Family Search for PF06916 (DUF1279)

PF06916.13 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

NAT2 potential N-terminal peptidyl-methionine acetyltransferase from Candida albicans (see paper)
Aligns to 33:157 / 212 (59.0%), covers 98.9% of PF06916, 112.6 bits

• CharProtDB CGD description: Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to toxic ergosterol analog

AT2G20940 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 3:114 / 129 (86.8%), covers 98.9% of PF06916, 101.2 bits

• A class-information-based penalized matrix decomposition for identifying plants core genes responding to abiotic stresses
  Liu, PloS one 2014
  • “...[40] At1g14360 Heat Heyndrickx et al. (2012) [40] At5g28540 Heat Koizumi et al. (1996) [53] At2g20940 Heat Heyndrickx et al. (2012) [40] At4g29520 Heat Heyndrickx et al. (2012) [40] At4g29330 Heat Heyndrickx et al. (2012) [40] At5g22060 Heat Heyndrickx et al. (2012) [40] At1g04980 Heat Heyndrickx...”

F210B_HUMAN / Q96KR6 Protein FAM210B, mitochondrial from Homo sapiens (Human) (see 2 papers)
NP_543011 protein FAM210B, mitochondrial from Homo sapiens
Aligns to 87:174 / 192 (45.8%), covers 100.0% of PF06916, 96.3 bits

• function: Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).
• FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.
  Yien, The Journal of biological chemistry 2018
  • GeneRIF: FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity
• Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.
  Sun, Cell death & disease 2017
  • GeneRIF: it was found that low expression of FAM210B was significantly correlated with decreased survival and enhanced metastasis in vivo and in vitro, and the loss of FAM210B led to an increased mitochondrial respiratory capacity and reduced glycolysis through the downregulation of pyruvate dehydrogenase kinase 4 (PDK4).
• Identification of a novel putative mitochondrial protein FAM210B associated with erythroid differentiation.
  Kondo, International journal of hematology 2016 (PubMed)
  • GeneRIF: Both human and murine FAM210B are abundantly expressed in the later stages of erythroblast development. Moreover, the deduced amino acid sequence predicted that FAM210B is a membrane protein, and Western blot analysis demonstrated its mitochondrial localization. Loss-of-function analysis in erythroid cells suggested that FAM210B may be involved in erythroid differentiation.
• Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
  Palmieri, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008
  • GeneRIF: Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
• Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.
  Ntai, Molecular & cellular proteomics : MCP 2016
  • “...and H101 NP_037519 Q9UDW1 Cytochrome b-c1 complex subunit 9 I47V I47 and V47 I47 NP_543011 Q96KR6 Protein FAM210B P126S P126 and S126 P126 a not detected. Fig. 2. Protein identifications in WHIM2 and WHIM16. ( A ) TD spectrum of gamma-synuclein displaying the distinctive pattern of...”
• Discovery of colorectal cancer biomarker candidates by membrane proteomic analysis and subsequent verification using selected reaction monitoring (SRM) and tissue microarray (TMA) analysis
  Kume, Molecular & cellular proteomics : MCP 2014
  • “...2 Q8N6Q3 CD177 antigen P07093 Glia-derived nexin Q96KR6 Transmembrane protein C20orf108 P09619 Beta-type platelet-derived growth factor receptor Q7L4E1 Protein...”

F210B_MOUSE / Q9D8B6 Protein FAM210B, mitochondrial from Mus musculus (Mouse) (see paper)
XP_006500122 protein FAM210B, mitochondrial isoform X1 from Mus musculus
Aligns to 85:172 / 190 (46.3%), covers 100.0% of PF06916, 94.8 bits

• function: Plays a role in erythroid differentiation. Involved in cell proliferation and tumor cell growth suppression. Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner.
• FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.
  Yien, The Journal of biological chemistry 2018
  • GeneRIF: FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity

SPBC106.07c N alpha-acetyltransferase Nat2 (predicted) (RefSeq) from Schizosaccharomyces pombe
Aligns to 52:155 / 167 (62.3%), covers 98.9% of PF06916, 90.8 bits

• Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast
  Guo, G3 (Bethesda, Md.) 2016
  • “...gim6 , pac10 Mitochondrion 39.19% (29) 14.10% (724) 1.89e05 SPAC1071.11 , SPAC1486.01 , SPAC823.10c , SPBC106.07c , SPBC336. 13 C , SPBC365.16 , SPBC3H7.03c , abc1 , atp1 , atp10 , atp11 , atp14 , atp2 , cit1 , coq11 , coq7 , eca39 , hot15...”
• A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression
  Graml, Developmental cell 2014
  • “...and mitochondria (Vps25, Vps66, Tlg2, Ryh1, SPAC823.10c, Tom7, SPAC1F3.03, Sat1, and Rrf1, SPAC823.10c, SPAC1610.02c, Cys11, SPBC106.07c, Coq5; slightly more microtubules) and tubulin folding (the Prefoldin complex subunits SPBC1D7.01, Pac10, SPAC227.10, Bob1; fewer microtubules). We next assessed whether differences in tubulin content could account for the mutants...”
• A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis
  Fang, Antimicrobial agents and chemotherapy 2012
  • “...complex subunit 2.0 0.5 Unknown functions SPBC1861.05 SPBC106.07c NA nat2b Carbohydrate kinase N-alpha-acetylation-related protein 2.0 2.0 0.5 0.5 php3 NA tom7...”
  • “...ubr11, amo1, apl3, tom7, ssr4, tom13, nat2 (SPBC106.07c), mss116 (SPBC691.04), SPBC1861.05, and SPCC1442.05c. It is interesting that tom13 deletion mutants...”
• Schizosaccharomyces pombe essential genes: a pilot study
  Decottignies, Genome research 2003
  • “...SPBC106.03 SPBC106.04 SPBC106.05c SPBC106.06 SPBC106.07c SPBC106.08c SPBC106.09/cut4 SPBC106.10/pka1 SPBC106.11c SPBC106.12c SPBC106.13 SPBC106.14c SPBC106.15...”

AT2G27290 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 101:184 / 201 (41.8%), covers 97.8% of PF06916, 86.1 bits

• Identification of miRNAs and Their Targets in the Liverwort Marchantia polymorpha by Integrating RNA-Seq and Degradome Analyses
  Lin, Plant & cell physiology 2016
  • “...CO-TRANSPORTER 1 Mpo-miR11677 LW11685 LW9386 NA AT1G48380 HYPOCOTYL 7 LW28862 NA EFJ23241 NA LW798 NA AT2G27290 NA LW8919 NA AT2G20780 Carbohydrate transmembrane transporter activity LW3390 NA AT1G55350 DEFECTIVE KERNEL 1 LW2282 NA AT4G38160 PIGMENT DEFECTIVE 191 LW3379 NA AT1G75200 Radical SAM domain-containing protein LW769 NA AT5G47390...”

Q5XIJ4 Protein FAM210A from Rattus norvegicus
Aligns to 125:212 / 273 (32.2%), covers 98.9% of PF06916, 83.2 bits

• Integrative proteomics and pharmacogenomics analysis of methylphenidate treatment response
  da, Translational psychiatry 2019
  • “...P84100 60S ribosomal protein L19 Rpl19 1.052 0.0373 Q4KM74 Vesicle-trafficking protein SEC22b Sec22b 1.048 0.0462 Q5XIJ4 Protein FAM210A Fam210a 1.035 0.0177 A0A0G2K4T7 General transcription factor II-I Gtf2i 1.031 0.0020 Q641Y2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Ndufs2 1.029 0.0243 P62332 ADP-ribosylation factor 6 Arf6 1.025...”

F210A_MOUSE / Q8BGY7 Protein FAM210A from Mus musculus (Mouse) (see paper)
XP_006525587 protein FAM210A isoform X1 from Mus musculus
Aligns to 125:212 / 273 (32.2%), covers 98.9% of PF06916, 82.3 bits

• function: May play a role in the structure and strength of both muscle and bone.
  subunit: Interacts with ATAD3A.
  disruption phenotype: Embryonic lethality in homozygotes mice after embryonic day 9.5 (PubMed:29618611). Tamoxifene-inducible Fam210a homozygous knockout mice exhibit decreased grip strength, lean mass of all limbs, bone mineral density, bone biomechanical strength, and elevated osteoclast activity with microarchitectural deterioration of trabecular and cortical bones (PubMed:29618611).
• Maternal High Fat Diet and in-Utero Metformin Exposure Significantly Impact upon the Fetal Renal Proteome of Male Mice.
  Nüsken, Journal of clinical medicine 2019
  • “...Ts, mitochondrial <0.05 4.6 0 3 Tsfm Q8R409 Protein HEXIM1 <0.05 4.4 0 3 Hexim1 Q8BGY7 Protein FAM210A <0.05 4.3 0 3 Fam210a O88665 Bromodomain-containing protein 7 <0.001 4.3 0 3 Brd7 Q3UIX4 N/A <0.05 4.1 0 3 Srsf11 # E9QMC1 Cingulin <0.05 4.0 0 3...”
• FAM210A is a novel determinant of bone and muscle structure and strength.
  Tanaka, Proceedings of the National Academy of Sciences of the United States of America 2018
  • GeneRIF: Fam210a was expressed in muscle mitochondria and cytoplasm but not in bone. Nevertheless, in genetically modified mouse models, Fam210a strongly influenced the structure and strength of both muscle and bone.

LOC100258627 uncharacterized protein LOC100258627 from Vitis vinifera
Aligns to 100:183 / 196 (42.9%), covers 97.8% of PF06916, 82.2 bits

• The Vitis vinifera C-repeat binding protein 4 (VvCBF4) transcriptional factor enhances freezing tolerance in wine grape
  Tillett, Plant biotechnology journal 2012
  • “...2 (CHL2) 1.514 0.035 1616275_at XP_002279285 LOC100252835 Unknown protein (DUF1279, thylakoid) 1.521 0.045 1619538_at XP_002271410 LOC100258627 Galactinol synthase 4-like 1.618 0.048 1608907_s_at XP_002265947 LOC100260266 Copper amine oxidase 1.675 0.045 1608650_at XP_002263349 LOC100257527 ABC transporter MRP4-like 1.703 0.049 1617849_at XP_002265012 LOC100253698 Secretory peroxidase 2.095 0.048 1621431_at XP_002269918...”

F210A_HUMAN / Q96ND0 Protein FAM210A from Homo sapiens (Human) (see paper)
NP_689565 protein FAM210A from Homo sapiens
Aligns to 124:211 / 272 (32.4%), covers 98.9% of PF06916, 79.8 bits

• function: May play a role in the structure and strength of both muscle and bone.
  subunit: Interacts with ATAD3A.
• Chronic Occupational Exposure to Ionizing Radiation Induces Alterations in the Structure and Metabolism of the Heart: A Proteomic Analysis of Human Formalin-Fixed Paraffin-Embedded (FFPE) Cardiac Tissue.
  Azimzadeh, International journal of molecular sciences 2020
  • “...1 alpha 7 0.59 8.36 10 3 Q9NQR4 NIT2 Omega-amidase NIT2 0.59 1.48 10 2 Q96ND0 FAM210A Protein FAM210A 0.58 3.74 10 2 P46109 CRKL Crk-like protein 0.58 2.56 10 2 Q13409 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 0.57 9.61 10 3 P62906 RPL10A 60S...”
• Advancing the Role of Gamma-Tocotrienol as Proteasomes Inhibitor: A Quantitative Proteomic Analysis of MDA-MB-231 Human Breast Cancer Cells
  Ramdas, Biomolecules 2019
  • “...Histone H2B type 1-K HIST1H2BK -1.88 Q01085 Nucleolysin TIAR TIAL1 -1.89 O75923 Dysferlin DYSF -1.23 Q96ND0 Protein FAM210A FAM210A -3.82 M2P21980 Protein-glutamine gamma-glutamyltransferase 2 TGM2 -1.54 * p < 0.05. biomolecules-10-00019-t003_Table 3 Table 3 List of the unique proteins in the union and intersections between the...”
• Presence of Round Cells Proteins do not Interfere with Identification of Human Sperm Proteins from Frozen Semen Samples by LC-MS/MS.
  Panner, International journal of molecular sciences 2019
  • “...UE Q8TF71 SLC16A10 Monocarboxylate transporter 10 2.0 VL 0.0 - 0.00 Unique to Group 2 Q96ND0 FAM210A Protein FAM210A 5.0 VL 0.7 VL 0.14 OE P12074 COX6A1 Cytochrome c oxidase subunit 6A1, mitochondrial 10.0 L 21.0 M 2.15 OE VL: very low; L: low; M: medium;...”
• FAM210A is a novel determinant of bone and muscle structure and strength.
  Tanaka, Proceedings of the National Academy of Sciences of the United States of America 2018
  • GeneRIF: Genetic variation near FAM210A, a gene of previously unknown function, was strongly associated with both appendicular and whole body lean mass, as well as bone mineral density.
• Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  Hendrickson, PloS one 2010
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)

NAT2_YEAST / P37293 Putative N-terminal acetyltransferase 2; Amino-terminal, alpha-amino, acetyltransferase 2; EC 2.3.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YGR147C N alpha-acetyl-transferase, transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins (RefSeq) from Saccharomyces cerevisiae
Aligns to 91:222 / 288 (45.8%), covers 98.9% of PF06916, 77.1 bits

• function: Maybe involved in N-terminal acetylation of proteins. N- acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover
  subunit: Heterooligomeric.
• Using Gene Essentiality and Synthetic Lethality Information to Correct Yeast and CHO Cell Genome-Scale Models
  Chowdhury, Metabolites 2015
  • “...CoA [m] + L-2 amino 3-oxobutanoate [m] acetyl-CoA [m] + L-glycine [m] GPR: YDL040C or YGR147C or YHR013C Correctly adds NAT1, NAT2 and ARD1 as GG This adds a missing reaction and identifies the associated genes correctly as non-essential. [ 36 ] [ 37 ] GPR...”
• Genome-wide association analysis of clinical vs. nonclinical origin provides insights into Saccharomyces cerevisiae pathogenesis
  Muller, Molecular ecology 2011
  • “...chromosome 7 overlaps with the heat shock transcription factor Hsf1p binding site between YGR146C-A and YGR147C (see Figure 3b ). The partially overlapping SFPs 65,184, 65,185 and 65,186 ( P -values 4.04 10 8 , ORs = ) are located within YHR102W ( KIC1 ) on...”
• Schizosaccharomyces pombe essential genes: a pilot study
  Decottignies, Genome research 2003
  • “...YGL022w/STT3 YKL086w YML035c/AMD1 YDL143w/CCT4 YGR147c YNL172w/APC1 YPL203w/TPK2 YIL097w YGR245c/SDA1 YPL117c/IDI1 YOL038w/PRE6 YNL277w/MET2 YOL127w/RPL25...”
  • “...deletion cassette. duplicated in S. cerevisiae. Similarly, the YGR147c, EXO70, and YMR093w ORFs of S. cerevisiae, which do not have essential homologs in...”
• Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae
  Polevoda, The EMBO journal 1999
  • “...ARD1 MAK3 NAT3 NAT2 VIP1 YDL040C YHR013C YPR051W YPR131C YGR147C YLR410W Mullen et al. (1989) Mullen et al. (1989) Tercero et al. (1993) this study Kulkarni and...”

Or search for genetic data about PF06916 in the Fitness Browser