Family Search for PF06749 (DUF1218)

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PF06749 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

DEAL2_ARATH / O81898 Protein DESIGUAL 2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 58:146 / 168 (53.0%), covers 98.9% of PF06749, 78.8 bits

• function: Involved, partially redundantly with VCC/DEAL1 and DEAL3, to ensure bilateral symmetry development and early leaf margin patterning, probably via the regulation of auxin and CUC2 distribution.
  disruption phenotype: Developmental defects of pistils, some being bent or coiled or twisted, and some showing unfused carpels with exposed ovules (PubMed:29139551). The vcc-3 deal2-1 double mutant shows leaf asymmetry (PubMed:29139551). The vcc-3 deal2-1 deal3-1 triple mutant shows a strong leaf asymmetry (PubMed:29139551).

DEAL1_ARATH / Q9ZV57 Protein VASCULATURE COMPLEXITY AND CONNECTIVITY; Protein DESIGUAL 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 58:146 / 163 (54.6%), covers 100.0% of PF06749, 76.4 bits

• function: Required, together with OPS, for embryo provasculature development and cotyledon vascular complexity and connectivity (PubMed:25149602). Necessary, partially redundantly with DEAL2 and DEAL3, to ensure bilateral symmetry development and early leaf margin patterning, probably via the regulation of auxin and CUC2 distribution (PubMed:29139551). Regulates cell proliferation but not cell expansion (PubMed:29139551).
  subunit: Interacts with OPS.
  disruption phenotype: Defects in vein connectivity early in mutant embryo development leading to reduced complexity of cotyledon vein networks and disconnected veins, including in embryos provasculatures (PubMed:25149602). The mutant deal1-1 exhibits a bilateral symmetry breaking but no obvious defects in dorsoventrality; early leaf primordia fail to acquire bilateral symmetry and instead form ectopic lobes and sinuses (PubMed:29139551). Developmental defects of pistils, some being bent or coiled or twisted, and some showing unfused carpels with exposed ovules (PubMed:29139551). In leaves, marginal cells expressing properly polarized PIN1 are badly recruited, thus leading to misplaced auxin maxima, as well as defects in cell proliferation but not in cell expansion (PubMed:29139551). Altered spatial pattern of CUC2 (PubMed:29139551). The double mutant vcc ops exhibits a complete loss of high-complexity vascular networks (PubMed:25149602). The vcc-3 deal2-1 and vcc-3 deal3-1 double mutants show leaf asymmetry (PubMed:29139551). The vcc-3 deal2-1 deal3-1 triple mutant shows a strong leaf asymmetry (PubMed:29139551).

MWL1_ARATH / A2RVU1 Protein MODIFYING WALL LIGNIN-1; MWL-1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 58:148 / 175 (52.0%), covers 98.9% of PF06749, 74.5 bits

• function: Together with MWL2, contributes to secondary cell wall biology, specifically lignin biosynthesis.
  subunit: Interacts with CRK19.
  disruption phenotype: No visible phenotype. Double mutants lacking both MWL1 and MWL2 exhibit smaller rosettes with a decrease in rosette fresh weight and stem height associated with a reduction in total lignin content and an increase in syringyl/guaiacyl (S/G) monomer ratio.

DEAL3_ARATH / A2RVQ4 Protein DESIGUAL 3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 65:153 / 184 (48.4%), covers 98.9% of PF06749, 68.8 bits

• function: Involved, partially redundantly with VCC/DEAL1 and DEAL2, to ensure bilateral symmetry development and early leaf margin patterning, probably via the regulation of auxin and CUC2 distribution.
  disruption phenotype: No visible phenotype (PubMed:29139551). The vcc-3 deal3-1 double mutant shows leaf asymmetry (PubMed:29139551). The vcc-3 deal2-1 deal3-1 triple mutant shows a strong leaf asymmetry (PubMed:29139551).

MWL2_ARATH / O65708 Protein MODIFYING WALL LIGNIN-2; MWL-2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 55:151 / 217 (44.7%), covers 96.8% of PF06749, 66.7 bits

• function: Together with MWL1, contributes to secondary cell wall biology, specifically lignin biosynthesis.
  disruption phenotype: No visible phenotype. Double mutants lacking both MWL1 and MWL2 exhibit smaller rosettes with a decrease in rosette fresh weight and stem height associated with a reduction in total lignin content and an increase in syringyl/guaiacyl (S/G) monomer ratio.

DEAL4_ARATH / O23040 Protein DESIGUAL 4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 66:156 / 204 (44.6%), covers 100.0% of PF06749, 43.4 bits

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