Family Search for PF07956 (DUF1690)

PF07956.11 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

MIC19_YEAST / P43594 MICOS complex subunit MIC19; Altered inheritance of mitochondria protein 13, mitochondrial; Mitochondrial contact site complex 19 kDa subunit from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
YFR011C Aim13p (RefSeq) from Saccharomyces cerevisiae
NP_116666 Mic19p from Saccharomyces cerevisiae S288C
Aligns to 18:168 / 170 (88.8%), covers 100.0% of PF07956, 148.3 bits

• function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
  subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.
  disruption phenotype: Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.
• Uniform nomenclature for the mitochondrial contact site and cristae organizing system
  Pfanner, The Journal of cell biology 2014
  • “...et al., 2011 ; Varabyova et al., 2013 Mic19 Aim13, Mcs19, CHCH-3, CHCHD3, and MINOS3 YFR011C Xie et al., 2007 ; Hess et al., 2009 ; Darshi et al., 2011 ; Head et al., 2011 ; Alkhaja et al., 2012 ; Ott et al., 2012 ;...”
• MAE-FMD: multi-agent evolutionary method for functional module detection in protein-protein interaction networks
  Ji, BMC bioinformatics 2014
  • “...10 ynr003c ypr190c ypr110c ynl113w yor116c ydr045c RNA polymerase III 100 1.93e-15 4.50e-16 4.50e-16 yor207c yfr011c ynl248c ykl144c 9 8 ybl023c ylr103c ylr274w yil150c yel032w ybr202w DNA replication preinitiation 75 2.93e-12 2.93e-12 3.92e-11 ymr216c ygl201c 10 6 ylr418c ybr279w yol145c yor123c ygl244w yml010w Transcription elongation factor...”
• Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria
  Schreiner, Molecular biology of the cell 2012 (no snippet)
• The mitochondrial contact site complex, a determinant of mitochondrial architecture
  Harner, The EMBO journal 2011
  • “...are Mcs29 (Ygr235c), Mcs27 (Ynl100w, AIM37), Mcs19 (Yfr011c, AIM13), Mcs12 (Ybr262c, AIM5), Mcs10 (Ycl057c-a) and Fcj1 (Ykr016w, AIM28). The MICOS complex...”
• Transcriptome analysis of a respiratory Saccharomyces cerevisiae strain suggests the expression of its phenotype is glucose insensitive and predominantly controlled by Hap4, Cat8 and Mig1
  Bonander, BMC genomics 2008
  • “...2.1 2.4 YDR175C RSM24 2.4 2.9 YFR049W YMR31 2.5 2.6 Other YBR262C AIM5 2.3 2.1 YFR011C AIM13 2.1 3.4 YLR168C AIM30 2.6 3.3 YML087C AIM33 4.2 11.6 YBR230C OM14 3.3 2.4 YDL104C QRI7 2.1 2.7 YOR187W TUF1 2.3 2.4 YKL067W YNK1 3.1 2.1 Not characterized YGR110W...”
• Repressors Nrg1 and Nrg2 regulate a set of stress-responsive genes in Saccharomyces cerevisiae
  Vyas, Eukaryotic cell 2005
  • “...QCR2, RIP1, RPM2, RSM10, SDP1, TUF1, YDR031W, YFR011C, YGL226W, YHR080C, YIL087C, YMR003W, YM31C, YMR157C, YMR252C, YNL200C, YNL274C, YOR161C, YPL183W-A Carbon...”
• Parallel identification of new genes in Saccharomyces cerevisiae
  Oshiro, Genome research 2002
  • “...opposite within YFR009W different frame opposite of YFR011c opposite of YGL042C intergenic intergenic opposite of YGL014W opposite of YHR073W intergenic within...”
• Transcriptome profiling to identify genes involved in peroxisome assembly and function
  Smith, The Journal of cell biology 2002
  • “...N/D 2 LSM8 o 1 YJL218W u 1 PSP1 o 13 PEX13 p 2 4 YFR011C u 2 LYS14 o 1 YJR120W o 1 SPC25 o 1 13 PXA1 p 1 4 YGL196W u 2 MCM1 o 1 YKL054C u 1 YHR140W u 1 13 RKI1...”
• More
• The Oxidation Status of Mic19 Regulates MICOS Assembly.
  Sakowska, Molecular and cellular biology 2015
  • GeneRIF: The findings suggest that Mic19 is a redox-dependent regulator of mitochondrial contact site and crista organizing system complex function.

G0S140 Uncharacterized protein from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Aligns to 16:154 / 167 (83.2%), covers 100.0% of PF07956, 147.9 bits

• Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions
  Hessenberger, Nature communications 2017
  • “...function. Methods Plasmids Codon-optimized cDNAs of Mic60 and Mic19 of C. thermophilum (UniProtID: G0SHY5 and G0S140, respectively) were commercially synthesized (Eurofins MWG). The genes were cloned into a modified pET28a vector encoding an amino-terminal His 6 -tag. Mutants were produced using site-directed mutagenesis 63 and overlap...”

MIC19_EMENI / Q5ASP0 MICOS complex subunit mic19 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
AN8690 UPF0726 protein AN8690 from Emericella nidulans (see paper)
Aligns to 18:196 / 209 (85.6%), covers 100.0% of PF07956, 129.9 bits

• function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity). Involved in osmoadaptation.
  subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
• CharProtDB Description: ORF that was absent from the original release of version 4 of the A. nidulans annotation, but present in a previous version; reinstated into version 4 in AspGD as of July 2009; Source:AspGD

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