Family Search for PF06740 (MAP_Futsch)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF06740 hits 1 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

FUTSC_DROME / Q9W596 Microtubule-associated protein futsch; MAP1B homolog from Drosophila melanogaster (Fruit fly) (see 9 papers)
51 alignments in 1516:4104 / 5495 (26.7%), covering up to 100.0% of PF06740, 1540.6 bits

• function: During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton (PubMed:10839355, PubMed:10839356, PubMed:11733059). Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by futsch (PubMed:10839355, PubMed:10839356, PubMed:11733059). Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching (PubMed:10839355, PubMed:10839356, PubMed:11733059). Translation is repressed by Fmr1 (PubMed:10839355, PubMed:10839356, PubMed:11733059). Together with ringer, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules (PubMed:31156389). Function with ringer in maintaining microtubule stability and dynamics, is essential for promoting axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury (PubMed:31919191). In response to axotomy, acts downstream of a stress response cascade involving Xbp1 splicing, to control axon regeneration (PubMed:31919191).
  subunit: Heterodimer of a heavy and a light chain (PubMed:18419581). Interacts with Fmr1 (PubMed:11733059). Found in a complex with tubulin and Futsch (PubMed:31156389).
  disruption phenotype: Flies lacking both Ringer and Futsch display a significant reduction in microtubule loops at the neuromuscular junctions (NMJ) and reduced acetylated-tubulin levels.

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