Family Search for PF06722 (DUF1205)

PF06722.12 hits 63 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

ERYC3_SACEN / A4F7P3 3-alpha-mycarosylerythronolide B desosaminyl transferase; Desosaminyl transferase EryCIII; Erythromycin biosynthesis protein CIII; EC 2.4.1.278 from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 3 papers)
CAA74710.1 TDP-desosamine: α-mycarosyl erythronolide B desosaminyltransferase (EryCIII;SACE_0726) (EC 2.4.1.-) (see protein)
YP_001102993 glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B (RefSeq) from Saccharopolyspora erythraea NRRL 2338
Aligns to 208:302 / 421 (22.6%), covers 100.0% of PF06722, 132.1 bits

• function: Catalyzes the conversion of alpha-L-mycarosylerythronolide B into erythromycin D in the erythromycin biosynthesis pathway.
  catalytic activity: 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+) (RHEA:32091)
  subunit: Heterotetramer composed of EryCII and EryCIII.
• Structural studies of the spinosyn forosaminyltransferase, SpnP
  Isiorho, Biochemistry 2014
  • “...substituted with other residues. The secondary structure is from SpnP. Accession numbers: SpnP, AAG23277; EryCIII, YP_001102993; MegCIII, CAC37820; DesVII, AAC68677; TylMII, CAA57472; CosG, ABC00729; DnrS, AAD15267; SnogD, AAF01811; SpnG, AAG23268; UrdGT2, AAF00209; CalG3, AAM94798; OleD, ABA42119; GtfA, AAB49292. (B) Stereodiagram of the three-helix motif showing the...”

STM2773 putative glycosyl transferase, related to UDP-glucuronosyltransferase (NCBI ptt file) from Salmonella typhimurium LT2
Aligns to 165:260 / 371 (25.9%), covers 100.0% of PF06722, 126.7 bits

• Horizontal Acquisition of a Multidrug-Resistance Module (R-type ASSuT) Is Responsible for the Monophasic Phenotype in a Widespread Clone of Salmonella Serovar 4,[5],12:i:
  García, Frontiers in microbiology 2016
  • “...is inserted between two chromosomal loci, named STM2759 (encoding a putative phosphotransferase) and iro B (STM2773, a putative glycosyl transferase), causing the deletion of the genomic fragment located in between (15,716 bp). The latter comprises the genes STM2760STM2769 (encoding different putative proteins), the fljAB operon (encoding...”
  • “...unknown function. The module is inserted between two chromosomal loci, named STM2759 and iro B (STM2773), causing the deletion of the genomic fragment located in between. Regarding the flanking chromosomal DNA of RR3, it shows high-level sequence identity to the corresponding regions of the biphasic S...”
• Characterization of Salmonella enterica serovar Typhimurium and Salmonella enterica serovar 4,[5],12:i:- isolates from pigs presenting with diarrhea in Korea
  Lee, The Journal of veterinary medical science 2015
  • “...25922 was used as a control strain. The expression of flagellar genes (STM1053-1997, STM2740, STM2757, STM2773, fljA , fljB and hin ) was assessed by PCR ( Table 1 ) as described previously [ 27 ]. DNA fragments were separated on a 1.5% agarose gel. Fragments...”
• Regulation of biofilm components in Salmonella enterica serovar Typhimurium by lytic transglycosylases involved in cell wall turnover
  Monteiro, Journal of bacteriology 2011
  • “...mutagenesis. We identified suppressor mutants in STM2680, STM2773, and STM4363 which restored rdar morphotype expression to wild-type levels. None of these...”
• Genetic evolution of the Spanish multidrug-resistant Salmonella enterica 4,5,12:i:- monophasic variant
  Laorden, Journal of clinical microbiology 2010
  • “...ending at nucleotide 639 of the iroB gene (STM2773); this sequence is available from GenBank (accession no. GQ402163.1). The fljAB2 deletion ended at nucleotide...”
• Salmonella enterica serotype 4,5,12:i:-, an emerging Salmonella serotype that represents multiple distinct clones
  Soyer, Journal of clinical microbiology 2009
  • “...STM2694 to STM2740) and cluster V (genes STM2758 to STM2773) as well as genes in the intervening regions and upstream and downstream were present in the...”
  • “...target STM2692, STM2694, STM2740, STM2741, STM2757, STM2758, STM2773 (iroB), and STM2774 (Fig. 1 shows primer locations). In addition, we designed primer...”
• Salmonella serovar identification using PCR-based detection of gene presence and absence
  Arrach, Journal of clinical microbiology 2008
  • “...STM2618, STM2630, STM2698, STM2709, STM2728, STM2733, STM2773, STM2901, STM2902, STM3170, STM3258, STM3666, STM3756, STM3767, STM3784, STM3906, STM3941,...”
• Comparison of Salmonella enterica serovar Typhimurium LT2 and non-LT2 salmonella genomic sequences, and genotyping of salmonellae by using PCR
  Kim, Applied and environmental microbiology 2006
  • “...with the type III secretion system of Salmonella (19). STM2773 (iroB), which was known as a Salmonella enterica-specific target gene, was not included in group...”
• DNA microarray-based typing of an atypical monophasic Salmonella enterica serovar
  Garaizar, Journal of clinical microbiology 2002
  • “...of atypical monophasic Salmonella strains. The gene annotated STM2773, located next to the phase-2 flagellar operon and coding for a glycosyl transferase...”
  • “...to to to to to STM0529 STM0929 STM2617 STM2740 STM2773 STM numbers correspond to the numbers in reference 18. No. of implicated genes Genetic event 13 37...”

t2668 putative glycosyl transferase (NCBI ptt file) from Salmonella enterica subsp. enterica serovar Typhi Ty2
Aligns to 165:260 / 371 (25.9%), covers 100.0% of PF06722, 125.5 bits

• Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18
  Deng, Journal of bacteriology 2003
  • “...for CT18 (22). Virulence-related genes iroBCDEN (Ty2 ORFs t2668 to t2672, encoding an iron uptake and storage system) and sopE (t4303, encoding an...”

iroB / A0A0H2V630 enterobactin C-glucosyltransferase (EC 2.4.1.369) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see 3 papers)
c1254 Putative glucosyltransferase (NCBI ptt file) from Escherichia coli CFT073
Aligns to 181:276 / 387 (24.8%), covers 100.0% of PF06722, 122.4 bits

• Transposon-Sequencing Analysis Unveils Novel Genes Involved in the Generation of Persister Cells in Uropathogenic Escherichia coli
  Molina-Quiroz, Antimicrobial agents and chemotherapy 2016
  • “...c0608 c0751 c0764 c0861 c0909 c0943 c1174 c1176 c1179 c1254 c1303 c1560 c1572 c1610 c1822 c1884 c1888 c1925 c1927 c1945 c1956 c2004 c2034 c2144 c2199 c2232...”
• Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities
  Vilchèze, Microbiology spectrum 2014
  • “...61 ) G413D ( 61 ) g32 del ( 154 ) A248D ( 154 ) c1254 del ( 154 ) A20 ins ( 62 ) Y250ST0P ( 154 ) g1268 del ( 154 ) a65 del ( 46 ) cg754 ins ( 62 ) c1290 del...”
• Ketamine-induced hepatoprotection: the role of heme oxygenase-1
  Suliburk, American journal of physiology. Gastrointestinal and liver physiology 2009 (secret)
• Quantitative profile of the uropathogenic Escherichia coli outer membrane proteome during growth in human urine
  Alteri, Infection and immunity 2007
  • “...AcrA ZipA YfgM YfiO OmpX DcrB FliC c3623 c4308 c2482 c1254 c0185 c3610 c1250 c5174 c0238 c1071 c3781 c1093 c2758 c4304 c0849 c4722 c4929 c3139 c1722 c0521 c2889...”
• The asymptomatic bacteriuria Escherichia coli strain 83972 outcompetes uropathogenic E. coli strains in human urine
  Roos, Infection and immunity 2006
  • “...sitB araE b2736 iutA ryhB iroN srlB c4310 c1596 c1254 c0669 c2701 b2165 b0584 c3627 b1018 c1600 c4315 b0061 b0063 c3624 b1498 b0593 b1616 b2737 c1599 b2841...”

NRG857_30008 salmochelin biosynthesis C-glycosyltransferase IroB from Escherichia coli O83:H1 str. NRG 857C
Aligns to 165:260 / 371 (25.9%), covers 100.0% of PF06722, 122.3 bits

• Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes
  Nash, BMC genomics 2010
  • “...microcin V common NRG857_30029 cma 99 structural gene for colicin M common Iron acquisition/Transport systems NRG857_30008 iroB 93 siderophore common NRG857_30010 iroC 91 siderophore common NRG857_30012 iroD 99 siderophore common NRG857_30013 iroE 93 siderophore common NRG857_30015 iroN 97 siderophore common NRG857_30235 iutA 95 cloacin DF13/aerobactin outer...”

UTI89_C1122 putative glucosyltransferase (NCBI) from Escherichia coli UTI89
O2ColV53 IroB (NCBI) from Escherichia coli
Aligns to 181:276 / 387 (24.8%), covers 100.0% of PF06722, 122.2 bits

• Metabolic Requirements of Escherichia coli in Intracellular Bacterial Communities during Urinary Tract Infection Pathogenesis
  Conover, mBio 2016
  • “...UTI89_C2178 ybtS 6.132778168 Salicylate synthase UTI89_C4033 chuT 5.365860462 Putative periplasmic binding protein with FepB/HutB regions UTI89_C1122 iroB 5.215178967 Putative glucosyl transferase UTI89_C1995 yeaR 4.653666496 Hypothetical protein UTI89_C0599 ybdB 4.367933273 Paal_thioesterasetetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for PA, phenylacetic...”
• The plasmid of Escherichia coli strain S88 (O45:K1:H7) that causes neonatal meningitis is closely related to avian pathogenic E. coli plasmids and is associated with high-level bacteremia in a neonatal rat meningitis model
  Peigne, Infection and immunity 2009
  • “...100 O2ColV98 O2ColV61 O2ColV59 O2ColV57 O2ColV56 O2ColV55 O2ColV54 O2ColV53 100 97.5 100 100 100 100 26.7 O2ColV188 O2ColV67 O2ColV67 O2ColV66 O2ColV65 O2ColV64...”

RJF2_RS26160 salmochelin biosynthesis C-glycosyltransferase IroB from Klebsiella pneumoniae subsp. pneumoniae
Aligns to 165:260 / 371 (25.9%), covers 100.0% of PF06722, 121.4 bits

• Whole-Genome-Sequencing characterization of bloodstream infection-causing hypervirulent Klebsiella pneumoniae of capsular serotype K2 and ST374
  Wang, Virulence 2018
  • “...rmpA2 ( RJF2_RS26605 ) , the iroBCDN gene clusters involved in salmochelin biosynthesis ( RJF2_RS26145 RJF2_RS26160 ), and the iucABCD/iutA gene cluster related to aerobactin biosynthesis ( RJF2_RS26550- RJF2_RS26570 ). These virulence determinants are encoded on pRJF293 or similar virulence plasmids reported in K. pneumoniae (120-230kb...”

CAC37820.1 dTDP-D-desosamine: 3-α-mycarosylerythronolide B desosaminyltransferase (MegCIII) (EC 2.4.1.-) (see protein)
Aligns to 209:303 / 422 (22.5%), covers 100.0% of PF06722, 121.0 bits

NOVM_STRNV / Q9L9F5 L-demethylnoviosyl transferase; Novobiocin biosynthesis protein M; EC 2.4.1.302 from Streptomyces niveus (Streptomyces spheroides) (see 3 papers)
novM / Q9L9F5 4-O-demethyl-L-noviosyl transferase (EC 2.4.1.302) from Streptomyces niveus (see paper)
Aligns to 166:262 / 379 (25.6%), covers 100.0% of PF06722, 119.2 bits

• function: Catalyzes the transfer of L-noviose from dTDP-4-O-demethyl- beta-L-noviose to the phenolic oxygen of novobiocic acid, creating the full ABC ring system in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Also shows activity with variant coumarin aglycones, suggesting it may be a promiscuous catalyst for noviosylation of a range of planar scaffolds. Does not show activity with TDP-L-rhamnose.
  catalytic activity: dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+) (RHEA:36695)

ERYBV_SACER / O33939 Erythronolide mycarosyltransferase; EC 2.4.1.328 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see paper)
eryBV / A4F7N6 dTDP-L-mycarosyl: erythronolide B mycarosyltransferase (EC 2.4.1.328) from Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) (see 2 papers)
Aligns to 207:298 / 415 (22.2%), covers 100.0% of PF06722, 114.6 bits

• function: Involved in the biosynthesis of the macrolide antibiotic erythromycin. Catalyzes the reversible transfer of mycarosyl from dTDP- beta-L-mycarose to erythronolide B to yield 3-alpha-L- mycarosylerythronolide B. It can also use TDP-beta-L-cladinose.
  catalytic activity: dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L- mycarosylerythronolide B + dTDP + H(+) (RHEA:41576)

oleG2 / O87831 oleandolide olivosyltransferase from Streptomyces antibioticus (see 3 papers)
Aligns to 206:300 / 426 (22.3%), covers 100.0% of PF06722, 108.2 bits

megDI / Q9F839 dTDP-L-megosamine:erythromycin C L-megosaminyltransferase from Micromonospora megalomicea subsp. nigra (see 2 papers)
CAC37807.1 rhodosaminyltransferase (MegDI) (EC 2.4.1.-) (see protein)
Aligns to 211:305 / 436 (21.8%), covers 100.0% of PF06722, 108.0 bits

Z1190 putative glucosyltransferase (NCBI ptt file) from Escherichia coli O157:H7 EDL933
Aligns to 164:259 / 374 (25.7%), covers 100.0% of PF06722, 103.8 bits

• Global effect of RpoS on gene expression in pathogenic Escherichia coli O157:H7 strain EDL933
  Dong, BMC genomics 2009
  • “...0.3 2 O-Island 43 Putative enzyme Z1185 11.5 0.2 10.3 0.2 2 O-Island 43 Unknown Z1190 12.2 0.7 7.9 0.2 20 O-Island 43 Putative enzyme Z1193 10.2 0.8 6.3 0.8 15 O-Island 43 Unknown Z1385 11.8 0.1 10.5 0.3 2 O-Island 44 Unknown (cryptic prophage CP-933M)...”

Q93GK9 DUF1205 domain-containing protein from Klebsiella pneumoniae
Aligns to 162:257 / 370 (25.9%), covers 100.0% of PF06722, 103.3 bits

• Involvement of enterobactin synthesis pathway in production of microcin H47
  Azpiroz, Antimicrobial agents and chemotherapy 2004 (secret)

DES7_STRVZ / Q9ZGH7 10-deoxymethynolide desosaminyltransferase; EC 2.4.1.277 from Streptomyces venezuelae (see 5 papers)
Q9ZGH7 10-deoxymethynolide desosaminyltransferase (EC 2.4.1.277); 3-alpha-mycarosylerythronolide B desosaminyl transferase (EC 2.4.1.278); erythronolide mycarosyltransferase (EC 2.4.1.328) from Streptomyces venezuelae (see 8 papers)
AAC68677.1 TDP-D-desosamine: 10-deoxymethynolide/narbonolide desosaminyltransferase (DesVII) (EC 2.4.1.-) (see protein)
Aligns to 207:302 / 426 (22.5%), covers 100.0% of PF06722, 102.9 bits

• function: Involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin. Catalyzes the attachment of dTDP-D-desosamine onto 12- and 14-membered macrolactone rings 10-deoxymethynolide and narbonolide to produce 10-deoxymethymycin (YC-17) and narbomycin. DesVII is unique among glycosyltransferases in that it requires an additional protein component, DesVIII, for its activity. DesVII can recognize and process not only cyclic substrates of different ring size, but also a variety of linear substrates albeit with reduced, but measurable activities (PubMed:18548476). Both L- sugars and D-sugars are recognized as substrates and variant substitutions at C-3 and C-4 are tolerated, but deoxygenation at C-6 is required (PubMed:16538696).
  catalytic activity: 10-deoxymethynolide + dTDP-alpha-D-desosamine = 10- deoxymethymycin + dTDP + H(+) (RHEA:31627)
  subunit: Forms a complex with DesVIII.
  disruption phenotype: Cells lacking this gene are not able to produce glycosylated macrolides.

Q83ZB1 Putative glycosyltransferase McmL from Escherichia coli
Aligns to 164:259 / 372 (25.8%), covers 100.0% of PF06722, 101.9 bits

• Involvement of enterobactin synthesis pathway in production of microcin H47
  Azpiroz, Antimicrobial agents and chemotherapy 2004 (secret)

Q83ZA2 DUF1205 domain-containing protein from Escherichia coli
Aligns to 164:259 / 372 (25.8%), covers 100.0% of PF06722, 101.8 bits

• Involvement of enterobactin synthesis pathway in production of microcin H47
  Azpiroz, Antimicrobial agents and chemotherapy 2004 (secret)

ABB52547.1 TDP-D-chalcose: macrolide chalcosyltransferase / TDP-D-desosamine: macrolide D-desosaminyltransferase (GerTII) (EC 2.4.1.-) (see protein)
Aligns to 211:306 / 425 (22.6%), covers 100.0% of PF06722, 101.6 bits

mycB / Q83WE1 protomycinolide IV desosaminyltransferase from Micromonospora griseorubida (see 2 papers)
Aligns to 207:302 / 428 (22.4%), covers 100.0% of PF06722, 101.3 bits

CAJ42338.1 steffimycin L-rhamnosyltransferase (StfG) (EC 2.4.1.-) (see protein)
Aligns to 205:300 / 420 (22.9%), covers 100.0% of PF06722, 97.7 bits

oleG1 / O87830 L-oleandrosyl-oleandolide desosaminyltransferase from Streptomyces antibioticus (see 2 papers)
Aligns to 205:302 / 426 (23.0%), covers 100.0% of PF06722, 93.3 bits

Sare_1263 protein of unknown function DUF1205 (RefSeq) from Salinispora arenicola CNS205
Aligns to 172:265 / 387 (24.3%), covers 98.9% of PF06722, 91.2 bits

• Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway in Micromonospora sp. Strain TP-A0468
  Zhou, Applied and environmental microbiology 2019
  • “...Sare_1256 (84/77) Sare_1257 (91/82) Sare_1264 (93/87) Sare_1263 (80/66) NA Sare_1265 (90/85) Sare_1262 (74/62) Sare_1270 (78/70) Sare_1271 (84/73) Sare_1272...”
• Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450
  Wilson, Journal of the American Chemical Society 2010
  • “...unknown function DUF1271 N/A N/A Sare_1262 * acetyltransferase, PapA5 orf20 58 1, 2, & 6 Sare_1263 * protein of unknown function DUF1205 orf7 66 WT Sare_1264 * DegT/DnrJ/EryC1/StrS aminotransferase orf6 86 WT Sare_1265 * aminotransferase class-III orf9 79 WT Sare_1266 * oxidoreductase domain protein orf10 70...”

AKNK_STRGJ / Q9L555 Aclacinomycin-T 2-deoxy-L-fucose transferase; AknK; L-2-deoxyfucosyltransferase; EC 2.4.1.327 from Streptomyces galilaeus (see paper)
aknK / Q9L555 L-rhodinosyltransferase (EC 2.4.1.327) from Streptomyces galilaeus (see paper)
Aligns to 215:309 / 440 (21.6%), covers 100.0% of PF06722, 90.0 bits

• function: Involved in the biosynthesis of the trisaccharide moiety characteristic of the antitumor drug aclacinomycins. In the first reaction, AknK catalyzes the transfer of 2-deoxy-beta-L-fucose from the activated donor dTDP-2-deoxy-beta-L-fucose to the mono-glycosylated aclacinomycin T (rhodosaminyl aklavinone), forming the di-glycosylated aclacinomycin S (L-2-deoxyfucosyl-L-rhodosaminyl aklavinone). It can also catalyze the addition of an alternate dTDP-L-sugar, dTDP-L- daunosamine, to aclacinomycin T and the addition of 2-deoxy-beta-L- fucose to the mono-glycosylated aglycones (monoglycosylated anthracyclines) such as daunomycin (daunorubicin), adriamycin (doxorubicin) and idarubicin. In vitro, AknK also catalyzes the addition of a second L-2-deoxyfucosyl moiety from dTDP-2-deoxy-beta-L- fucose, albeit with reduced activity, to the natural disaccharide chain of aclacinomycin S to produce L-deoxyfucosyl-L-deoxyfucosyl-L- rhodosaminyl aklavinone (2-deoxy-alpha-D-fucosyl-aclacinomycin S), a variant of the natural aclacinomycin A.
  catalytic activity: aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+) (RHEA:41568)

DNRS_STRPE / Q54824 TDP-daunosamine transferase DnrS; 2,3,6-trideoxy-3-aminohexose transferase; EC 2.4.1.- from Streptomyces peucetius (see 2 papers)
dnmS / Q54824 dTDP-daunosamine transferase from Streptomyces peucetius (see 2 papers)
Aligns to 207:304 / 431 (22.7%), covers 100.0% of PF06722, 88.8 bits

• function: Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the addition of the TDP activated glycoside, L-daunosamine-TDP (2,3,6- trideoxy-3-aminohexose-TDP) at position C-7 of epsilon-rhodomycinone to yield rhodomycin D. Glycosylation is a prerequisite for biological activity of anthracyclines and requires DnrQ which seems to act as an activator.
  catalytic activity: dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D (RHEA:45760)
• Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
  Hu, Proceedings of the National Academy of Sciences of the United States of America 2003
  • “...GT (daunosamine transferase, Stretomyces peucetius, Q54824); zeaxanthin GluT (zeaxanthin glucosyltransferase, Erwinia ananus, P21686); oleandomycin GT...”

AKNS_STRGJ / Q9L4U6 Aklavinone 7-beta-L-rhodosaminyltransferase; EC 2.4.1.326 from Streptomyces galilaeus (see 2 papers)
aknS / Q9L4U6 L-rhodosaminyltransferase (EC 2.4.1.326) from Streptomyces galilaeus (see 4 papers)
AAF73455.1 dTDP-L-rhodosamine:aklavinone α-L-rhodosaminyltransferase (AknS) (EC 2.4.1.-) (see protein)
Aligns to 215:312 / 443 (22.1%), covers 100.0% of PF06722, 88.2 bits

• function: Involved in the biosynthesis of the anthracycline antitumor agent aclacinomycin A. Catalyzes the transfer of the proximal deoxyhexose, L-rhodosamine, from dTDP-beta-L-rhodosamine to the C7-OH of aklavinone aglycone to yield aclacinomycin T (rhodosaminyl- aklavinone). It can also use dTDP-2-deoxy-beta-L-fucose, TDP-2- deoxyfucose, dTDP-4-amino-2-deoxyrhamnose, TDP-L-rhodosamine as sugar donor and epsilon-rhodomycinone as sugar acceptor.
  catalytic activity: aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+) (RHEA:41564)

ABC00729.1 cosmomycin α-L-rhodosaminyltransferase (CosG) (EC 2.4.1.-) (see protein)
Aligns to 207:304 / 426 (23.0%), covers 100.0% of PF06722, 87.2 bits

SSHG_05324 activator-dependent family glycosyltransferase from Streptomyces albidoflavus
Aligns to 214:307 / 426 (22.1%), covers 94.7% of PF06722, 87.2 bits

• New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis
  González, Microbial cell factories 2016
  • “...SARP-family transcriptional regulator Pau13 (99/100) PauY13 (100/100) SSHG_05323 Plm11 Cytochrome P450-like Pau14 (99/99) PauY14 (98/99) SSHG_05324 Plm12 Glycosyltransferase Pau15 (99/99) PauY15 (99/99) SSHG_05325 Plm13 NDP-hexose 2,3-dehydratase Pau16 (99/99) PauY16 (99/99) SSHG_05326 Plm14 3-hydroxybenzoate 6-hydroxylase Pau17 (99/100) PauY17 (99/99) SSHG_05327 Plm15 Anthranilate synthase Pau18 (99/99) PauY18 (99/99)...”
• Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
  Olano, Microbial biotechnology 2014
  • “...determining the biosynthesis of 2,6-deoxyhexoses. This cluster contains in addition two genes encoding glycosyltransferases ( sshg_05324 and sshg_05335 ). Activation of a small NRPS cluster for the biosynthesis of the blue pigment indigoidine In order to activate some cryptic/silent gene clusters in S.albus J1074, we decided...”

BAD08357.1 dTDP-vicenisamine: vicenilactam β-vicenisaminyltransferase (VinC) (EC 2.4.1.-) (see protein)
Aligns to 206:300 / 419 (22.7%), covers 97.9% of PF06722, 87.1 bits

TYLM2_STRFR / P95747 Tylactone mycaminosyltransferase; EC 2.4.1.316 from Streptomyces fradiae (Streptomyces roseoflavus) (see paper)
P95747 tylactone mycaminosyltransferase (EC 2.4.1.316) from Streptomyces fradiae (see paper)
tylM2 / P95747 tylactone mycaminosyltransferase (EC 2.4.1.316) from Streptomyces fradiae (see paper)
CAA57472.2 TDP-D-mycaminose : tylactone mycaminyltransferase (TylMII;Orf2*) (EC 2.4.1.-) (see protein)
Aligns to 231:326 / 452 (21.2%), covers 98.9% of PF06722, 85.3 bits

• function: Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of alpha-D-mycaminosyl from dTDP-alpha-D-mycaminose to the 5- hydroxyl group of tylactone to yield 5-O-mycaminosytylactone. It can also accept 16-membered tylactone and 12-membered ring macrolide.
  catalytic activity: dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D- mycaminosyltylactone + dTDP + H(+) (RHEA:21468)

ABL09968.1 TDP-L-Rha: CBS000020 α-L-rhamnosyltransferase (aranciamycin synthase) (AraGT;Orf21) (EC 2.4.1.-) (see protein)
Aligns to 211:310 / 427 (23.4%), covers 100.0% of PF06722, 83.4 bits

ABC00725.1 glycosyltransferase (CosK) (EC 2.4.1.-) (see protein)
Aligns to 215:312 / 430 (22.8%), covers 97.9% of PF06722, 80.1 bits

CAE17535.1 dideacetyl-prechromomycin A4 D-olivosyltransferase (CmmGI) (EC 2.4.1.-) (see protein)
Aligns to 174:270 / 393 (24.7%), covers 94.7% of PF06722, 77.2 bits

spnP / Q9ALN7 spinosyn forosaminyltransferase from Saccharopolyspora spinosa (see 2 papers)
Aligns to 222:327 / 455 (23.3%), covers 100.0% of PF06722, 77.1 bits

Q53881 Glycosyltransferase from Streptomyces sp. (strain C5)
Aligns to 212:307 / 442 (21.7%), covers 100.0% of PF06722, 76.9 bits

• Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
  Hu, Proceedings of the National Academy of Sciences of the United States of America 2003
  • “...baumycin GT (baumycin GTase, Streptomyces sp. C5, Q53881); and MGD (monogalactosyldiacylglycerol synthase, Arabidopsis thaliana, O82730). In E. coli MurG, the...”

CAC37814.1 mycarosyltransferase (MegBV) (EC 2.4.1.-) (see protein)
Aligns to 207:298 / 417 (22.1%), covers 100.0% of PF06722, 76.8 bits

ABX71119.1 lactonamycinone glycosyltransferase (Lct36) (EC 2.4.1.-) (see protein)
Aligns to 210:306 / 429 (22.6%), covers 100.0% of PF06722, 76.5 bits

AAD13553.1 8-O-tetrangulol β-D-olivosyltransferase (LanGT2) (EC 2.4.1.-) (see protein)
Aligns to 171:264 / 373 (25.2%), covers 100.0% of PF06722, 74.9 bits

ABX71153.1 lactonamycin glycosyltransferase (Lcz36) (EC 2.4.1.-) (see protein)
Aligns to 210:306 / 427 (22.7%), covers 98.9% of PF06722, 71.9 bits

ABO27084.1 SaqAE1 (L-rhodinose) α-1,4-L-rhodinosyltransferase (SaqGT1) (EC 2.4.1.-) (see protein)
Aligns to 203:299 / 424 (22.9%), covers 98.9% of PF06722, 71.6 bits

ABO27085.1 aquayamycin α-L-rhodinosyltransferase (SaqGT2) (EC 2.4.1.-) (see protein)
Aligns to 211:307 / 443 (21.9%), covers 98.9% of PF06722, 71.0 bits

AAD13555.1 olivosyltransferase (LanGT1) (EC 2.4.1.-) (see protein)
Aligns to 175:273 / 390 (25.4%), covers 98.9% of PF06722, 68.5 bits

CAE17545.1 D-olivosyltransferase (CmmGIII) (EC 2.4.1.-) (see protein)
Aligns to 186:281 / 397 (24.2%), covers 98.9% of PF06722, 68.1 bits

AAF01811.1 TDP-nogalamine : 3prime,4prime-demethoxynogalose-1-hydroxynogalamycinone nogalaminyltransferase (SnogD) (EC 2.4.1.-) (see protein)
Aligns to 183:281 / 390 (25.4%), covers 87.4% of PF06722, 67.5 bits

CAE17547.1 D-olivosyltransferase (CmmGIV) (EC 2.4.1.-) (see protein)
Aligns to 191:287 / 421 (23.0%), covers 100.0% of PF06722, 66.5 bits

mtmGIV / Q194Q0 MtmGIV from Streptomyces argillaceus (see 2 papers)
AAD55582.1 premithramycinone D-olivosyltransferase (MtmGIV) (EC 2.4.1.-) (see protein)
Aligns to 191:289 / 407 (24.3%), covers 95.8% of PF06722, 65.3 bits

AAD13562.1 L-rhodinosyltransferase (LanGT4) (EC 2.4.1.-) (see protein)
Aligns to 202:299 / 417 (23.5%), covers 100.0% of PF06722, 64.7 bits

SSHG_05335 DUF1205 domain-containing protein from Streptomyces albidoflavus
Aligns to 171:262 / 375 (24.5%), covers 93.7% of PF06722, 63.7 bits

• New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis
  González, Microbial cell factories 2016
  • “...SSHG_05333 Plm21 D-glucose-1-phosphate synthase Pau23 (99/99) PauY23 (99/99) SSHG_05334 Plm22 Isovaleryltransferase Pau24 (99/99) PauY24 (99/99) SSHG_05335 Plm23 C-glycosyltransferase Pau25 (100/100) PauY25 (99/99) SSHG_05336 Plm24 Glyoxalase Pau26 (99/100) PauY26 (99/100) SSHG_05337 Plm25 FAD-binding monooxygenase Pau27 (99/100) PauY27 (99/99) SSHG_05338 Plm26 Hypothetical protein, Reductase Pau28 (99/99) PauY28 (99/99)...”
• Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
  Olano, Microbial biotechnology 2014
  • “...biosynthesis of 2,6-deoxyhexoses. This cluster contains in addition two genes encoding glycosyltransferases ( sshg_05324 and sshg_05335 ). Activation of a small NRPS cluster for the biosynthesis of the blue pigment indigoidine In order to activate some cryptic/silent gene clusters in S.albus J1074, we decided to use...”

AAF00214.1 C-12β-L-rhodinosyltransferase (UrdGT1a) (EC 2.4.1.-) (see protein)
Aligns to 211:307 / 426 (22.8%), covers 98.9% of PF06722, 63.0 bits

ACP19375.1 SaqAE62 α-1,4-L-2-deoxyfucosyltransferase (SaqGT6) (EC 2.4.1.-) (see protein)
Aligns to 201:296 / 416 (23.1%), covers 100.0% of PF06722, 60.5 bits

mtmGIII / Q194P9 MtmGIII from Streptomyces argillaceus (see paper)
AAD55583.1 premithramycin A1 D-olivosyltransferase (MtmGIII) (EC 2.4.1.-) (see protein)
Aligns to 181:278 / 396 (24.7%), covers 100.0% of PF06722, 59.5 bits

CAE17548.1 premithramycin A1 / deacteyl-prechromomycin A3 D-olivosyltransferase (CmmGII) (EC 2.4.1.-) (see protein)
Aligns to 172:264 / 396 (23.5%), covers 98.9% of PF06722, 59.2 bits

spnG / Q9ALM8 spinosyn rhamnosyltransferase subunit from Saccharopolyspora spinosa (see paper)
AAG23268.1 TDP-β-L-Rha: spinosyn 9-O-α-L-rhamnosyltransferase (SpnG) (EC 2.4.1.-) (see protein)
Aligns to 178:272 / 390 (24.4%), covers 98.9% of PF06722, 58.4 bits

AAF00215.1 (12b -derhodinosyl-)urdamycin G D-olivosyltransferase (UrdGT1b) (EC 2.4.1.-) (see protein)
Aligns to 176:272 / 388 (25.0%), covers 98.9% of PF06722, 52.0 bits

AAF00209.1 D-olivosyltransferase (UrdGT2) (EC 2.4.1.-) (see protein)
Aligns to 158:254 / 365 (26.6%), covers 95.8% of PF06722, 50.4 bits

AAF00217.1 aquayamycin / urdamycinone B L-rhodinosyltransferase (UrdGT1c) (EC 2.4.1.-) (see protein)
Aligns to 176:271 / 391 (24.6%), covers 98.9% of PF06722, 50.2 bits

SACE_0652 putative glucosyltransferase (RefSeq) from Saccharopolyspora erythraea NRRL 2338
Aligns to 179:268 / 383 (23.5%), covers 88.4% of PF06722, 49.3 bits

• Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain
  Peano, Microbial cell factories 2012
  • “...tauD Missense (G177S) Taurine dioxygenase, 2-oxoglutarate-dependent SACE_6133 158 cdo2 Missense (P151S) Cysteine dioxygenase Sugar metabolism SACE_0652 383 iroB Missense (A325V) Glycosyl transferase, related to UDP-glucuronosy transferase SACE_1940 788 lacZ2 Missense (A769V) Beta-galactosidase/beta-glucuronidase SACE_3069 207 gmhA Frameshift (-G 429) Phosphoheptose isomerase SACE_3071 223 gmhA Frameshift (-C 75,-C...”

ABO27086.1 SaqAE3 (L-rhodinose) β-1,4A-olivosyltransferase (SaqGT3) (EC 2.4.1.-) (see protein)
Aligns to 176:279 / 404 (25.7%), covers 100.0% of PF06722, 48.7 bits

mtmGI / Q194P5 premithramycin A3:dTDP-D-olivose D-olivosyltransferase from Streptomyces argillaceus (see paper)
AAC64928.1 D-olivosyltransferase (MtmGI) (EC 2.4.1.-) (see protein)
Aligns to 172:265 / 393 (23.9%), covers 100.0% of PF06722, 45.1 bits

AAD13559.1 olivosyltransferase (LanGT3) (EC 2.4.1.-) (see protein)
Aligns to 178:282 / 401 (26.2%), covers 98.9% of PF06722, 37.7 bits

AAS20331.1 β-olivosyltransferase (LndGT1) (EC 2.4.1.-) (see protein)
Aligns to 175:273 / 389 (25.4%), covers 98.9% of PF06722, 37.5 bits

jadS / Q939Q6 2,6-dideoxy-α-L-ribohexopyranosyl-O-glycosyltransferase from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see 2 papers)
Aligns to 172:276 / 396 (26.5%), covers 81.1% of PF06722, 32.5 bits

ELMGT_STROV / Q9F2F9 Elloramycin glycosyltransferase ElmGT; EC 2.4.1.331 from Streptomyces olivaceus (see 2 papers)
Q9F2F9 8-demethyltetracenomycin C L-rhamnosyltransferase (EC 2.4.1.331) from Streptomyces olivaceus (see 5 papers)
elmGT / Q9F2F9 8-demethyltetracenomycin C rhamnosyltransferase (EC 2.4.1.331) from Streptomyces olivaceus (see 2 papers)
CAC16413.2 dTDP-L-Rha: 8-demethyl-tetracenomycin C α-L-rhamnosyltransferase / elloramycin glycosyltransferase (ElmGT) (EC 2.4.1.-) (see protein)
Aligns to 173:267 / 382 (24.9%), covers 94.7% of PF06722, 32.4 bits

• function: Glycosyltransferase that transfers an L-rhamnose moiety from dTDP-L-rhamnose to the elloramycin aglycone 8-demethyl-tetracenomycin C (8DMTC) in elloramycin biosynthesis, an antitumor polyketide. Possesses donor substrate flexibility: able to transfer at least 11 different sugars to 8DMTC, such as NDP-D-glucose, as well as NDP-L-digitoxose, including both L- and D-isomeric forms of some sugars.
  catalytic activity: 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8- demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) (RHEA:42848)

mtmGII / Q194P6 3A-deolivosylpremithramycin B:dTDP-D-olivose D-olivosyltransferase from Streptomyces argillaceus (see paper)
AAC64927.1 3A-Deolivosylpremithramycin B D-olivosyltransferase (premithramycin B synthase) (MtmGII) (EC 2.4.1.-) (see protein)
Aligns to 170:264 / 379 (25.1%), covers 87.4% of PF06722, 32.0 bits

Or search for genetic data about PF06722 in the Fitness Browser