Family Search for PF08213 (COX24_C)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF08213

PF08213 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

AKIP_HUMAN / Q9NWT8 Small ribosomal subunit protein mS38; 28S ribosomal protein S38, mitochondrial; MRP-S38; Aurora kinase A-interacting protein; AURKA-interacting protein from Homo sapiens (Human) (see 4 papers)
Aligns to 127:159 / 199 (16.6%), covers 97.0% of PF08213, 47.4 bits

• function: May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation
  subunit: Component of the mitochondrial small ribosomal subunit (mt- SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25838379). Interacts with Aurora-A (PubMed:12244051).

COX24_SCHPO / Q9P7H5 Small ribosomal subunit protein mS38; Mitochondrial mRNA-processing protein cox24 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 143:175 / 175 (18.9%), covers 97.0% of PF08213, 47.2 bits

• function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS38 is also involved in the splicing of the COX1 mRNA.
  subunit: Component of the mitochondrial small ribosomal subunit (mt- SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and at least 32 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and at least 45 different proteins.

COX24_YEAST / P32344 Small ribosomal subunit protein mS38; Mitochondrial mRNA-processing protein COX24 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
Aligns to 77:109 / 111 (29.7%), covers 97.0% of PF08213, 45.6 bits

• function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). mS38 is also involved in the splicing of the COX1 mRNA (PubMed:16339141).
  subunit: Component of the mitochondrial small ribosomal subunit (mt- SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.

COX24_NEUCR / Q7SHR6 Small ribosomal subunit protein mS38 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see paper)
Aligns to 311:343 / 344 (9.6%), covers 97.0% of PF08213, 32.3 bits

• function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
  subunit: Component of the mitochondrial small ribosomal subunit (mt- SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.

Or search for genetic data about PF08213 in the Fitness Browser