Family Search for PF06736 (TMEM175)

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PF06736 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TM175_HUMAN / Q9BSA9 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; hTMEM175 from Homo sapiens (Human) (see 12 papers)
2 alignments in 35:356 / 504 (37.1%), covering up to 100.0% of PF06736, 149.2 bits

• function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034, PubMed:35333573, PubMed:37390818). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (PubMed:35750034). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472, PubMed:32267231). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:28723891, PubMed:32228865, PubMed:32267231, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021).
  catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
  catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
  subunit: Homodimer (PubMed:28723891, PubMed:32228865, PubMed:35608336). Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021). Interacts with LAMP1; inhibiting the proton channel activity of TMEM175 (PubMed:37390818). Interacts with LAMP2; inhibiting the proton channel activity of TMEM175 (PubMed:37390818).

TM175_RAT / Q6AY05 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175 from Rattus norvegicus (Rat) (see paper)
2 alignments in 32:353 / 499 (37.5%), covering up to 100.0% of PF06736, 144.8 bits

• function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (By similarity). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (By similarity). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (By similarity). Constitutes the pore- forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (By similarity). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (By similarity). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:32799888) (Probable).
  catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
  catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
  subunit: Homodimer. Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel. Interacts with LAMP1; inhibiting the proton channel activity of TMEM175. Interacts with LAMP2; inhibiting the proton channel activity of TMEM175.

TM175_MOUSE / Q9CXY1 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; mTMEM175 from Mus musculus (Mouse) (see 3 papers)
2 alignments in 32:353 / 499 (37.5%), covering up to 100.0% of PF06736, 144.5 bits

• function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021).
  catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
  catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
  subunit: Homodimer (By similarity). Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021). Interacts with LAMP1; inhibiting the proton channel activity of TMEM175 (By similarity). Interacts with LAMP2; inhibiting the proton channel activity of TMEM175 (By similarity).
  disruption phenotype: Mice display accelerated loss of dopaminergic neurons and impaired motor skills (PubMed:33505021). Knockout neurons show increased damage in response to insults and an accumulation of alpha-synuclein (PubMed:33505021, PubMed:35750034). The accumulation of alpha-synuclein leads to increased damage to the integrity of lysosomal membranes (PubMed:33505021, PubMed:35750034).

TM175_CHRP1 / A0A086F3E3 Potassium channel HX13_20290 from Chryseobacterium sp. (strain P1-3) (see paper)
Aligns to 5:89 / 192 (44.3%), covers 100.0% of PF06736, 119.8 bits

• function: Potassium channel.
  catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
  subunit: Homotetramer (PubMed:28723891).

TM175_STRC3 / S5VBU1 Potassium channel B446_29190 from Streptomyces collinus (strain DSM 40733 / Tue 365) (see paper)
Aligns to 6:94 / 206 (43.2%), covers 100.0% of PF06736, 113.3 bits

• function: Potassium channel.
  catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
  subunit: Homotetramer (PubMed:28723891).

TM175_CHAP6 / K9UJK2 Potassium channel Cha6605_3372; Transmembrane protein 175; CmTMEM175 from Chamaesiphon minutus (strain ATCC 27169 / PCC 6605) (see paper)
Aligns to 12:102 / 203 (44.8%), covers 100.0% of PF06736, 99.1 bits

• function: Potassium channel (PubMed:28723891). The channel is permeable for K(+), Rb(+) and Cs(+), while it is unable to conduct Na(+) (PubMed:28723891).
  catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
  subunit: Homotetramer (PubMed:28723891).

TM175_MARTH / E4TN31 Potassium channel Ftrac_2467; Transmembrane protein 175; MtTMEM175 from Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus) (see paper)
Aligns to 24:105 / 247 (33.2%), covers 96.6% of PF06736, 50.7 bits

• function: Potassium channel; forms a potassium-permeable leak-like channel with weak selectivity for potassium (PubMed:32267231). The channel is permeable for K(+), Rb(+) and Cs(+) (PubMed:32267231).
  catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
  subunit: Homotetramer.

Or search for genetic data about PF06736 in the Fitness Browser