Family Search for PF08508 (DUF1746)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF08508 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
XP_010759941 uncharacterized protein from Paracoccidioides brasiliensis Pb18
Aligns to 70:184 / 341 (33.7%), covers 100.0% of PF08508, 152.4 bits
Afu3g08340, XP_754780 conserved hypothetical protein from Aspergillus fumigatus Af293
Aligns to 60:173 / 331 (34.4%), covers 100.0% of PF08508, 150.1 bits
NCU02676 hypothetical protein from Neurospora crassa OR74A
Aligns to 90:203 / 373 (30.6%), covers 100.0% of PF08508, 147.9 bits
- Deciphering the Regulatory Network between the SREBP Pathway and Protein Secretion in Neurospora crassa
Qin, mBio 2017 - “...E3 ligase complex were named tul-1 (here dsc-1 ; NCU03740), dsc-2 (NCU03459), dsc-3 (NCU11245), dsc-4 (NCU02676), dsc-5 (NCU01928), and dsc-6 (NCU00018). The homolog of the peptide peptidase SppA was named spp-1 (NCU00568) and the homolog of the rhomboid protease Rbd-2/RbdB was named rbd-2 (NCU02371). Among these...”
- Deletion of homologs of the SREBP pathway results in hyper-production of cellulases in Neurospora crassa and Trichoderma reesei
Reilly, Biotechnology for biofuels 2015 - “...crassa genome contains predicted proteins with low, but significant similarity to Dsc3 (NCU11245) and Dsc4 (NCU02676) (Additional file 3 : Figure S2C, D) and a transcription factor similar to Sre1/SreA (NCU04731) (Additional file 3 : Figure S2E). A strain carrying a deletion of NCU04731 was previously...”
- “...also show a cellulolytic hyper-production phenotype. To test this hypothesis, single-gene deletion mutant strains for NCU02676 ( dsc - 4 ) and sah - 2 (NCU04731) were assessed for their protein production under cellulolytic conditions. As observed for the dsc - 2 and tul - 1...”
DSC4_SCHPO / O14175 DSC E3 ubiquitin ligase complex subunit 4; Defective for SREBP cleavage protein 4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
NP_594964, SPAC4D7.11 conserved fungal protein from Schizosaccharomyces pombe
Aligns to 18:129 / 281 (39.9%), covers 100.0% of PF08508, 111.1 bits
- function: Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation.
subunit: Component of the DSC E3 ubiquitin ligase complex composed of dsc1, dsc2, dsc3 and dsc4. - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast
Burr, The Journal of biological chemistry 2016 - “...ND ND ND Protein modification SPBC947.10 SPAC1486.02c SPAC20H4.02 SPAC4D7.11 SPBC4F6.06 SPCC1919.03c dsc1 dsc2 dsc3 dsc4 kin1 amk2 Golgi Dsc E3 ligase complex...”
- Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus
Lima, PLoS neglected tropical diseases 2015 - “...pombe Sre 1(NP_595694) Scp1 (NP_596673) Ins1 (NP_587813) _ Dsc1 (NP_595266) Dsc2 (NP_594090) Dsc3 (NP_593622) Dsc4 (NP_594964) [ 27 , 33 , 86 , 87 ]. Ser 2 (NP_595229) Cryptococcus neoformans Sre 1 (XP_567526) Scp1 (XP_569410) _ Stp1 (XP_571333) _ _ _ _ [ 27 , 35...”
- Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex
Stewart, Molecular cell 2011 - “...Tul1 dsc14 were uncharacterized in S. pombe and correspond to SPBC947.10, SPAC1486.02c, SPAC20H4.02 , and SPAC4D7.11 . Bioinformatic analyses predicted that each Dsc protein contains multiple transmembrane segments and that Dsc1 and Dsc2 contain N-terminal signal sequences ( Figure 2A ). Notably, Dsc1 is the fission...”
- Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance
Deshpande, DNA repair 2009 - “...Homology to pentatricopeptide repeat protein 17 SPBC725.12 0.8 10 CFP 18 SPBC557.02c 0.8 CFP 19 SPAC4D7.11 0.8 CFP 20 SPCC18.09c 0.8 CEP Aprataxin 21 SPCC594.02c 0.8 CFP 22 SPBC21.02 0.8 CEF Contains TLD domain 23 SPCC4G3.11 10 CFP * Status from GeneDB. CEP:Conserved Eukaryotic Protein; CFP:...”
CNAG_05967 hypothetical protein from Cryptococcus neoformans var. grubii H99
Aligns to 13:120 / 346 (31.2%), covers 94.8% of PF08508, 30.4 bits
- A Predicted Mannoprotein Cmp1 Regulates Fungal Virulence in Cryptococcus neoformans
Han, Pathogens (Basel, Switzerland) 2020 - “...synthase 1 1.36597408 1 CNAG_01193 Uncharacterized protein 1.36434725 1 CNAG_05817 GDP-mannose transporter 1 1.35714493 0 CNAG_05967 Uncharacterized protein 1.35536384 1 CNAG_04327 SCP160 protein 1.35312155 1 CNAG_00634 Uncharacterized protein 1.3519146 1 CNAG_05173 DNA-3-methyladenine glycosylase II 1.34218534 0 CNAG_03281 Glycine-rich RNA binding protein, variant 2 1.33612571 0 pathogens-09-00881-t002_Table...”
Or search for genetic data about PF08508 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory