Family Search for PF07786 (HGSNAT_cat)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF07786

PF07786 hits 28 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

Echvi_1106 transmembrane glucosamine N-acetyltransferase NagX from Echinicola vietnamensis KMM 6221, DSM 17526
Aligns to 5:251 / 369 (66.9%), covers 89.6% of PF07786, 49.5 bits

• mutant phenotype: Specifically important for glucosamine utilization. NagX proteins are distantly related to human HGSNAT (uniprot:Q68CP4), which is a transmembrane acetyl-CoA:alpha-glucosaminide N-acetyltransferase.

HGNAT_HUMAN / Q68CP4 Heparan-alpha-glucosaminide N-acetyltransferase; Transmembrane protein 76; EC 2.3.1.78 from Homo sapiens (Human) (see 13 papers)
Q68CP4 heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) from Homo sapiens (see 6 papers)
Aligns to 267:425 / 663 (24.0%), covers 52.3% of PF07786, 30.3 bits

• function: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.
  catalytic activity: acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) (RHEA:15125)
  subunit: Homooligomer. Homooligomerization is necessary for enzyme activity.

HGNAT_MOUSE / Q3UDW8 Heparan-alpha-glucosaminide N-acetyltransferase; Transmembrane protein 76; EC 2.3.1.78 from Mus musculus (Mouse) (see 2 papers)
Q3UDW8 heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) from Mus musculus (see paper)
Aligns to 260:434 / 656 (26.7%), covers 52.7% of PF07786, 29.2 bits

• function: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase.
  catalytic activity: acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) (RHEA:15125)
  subunit: Homooligomer. Homooligomerization is necessary for enzyme activity (By similarity).

Or search for genetic data about PF07786 in the Fitness Browser