Family Search for PF06916 (FAM210A-B_dom)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF06916

PF06916 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

F210B_HUMAN / Q96KR6 Protein FAM210B, mitochondrial from Homo sapiens (Human) (see 2 papers)
Aligns to 87:174 / 192 (45.8%), covers 100.0% of PF06916, 107.0 bits

• function: Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).

F210B_MOUSE / Q9D8B6 Protein FAM210B, mitochondrial from Mus musculus (Mouse) (see paper)
Aligns to 85:172 / 190 (46.3%), covers 100.0% of PF06916, 105.0 bits

• function: Plays a role in erythroid differentiation. Involved in cell proliferation and tumor cell growth suppression. Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner.

F210A_MOUSE / Q8BGY7 Protein FAM210A from Mus musculus (Mouse) (see paper)
Aligns to 125:212 / 273 (32.2%), covers 98.9% of PF06916, 96.9 bits

• function: May play a role in the structure and strength of both muscle and bone.
  subunit: Interacts with ATAD3A.
  disruption phenotype: Embryonic lethality in homozygotes mice after embryonic day 9.5 (PubMed:29618611). Tamoxifen-inducible Fam210a homozygous knockout mice exhibit decreased grip strength, lean mass of all limbs, bone mineral density, bone biomechanical strength, and elevated osteoclast activity with microarchitectural deterioration of trabecular and cortical bones (PubMed:29618611).

F210A_HUMAN / Q96ND0 Protein FAM210A from Homo sapiens (Human) (see paper)
Aligns to 124:211 / 272 (32.4%), covers 98.9% of PF06916, 92.8 bits

• function: May play a role in the structure and strength of both muscle and bone.
  subunit: Interacts with ATAD3A.

NAT2_YEAST / P37293 Putative N-terminal acetyltransferase 2; Amino-terminal, alpha-amino, acetyltransferase 2; EC 2.3.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Aligns to 91:222 / 288 (45.8%), covers 96.6% of PF06916, 63.4 bits

• function: Maybe involved in N-terminal acetylation of proteins. N- acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover
  subunit: Heterooligomeric.

Or search for genetic data about PF06916 in the Fitness Browser