Family Search for PF07933 (DUF1681)
PF07933 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
Q6DBU3 LOC553536 protein (Fragment) from Danio rerio
Aligns to 7:164 / 258 (61.2%), covers 100.0% of PF07933, 203.6 bits
- Proteomic analysis of zebrafish (Danio rerio) embryos exposed to benzyl benzoate
Kwon, Environmental science and pollution research international 2023 - “...type V alpha-3b 0.575 1.6E-03 25 A5PLK2 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.382 9.3E-11 26 Q6DBU3 LOC553536 protein 0.651 3.7E-02 27 Q6PC37 Nucleoside diphosphate kinase 0.65 3.7E-02 28 Q32Q48 Rbx1 protein 0.01 4.1E-16 29 Q6P3I0 HEAT repeat-containing 3 0.624 1.4E-02 30 A4JYG8 Cntn2 0.101 4.1E-16 31...”
C0NNW9 NECAP PHear domain-containing protein from Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
Aligns to 18:250 / 354 (65.8%), covers 100.0% of PF07933, 201.1 bits
W8CD89 NECAP-like protein CG9132 from Ceratitis capitata
Aligns to 3:158 / 247 (63.2%), covers 99.4% of PF07933, 200.8 bits
NECP2_RAT / Q6P756 Adaptin ear-binding coat-associated protein 2; NECAP-2 from Rattus norvegicus (Rat) (see paper)
Aligns to 6:163 / 263 (60.1%), covers 99.4% of PF07933, 199.4 bits
- function: Involved in endocytosis.
subunit: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity). - Mechanism of electroacupuncture and herb-partitioned moxibustion on ulcerative colitis animal model: A study based on proteomics
Qi, World journal of gastroenterology 2022 - “...1.26 0.002 0.80 0.004 P31399 ATP synthase subunit d, mitochondrial Atp5h 1.34 0.003 0.77 0.004 Q6P756 Adaptin ear-binding coat-associated protein 2 Necap2 1.48 0.011 0.83 0.023 P19511 ATP synthase F (0) complex subunit B1, mitochondrial Atp5f1 1.24 0.003 0.83 0.004 A0A0G2K950 3-phosphoadenosine 5-phosphosulfate synthase 2 Papss2...”
- Inflect: Optimizing Computational Workflows for Thermal Proteome Profiling Data Analysis
McCracken, Journal of proteome research 2021 - “...Pip5k2c 31543514 Q9R0J8 legumain Lgmn Prsc1 40786432 Q10758 keratin, type II cytoskeletal8 Krt8 Krt28 40018562 Q6P756 adaptin ear-binding coat-associated protein2 Necap2 164519066 P14270 cAMP-specific 3,5-cyclic phosphodiesterase 4D Pde4d 32189350 Q09073 ADP/ATP translocase2 Slc25a5 Ant2 29789307 O88658 kinesin-like protein KIF1B Kif1b 21489985 Q8VHE9 all-trans-retinol 13,14-reductase Retsat Ppsig...”
- Comparative proteomic analysis of the brain and colon in three rat models of irritable bowel syndrome.
Zhang, Proteome science 2020 - “...CB Protein Zyx D4A7U1 metal ion binding;zinc ion binding CB Adaptin ear-binding coat-associated protein 2 Q6P756 / protein transport CB Protein Ttc1 Q66H09 unknown CB NSFL1 cofactor p47 O35987 lipid binding; ubiquitin binding CB Toll-interacting protein A2RUW1 /inflammatory response; innate immune response; signal transduction CB Cystatin-C...”
- High throughput metabolomics-proteomics investigation on metabolic phenotype changes in rats caused by Radix Scrophulariae using ultra-performance liquid chromatography with mass spectrometry.
Lu, RSC advances 2019 - “...Amacr Alpha-methylacyl-CoA racemase 0.6981 Down** 0.0003 L10 M0RAJ5 Prr14l Protein Prr14l 0.7129 Down** 0.0069 L11 Q6P756 Necap2 Adaptin ear-binding coat-associated protein 2 0.7407 Down* 0.0151 L12 Q80W92 Vac14 Protein VAC14 homolog 0.7429 Down* 0.0338 L13 A0A097PE04 COX2 Cytochrome c oxidase subunit 2 0.7470 Down** 0.0005 L14...”
Q9NVZ3 Adaptin ear-binding coat-associated protein 2 from Homo sapiens
NP_060560 adaptin ear-binding coat-associated protein 2 isoform 1 from Homo sapiens
Aligns to 6:163 / 263 (60.1%), covers 99.4% of PF07933, 197.7 bits
NECP2_MOUSE / Q9D1J1 Adaptin ear-binding coat-associated protein 2; NECAP endocytosis-associated protein 2; NECAP-2 from Mus musculus (Mouse) (see 2 papers)
Aligns to 6:163 / 266 (59.4%), covers 99.4% of PF07933, 197.3 bits
- function: Involved in endocytosis.
subunit: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3.
NECP1_MOUSE / Q9CR95 Adaptin ear-binding coat-associated protein 1; NECAP endocytosis-associated protein 1; NECAP-1 from Mus musculus (Mouse) (see 4 papers)
NP_080543 adaptin ear-binding coat-associated protein 1 from Mus musculus
Aligns to 7:164 / 275 (57.5%), covers 100.0% of PF07933, 196.5 bits
- function: Involved in endocytosis.
subunit: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3. - NECAP1 loss of function leads to a severe infantile epileptic encephalopathy.
Alazami, Journal of medical genetics 2014 (PubMed)- GeneRIF: NECAP1 mutation links trafficking pathway in early infantile epileptic encephalopathy.
- Phosphoinositide-binding proteins mark, shape and functionally modulate highly-diverged endocytic compartments in the parasitic protist Giardia lamblia
Cernikova, PLoS pathogens 2020 - “...Caenorhabditis elegans (Q9N489), Echinococcus multilocularis (A0A087VZS0), Ceratitis capitata (W8CD89), Homo sapiens (Q8NC96) and Mus musculus (Q9CR95) identifies conserved motifs and residues for interaction with AP2. Gl NECAP1 presents partial conservation, with a WXXF motif (orange) shifted to the N-terminus with respect to other orthologues. (B) Ab...”
- Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury
Harper, Heliyon 2020 - “...kDa 0 1 L7N221 Vmn2r112 Adaptin ear-binding coat-associated protein 1 IPI00225533 30 kDa 0 1 Q9CR95 Necap1 Transcriptional activator protein Pur-beta IPI00128867 34 kDa 0 1 O35295 Purb Isoform 1 of D-aminoacyl-tRNA deacylase 1 IPI00133713 23 kDa 0 1 Q9DD18 Dtd1 Endophilin-A1 IPI00331110 (+3) 40 kDa...”
- SQYZ granules, a traditional Chinese herbal, attenuate cognitive deficits in AD transgenic mice by modulating on multiple pathogenesis processes.
An, American journal of translational research 2018 - Sex-Specific Differences in Oxytocin Receptor Expression and Function for Parental Behavior.
Mitre, Gender and the genome 2017 - Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus
Parente, Molecular genetics and metabolism 2016 - “...gene 5835; ribosomal protein L4 P61620 Sec61a1 0.004 2.58 Sec61 alpha 1 subunit (S. cerevisiae) Q9CR95 Necap1 0.016 2.57 NECAP endocytosis associated 1 P03893 Mtnd2 0.028 2.45 NADH-ubiquinone oxidoreductase chain 2 Q9ESW4 Agk 0.004 2.38 predicted gene 8546; acylglycerol kinase Q8JZR6 Slc4a8 0.015 2.35 solute carrier...”
- Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion.
Di, Journal of neurochemistry 2012 - “...P42669 1e-015 10/39 Hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1) P00493 5e-012 3/5 Adaptin ear-binding coat-associated protein (NECAP1) Q9CR95 1e-030 4/8 Mu-crystallin homolog (CRYM) O54983 4e-015 7/13 Malate dehydrogenase, cytoplasmic (MDH1) P14152 1e-030 4/7 Fructose-bisphosphate aldolase C (ALDOC) P05063 6e-015 15/47 Dihydropteridine reductase (QDPR) Q8BVI4 6e-015 4/8 Cytochrome b-c1...”
XP_038295023 adaptin ear-binding coat-associated protein 1 from Canis lupus familiaris
Aligns to 7:164 / 275 (57.5%), covers 100.0% of PF07933, 196.4 bits
Q3T093 Adaptin ear-binding coat-associated protein 1 from Bos taurus
Aligns to 7:164 / 275 (57.5%), covers 100.0% of PF07933, 196.3 bits
NECP1_HUMAN / Q8NC96 Adaptin ear-binding coat-associated protein 1; NECAP endocytosis-associated protein 1; NECAP-1 from Homo sapiens (Human) (see paper)
NP_056324 adaptin ear-binding coat-associated protein 1 from Homo sapiens
Aligns to 7:164 / 275 (57.5%), covers 99.4% of PF07933, 196.0 bits
- function: Involved in endocytosis.
subunit: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity). - Effects of Fluid Shear Stress on Human Intervertebral Disc Nucleus Pulposus Cells Based on Label-Free Quantitative Proteomics.
Xie, Disease markers 2022 - “...0.015 Down 2 O60507 TPST1 0.49 0.020 Down 3 P09972 ALDOC 0.48 0.022 Down 4 Q8NC96 NECAP1 0.48 0.002 Down 5 O00213 APBB1 0.48 0.023 Down 6 P06737 PYGL 0.47 0.022 Down 7 P98082 DAB2 0.47 0.003 Down 8 P49247 RPIA 0.47 0.007 Down 9 Q9NWM8...”
- Phosphoinositide-binding proteins mark, shape and functionally modulate highly-diverged endocytic compartments in the parasitic protist Giardia lamblia
Cernikova, PLoS pathogens 2020 - “...Q84WV7), Trichinella pseudospiralis (A0A0V1JQ20), Caenorhabditis elegans (Q9N489), Echinococcus multilocularis (A0A087VZS0), Ceratitis capitata (W8CD89), Homo sapiens (Q8NC96) and Mus musculus (Q9CR95) identifies conserved motifs and residues for interaction with AP2. Gl NECAP1 presents partial conservation, with a WXXF motif (orange) shifted to the N-terminus with respect to...”
- Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Wrobel, Developmental cell 2019 - GeneRIF: NECAP recruits drivers of late stages of clathrin-coated pit (CCP) formation, including SNX9, via a site distinct from where NECAP binds AP2.
- NECAP1 loss of function leads to a severe infantile epileptic encephalopathy.
Alazami, Journal of medical genetics 2014 (PubMed)- GeneRIF: NECAP1 mutation links trafficking pathway in early infantile epileptic encephalopathy.
- New genetic associations detected in a host response study to hepatitis B vaccine.
Davila, Genes and immunity 2010 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
NECP1_RAT / P69682 Adaptin ear-binding coat-associated protein 1; NECAP endocytosis-associated protein 1; NECAP-1 from Rattus norvegicus (Rat) (see 2 papers)
NP_001025090 adaptin ear-binding coat-associated protein 1 from Rattus norvegicus
Aligns to 7:164 / 277 (57.0%), covers 100.0% of PF07933, 195.4 bits
AT1G03900 ATNAP4 (Arabidopsis thaliana non-intrinsic ABC protein 4); ATPase, coupled to transmembrane movement of substances / transporter (RefSeq) from Arabidopsis thaliana
Aligns to 12:175 / 272 (60.3%), covers 99.4% of PF07933, 188.5 bits
Bm1_42615 Uncharacterized protein from Brugia malayi
Aligns to 5:160 / 213 (73.2%), covers 100.0% of PF07933, 177.9 bits
- Multiplex proteomics analysis of gender-associated proteins in Brugia malayi
Jiang, International journal for parasitology 2012 - “...and dynamics Bm1_57630 retinoblastoma-binding protein, putative PF00400 Uncharacterized Bm1_38615 hypothetical protein Bm1_51000 conserved hypothetical protein Bm1_42615 MGC64450 protein, putative PF07933 Bm1_41425 BM20, putative PF05823 Nematode fatty acid retinoid binding protein Bm1_21695 hypothetical protein Bm1_26585 Hypothetical UPF0205 protein C40H1.5 in chromosome III precursor, putative PF01060 Defense mechanisms...”
- “...2 1 1 Bm1_25705 1 2 1 1 1 Bm1_04840 2 2 2 2 1 Bm1_42615 2 2 2 2 1 1 Bm1_08205 1 2 2 2 1 2 Bm1_03430 2 2 2 2 1 1 2 Bm1_51495 2 3 1 3 3 2 2 2...”
Q9N489 NECAP PHear domain-containing protein from Caenorhabditis elegans
NP_494398 NECAP PHear domain-containing protein from Caenorhabditis elegans
Aligns to 4:158 / 236 (65.7%), covers 100.0% of PF07933, 177.6 bits
- Phosphoinositide-binding proteins mark, shape and functionally modulate highly-diverged endocytic compartments in the parasitic protist Giardia lamblia
Cernikova, PLoS pathogens 2020 - “...NECAP1 and NECAP1 orthologues from Arabidopsis thaliana (Uniprot accession Q84WV7), Trichinella pseudospiralis (A0A0V1JQ20), Caenorhabditis elegans (Q9N489), Echinococcus multilocularis (A0A087VZS0), Ceratitis capitata (W8CD89), Homo sapiens (Q8NC96) and Mus musculus (Q9CR95) identifies conserved motifs and residues for interaction with AP2. Gl NECAP1 presents partial conservation, with a WXXF...”
- A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex.
Partlow, eLife 2019 - GeneRIF: The site of AP2 phosphorylation is directly coordinated by residues of the NECAP PHear domain that are predicted from genetic screens in Caenorhabditis elegans.
- NECAPs are negative regulators of the AP2 clathrin adaptor complex.
Beacham, eLife 2018 - GeneRIF: Consistent with this model, NECAPs preferentially bind open and phosphorylated forms of AP2 in vitro and localize with constitutively open AP2 mutants in vivo. NECAPs do not associate with phosphorylation-defective AP2 mutants, implying that phosphorylation precedes NECAP recruitment.
6rh6A / Q8NC96 Solution structure and 1h, 13c and 15n chemical shift assignments for the complex of necap1 phear domain with phosphorylated ap2 mu2 148- 163 (see paper)
Aligns to 12:138 / 138 (92.0%), covers 80.1% of PF07933, 176.0 bits
Q84WV7 Adaptin ear-binding coat-associated protein 1 NECAP-1 from Arabidopsis thaliana
Aligns to 32:192 / 302 (53.3%), covers 99.4% of PF07933, 172.1 bits
B5XFU5 Adaptin ear-binding coat-associated protein 1 from Salmo salar
Aligns to 7:151 / 164 (88.4%), covers 81.4% of PF07933, 164.7 bits
GL50803_17195 hypothetical protein from Giardia intestinalis
A8BII4 NECAP PHear domain-containing protein from Giardia intestinalis (strain ATCC 50803 / WB clone C6)
Aligns to 3:157 / 178 (87.1%), covers 98.7% of PF07933, 133.9 bits
Or search for genetic data about PF07933 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory