Family Search for PF07954 (DUF1689)

PF07954 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

PUP1_YEAST / P40508 PUP1 protein homolog from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
YIL077C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) from Saccharomyces cerevisiae
Aligns to 33:202 / 320 (53.1%), covers 100.0% of PF07954, 178.1 bits

• Fully automated web-based tool for identifying regulatory hotspots
  Choi, BMC genomics 2020
  • “...RRM3 12 * chrVIII:463786_G/A STB5 , OYE2, YHR177W, YHR182W, GND1 13 chrIX:216335_C/T SPO22, THS1, SER33, YIL077C, SEC28 14 chrX:489283_A/G RAD26, CPR7, RAV1, RBH2 15 chrX:568363_G/A MOG1, OPI3, HAM1, HOC1, NPA3, CDC11 16 * chrXI:232567_T/C AAT1, HAP4, KTI12 , YKL107W, APN1, SEG2, RAD27 17 * chrXII:514845_A/C YLR179C,...”
• RNAi as a Tool to Study Virulence in the Pathogenic Yeast Candida glabrata
  Ishchuk, Frontiers in microbiology 2019
  • “...that down-regulation of this gene affects survival in human macrophages. Its ortholog ( RCI37 / YIL077C ) is poorly studied in S. cerevisiae . Although it is known to localize in the mitochondria and interact with the respiratory chain ( Morgenstern et al., 2017 ), the...”
• Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale
  Morgenstern, Cell reports 2017
  • “...Load= 5% (C and D) or 0.4% (E); eluate= 100%. (D, lanes 514) 35 S-labeled Yil077c was imported into mitochondria isolated from wild-type (WT) or yil077c strains for the indicated periods at 25C and subsequently treated with proteinase K. Where indicated (), the membrane potential was...”
  • “...). Rcf3 may thus function as mediator between respiratory chain IIIIV supercomplexes and MICOS. (6) Yil077c assembled into large blue native gel complexes that are characteristic for IIIIV supercomplexes ( Figures 7 A and 7D, right panel), in agreement with the co-purification of Yil077c with Rcf3...”
• STB5 is a negative regulator of azole resistance in Candida glabrata
  Noble, Antimicrobial agents and chemotherapy 2013
  • “...4.24 1.52 1.13 1.70 1.03 CAGL0M12947g CAGL0J04004g YIL077c (PUP1) YOR228c Protein required for nuclear migration Involved in mitochondrial function or...”
  • “...YIM1, the mitochondrial membrane protein encoded by YIL077c (PUP1), the L-malate dehydrogenase MDH2, and the open reading frame CAGL0M14091g, which encodes...”
• Chemical genomic screening of a Saccharomyces cerevisiae genomewide mutant collection reveals genes required for defense against four antimicrobial peptides derived from proteins found in human saliva
  Lis, Antimicrobial agents and chemotherapy 2013
  • “...YKL180W YMR077C YJL159W YIL065C YOR030W YMR154C YJL186W YIL077C YNR052C YOR179C YDL047W YJR043C YCR087C-A YBR006W YHL027W YNL166C YGR122W YIL098C YIL053W...”
  • “...WHI2 COG3 RPL17A VPS20 HSP150 FIS1 DFG16 RIM13 MNN5 YIL077C POP2 SYC1 SIT4 POL32 LUG1 UGA2 RIM101 BNI5 YGR122W FMC1 RHR2 GIM4 GVP36 HPM1 RPS27B SSH1 YCL001W-A...”
• Genomewide expression profile analysis of the Candida glabrata Pdr1 regulon
  Caudle, Eukaryotic cell 2011
  • “...Alcohol acetyltransferase IPF5152 RTA1 CAGL0K00715g IPF6116 YIL077c CAGL0M12947g IPF7689 AGA1 CAGL0I10120g IPF1834 IPF2503 IPF2933 IPF3323 IPF5753 IPF7335...”
  • “...isolates. Of these 28 genes, 7 genes, CgCDR1, HFD1, RTA1, YIL077c, LCB5, YOR1, and YIM1, were also upregulated in strain F15. Likewise, of the 19 genes found to...”
• Multiple means to the same end: the genetic basis of acquired stress resistance in yeast
  Berry, PLoS genetics 2011
  • “...of ESCRT-I Complex CAB2 Coenzyme A Biosynthesis PFK26 6-phosphofructo-2-kinase FIS1 Mitochondrial fission PPT2 Phosphopantetheine:protein transferase YIL077C Unknown Function YJL120W Dubious ORF, unknown function PSY1 Dubious ORF, unknown function YPL238C Dubious ORF, unknown function The 28 genes with a defect in acquired H 2 O 2 resistance...”
• Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata
  Ferrari, PloS one 2011
  • “...P DR1 UP regulated gene) in the present study. This gene is highly similar to YIL077c , a gene encoding a protein of unknown function thought be located in the mitochondria. We tested this hypothesis in C. glabrata by the expression of a GFP-tagged version of...”
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PUP1_CANGA / Q6FIN8 PDR1 up-regulated protein 1 from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus) (see 4 papers)
Aligns to 18:182 / 211 (78.2%), covers 98.0% of PF07954, 146.4 bits

• function: Mitochondrial protein that contributes to the enhanced virulence of C.glabrata strains that acquired azole resistance.
  disruption phenotype: Leads to an increase in phagocytosis but does not influence binding to host macrophages in infected mice, when the pleiotropic ABC efflux transporter of multiple drugs CDR1 is also deleted.

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