Family Search for PF06740 (MAP_Futsch)

PF06740 hits 1 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

FUTSC_DROME / Q9W596 Microtubule-associated protein futsch; MAP1B homolog from Drosophila melanogaster (Fruit fly) (see 9 papers)
NP_001245461 futsch, isoform F from Drosophila melanogaster
51 alignments in 1516:4104 / 5495 (26.7%), covering up to 100.0% of PF06740, 1540.6 bits

• function: During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton (PubMed:10839355, PubMed:10839356, PubMed:11733059). Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by futsch (PubMed:10839355, PubMed:10839356, PubMed:11733059). Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching (PubMed:10839355, PubMed:10839356, PubMed:11733059). Translation is repressed by Fmr1 (PubMed:10839355, PubMed:10839356, PubMed:11733059). Together with ringer, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules (PubMed:31156389). Function with ringer in maintaining microtubule stability and dynamics, is essential for promoting axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury (PubMed:31919191). In response to axotomy, acts downstream of a stress response cascade involving Xbp1 splicing, to control axon regeneration (PubMed:31919191).
  subunit: Heterodimer of a heavy and a light chain (PubMed:18419581). Interacts with Fmr1 (PubMed:11733059). Found in a complex with tubulin and Futsch (PubMed:31156389).
  disruption phenotype: Flies lacking both Ringer and Futsch display a significant reduction in microtubule loops at the neuromuscular junctions (NMJ) and reduced acetylated-tubulin levels.
• A presynaptic role of microtubule-associated protein 1/Futsch in Drosophila: regulation of active zone number and neurotransmitter release.
  Lepicard, The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
  • GeneRIF: our data are in favor of a model by which Futsch locally stabilizes synaptic active zones, by reinforcing their link with the underlying microtubule cytoskeleton.
• TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization.
  Godena, PloS one 2011
  • GeneRIF: TDP-43 physically interacts with futsch mRNA and that its RNA binding capacity is required to prevent futsch down regulation and synaptic defects.
• MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site.
  Zou, The Biochemical journal 2008 (PubMed)
  • GeneRIF: Microtubule-associated protein 1 function is fulfilled by light chain and heavy chain FUTSCH-encoded precursor polypeptide subunits, identified following proteolytic processing at a conserved cleavage site.

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