeneRIF: the in vitro glucuronidation of raloxifene in humans and monkeys was examined using liver and intestinal microsomes and recombinant UGT enzymes (UGT1A1, UGT1A8 and UGT1A9).
- Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes.
Dai, Biopharmaceutics & drug disposition 2015 (PubMed)- GeneRIF: Data suggest UGT1A8 is involved in differential metabolism of dietary flavonoids (glucosides and aglycones); glucuronidation of flavonoid glucosides is considerably slower than glucuronidation of flavonoid aglycones in microsomes of intestine/liver.
- Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo.
Sun, Cancer prevention research (Philadelphia, Pa.) 2013 - GeneRIF: UGT1A8 Polymorphism is associated with response to raloxifene in breast cancer.
- Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations.
Deng, Die Pharmazie 2013 (PubMed)- GeneRIF: A much higher frequency of UGT1A8*2 variant allele was found in Chinese than in Caucasians and Africans
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NP_001284545 UDP-glucuronosyltransferase 2B4 isoform 3 from Homo sapiens
Aligns to 186:322 / 392 (34.9%), covers 71.7% of PF06722, 58.2 bits
- Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan.
Wang, Scientific reports 2023 - GeneRIF: Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan.
- Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti-tuberculosis drug-induced liver injury in a Western Chinese population.
Chen, Journal of clinical pharmacy and therapeutics 2021 (PubMed)- GeneRIF: Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti-tuberculosis drug-induced liver injury in a Western Chinese population.
- Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .
Kahma, Drug metabolism and disposition: the biological fate of chemicals 2018 (PubMed)- GeneRIF: Clopidogrel carboxylic acid is metabolized mainly by UGT2B7 and UGT2B4 in the liver and by UGT2B17 in the small intestinal wall.
- UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.
Yermachenko, Gene 2016 (PubMed)- GeneRIF: UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.
- Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.
Barrett, Drug metabolism and disposition: the biological fate of chemicals 2015 - GeneRIF: These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity
- Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.
Gelston, British journal of clinical pharmacology 2012 - GeneRIF: Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo
- High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.
Dura, International journal of oncology 2012 (PubMed)- GeneRIF: The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma.
- A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk.
Sun, Human genetics 2011 - GeneRIF: The variation pattern upstream UGT2B4 is highly unusual and may be the result of balancing selection.
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AAB84259.1 Glucuronosyltransferase 1A8 (Ugt1a8) (EC 2.4.1.17) (see protein)
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.2 bits
UD19_HUMAN / O60656 UDP-glucuronosyltransferase 1A9; UGT1A9; UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UDP-glucuronosyltransferase 1-I; UGT-1I; UGT1I; lugP4; EC 2.4.1.17 from Homo sapiens (Human) (see 11 papers)
O60656 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 37 papers)
AAC31425.1 UDP-GlcA: glucuronosyltransferase 1A9 (Ugt1a9) (EC 2.4.1.17) (see protein)
NP_066307 UDP-glucuronosyltransferase 1A9 precursor from Homo sapiens
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.2 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:15472229, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:19545173). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10- hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:20610558). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta- estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53040)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O- (beta-D-glucuronate) + H(+) + UDP (RHEA:53060)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 (PubMed:20610558). - Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.
Zhou, Drug metabolism and disposition: the biological fate of chemicals 2024 (PubMed)- GeneRIF: Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.
- Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma.
Matsumoto, Molecular and cellular biochemistry 2023 (PubMed)- GeneRIF: Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma.
- UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro.
Li, Molecules (Basel, Switzerland) 2022 - GeneRIF: UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro.
- Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers.
Borrego-Soto, The pharmacogenomics journal 2020 - GeneRIF: Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers.
- Worsening of Kidney Transplant Function During 2-Year Follow-up Is Associated With the Genetic Variants of CYP3A4, MDR1, and UGT1A9.
Hryniewiecka, Transplantation proceedings 2020 (PubMed)- GeneRIF: Worsening of Kidney Transplant Function During 2-Year Follow-up Is Associated With the Genetic Variants of CYP3A4, MDR1, and UGT1A9.
- Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis
Flynn, PLoS neglected tropical diseases 2019 - “...against the Bm-UGT peptide sequence. The following are the orthologs selected for analyses: Homo sapiens (NP_066307), Canis lupus familiaris (XP_005635657), and Felis catus (BAA2492). Structural analysis of Bm-UGT The Bm-UGT sequence was initially analyzed for properties including signal peptide sequence, and potential transmembrane sequence using InterPro,...”
- Epigenetic regulation of UDP-Glucuronosyltransferase by microRNA-200a/-183: implications for responses to sorafenib treatment in patients with hepatocellular carcinoma.
Ge, Cancer letters 2019 (PubMed)- GeneRIF: Direct binding was further demonstrated by luciferase reporter gene vector carrying wild-type or binding site truncated UGT1A9 3'-UTR. MicroRNA-200a/-183 downregulated UGT1A9 expression in a dose-dependent manner and significantly reduced sorafenib beta-D-glucuronide formation in HCC cells.
- Novel analytical methods to interpret large sequencing data from small sample sizes.
Lichou, Human genomics 2019 - GeneRIF: Using a graphical representation, from 708 identified polymorphisms, a reduced list of 115 candidates was obtained. Then, by analyzing each gene and the distribution of variant alleles, several candidates were highlighted such as UGT1A9, PTPN22, and ERCC5. These genes were already associated with the transport, the metabolism, and even the sensitivity to imatinib in previous studies.
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- Cuproptosis gene-related, neural network-based prognosis prediction and drug-target prediction for KIRC.
Liu, Cancer medicine 2023 - “...2D6 DB06486 Enzastaurin P10635 Cytochrome P450 2D6 DB08073 A443654 P10635 Cytochrome P450 2D6 DB00307 Bexarotene O60656 UDPglucuronosyltransferase 1A9 DB06486 Enzastaurin O60656 UDPglucuronosyltransferase 1A9 DB08073 A443654 O60656 UDPglucuronosyltransferase 1A9 DB00307 Bexarotene P07949 Protooncogene tyrosineprotein kinase receptor Ret DB08073 A443654 P07949 Protooncogene tyrosineprotein kinase receptor Ret DB06486 Enzastaurin...”
- KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study.
Füzi, Journal of cheminformatics 2022 - “...often downregulated by the mostDILI than the noDILI group Uniprot_ID Gene_name Significance_score P23219 PTGS1 16.0 O60656 UGT1A9 14.0 O94956 SLCO2B1 11.0 Q92887 ABCC2 9.0 P11509 CYP2A6 9.0 P22309 UGT1A1 7.5 Q9Y694 SLC22A7 7.0 P05177 CYP1A2 6.0 Q9NPD5 SLCO1B3 6.0 Q9Y6L6 SLCO1B1 6.0 P11712 CYP2C9 5.8 P02763...”
- “...Table 7 Example of a causal network output row target_uniprot_id typeA Interactor_uniprot_id typeB Effect moi O60656 protein P20823 protein up-regulates quantity by expression 1 Table 8 Upregulated proteins by the downregulated proteins significantly connected to the mostDILI group target_uniprot_id Interactor_uniprot_id O60656 P20823 P22309 P35869 P22309 P20823...”
- Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families.
Yang, International journal of molecular sciences 2022 - “...input of the human UGT1A7, UGT1A8, UGT1A9, UGT1A10 and UGT2A1 sequence (UniProt, Identifiers: Q9HAW7, Q9HAW9, O60656, Q9HAW8 and P0DTE4), respectively. The crystal structure of sterol 3-beta-glucosyltransferase in complex with its cofactor UDP-glucose (PDB code: 5GL5 [ 45 ]) was chosen as the template, for all the...”
- Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy
Ye, BMC complementary medicine and therapies 2020 - “...topoisomerase II alpha None 55 P35503 UGT1A3 UDP glucuronosyltransferase family 1 member A3 None 56 O60656 UGT1A9 UDP glucuronosyltransferase family 1 member A9 None 57 P04035 HMGCR 3-hydroxy-3-methylglutaryl -CoA reductase None 58 P10636 MAPT microtubule associated protein tau None 59 P26358 DNMT1 DNA methyltransferase 1 None...”
- Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver transplantation
Jia, Annals of translational medicine 2020 - “...O43175 D-3-phosphoglycerate dehydrogenase PHGDH 0.604 Q15493 Regucalcin RGN 0.604 Q6NVY1 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.605 O60656 UDP-glucuronosyltransferase 1-9 UGT1A9 0.607 P49326 Dimethylaniline monooxygenase [N-oxide-forming] 5 FMO5 0.609 Q7Z4W1 L-xylulose reductase DCXR 0.609 Q14353 Guanidinoacetate N-methyltransferase GAMT 0.615 P08684 Cytochrome P450 3A4 CYP3A4 0.619 Q02252 Methylmalonate-semialdehyde dehydrogenase...”
- Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis
Zhu, Medical science monitor : international medical journal of experimental and clinical research 2019 - “...Drugbank P35503 UGT1A3 UDP-glucuronosyltransferase 1-3 Homo sapiens Drugbank Q9HAW9 UGT1A8 UDP-glucuronosyltransferase 1-8 Homo sapiens Drugbank O60656 UGT1A9 UDP-glucuronosyltransferase 1-9 Homo sapiens Drugbank P06133 UGT2B4 UDP-glucuronosyltransferase 2B4 Homo sapiens Drugbank P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 Homo sapiens Drugbank P02768 ALB Serum albumin Homo sapiens Drugbank, Genecards P23219 PTGS1...”
- Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen, Molecular pharmaceutics 2018 - “...at www.uniprot.org (UniProt Consortium, 2015). The accession codes for the retrieved UGT1As were: Q9HAW8 (1A10), O60656 (1A9), Q9HAW9 (1A8), Q9HAW7 (1A7), P19224 (1A6), P35504 (1A5), P22310 (1A4), P35503 (1A3), and P22039 (1A1). To identify template protein structures for homology modeling purposes, the retrieved UGT sequences were...”
- Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.
Uzozie, Molecular & cellular proteomics : MCP 2014
AAK16234.1 UDP-Gal: ceramide galactosyltransferase (EC 2.4.1.47) (see protein)
Q98TB5 UDP-galactose ceramide galactosyltransferase from Gallus gallus
Aligns to 306:442 / 541 (25.3%), covers 75.9% of PF06722, 58.1 bits
NDPGT_BACLD / Q65JC2 NDP-glycosyltransferase YjiC; UDP-glucosyltransferase YjiC; EC 2.4.1.384 from Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) (see 8 papers)
Q65JC2 flavone 7-O-beta-glucosyltransferase (EC 2.4.1.81) from Bacillus licheniformis (see paper)
AAU40842.1 UDP-Glc: isoflavonoid β-glucosyltransferase (YjiC;BLi01948;BL00446) (EC 2.4.1.-) (see protein)
Aligns to 245:389 / 396 (36.6%), covers 80.0% of PF06722, 58.1 bits
- function: Glycosyltransferase that can glycosylate a wide range of substrates, including various flavonoids (flavones, flavonols, flavanones, flavanols, chalcones), isoflavonoids and stilbenes, to produce multiple glycosylated products (PubMed:23542617, PubMed:23974133, PubMed:24170092, PubMed:24893262, PubMed:24949266, PubMed:25239890, PubMed:27444326, PubMed:32238768). It can accept diverse nucleotide diphosphate-D/L-sugars as donors, including ADP-, GDP-, CDP-, TDP- or UDP-alpha-D-glucose, and catalyzes O-, N-, or S- glycosylation (PubMed:23542617, PubMed:23974133, PubMed:24170092, PubMed:24893262, PubMed:24949266, PubMed:25239890, PubMed:27444326, PubMed:32238768). In vitro, catalyzes the glycosylation of, among others, apigenin, 3-hydroxyflavone, phloretin or resveratrol, resulting in multiple glucosylated products, along with mono-, di-, tri- and tetraglucosides (PubMed:23542617, PubMed:23974133, PubMed:24170092, PubMed:24893262, PubMed:25239890, PubMed:27444326). Can also catalyze the glycosylation of the macrolide epothilone A with diverse NDP-D/L- sugars, forming different epothilone A glycoside derivatives (PubMed:24949266).
catalytic activity: an NDP-glycose + an acceptor = a glycosylated acceptor + NDP. - Polyphenol Utilization Proteins in the Human Gut Microbiome.
Zheng, Applied and environmental microbiology 2022 - “...Figure 3 and Fig. S1 showed that the 60 PUP seeds (except for I5AX49 and Q65JC2 ) contain in total 40 unique Pfam protein domains. According to a set of criteria (see Materials and Methods) and the sequence similarity network (SSN) analysis ( Fig. 3 ),...”
- “...Pfam domain or multidomain combination ( Table 1 ). The two PUPs ( I5AX49 and Q65JC2 ) without Pfam domains were defined as two unclassified families. Therefore, dbPUP contains in total 26 protein families of six enzymatic classes according to their enzyme commission (EC) numbers at...”
AAB81537.1 glucuronosyltransferase 1A10 (Ugt1a10) (EC 2.4.1.17) (see protein)
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.0 bits
UD17_HUMAN / Q9HAW7 UDP-glucuronosyltransferase 1A7; UGT1A7; UDP-glucuronosyltransferase 1-7; UDPGT 1-7; UGT1*7; UGT1-07; UGT1.7; UDP-glucuronosyltransferase 1-G; UGT-1G; UGT1G; EC 2.4.1.17 from Homo sapiens (Human) (see 11 papers)
Q9HAW7 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 20 papers)
NP_061950 UDP-glucuronosyltransferase 1A7 precursor from Homo sapiens
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.0 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:20610558, PubMed:23360619). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol (PubMed:18719240). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10- hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558, PubMed:23360619). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP (RHEA:63704)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D- glucuronide + UDP (RHEA:63612)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558). - Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families.
Yang, International journal of molecular sciences 2022 - “...with an input of the human UGT1A7, UGT1A8, UGT1A9, UGT1A10 and UGT2A1 sequence (UniProt, Identifiers: Q9HAW7, Q9HAW9, O60656, Q9HAW8 and P0DTE4), respectively. The crystal structure of sterol 3-beta-glucosyltransferase in complex with its cofactor UDP-glucose (PDB code: 5GL5 [ 45 ]) was chosen as the template, for...”
- Interpreting the Molecular Mechanisms of Yinchenhao Decoction on Hepatocellular Carcinoma through Absorbed Components Based on Network Pharmacology
Sun, BioMed research international 2021 - “...Q9HAW8 Tar096 UGT1A3 UDP-glucuronosyltransferase 1A3 P35503 Tar097 UGT1A6 UDP-glucuronosyltransferase 1-6 Q64435 Tar098 UGT1A7 UDP-glucuronosyltransferase 1A7 Q9HAW7 Tar099 UGT1A8 UDP-glucuronosyltransferase 1A8 Q9HAW9 Tar100 UGT1A9 UDP-glucuronosyltransferase 1A9 Q62452 Tar101 UGT2B15 UDP-glucuronosyltransferase 2B15 P54855 Tar102 UGT2B17 UDP-glucuronosyltransferase 2B17 O75795 Tar103 VCAM1 Vascular cell adhesion protein 1 P19320 Tar104 VEGFA...”
- Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen, Molecular pharmaceutics 2018 - “...2015). The accession codes for the retrieved UGT1As were: Q9HAW8 (1A10), O60656 (1A9), Q9HAW9 (1A8), Q9HAW7 (1A7), P19224 (1A6), P35504 (1A5), P22310 (1A4), P35503 (1A3), and P22039 (1A1). To identify template protein structures for homology modeling purposes, the retrieved UGT sequences were used in blast searches...”
- Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.
Uzozie, Molecular & cellular proteomics : MCP 2014 - [Gene mutation pattern of Gilbert's syndrome combined with viral hepatitis and its relationship with the exploration of clinical data].
Ning, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2020 (PubMed)- GeneRIF: [Gene mutation pattern of Gilbert's syndrome combined with viral hepatitis and its relationship with the exploration of clinical data].
- Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population.
Abudahab, Current drug metabolism 2019 (PubMed)- GeneRIF: We found that Circassians and Chechens have significantly higher allele frequencies of UGT1A7*2, UGT1A7*3 and UGT1A7*4 than the Jordanian-Arab population, but all three populations have similar frequencies of UGT1A1*28. Therefore, Circassians and Chechens are expected to have significantly lower levels of the UGT1A7 enzyme with almost 90% of these populations having genes that encode low or intermediate enzyme activity.
- Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland.
Lacko, Head & neck 2016 (PubMed)- GeneRIF: high activity UGT1A7 genotype is associated with an increased risk for Warthin's tumor.
- Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer.
Yilmaz, Asian Pacific journal of cancer prevention : APJCP 2015 (PubMed)- GeneRIF: Increased UGT1A7 expression is associated with pancreatic cancer.
- Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.
Ishii, Drug metabolism and disposition: the biological fate of chemicals 2014 (PubMed)- GeneRIF: Results suggest that CYP3A4 changes the catalytic function of the UGT1A subfamily in a UGT isoform-specific manner.
- Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations.
Maeda, Molecular diagnosis & therapy 2014 - GeneRIF: The rate of Results show that UGT1A7*12 allele frequency was not significantly different between the Uzbek and Japanese populations.
- The association between UGT1A7 polymorphism and cancer risk: a meta-analysis.
Han, Cancer epidemiology 2012 (PubMed)- GeneRIF: the UGT1A7*3 allele is a risk factor for cancer among Asians, especially for hepatocellular carcinoma (Meta-Analysis)
- Association between polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and colorectal cancer risk.
Osawa, Asian Pacific journal of cancer prevention : APJCP 2012 (PubMed)- GeneRIF: Polymorphism in UDP-glucuronosyltransferase 1A7 is associated with colorectal cancer.
- More
UD110_HUMAN / Q9HAW8 UDP-glucuronosyltransferase 1A10; UGT1A10; UDP-glucuronosyltransferase 1-10; UDPGT 1-10; UGT1*10; UGT1-10; UGT1.10; UDP-glucuronosyltransferase 1-J; UGT-1J; UGT1J; EC 2.4.1.17 from Homo sapiens (Human) (see 12 papers)
Q9HAW8 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 18 papers)
NP_061948 UDP-glucuronosyltransferase 1A10 precursor from Homo sapiens
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 58.0 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:26220143). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:18719240, PubMed:23288867, PubMed:26220143). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52468)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52876)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52924)
catalytic activity: 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha- hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52448)
catalytic activity: estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D- glucuronate) + H(+) + UDP (RHEA:52476)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D- glucuronoside + UDP (RHEA:63724)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta- D-glucuronide + UDP (RHEA:63728)
catalytic activity: UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N- beta-D-glucuronide (RHEA:63744)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A9 (PubMed:20610558). - Complete Reaction Phenotyping of Propranolol and 4-Hydroxypropranolol with the 19 Enzymes of the Human UGT1 and UGT2 Families.
Yang, International journal of molecular sciences 2022 - “...of the human UGT1A7, UGT1A8, UGT1A9, UGT1A10 and UGT2A1 sequence (UniProt, Identifiers: Q9HAW7, Q9HAW9, O60656, Q9HAW8 and P0DTE4), respectively. The crystal structure of sterol 3-beta-glucosyltransferase in complex with its cofactor UDP-glucose (PDB code: 5GL5 [ 45 ]) was chosen as the template, for all the homology...”
- Interpreting the Molecular Mechanisms of Yinchenhao Decoction on Hepatocellular Carcinoma through Absorbed Components Based on Network Pharmacology
Sun, BioMed research international 2021 - “...brown fat uncoupling protein 1 P25874 Tar094 UGT1A1 UDP-glucuronosyltransferase 1A1 P22309 Tar095 UGT1A10 UDP-glucuronosyltransferase 1A10 Q9HAW8 Tar096 UGT1A3 UDP-glucuronosyltransferase 1A3 P35503 Tar097 UGT1A6 UDP-glucuronosyltransferase 1-6 Q64435 Tar098 UGT1A7 UDP-glucuronosyltransferase 1A7 Q9HAW7 Tar099 UGT1A8 UDP-glucuronosyltransferase 1A8 Q9HAW9 Tar100 UGT1A9 UDP-glucuronosyltransferase 1A9 Q62452 Tar101 UGT2B15 UDP-glucuronosyltransferase 2B15 P54855...”
- Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis
Zhu, Medical science monitor : international medical journal of experimental and clinical research 2019 - “...Drugbank P48775 TDO2 Tryptophan 2,3-dioxygenase Homo sapiens Drugbank P22309 UGT1A1 UDP-glucuronosyltransferase 1-1 Homo sapiens Drugbank Q9HAW8 UGT1A10 UDP-glucuronosyltransferase 1-10 Homo sapiens Drugbank P35503 UGT1A3 UDP-glucuronosyltransferase 1-3 Homo sapiens Drugbank Q9HAW9 UGT1A8 UDP-glucuronosyltransferase 1-8 Homo sapiens Drugbank O60656 UGT1A9 UDP-glucuronosyltransferase 1-9 Homo sapiens Drugbank P06133 UGT2B4 UDP-glucuronosyltransferase...”
- Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen, Molecular pharmaceutics 2018 - “...UniProt Knowledgebase at www.uniprot.org (UniProt Consortium, 2015). The accession codes for the retrieved UGT1As were: Q9HAW8 (1A10), O60656 (1A9), Q9HAW9 (1A8), Q9HAW7 (1A7), P19224 (1A6), P35504 (1A5), P22310 (1A4), P35503 (1A3), and P22039 (1A1). To identify template protein structures for homology modeling purposes, the retrieved UGT...”
- Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.
Uzozie, Molecular & cellular proteomics : MCP 2014 - Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.
Mubarokah, Molecular pharmacology 2018 (PubMed)- GeneRIF: studies lead to a model for the developmental patterning of UGT1A8, UGT1A9, and UGT1A10 in hepatic and/or extrahepatic tissues involving discrete regulatory modules that may function (independently and cooperatively) in a context-dependent manner
- Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10.
Gramec, Xenobiotica; the fate of foreign compounds in biological systems 2015 (PubMed)- GeneRIF: UGT1A10 exhibited somewhat higher BPA glucuronidation activity than UGT1A9, but it was lower than UGT2A1 and UGT2B15. 4.
- Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.
Kallionpää, The Journal of steroid biochemistry and molecular biology 2015 (PubMed)- GeneRIF: In further studies with UGT1A10, mutant F93G exhibited increased glucuronidation rates of 16alpha-hydroxyestrone, but not estrone
- Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10.
Oda, Biochemical pharmacology 2014 (PubMed)- GeneRIF: DNA hypermethylation results in defective expression of UGT1A10 in the liver.
- Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.
Lu, Chemical communications (Cambridge, England) 2014 (PubMed)- GeneRIF: A graphene nanocage with regulatable space for the assembly of a CYP1A2-UGT1A10 bienzyme complex has been constructed via a click reaction, and used to study drug sequential metabolism using an electrochemically-driven method.
- Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
Pawlowska, Drug metabolism and disposition: the biological fate of chemicals 2013 - GeneRIF: Suggest that extrahepatic UGT1A10 plays an important role in the metabolism and the bioactivation of the antitumor agent C-1305.
- Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.
Shiraga, Drug metabolism and disposition: the biological fate of chemicals 2012 (PubMed)- GeneRIF: Data suggest that darexaban glucuronidation in jejunum microsomes is mainly catalyzed by UGT1A10; studies include kinetics of recombinant UGT proteins, liver microsomes, and jejunal microsomes (and UGT isoform-specific inhibitors/substrates).
- Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
Fedejko-Kap, Drug metabolism and disposition: the biological fate of chemicals 2012 - GeneRIF: Triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311 are glucuronidated in human liver and intestine.
- More
UD11_HUMAN / P22309 UDP-glucuronosyltransferase 1A1; UGT1A1; Bilirubin-specific UDPGT isozyme 1; hUG-BR1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UDP-glucuronosyltransferase 1A isoform 1; EC 2.4.1.17 from Homo sapiens (Human) (see 40 papers)
P22309 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 44 papers)
AAA63195.1 UDP-GlcA: glucuronosyltransferase 1A1 (Ugt1a1;Ugt1;Gnt1) (EC 2.4.1.17) (see protein)
NP_000454 UDP-glucuronosyltransferase 1A1 precursor from Homo sapiens
Q5DT03 UDP-glucuronosyltransferase from Homo sapiens
Aligns to 322:459 / 533 (25.9%), covers 73.8% of PF06722, 58.0 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:18004206, PubMed:18004212, PubMed:18719240, PubMed:19830808, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004206, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:15472229, PubMed:18719240, PubMed:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PubMed:17187418, PubMed:18004206, PubMed:19830808). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10- hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53048)
catalytic activity: 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53004)
catalytic activity: 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2- methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:53072)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52880)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D- glucuronide + UDP (RHEA:63588)
catalytic activity: SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D- glucuronide + UDP (RHEA:63696)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2 (PubMed:17187418, PubMed:20610558). Isoform 1 also interacts with respective i2 isoforms of UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558). - Similarities in Structure and Function of UDP-Glycosyltransferase Homologs from Human and Plants.
Lethe, International journal of molecular sciences 2024 - “...colon, and small intestine, corresponding to their role as catalysts in phase II metabolism (Uniprot P22309, 2023). The UGT1A and UGT2B subfamilies have vital roles in phenolic drug elimination, which are not limited to acetaminophen, SN38, morphine, and assorted cancer drugs like irinotecan [ 15 ]....”
- “...UDP (tan, PDB#: 2ACW); UGT1A1 was predicted using the AI software AlphaFold2 (light blue; UniProt# P22309; AlphaFold Protein Structure Database# AF-P22309-F1). UGT1A1 has a helical transmembrane-spanning region that is cropped from the image. Figure 4 Size comparison of the acceptor-binding pocket of UGT71G1 with PaGT3. The...”
- The Effect of Citrus aurantium on Non-Small-Cell Lung Cancer: A Research Based on Network and Experimental Pharmacology
Yao, BioMed research international 2023 - “...Cytochrome P450 19A1 CYP19A1 P11511 32 Glutathione S-transferase P GSTP1 P09211 33 UDP-glucuronosyltransferase 1-1 UGT1A1 P22309 34 Glutathione reductase, mitochondrial GSTO1 P78417 35 Adiponectin ADIPOQ Q15848 36 Aldo-keto reductase family 1 member C1 AKR1C2 P52895 37 Liver carboxylesterase 1 CES1 P23141 38 Nitric oxide synthase, inducible...”
- Characterizing common and rare variations in non-traditional glycemic biomarkers using multivariate approaches on multi-ancestry ARIC study.
Ray, medRxiv : the preprint server for health sciences 2023 - “...for proteins encoded by both UGT1A1 ( p = 2.0 10 278 , Uniprot ID P22309) and UGT1A6 ( p = 5.6 10 104 , Uniprot ID P19224) corresponding to isoforms of the UDP-glucuronosyltransferase 1A protein complex ( Figure 1 ). It was identified as cis...”
- Evaluation of tea (Camellia sinensis L.) phytochemicals as multi-disease modulators, a multidimensional in silico strategy with the combinations of network pharmacology, pharmacophore analysis, statistics and molecular docking.
Nag, Molecular diversity 2023 - “...17 P22303 1B41 [ 71 ] Acetylcholinesterase Yt blood group antigen (#112,100) Pyridostigmine (DB00545) 18 P22309 Homologous model UDP-glucuronosyltransferase 11 Hyperbilirubinemia (H00208), Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 (#601,816) Adenine (DB00173) 19 P22310 Homologous model UDP-glucuronosyltransferase 14 Gilbert syndrome (#143,500) Idelalisib (DB09054) 20...”
- “...of the homology modeled proteins The homology modeling of two proteins (UDP-glucuronosyltransferase 11: UniProt id P22309 and UDP-glucuronosyltransferase 14: UniProt id P22310) were performed by SWISS-Model server, based on the templates of PDB id 6KVJ.1.A and 6O86.1.A. The quality analysis was done by the parameters MolProbity...”
- Cuproptosis gene-related, neural network-based prognosis prediction and drug-target prediction for KIRC.
Liu, Cancer medicine 2023 - “...Protooncogene tyrosineprotein kinase receptor Ret DB08073 A443654 P07949 Protooncogene tyrosineprotein kinase receptor Ret DB06486 Enzastaurin P22309 UDPglucuronosyltransferase 1A1 DB00307 Bexarotene P22309 UDPglucuronosyltransferase 1A1 DB00544 5Fluorouracil O60656 UDPglucuronosyltransferase 1A9 DB08073 A443654 P21802 Fibroblast growth factor receptor 2 DB00544 5Fluorouracil P07949 Protooncogene tyrosineprotein kinase receptor Ret DB08073 A443654...”
- Mechanism of Peitu Shengjin Formula Shenlingbaizhu Powder in Treating Bronchial Asthma and Allergic Colitis through Different Diseases with Simultaneous Treatment Based on Network Pharmacology and Molecular Docking
Zeng, Evidence-based complementary and alternative medicine : eCAM 2022 - “...factor receptor MET P08581 80 Interferon regulatory factor 1 IRF1 P10914 6 UDP-glucuronosyltransferase 11 UGT1A1 P22309 81 Arachidonate 5-lipoxygenase ALOX5 P09917 7 Protein kinase C beta type PRKCB P05771 82 Gap junction alpha-1 protein GJA1 P17302 8 Collagen alpha-1(I) chain COL1A1 P02452 83 Claudin-4 CLDN4 O14493...”
- KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study.
Füzi, Journal of cheminformatics 2022 - “...P23219 PTGS1 16.0 O60656 UGT1A9 14.0 O94956 SLCO2B1 11.0 Q92887 ABCC2 9.0 P11509 CYP2A6 9.0 P22309 UGT1A1 7.5 Q9Y694 SLC22A7 7.0 P05177 CYP1A2 6.0 Q9NPD5 SLCO1B3 6.0 Q9Y6L6 SLCO1B1 6.0 P11712 CYP2C9 5.8 P02763 ORM1 5.0 P35503 UGT1A3 5.0 Network Similarly to the causal target part,...”
- “...proteins by the downregulated proteins significantly connected to the mostDILI group target_uniprot_id Interactor_uniprot_id O60656 P20823 P22309 P35869 P22309 P20823 P22309 O75469 P22309 Q14994 P22309 P04150 Q92887 Q14653 Enrichment analysis With the last part of the workflow, different network-based enrichment analyses can be performed. In this section...”
- Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1.
Pang, Frontiers in pharmacology 2022 - “...2008 ). The 3D structure of hUGT1A1 was recently predicted by the AlphaFold (UniProt code: P22309) ( Luo et al., 2008 ). Firstly, the structure of UDPGA was docked into the catalytic domain of hUGT1A1 by the alignment function of PyMOL (The PyMOL Molecular Graphics System...”
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- Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.
Fan, BMC pediatrics 2024 - GeneRIF: Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.
- [UGT1A1 gene mutation spectrum with indirect hyperbilirubinemia in children].
Shen, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2024 (PubMed)- GeneRIF: [UGT1A1 gene mutation spectrum with indirect hyperbilirubinemia in children].
- Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury.
Jiang, World journal of gastroenterology 2024 - GeneRIF: Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury.
- [Correlation between the mutation spectrum of the UGT1A1 gene and clinical phenotype in patients with inherited hyperunconjugated bilirubinemia].
Xiong, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2024 (PubMed)- GeneRIF: [Correlation between the mutation spectrum of the UGT1A1 gene and clinical phenotype in patients with inherited hyperunconjugated bilirubinemia].
- Concurrence of novel mutations causing Gilbert's and Dubin-Johnson syndrome with poor clinical outcomes in a Han Chinese family.
Zhou, Journal of human genetics 2023 (PubMed)- GeneRIF: Concurrence of novel mutations causing Gilbert's and Dubin-Johnson syndrome with poor clinical outcomes in a Han Chinese family.
- The association between UGT1A1 polymorphisms and treatment toxicities of liposomal irinotecan.
Su, ESMO open 2023 - GeneRIF: The association between UGT1A1 polymorphisms and treatment toxicities of liposomal irinotecan.
- [A family study of the compound heterozygous mutation of the UGT1A1 gene causing Crigler-Najjar syndrome type II].
Luo, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2023 (PubMed)- GeneRIF: [A family study of the compound heterozygous mutation of the UGT1A1 gene causing Crigler-Najjar syndrome type II].
- Il-6 and UGT1A1 variations may related to furosemide resistance in heart failure patients.
Koprululu, IUBMB life 2023 (PubMed)- GeneRIF: Il-6 and UGT1A1 variations may related to furosemide resistance in heart failure patients.
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- Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis.
Wu, Current drug metabolism 2011 - “...for homology modeling. The aligned sequence identity is 13.7%. The full length UGT1A1 sequence (Accession: Q5DT03) was downloaded from the SwissProt database ( http://www.uniprot.org/ ). Approximately 450 amino acids long sequence of human 1A1 (excluding N-terminal signal peptide, C-terminal transmembrane domain and cytosolic tail) was aligned...”
AAK31597.1 UDP-glucuronosyltransferase UGT1A01 (EC 2.4.1.17) (see protein)
Aligns to 324:459 / 533 (25.5%), covers 73.8% of PF06722, 57.9 bits
UD16_HUMAN / P19224 UDP-glucuronosyltransferase 1-6; UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; Phenol-metabolizing UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-F; UGT-1F; UGT1F; UDP-glucuronosyltransferase 1A6; EC 2.4.1.17 from Homo sapiens (Human) (see 5 papers)
P19224 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 30 papers)
AAG30420.1 UDP-GlcA: glucuronosyltransferase 1A6 (Ugt1a6) (EC 2.4.1.17) (see protein)
Aligns to 321:458 / 532 (25.9%), covers 73.8% of PF06722, 57.9 bits
- function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
subunit: Isoform 1 interacts with isoform 3/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 3. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A7, UGT1A8, UGT1A9 and UGT1A10. - Characterizing common and rare variations in non-traditional glycemic biomarkers using multivariate approaches on multi-ancestry ARIC study.
Ray, medRxiv : the preprint server for health sciences 2023 - “..., Uniprot ID P22309) and UGT1A6 ( p = 5.6 10 104 , Uniprot ID P19224) corresponding to isoforms of the UDP-glucuronosyltransferase 1A protein complex ( Figure 1 ). It was identified as cis -eQTL for UGT1A3 and UGT1A8 in the same complex of alternatively spliced...”
- IgGFc-binding protein and MUC2 mucin produced by colonic goblet-like cells spatially interact non-covalently and regulate wound healing.
Gorman, Frontiers in immunology 2023 - “...P12277 0.719577745 RBM39 RNA-binding protein 39 Q14498 0.735175542 INF2 Inverted formin-2 Q27J81 0.752149128 UGT1A6 UDP-glucuronosyltransferases P19224 0.763751492 EPB41L2 Band 4.1-like protein 2 O43491 0.777451278 HSP90AB2P Putative heat shock protein HSP 90-beta 2 Q58FF8 0.789186704 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 P05023 0.801241448 BSG Basigin P35613 0.809002775 CD9...”
- Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.
Schmidt, Science advances 2023 - “...Inhibitor ISK2 (P20155) LYAM2 (P16581) Indirectly druggable None None Harmful 3 3 Antagonist, inhibitor UD16 (P19224) Currently not druggable Left Harmful Harmful 0 0 CD33 (P20138) Directly drugged Left Harmful Beneficial 4 6 Binding agent, other CAH6 (P23280) Directly drugged Right Harmful Harmful 4 1 Inhibitor...”
- Intra- and Inter-individual Differences in the Human Intestinal Microbial Conversion of (-)-Epicatechin and Bioactivity of Its Major Colonic Metabolite 5-(3',4'-Dihydroxy-Phenyl)-γ-Valerolactone in Regulating Nrf2-Mediated Gene Expression.
Liu, Frontiers in nutrition 2022 - “...glutathione peroxidase 8 GPX8 2.11 (0.376) 0.97 (0.979) Q13162 Peroxiredoxin-4 PRDX4 1.57 (0.034) 1.24 (0.410) P19224 UDP-glucuronosyltransferase UGT1A6 1.10 (0.749) 1.31 (0.344) P34913 Bifunctional epoxide hydrolase 2 EPHX2 1.14 (0.440) 1.40 (0.043) Q13501 Sequestosome-1 SQSTM1 1.05 (0.969) 1.21 (0.874) O75027 ABCB7 ABCB7 0.49 (0.526) 2.31 (0.297)...”
- Homology Modeling of Human Uridine-5'-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding
Smith, ACS omega 2020 - “...Modeling of UGT1A6 Homology models of the human UGT1A6 protein (GenBank accession #: NP_001063.2, Uniprot: P19224) were produced using the I-TASSER server. 64 66 UGT1A6 possesses a 26-amino acid N-terminal signal peptide which acts to target the immature protein to the ER. 40 Once inserted into...”
- Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen, Molecular pharmaceutics 2018 - “...accession codes for the retrieved UGT1As were: Q9HAW8 (1A10), O60656 (1A9), Q9HAW9 (1A8), Q9HAW7 (1A7), P19224 (1A6), P35504 (1A5), P22310 (1A4), P35503 (1A3), and P22039 (1A1). To identify template protein structures for homology modeling purposes, the retrieved UGT sequences were used in blast searches against the...”
- Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.
Uzozie, Molecular & cellular proteomics : MCP 2014
AAA26780.1 macrolide glycosyltransferase (Mgt;UGT102A1) (EC 2.4.1.-) (see protein)
Q54387 Macrolide glycosyltransferase from Streptomyces lividans
Aligns to 280:410 / 418 (31.3%), covers 75.2% of PF06722, 57.9 bits
F7GW14 glucuronosyltransferase from Macaca mulatta
Aligns to 338:465 / 539 (23.7%), covers 73.8% of PF06722, 57.9 bits
Q20CK7 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.8 bits
Q20CK6 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.8 bits
UD15_HUMAN / P35504 UDP-glucuronosyltransferase 1A5; UGT1A5; UDP-glucuronosyltransferase 1-5; UDPGT 1-5; UGT1*5; UGT1-05; UGT1.5; UDP-glucuronosyltransferase 1-E; UGT-1E; UGT1E; EC 2.4.1.17 from Homo sapiens (Human) (see 2 papers)
P35504 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 4 papers)
AAG30421.1 glucuronosyltransferase 1A5 (Ugt1a5) (EC 2.4.1.17) (see protein)
NP_061951 UDP-glucuronosyltransferase 1A5 precursor from Homo sapiens
Aligns to 323:460 / 534 (25.8%), covers 73.8% of PF06722, 57.7 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18674515). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18674515). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515).
function: [Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N- beta-D-glucuronide (RHEA:63744)
subunit: Homodimer (By similarity). Homooligomer (By similarity). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (By similarity). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (By similarity). - Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen, Molecular pharmaceutics 2018 - “...for the retrieved UGT1As were: Q9HAW8 (1A10), O60656 (1A9), Q9HAW9 (1A8), Q9HAW7 (1A7), P19224 (1A6), P35504 (1A5), P22310 (1A4), P35503 (1A3), and P22039 (1A1). To identify template protein structures for homology modeling purposes, the retrieved UGT sequences were used in blast searches against the protein data...”
- Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.
Uzozie, Molecular & cellular proteomics : MCP 2014 - A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding.
Yang, FEBS letters 2018 (PubMed)- GeneRIF: Extensive molecular dynamics simulations revealed that the Gly259Arg mutation stabilizes helix Q through a newly formed hydrogen bonding network, which places the cofactor in a much more favorable geometry in UGT1A5*8 as compared to the wild-type.
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey, Diabetes care 2010 - GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
- Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
Ross, Nature genetics 2009 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud, American journal of human genetics 2009 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.
Yea, Therapeutic drug monitoring 2008 (PubMed)- GeneRIF: Observational study of genotype prevalence. (HuGE Navigator)
AAG21377.1 UDP-Glucuronosyltransferase UGT2B9*2 (EC 2.4.1.17) (see protein)
Aligns to 321:458 / 529 (26.1%), covers 71.7% of PF06722, 57.7 bits
NP_001336952 UDP glucuronosyltransferase 1 family, polypeptide A8 precursor from Macaca fascicularis
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.7 bits
AAF15548.1 UDP-glucuronosyltransferase UGT1A08 (EC 2.4.1.17) (see protein)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.7 bits
Q9TSL7 glucuronosyltransferase (EC 2.4.1.17) from Macaca fascicularis (see 2 papers)
AAF15549.1 UDP-glucuronosyltransferase UGT1A01 (EC 2.4.1.17) (see protein)
Aligns to 324:459 / 533 (25.5%), covers 73.8% of PF06722, 57.6 bits
Q20CL6 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 324:459 / 533 (25.5%), covers 73.8% of PF06722, 57.6 bits
D2SMM6 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:459 / 528 (26.3%), covers 71.7% of PF06722, 57.6 bits
UGT1A4 / P22310 UDP-glucuronosyltransferase 1-4 (EC 2.4.1.17) from Homo sapiens (see 6 papers)
UD14_HUMAN / P22310 UDP-glucuronosyltransferase 1A4; UGT1A4; Bilirubin-specific UDPGT isozyme 2; hUG-BR2; UDP-glucuronosyltransferase 1-4; UDPGT 1-4; UGT1*4; UGT1-04; UGT1.4; UDP-glucuronosyltransferase 1-D; UGT-1D; UGT1D; EC 2.4.1.17 from Homo sapiens (Human) (see 8 papers)
P22310 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 27 papers)
AAA63196.1 UDP-GlcA: glucuronosyltransferase 1A4 (Ugt1a4) (EC 2.4.1.17) (see protein)
NP_009051 UDP-glucuronosyltransferase 1A4 precursor from Homo sapiens
Aligns to 323:460 / 534 (25.8%), covers 73.8% of PF06722, 57.6 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18177842, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18177842). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption (PubMed:18177842).
function: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D- glucuronide) + H(+) + UDP (RHEA:55840)
catalytic activity: calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D- glucuronide) + H(+) + UDP (RHEA:55844)
catalytic activity: calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta- D-glucuronide) + H(+) + UDP (RHEA:55836)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558). - Evaluation of tea (Camellia sinensis L.) phytochemicals as multi-disease modulators, a multidimensional in silico strategy with the combinations of network pharmacology, pharmacophore analysis, statistics and molecular docking.
Nag, Molecular diversity 2023 - “...Hyperbilirubinemia (H00208), Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 (#601,816) Adenine (DB00173) 19 P22310 Homologous model UDP-glucuronosyltransferase 14 Gilbert syndrome (#143,500) Idelalisib (DB09054) 20 P22748 1ZNC [ 72 ] Carbonic anhydrase 4 Retinitis pigmentosa (H00527) Topiramate (DB00273) 21 P24385 2W9Z [ 67 ] G1/S-specific...”
- “...homology modeling of two proteins (UDP-glucuronosyltransferase 11: UniProt id P22309 and UDP-glucuronosyltransferase 14: UniProt id P22310) were performed by SWISS-Model server, based on the templates of PDB id 6KVJ.1.A and 6O86.1.A. The quality analysis was done by the parameters MolProbity score, QMEAN and GMQE (Global Model...”
- Abnormal ECA-Binding Membrane Glycans and Galactosylated CAT and P4HB in Lesion Tissues as Potential Biomarkers for Hepatocellular Carcinoma Diagnosis.
Kong, Frontiers in oncology 2022 - “...36.106 17 7.35 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 453 48.443 18 6.67 P22310 UGT1A4 UDP-glucuronosyltransferase 1-4 534 60.025 19 6.53 P11509 CYP2A6 Cytochrome P450 2A6 494 56.501 20 6.45 Q8NBX0 SCCPDH Saccharopine dehydrogenase-like oxidoreductase 429 47.151 20 proteins with the highest Unuesd scores....”
- Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen, Molecular pharmaceutics 2018 - “...retrieved UGT1As were: Q9HAW8 (1A10), O60656 (1A9), Q9HAW9 (1A8), Q9HAW7 (1A7), P19224 (1A6), P35504 (1A5), P22310 (1A4), P35503 (1A3), and P22039 (1A1). To identify template protein structures for homology modeling purposes, the retrieved UGT sequences were used in blast searches against the protein data bank (PDB)...”
- A nanoparticle formula for delivering siRNA or miRNAs to tumor cells in cell culture and in vivo.
Choi, Nature protocols 2014 - “...see Table 1 for RNA sequences) Paclitaxel, Oregon Green 488 conjugate (OG-PTX; Invitrogen, cat. no. P22310) pcDNA3.1 (Invitrogen, cat. no. V790-20) Potassium carbonate (K 2 CO 3 ; Sigma-Aldrich, cat. no. 209619) 1-Propanol (Sigma-Aldrich, cat. no. 402893) ! CAUTION It is volatile and flammable. RNA annealing/dilution...”
- Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.
Uzozie, Molecular & cellular proteomics : MCP 2014 - Protein targets of reactive electrophiles in human liver microsomes.
Shin, Chemical research in toxicology 2007 - Hepatotoxicity with High-Dose Green Tea Extract: Effect of Catechol-O-Methyltransferase and Uridine 5'-Diphospho-glucuronosyltransferase 1A4 Genotypes.
Acosta, Journal of dietary supplements 2023 - GeneRIF: Hepatotoxicity with High-Dose Green Tea Extract: Effect of Catechol-O-Methyltransferase and Uridine 5'-Diphospho-glucuronosyltransferase 1A4 Genotypes.
- Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy.
Božina, European journal of clinical pharmacology 2023 (PubMed)- GeneRIF: Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy.
- A validation study of the UGT1A4 rs2011404 variant and the risk of anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population.
Zhu, Journal of clinical pharmacy and therapeutics 2021 (PubMed)- GeneRIF: A validation study of the UGT1A4 rs2011404 variant and the risk of anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population.
- Association of CYP2C19 and UGT1A4 polymorphisms with voriconazole-induced liver injury.
Song, Personalized medicine 2020 (PubMed)- GeneRIF: Association of CYP2C19 and UGT1A4 polymorphisms with voriconazole-induced liver injury.
- The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine.
Hattori, BMC psychiatry 2020 - GeneRIF: The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine.
- Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients' Population.
Bojanic, International journal of environmental research and public health 2020 - GeneRIF: Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients' Population.
- The Effect of Polymorphism in UGT1A4 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Patients With Breast Cancer in China.
Lan, Clinical breast cancer 2019 (PubMed)- GeneRIF: Chinese patients with A/A or G/A genotype in the promoter region of bilirubin glucuronoside glucuronosyltransferase (UGT1A4) have a lower 5-year disease-free survival (DFS) rate than those with the wild-type G/G genotype when treated with adjuvant tamoxifen. The rs869283 genotype remains an independent prognostic marker for DFS in multivariate analysis.
- UGT polymorphisms and lamotrigine clearance during pregnancy.
Petrenaite, Epilepsy research 2018 (PubMed)- GeneRIF: Genetic polymorphism in UGT1A4 and UGT2B7 may play a modest role in lamotrigine clearance changes during pregnancy. In addition, study indicates that the sex of the foetus influenced significantly the change in LTG clearance.
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UGT1A3 / P35503 UDP-glucuronosyltransferase 1A3 (EC 2.4.1.17) from Homo sapiens (see 4 papers)
UD13_HUMAN / P35503 UDP-glucuronosyltransferase 1A3; UGT1A3; UDP-glucuronosyltransferase 1-3; UDPGT 1-3; UGT1*3; UGT1-03; UGT1.3; UDP-glucuronosyltransferase 1-C; UGT-1C; UGT1C; UDP-glucuronosyltransferase 1A isoform 3; EC 2.4.1.17 from Homo sapiens (Human) (see 9 papers)
P35503 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 26 papers)
AAG30423.1 UDP-GlcA: glucuronosyltransferase 1A3 (Ugt1a3;UGT1C;UGT1;GNT1) (EC 2.4.1.17) (see protein)
NP_061966 UDP-glucuronosyltransferase 1A3 precursor from Homo sapiens
Aligns to 323:460 / 534 (25.8%), covers 73.8% of PF06722, 57.6 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23288867, PubMed:23756265, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515).
function: [Isoform 2]: Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52460)
catalytic activity: 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52464)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52868)
catalytic activity: estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D- glucuronate) + H(+) + UDP (RHEA:52476)
catalytic activity: chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP (RHEA:52940)
catalytic activity: deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52948)
catalytic activity: lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O- (beta-D-glucuronate) + UDP (RHEA:52952)
catalytic activity: hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl- 24-O-(beta-D-glucuronate) + UDP (RHEA:52956)
catalytic activity: hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta- D-glucuronate) + UDP (RHEA:52960)
catalytic activity: calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D- glucuronide) + H(+) + UDP (RHEA:55840)
catalytic activity: losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D- glucuronide + UDP (RHEA:63720)
catalytic activity: candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta- D-glucuronide + UDP (RHEA:63728)
catalytic activity: UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-2-N- beta-D-glucuronide (RHEA:63748)
subunit: Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558). - KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study.
Füzi, Journal of cheminformatics 2022 - “...P05177 CYP1A2 6.0 Q9NPD5 SLCO1B3 6.0 Q9Y6L6 SLCO1B1 6.0 P11712 CYP2C9 5.8 P02763 ORM1 5.0 P35503 UGT1A3 5.0 Network Similarly to the causal target part, the network part of the workflow also provides the possibility for different types of analyses. Here we present a subsequential analysis...”
- Interpreting the Molecular Mechanisms of Yinchenhao Decoction on Hepatocellular Carcinoma through Absorbed Components Based on Network Pharmacology
Sun, BioMed research international 2021 - “...P25874 Tar094 UGT1A1 UDP-glucuronosyltransferase 1A1 P22309 Tar095 UGT1A10 UDP-glucuronosyltransferase 1A10 Q9HAW8 Tar096 UGT1A3 UDP-glucuronosyltransferase 1A3 P35503 Tar097 UGT1A6 UDP-glucuronosyltransferase 1-6 Q64435 Tar098 UGT1A7 UDP-glucuronosyltransferase 1A7 Q9HAW7 Tar099 UGT1A8 UDP-glucuronosyltransferase 1A8 Q9HAW9 Tar100 UGT1A9 UDP-glucuronosyltransferase 1A9 Q62452 Tar101 UGT2B15 UDP-glucuronosyltransferase 2B15 P54855 Tar102 UGT2B17 UDP-glucuronosyltransferase 2B17 O75795...”
- Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy
Ye, BMC complementary medicine and therapies 2020 - “...LDLR low density lipoprotein receptor None 54 P11388 TOP2A DNA topoisomerase II alpha None 55 P35503 UGT1A3 UDP glucuronosyltransferase family 1 member A3 None 56 O60656 UGT1A9 UDP glucuronosyltransferase family 1 member A9 None 57 P04035 HMGCR 3-hydroxy-3-methylglutaryl -CoA reductase None 58 P10636 MAPT microtubule associated...”
- Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis
Zhu, Medical science monitor : international medical journal of experimental and clinical research 2019 - “...Drugbank P22309 UGT1A1 UDP-glucuronosyltransferase 1-1 Homo sapiens Drugbank Q9HAW8 UGT1A10 UDP-glucuronosyltransferase 1-10 Homo sapiens Drugbank P35503 UGT1A3 UDP-glucuronosyltransferase 1-3 Homo sapiens Drugbank Q9HAW9 UGT1A8 UDP-glucuronosyltransferase 1-8 Homo sapiens Drugbank O60656 UGT1A9 UDP-glucuronosyltransferase 1-9 Homo sapiens Drugbank P06133 UGT2B4 UDP-glucuronosyltransferase 2B4 Homo sapiens Drugbank P16662 UGT2B7 UDP-glucuronosyltransferase...”
- Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen, Molecular pharmaceutics 2018 - “...were: Q9HAW8 (1A10), O60656 (1A9), Q9HAW9 (1A8), Q9HAW7 (1A7), P19224 (1A6), P35504 (1A5), P22310 (1A4), P35503 (1A3), and P22039 (1A1). To identify template protein structures for homology modeling purposes, the retrieved UGT sequences were used in blast searches against the protein data bank (PDB) structures. Based...”
- Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction
Bürgi, PloS one 2016 - “...calcium binding protein involved in synaptic vesicles fusion. (E) Disorder prediction of UDP-glucuronosyltranferase 13 (UniProtID: P35503), an enzyme involved in the addition of glucoronic acid moieties to various compounds and important in detoxification. For (D and E) the blue dots represent the average disorder score using...”
- Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.
Uzozie, Molecular & cellular proteomics : MCP 2014 - Prediction of potential drug targets based on simple sequence properties.
Li, BMC bioinformatics 2007 - “...Q9NV96 Cell cycle control protein 50A 1.777 19 P51674 Neuronal membrane glycoprotein M6-a 1.776 20 P35503 UDP-glucuronosyltransferase 13 1.769 21 Q99571 P2X purinoceptor 4 1.744 22 P53396 ATP-citrate synthase 1.735 23 P08237 6-phosphofructokinase, muscle type 1.724 24 O00144 Frizzled-9 1.722 25 O95498 Vascular non-inflammatory molecule 2...”
- Evaluation of pharmacogenomics and hepatic nuclear imaging-related covariates by population pharmacokinetic models of irinotecan and its metabolites.
Liu, European journal of clinical pharmacology 2022 (PubMed)- GeneRIF: Evaluation of pharmacogenomics and hepatic nuclear imaging-related covariates by population pharmacokinetic models of irinotecan and its metabolites.
- Identification of low-frequency variants of UGT1A3 associated with bladder cancer risk by next-generation sequencing.
Zheng, Oncogene 2021 - GeneRIF: Identification of low-frequency variants of UGT1A3 associated with bladder cancer risk by next-generation sequencing.
- UGT1A3 and Sex Are Major Determinants of Telmisartan Pharmacokinetics-A Comprehensive Pharmacogenomic Study.
Hirvensalo, Clinical pharmacology and therapeutics 2020 (PubMed)- GeneRIF: UGT1A3 and Sex Are Major Determinants of Telmisartan Pharmacokinetics-A Comprehensive Pharmacogenomic Study.
- Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma.
Wang, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 (PubMed)- GeneRIF: our study demonstrated that UGT1A3 functioned as an oncogenic factor in lung adenocarcinoma progression
- Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes.
Wang, Xenobiotica; the fate of foreign compounds in biological systems 2018 - GeneRIF: Icaritin was subjected to significant glucuronidation, wherein UGT1A3, 1A7, 1A8, 1A9 and 2B7 were main contributing enzymes.
- Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer.
Yilmaz, Asian Pacific journal of cancer prevention : APJCP 2015 (PubMed)- GeneRIF: Increased UGT1A3 expression is associated with pancreatic cancer.
- Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.
Wang, Endocrinology 2014 - GeneRIF: Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3.
- Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.
Kato, Drug metabolism and disposition: the biological fate of chemicals 2013 (PubMed)- GeneRIF: the substrate specificity of UGT2B10, highlighting its preference for tertiary amines with higher affinities and clearance values than those of UGT1A4 and UGT1A3.
- More
SACE_3599 antibiotic resistance macrolide glycosyltransferase from Saccharopolyspora erythraea NRRL 2338
Aligns to 257:377 / 392 (30.9%), covers 72.4% of PF06722, 57.6 bits
- Identification and Characterization of a Novel N- and O-Glycosyltransferase from Saccharopolyspora erythraea
Gutacker, Molecules (Basel, Switzerland) 2020 - “...to find the responsible glycosyltransferase, gene deletion experiments were performed and we identified the glycosyltransferase Sace_3599, which belongs to the CAZy family 1. When Streptomyces albus J1074, containing the dTDP- d -glucose synthase gene oleS and the plasmid pUWL-A- sace_3599 , was used as host, U3...”
- “...show homology to Uridine diphosphate (UDP)-glucosyltransferases and N -GTs of family 1 ( sace_1884 , sace_3599 , sace_4470 ). All these GT genes are not located close to biosynthetic gene clusters, but distributed throughout the genome. 2.3. Heterologous Expression of Sace_3599 in S. albus Gluc To...”
- Transcriptome-guided target identification of the TetR-like regulator SACE_5754 and engineered overproduction of erythromycin in Saccharopolyspora erythraea
Wu, Journal of biological engineering 2019 - “...the targets of SACE_5754, and confirmed that transcription of SACE_0388 (encoding a pyruvate, water diknase), SACE_3599 (encoding an antibiotic resistance macrolide glycosyltransferase) and SACE_6149 (encoding a FAD-binding monooxygenase) were directly repressed by SACE_5754. A consensus palindromic sequence TYMAGG-n2/n4/n11-KKTKRA (Y: C/T, M: A/C, K: T/G, R: A/G)...”
- “...and SACE_6148 were not affected by SACE_5754 deletion, but the transcriptional levels of SACE_0388 , SACE_3599 and SACE_6149 were increased by 158-, 4.7- and 95- folds, respectively (Fig. 3 d). It seemed that SACE_5754 directly represses the transcription of SACE_0388 , SACE_3599 and SACE_6149 . Fig....”
- Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria
Ogawara, Molecules (Basel, Switzerland) 2019 - “...further rRNA methyltransferases are present in the genome. Furthermore, two putative macrolide glycosyltransferases (SACE_1884, and SACE_3599), and a number of efflux proteins for antibiotics exist outside of the cluster ( Table S1 ) [ 105 ]. These genes may be involved in the self-resistance. Oleandomycin is...”
Q20CL4 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 333:460 / 534 (24.0%), covers 73.8% of PF06722, 57.6 bits
Q20CK9 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.6 bits
CAC33935.1 SCO6090 or SCBAC1A6.14 (EC 2.4.1.-) (see protein)
Aligns to 280:411 / 418 (31.6%), covers 75.2% of PF06722, 57.5 bits
UD2B4_HUMAN / P06133 UDP-glucuronosyltransferase 2B4; UDPGT 2B4; UGT2B4; HLUG25; Hyodeoxycholic acid-specific UDPGT; UDPGTh-1; EC 2.4.1.17 from Homo sapiens (Human) (see 3 papers)
P06133 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see 8 papers)
AAF78145.1 UDP-GlcA: glucuronosyltransferase 2B4 (Ugt2b4) (EC 2.4.1.17) (see protein)
Aligns to 321:459 / 528 (26.3%), covers 71.7% of PF06722, 57.5 bits
- function: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867).
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
catalytic activity: 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha- estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52872)
catalytic activity: 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP (RHEA:52916) - AOPM: Application of Antioxidant Protein Classification Model in Predicting the Composition of Antioxidant Drugs.
Zhai, Frontiers in pharmacology 2021 - “...of 36 protein sequences. UniProt ID Drug Type P47989 Carvedilol, Allopurinol enzyme P16662 Carvedilol enzyme P06133 Carvedilol enzyme P22309 Carvedilol, Silibinin enzyme Q16881 Ascorbic acid, Selenium enzyme P00441 Vitamin E, alpha-Tocopherol succinate enzyme Q96I15 Selenium enzyme P16435 Lipoic acid enzyme P15559 Vitamin E, alpha-Tocopherol succinate enzyme...”
- Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver transplantation
Jia, Annals of translational medicine 2020 - “...carrier 2 MPC2 0.559 Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase GRHPR 0.561 P07108 Acyl-CoA-binding protein DBI 0.564 P06133 UDP-glucuronosyltransferase 2B4 UGT2B4 0.574 P00167 Cytochrome b5 CYB5A 0.576 Q9UI17 Dimethylglycine dehydrogenase, mitochondrial DMGDH 0.591 P16930 Fumarylacetoacetase FAH 0.594 P27338 Amine oxidase [flavin-containing] B MAOB 0.594 P20813 Cytochrome P450 2B6...”
- Network Pharmacology Identifies the Mechanisms of Action of Shaoyao Gancao Decoction in the Treatment of Osteoarthritis
Zhu, Medical science monitor : international medical journal of experimental and clinical research 2019 - “...Drugbank Q9HAW9 UGT1A8 UDP-glucuronosyltransferase 1-8 Homo sapiens Drugbank O60656 UGT1A9 UDP-glucuronosyltransferase 1-9 Homo sapiens Drugbank P06133 UGT2B4 UDP-glucuronosyltransferase 2B4 Homo sapiens Drugbank P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 Homo sapiens Drugbank P02768 ALB Serum albumin Homo sapiens Drugbank, Genecards P23219 PTGS1 Prostaglandin G/H synthase 1 Homo sapiens Drugbank,...”
- Effect of Inulin on Proteome Changes Induced by Pathogenic Lipopolysaccharide in Human Colon
Guarino, PloS one 2017 - “...Homo sapiens GN = UGT2B17 PE = 2 SV = 1 - [UDB17_HUMAN] 1,0 1,7 P06133 UDP-glucuronosyltransferase 2B4 OS = Homo sapiens GN = UGT2B4 PE = 1 SV = 2 - [UD2B4_HUMAN] 1,0 1,5 Q01995 Transgelin OS = Homo sapiens GN = TAGLN PE =...”
Q20CL0 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.5 bits
D2SMM4 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:459 / 528 (26.3%), covers 71.7% of PF06722, 57.5 bits
Q20CK8 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.5 bits
Q20CL2 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 325:460 / 534 (25.5%), covers 73.8% of PF06722, 57.5 bits
ABA28305.1 macrolide glycosyltransferase (MGT) (EC 2.4.1.-) (see protein)
Aligns to 279:410 / 417 (31.7%), covers 75.2% of PF06722, 57.5 bits
Q20CL3 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 325:460 / 534 (25.5%), covers 73.8% of PF06722, 57.4 bits
Q9TSM0 glucuronosyltransferase (EC 2.4.1.17) from Macaca fascicularis (see paper)
AAF15546.1 UDP-glucuronosyltransferase UGT1A09 (EC 2.4.1.17) (see protein)
Aligns to 321:456 / 530 (25.7%), covers 73.8% of PF06722, 57.4 bits
UDB23_MACFA / Q9TSL6 UDP-glucuronosyltransferase 2B23; UDPGT 2B23; EC 2.4.1.17 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
AAF14353.1 UDP-glucuronosyltransferase 2B23 (EC 2.4.1.17) (see protein)
Aligns to 321:458 / 529 (26.1%), covers 72.4% of PF06722, 57.3 bits
- function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on 6 steroids and the bile acid, hyodeoxycholic acid. May potentially play an important role in estrogen and androgen catabolism in peripheral steroid target tissues
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
Q9TSL9 glucuronosyltransferase (EC 2.4.1.17) from Macaca fascicularis (see paper)
AAF15547.1 UDP-glucuronosyltransferase UGT1A06 (EC 2.4.1.17) (see protein)
Aligns to 331:458 / 532 (24.1%), covers 73.8% of PF06722, 57.3 bits
Npun_R3449 glycosyl transferase family protein from Nostoc punctiforme
Aligns to 270:416 / 425 (34.6%), covers 69.7% of PF06722, 57.3 bits
UD3A2_MOUSE / Q8JZZ0 UDP-glucuronosyltransferase 3A2; UDPGT 3A2; EC 2.4.1.17 from Mus musculus (Mouse) (see paper)
Aligns to 314:456 / 523 (27.3%), covers 82.8% of PF06722, 57.3 bits
Q20CL5 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 325:460 / 534 (25.5%), covers 73.8% of PF06722, 57.3 bits
Q20CL1 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 331:458 / 532 (24.1%), covers 73.8% of PF06722, 57.2 bits
LOC100515394 UDP-glucuronosyltransferase 2C1 from Sus scrofa
Aligns to 322:458 / 529 (25.9%), covers 73.1% of PF06722, 57.1 bits
- Whole-genome sequencing of European autochthonous and commercial pig breeds allows the detection of signatures of selection for adaptation of genetic resources to different breeding and production systems
Bovo, Genetics, selection, evolution : GSE 2020 - “...LOC100516628 b , LOC100624891 d , LOC110262115 d , LOC110262116 d , LOC100623504 d , LOC100515394 d , UGT2B31 b 8:66,900,00167,000,001 Bsara, Sarda LOC110262013 d , CABS1 d , LOC110262014 d , ODAM d , LOC100624541 d , PRR27 d , CSN1S2 b , LOC110262119 d...”
SACE_4470 glycosyltransferase; possible macrolide glycosyltransferase from Saccharopolyspora erythraea NRRL 2338
Aligns to 246:382 / 403 (34.0%), covers 82.8% of PF06722, 57.0 bits
- Identification and Characterization of a Novel N- and O-Glycosyltransferase from Saccharopolyspora erythraea
Gutacker, Molecules (Basel, Switzerland) 2020 - “...to Uridine diphosphate (UDP)-glucosyltransferases and N -GTs of family 1 ( sace_1884 , sace_3599 , sace_4470 ). All these GT genes are not located close to biosynthetic gene clusters, but distributed throughout the genome. 2.3. Heterologous Expression of Sace_3599 in S. albus Gluc To identify the...”
- “...by the constitutive ermE* promoter [ 37 ]. Plasmids containing sace_1884 , sace_3599 , and sace_4470 were introduced into S. albus Gluc, leading to S. albus Gluc x pUWL-A- sace_1884 , S. albus Gluc x pUWL-A- sace_3599 , and S. albus Gluc x pUWL-A- sace_4470 ,...”
AAB81536.1 Glucuronosyltransferase 1A7 (Ugt1a7) (EC 2.4.1.17) (see protein)
Aligns to 319:456 / 530 (26.0%), covers 73.8% of PF06722, 56.9 bits
D4A147 UDP-glucuronosyltransferase from Rattus norvegicus
Aligns to 317:456 / 462 (30.3%), covers 73.8% of PF06722, 56.8 bits
LOC105219094 UDP-glucosyltransferase 2 from Zeugodacus cucurbitae
Aligns to 311:453 / 522 (27.4%), covers 77.9% of PF06722, 56.5 bits
- Identification of testis development-related genes by combining Iso-Seq and RNA-Seq in Zeugodacus tau
Liu, Frontiers in cell and developmental biology 2024 - “...the expression level of 1 DGAT ( Dgat1_0 ) and 6 UGT (LOC105210436, LOC105218581, LOC105219093, LOC105219094, LOC105220158, and LOC105221422) was significantly increased and plateaued ( Table 2 ). Therefore, these retinol metabolism-associated DEGs with specific expression patterns were highly likely to be involved in testis development....”
- “...11.32484 * * LOC105218581 1.9247 4.529353 3.680961 * * LOC105219093 0.553394 2.890756 2.247317 * * LOC105219094 2.26124 14.76726 11.56811 * * LOC105220158 12.73465 27.6289 27.27457 * * LOC105221422 2.08642 5.149338 5.300399 * * Vitamin B6 metabolism PNPO LOC105219330 4.915588 10.87719 9.781125 * * PDXK LOC105220897 4.831618...”
W5PH14 UDP-glucuronosyltransferase from Ovis aries
Aligns to 328:464 / 535 (25.6%), covers 73.1% of PF06722, 56.4 bits
LOC100624891 UDP-glucuronosyltransferase 2C1 from Sus scrofa
Aligns to 312:459 / 529 (28.0%), covers 75.9% of PF06722, 56.3 bits
- Whole-genome sequencing of European autochthonous and commercial pig breeds allows the detection of signatures of selection for adaptation of genetic resources to different breeding and production systems
Bovo, Genetics, selection, evolution : GSE 2020 - “...Lithuanian Indigenous Wattle LOC100515222 d , YTHDC1 d , LOC100515741 d , LOC100516628 b , LOC100624891 d , LOC110262115 d , LOC110262116 d , LOC100623504 d , LOC100515394 d , UGT2B31 b 8:66,900,00167,000,001 Bsara, Sarda LOC110262013 d , CABS1 d , LOC110262014 d , ODAM d...”
D2SMM3 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 322:459 / 529 (26.1%), covers 71.7% of PF06722, 56.2 bits
LOC110262116 UDP-glucuronosyltransferase 2C1-like from Sus scrofa
Aligns to 315:459 / 529 (27.4%), covers 75.9% of PF06722, 56.2 bits
- Whole-genome sequencing of European autochthonous and commercial pig breeds allows the detection of signatures of selection for adaptation of genetic resources to different breeding and production systems
Bovo, Genetics, selection, evolution : GSE 2020 - “...YTHDC1 d , LOC100515741 d , LOC100516628 b , LOC100624891 d , LOC110262115 d , LOC110262116 d , LOC100623504 d , LOC100515394 d , UGT2B31 b 8:66,900,00167,000,001 Bsara, Sarda LOC110262013 d , CABS1 d , LOC110262014 d , ODAM d , LOC100624541 d , PRR27 d...”
LOC656120 UDP-glycosyltransferase UGT5 from Tribolium castaneum
Aligns to 317:456 / 528 (26.5%), covers 80.7% of PF06722, 56.2 bits
UDB28_HUMAN / Q9BY64 UDP-glucuronosyltransferase 2B28; UDPGT 2B28; UGT2B28; EC 2.4.1.17 from Homo sapiens (Human) (see paper)
Q9BY64 glucuronosyltransferase (EC 2.4.1.17) from Homo sapiens (see paper)
Aligns to 322:457 / 529 (25.7%), covers 68.3% of PF06722, 56.2 bits
- function: [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:11300766). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:11300766). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone) (PubMed:11300766). Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption (PubMed:11300766). Displays glucuronidation activity toward the phenolic compounds eugenol (PubMed:11300766).
function: [Isoform 2]: Lack UDP-glucuronosyltransferase (UGT) activity.
catalytic activity: glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP (RHEA:21032)
D2SMM2 glucuronosyltransferase (EC 2.4.1.17) from Papio anubis (see paper)
Aligns to 321:459 / 529 (26.3%), covers 71.7% of PF06722, 56.1 bits
NP_690024 UDP-glucuronosyltransferase 2B4 precursor from Mus musculus
Q8R084 UDP-glucuronosyltransferase from Mus musculus
Aligns to 322:460 / 529 (26.3%), covers 73.1% of PF06722, 56.1 bits
LOC101118189 UDP-glucuronosyltransferase 2B4-like from Ovis aries
Aligns to 328:464 / 535 (25.6%), covers 72.4% of PF06722, 56.0 bits
- Whole-genome resequencing of the native sheep provides insights into the microevolution and identifies genes associated with reproduction traits
Zhu, BMC genomics 2023 - “...reported (e.g., GDP9, CYP19A1, 3-HSD, PLCB1, MED12L, PER1, FSHR, WNT4, NOTCH2, RXRG, LHR, HTR5A, PIK3R3, LOC101118189, LOC101122280, et al.). And the PAK1, GNAQ, TSHR genes were also associated with reproductive traits by selective signature analysis. They were mainly enriched in ovarian steroidogenesis, steroid biosynthesis, cAMP signaling...”
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by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory