Family Search for PF07950 (DUF1691)

PF07950.11 hits 1 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

MCP1_YEAST / Q12106 MDM10-complementing protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YOR228C Protein of unknown function, localized to the mitochondrial outer membrane (RefSeq) from Saccharomyces cerevisiae
NP_014871 Mcp1p from Saccharomyces cerevisiae S288C
2 alignments in 67:278 / 302 (66.2%), covering up to 97.2% of PF07950, 110.7 bits

• function: Involved in mitochondrial lipid homeostasis.
• Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes
  Leśniewska, Open biology 2017
  • “...occupied by all three components of the Pol III machinery, and four others, YGR258C , YOR228C , YBR154C and YOL141W , by TFIIIC only [ 32 ]. A region near YML089C was also occupied by all three components of Pol III machinery and was named zone...”
• Selective sorting and destruction of mitochondrial membrane proteins in aged yeast
  Hughes, eLife 2016
  • “...Outer membrane OM14 YBR230C Outer membrane SEN15 YMR059W Outer membrane PTH2 YBL057C Outer membrane MCP1 YOR228C Outer membrane SCM4 YGR049W Outer membrane MIR1 b YJR077C Inner membrane CTP1 b YBR291C Inner membrane DIC1 b YLR348C Inner membrane OAC1 b YKL120W Inner membrane MTM1 b YGR257C Inner...”
• Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis
  Tan, Journal of cell science 2013 (PubMed)
  • “...identified two novel mitochondrial proteins (open reading frames YOR228c and YLR253w) that we named Mdm10 complementing protein (Mcp) 1 and Mcp2. Overexpression...”
  • “...Two other plasmids contained a DNA fragment encoding ARS1523, YOR228C and WTM2 as annotated sequence features (Fig. 1A, #15, and data not shown). ARS1523 is an...”
• STB5 is a negative regulator of azole resistance in Candida glabrata
  Noble, Antimicrobial agents and chemotherapy 2013
  • “...1.13 1.70 1.03 CAGL0M12947g CAGL0J04004g YIL077c (PUP1) YOR228c Protein required for nuclear migration Involved in mitochondrial function or organization...”
• TFIIIC localizes budding yeast ETC sites to the nuclear periphery
  Hiraga, Molecular biology of the cell 2012 (no snippet)
• An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis
  Chen, Cell host & microbe 2011
  • “...iron-responsive genes Iron regulation: transcription factor 3.5 17.1 5.9 Hap43 orf19.6550 Putative ortholog of S.c. Yor228c, a mitochondrial outer membrane protein Mitochondrial function 3.7 2.9 Hap43 orf19.6948 CCC1 Putative vacuolar Fe2+/Mn2+ transporter Iron storage: vacuolar, Transporter: ions 3.8 2.6 Hap43 orf19.1742 HEM3 Hydroxymethylbilane synthase (uroporphyrinogen I...”
• Detection of heterozygous mutations in the genome of mismatch repair defective diploid yeast using a Bayesian approach
  Zanders, Genetics 2010
  • “...YNL225C/CMN67 YNL101W/AVT4 YNL121C/TOM70 YNR058W/BIO3 YOR296W YOR228C YOR267C/HRK1 YPL216W YPL222W/FMP40 YPL022W/RAD1 YPR007C/REC8 1284-1286 36-38 678-680...”
• The WTM genes in budding yeast amplify expression of the stress-inducible gene RNR3
  Tringe, Genetics 2006
  • “...at the RNR3 locus. The region from the BglII site in YOR228C to the StuI site between WTM2 and WTM1 was subcloned and sequenced and found to be identical to the...”
  • “...oligonucleotide oSG1 to change the first two codons of YOR228C to stop codons and introduce a SnaBI site for screening. The 0.6-kb NcoI-NdeI fragment from...”
• More
• Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites.
  John, The Journal of cell biology 2017
  • GeneRIF: findings support a model in which Mcp1 and Vps13 work as functional effectors of vacuole-mitochondria contact sites, while tethering is mediated by other factors, including Vps39.

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