Family Search for PF07139 (DUF1387)

PF07139.11 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Q5U2T3 SPATS2-like protein from Rattus norvegicus
Aligns to 59:368 / 558 (55.6%), covers 100.0% of PF07139, 431.9 bits

• Alterations in the rat serum proteome induced by prepubertal exposure to bisphenol a and genistein.
  Betancourt, Journal of proteome research 2014
  • “...2.99 1.11 Q24JW6 serine(orcysteine)proteinaseinhibitor,cladeA(SERPINA1) 0.94 2 1.77 0.9 1305576 d SETdomaincontaining2(SETD2) 0.90 4 +1.61 1.02 Q5U2T3 SPATS2-likeprotein 0.94 3 +1.59 0.85 A8C4G9 spinousandkaryoplasmicprotein 1.00 4 +1.56 1.71 P03957 matrixmetalloproteinase3(MMP3) 0.90 2 2.39 1.12 Q32PX5 structuralmaintenanceofchromosomes4 1.00 3 +3.01 0.95 D3ZDG1 syntaxinbindingprotein5-like 1.00 3 +1.54 1.05 D4A3V9...”

Q91WJ7 SPATS2-like protein from Mus musculus
Aligns to 59:368 / 558 (55.6%), covers 100.0% of PF07139, 430.3 bits

• Extrathymic production of thymulin induced by oxidative stress, heat shock, apoptosis, or necrosis.
  Lunin, International journal of immunopathology and pharmacology 2017
  • “...a SPATS2-like protein that contains a thymulin-like sequence. In the mouse, this protein (accession number Q91WJ7) consists of 558 amino acids and contains SPATS2L 449-457 = PAKSQGGGN. In human, SPATS2-like protein (accession number Q9NUQ6) also consists of 558 amino-acids and contains SPATS2L 449-457 = PAKSQGSGN. Thus,...”

SPS2L_HUMAN / Q9NUQ6 SPATS2-like protein; DNA polymerase-transactivated protein 6; Stress granule and nucleolar protein; SGNP from Homo sapiens (Human) (see paper)
NP_001269664 SPATS2-like protein isoform a from Homo sapiens
Aligns to 59:368 / 558 (55.6%), covers 100.0% of PF07139, 428.8 bits

• HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
  Miikkulainen, Cancer & metabolism 2017
  • “...PECA analysis under hypoxia Accession Protein name Gene name Log 2 fold change FDR Upregulated Q9NUQ6 SPATS2-like protein SPATS2L DNAPTP6 SP1224 5.3018 0.0001 P09382 Galectin-1 LGALS1 3.4357 0.0003 P14314 Glucosidase 2 subunit beta PRKCSH G19P1 3.2139 0.0003 P61769 Beta-2-microglobulin B2M CDABP0092 HDCMA22P 2.7460 0.0015 Q15436 Protein...”
• Extrathymic production of thymulin induced by oxidative stress, heat shock, apoptosis, or necrosis.
  Lunin, International journal of immunopathology and pharmacology 2017
  • “...558 amino acids and contains SPATS2L 449-457 = PAKSQGGGN. In human, SPATS2-like protein (accession number Q9NUQ6) also consists of 558 amino-acids and contains SPATS2L 449-457 = PAKSQGSGN. Thus, there are only two differences: P (proline) in SPATS2L instead of U (5-oxiproline or pyroglutamate) in thymulin, and...”
• Identification of cellular genes and pathways important for tumorigenicity of hepatocellular carcinoma cell lines by proteomic profiling.
  Zamani, Oncotarget 2017
  • “...Exp fold change PARK7 parkinson protein 7 Q99497 13.686 Nucleus enzyme SPATS2L spermatogenesis associated,serine-rich 2-like Q9NUQ6 13.686 Nucleus other IQGAP1 IQ motif containing GTPaseactivating protein 1 P46940 12.709 Cytoplasm other ATP2B1 ATPase, Ca++ transporting,plasma membrane 1 P20020 9.776 Plasma Membrane transporter RRM2 ribonucleotide reductase M2 P31350...”
• Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection
  Carter, Proteomics 2015
  • “...5 5 13.0 9.19E-48 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 0.51 2.53E-02 5.63E-02 9 9 15.8 7.15E-185 Q9NUQ6 SPATS2L SPATS2-like protein 0.51 3.67E-02 7.42E-02 7 7 15.5 4.22E-44 Q4LE64 NUMA1 NUMA1 variant protein 0.51 4.96E-03 8.08E-04 44 44 29.4 0.00E+00 P23497 SP100 Nuclear autoantigen Sp-100 0.50 5.72E-07 2.45E-05...”
• A ribonucleoprotein complex protects the interleukin-6 mRNA from degradation by distinct herpesviral endonucleases
  Muller, PLoS pathogens 2015
  • “...0 4 1 ZC3H11A O75152 Zinc finger CCCH-type containing 11A 5 0 3 0 SPATS2L Q9NUQ6 spermatogenesis associated, serine-rich 2-like 7 0 1 0 PLRG1 O43660 Pleiotropic regulator 1 3 0 4 0 HNRNPA3 P51991 Heterogeneous nuclear ribonucleoprotein A3 4 0 3 0 STRBP Q96SI9 Spermatid...”
• Genetic determinants of acute asthma therapy response in children with moderate-to-severe asthma exacerbations.
  Tse, Pediatric pulmonology 2019 (PubMed)
  • GeneRIF: While controlling for clinical determinants, in acute asthma therapy response, SNP rs295137 in SPATS2L (OR = 1.77, 95%CI: 1.17, 2.68) was significantly associated with increased odds of emergency department (ED) management failure. Two SNPs in IL33 were associated with decreased odds of ED management failure: rs7037276 (OR = 0.55, 95%CI: 0.33, 0.90), and rs1342326 (OR = 0.52, 95%CI: 0.32, 0.86).
• Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain.
  Reddy, BMC medical genomics 2014
  • GeneRIF: Down-regulation of SPATS2L expression may be related to the etiology of poor sleep quality and chronic abdominal pain.
• Fine-mapping of restless legs locus 4 (RLS4) identifies a haplotype over the SPATS2L and KCTD18 genes.
  Pichler, Journal of molecular neuroscience : MN 2013 (PubMed)
  • GeneRIF: A haplotype of 23 SNPs spanning 131.6 Kb shared by all affected members of 3 linked families with restless legs syndrome was identified. The shared candidate region covers 46.9 Kb over the potassium channel-related gene KCTD18 and exons 10-13 of SPATS2L.
• Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.
  Himes, PLoS genetics 2012
  • GeneRIF: Our results suggest that SPATS2L may be an important regulator of beta(2)-adrenergic receptor down-regulation and that there is promise in gaining a better understanding of the biological mechanisms of differential response to beta(2)-agonists through GWAS.
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey, Diabetes care 2010
  • GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud, American journal of human genetics 2009
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
• SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport.
  Zhu, PloS one 2008
  • GeneRIF: SGNP is localized in both the cytoplasm and nucleolus and defines a non-nucleolar compartment containing 5.8S rRNA. Under oxidative stress, SGNP nucleolar localization decreases and it rapidly co-localizes with stress granules.

SPAS2_MOUSE / Q8K1N4 Spermatogenesis-associated serine-rich protein 2; Serine-rich spermatocytes and round spermatid 59 kDa protein; p59scr from Mus musculus (Mouse) (see paper)
Aligns to 81:385 / 545 (56.0%), covers 100.0% of PF07139, 427.5 bits

F1LX68 Spermatogenesis-associated, serine-rich 2 from Rattus norvegicus
Aligns to 81:385 / 550 (55.5%), covers 100.0% of PF07139, 424.7 bits

• The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
  Carrat, Molecular metabolism 2020
  • “...0.002435 Nuclear cap-binding protein subunit 1 Q63570 Psmc4 3.7556 0.006621 26S proteasome regulatory subunit 6B F1LX68 Spats2 4.2439 0.006621 Spermatogenesis-associated, serine-rich 2 Q3B8Q1 Ddx21 3.1883 0.006621 Nucleolar RNA helicase 2 A0A0G2QC21 Arhgef7 5.1017 0.006621 Rho guanine nucleotide exchange factor 7 Q5XIW8 Sart1 3.6068 0.006621 U4/U6.U5 tri-snRNP-associated...”

NP_001280214 spermatogenesis-associated serine-rich protein 2 from Homo sapiens
Aligns to 81:385 / 545 (56.0%), covers 100.0% of PF07139, 423.4 bits

• Comprehensive evaluation of SPATS2 expression and its prognostic potential in liver cancer.
  Xing, Medicine 2020
  • GeneRIF: Gene Set Enrichment Analysis (GSEA) was used to identify signaling pathways related to SPATS2 expression. SPATS2 expression could be a novel diagnostic and prognostic biomarker in liver cancer.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

B8ZZZ7 DNA polymerase-transactivated protein 6, isoform CRA_b from Homo sapiens
Aligns to 1:308 / 498 (61.8%), covers 99.4% of PF07139, 421.0 bits

• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...parkin OS=Homo sapiens GN=PARK2 PE=2 SV=1 - [Q5VVX1_HUMAN] 8.39 7 1 1 274 30.6 6.74 B8ZZZ7 DNA polymerase-transactivated protein 6, isoform CRA_b OS=Homo sapiens GN=SPATS2L PE=4 SV=1 - [B8ZZZ7_HUMAN] 4.02 4 1 1 498 54.9 9.73 D6RB33 DCN1, defective in cullin neddylation 1, domain containing 4...”

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