Family Search for PF08508 (DUF1746)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF08508 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

DSC4_SCHPO / O14175 DSC E3 ubiquitin ligase complex subunit 4; Defective for SREBP cleavage protein 4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
Aligns to 18:129 / 281 (39.9%), covers 100.0% of PF08508, 111.1 bits

• function: Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation.
  subunit: Component of the DSC E3 ubiquitin ligase complex composed of dsc1, dsc2, dsc3 and dsc4.

Or search for genetic data about PF08508 in the Fitness Browser