Family Search for PF07092 (DUF1356)
PF07092.12 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
XP_006505232 transmembrane protein 106B isoform X1 from Mus musculus
Aligns to 28:259 / 275 (84.4%), covers 97.8% of PF07092, 396.6 bits
- Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
Nicholson, Acta neuropathologica communications 2018 - GeneRIF: This work suggests that the protective TMEM106B haplotype may exert its effect in expansion carriers by counteracting lysosomal dysfunction resulting from a loss of C9ORF72.
- TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.
Kundu, Nature communications 2018 - GeneRIF: TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.
- Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown.
Clayton, Brain : a journal of neurology 2018 - GeneRIF: Data show that the frontotemporal dementia (FTD)-causing C-terminal truncation of CHMP2B results in dendritic endolysosomal trafficking defects. Strikingly, we found that this trafficking defect could be rescued by the knockdown of the FTD risk factor Tmem106b.
- Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
Klein, Neuron 2017 - GeneRIF: Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration
- Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).
Brady, The Journal of biological chemistry 2014 - GeneRIF: Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).
T106B_RAT / Q6AYA5 Transmembrane protein 106B from Rattus norvegicus (Rat) (see paper)
Aligns to 28:259 / 275 (84.4%), covers 97.8% of PF07092, 396.5 bits
- function: Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
subunit: Interacts with MAP6.
T106B_HUMAN / Q9NUM4 Transmembrane protein 106B from Homo sapiens (Human) (see 10 papers)
NP_060844 transmembrane protein 106B from Homo sapiens
Aligns to 27:258 / 274 (84.7%), covers 97.8% of PF07092, 395.6 bits
- function: Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
subunit: Interacts with MAP6. - Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas.
Drendel, Clinical proteomics 2018 - “...reductase) (Putative sterol reductase SR-1) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) 1.92 0.05 0.01 Q9NUM4 Transmembrane protein 106B 0.71 0.38 0.00 Q12792 Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) 0.40 1.13 0.00 O15498 Synaptobrevin homolog YKT6 (EC 2.3.1.-) Fig.2 a Statistical analysis using linear models...”
- Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
Yang, Neuron 2020 - GeneRIF: Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
- TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia.
Tropea, Annals of neurology 2019 - GeneRIF: TMEM106B acts as a genetic modifier for cognitive trajectory in Parkinson's disease.
- TMEM106B haplotypes have distinct gene expression patterns in aged brain.
Ren, Molecular neurodegeneration 2018 - GeneRIF: These findings illustrate the profound effect of TMEM106B haplotypes on brain health and highlight the importance to better understand TMEM106B's function and dysfunction in the context of neurodegenerative diseases.
- TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.
Kundu, Nature communications 2018 - GeneRIF: TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.
- TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain.
Kang, PloS one 2018 - GeneRIF: TMEM106B is a risk factor for frontotemporal lobar degeneration and aging; its intrinsic disorder may allow the TMEM106B cytoplasmic domain to dynamically and transiently interact with a variety of distinct partners
- Variation in TMEM106B in chronic traumatic encephalopathy.
Cherry, Acta neuropathologica communications 2018 - GeneRIF: The results of this study suggested that the variation in TMEM106B may have a protective effect on CTE-related outcomes.
- Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency.
Zhou, Acta neuropathologica communications 2017 - GeneRIF: Study developed a TMEM106B transgenic mouse model that recapitulates the interaction between progranulin and TMEM106B in human patients and supports a regulation of TMEM106B by progranulin in the aged brain and a role of TMEM106B in frontotemporal lobar degeneration-progranulin disease progression.
- Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes.
Rhinn, Cell systems 2017 (PubMed)- GeneRIF: Genetic variation within TMEM106B is associated with aging phenotypes.
- More
Q8N353 TMEM106B protein (Fragment) from Homo sapiens
Aligns to 67:298 / 314 (73.9%), covers 97.8% of PF07092, 394.6 bits
Q1LWC2 Transmembrane protein 106B from Danio rerio
Aligns to 24:254 / 267 (86.5%), covers 96.6% of PF07092, 383.6 bits
T106A_HUMAN / Q96A25 Transmembrane protein 106A from Homo sapiens (Human) (see 2 papers)
NP_001278515 transmembrane protein 106A isoform a from Homo sapiens
Aligns to 25:252 / 262 (87.0%), covers 98.7% of PF07092, 377.9 bits
T106A_MOUSE / Q8VC04 Transmembrane protein 106A from Mus musculus (Mouse) (see paper)
NP_659079 transmembrane protein 106A from Mus musculus
Aligns to 24:251 / 261 (87.4%), covers 99.6% of PF07092, 371.5 bits
- function: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway (PubMed:26215746). Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (PubMed:26215746). May play a role in inhibition of proliferation and migration (By similarity).
- Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways.
Dai, Scientific reports 2015 - GeneRIF: data suggest that mouse Tmem106a might be a new trigger of macrophage activation and have some influence toward the M1 state through the activation of the MAPKs and NF-kappaB pathway
T106C_HUMAN / Q9BVX2 Transmembrane protein 106C; Endoplasmic reticulum membrane protein overexpressed in cancer from Homo sapiens (Human)
Aligns to 17:248 / 250 (92.8%), covers 98.7% of PF07092, 329.8 bits
Or search for genetic data about PF07092 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory