Family Search for PF08538 (DUF1749)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF08538 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
YKM6_SCHPO / Q9C0Y8 UPF0613 protein PB24D3.06c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPAPB24D3.06c DUF1749 family protein from Schizosaccharomyces pombe
Aligns to 1:311 / 316 (98.4%), covers 100.0% of PF08538, 403.8 bits
- Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast
Hu, Genome biology and evolution 2015 - “...nine other protein-coding genes ( SPAPB2C8.01 , toe3 , SPAPB24D3.02c , SPAPB24D3.03 , mag1 , SPAPB24D3.06c , SPAPB24D3.07c , SPAPB24D3.08c , pdr1 ) are lost due to this 34-kb deletion. The loss of some of these genes may have also resulted in permanent physiological changes like...”
- Essential gene discovery in the basidiomycete Cryptococcus neoformans for antifungal drug target prioritization
Ianiri, mBio 2015 - “...CNAG_04247 Hypothetical protein with an Sfi1 spindle body protein domain 8/43 0 Inviable Centrin-binding protein SPAPB24D3.06c CNAG_00592 Dolichol-phosphate mannosyltransferase 24/38 21 Viable Unknown function THP1 CNAG_01697 Nuclear pore 24/42 16 Viable mRNA export from nucleus TIM54 CNAG_05234 Mitochondrial import inner membrane translocase subunit TIM54 32/47 (strain...”
- “...PDC1 , RIB2 , RIB3 , RSC9 , SAF2 , SEC5 , THP1 , and SPAPB24D3.06c were replaced by targeted mutagenesis, and none were required for viability. The S.pombe gene saf2 , which is absent in the S.cerevisiae genome, encodes a splicing-associated factor, and it contains...”
CNAG_00592 dolichol-phosphate mannosyltransferase from Cryptococcus neoformans var. grubii H99
Aligns to 1:293 / 296 (99.0%), covers 98.0% of PF08538, 347.8 bits
- Essential gene discovery in the basidiomycete Cryptococcus neoformans for antifungal drug target prioritization
Ianiri, mBio 2015 - “...Hypothetical protein with an Sfi1 spindle body protein domain 8/43 0 Inviable Centrin-binding protein SPAPB24D3.06c CNAG_00592 Dolichol-phosphate mannosyltransferase 24/38 21 Viable Unknown function THP1 CNAG_01697 Nuclear pore 24/42 16 Viable mRNA export from nucleus TIM54 CNAG_05234 Mitochondrial import inner membrane translocase subunit TIM54 32/47 (strain #1)...”
- “...basidiospores were obtained, indicating that THP1 is not an essential gene in C.neoformans . Lastly, CNAG_00592, which is the C.neoformans ortholog of another essential gene in S.pombe ( SPAPB24D3.06c ), was analyzed. CNAG_00592 is a dolichol-phosphate mannosyltransferase with three different domains: DUF1749, which plays an unknown...”
SIDJ_ASPFU / Q4WF56 Fusarinine C esterase sidJ; EC 3.1.-.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
AFUA_3G03390, Afu3g03390 siderophore biosynthesis lipase/esterase, putative from Aspergillus fumigatus Af293
Aligns to 4:349 / 354 (97.7%), covers 97.7% of PF08538, 331.2 bits
- function: Displays specific fusarinine C (FsC) esterase activity but does not hydrolyze triacetylfusarinine C (TAFC), which has the same core structure as fusarinine C (PubMed:24038704). Both extra- and intracellular siderophores have been shown to be crucial for the virulence (PubMed:24038704). Subsequent to chelation of iron and uptake, FsC and TAFC are hydrolyzed and the iron is transferred to the metabolism or to the intracellular siderophore ferricrocin (FC) for transport and storage of iron (PubMed:24038704).
disruption phenotype: Leads to decreased growth and increased intracellular accumulation of hydrolysis products of the siderophore fusarinine C (PubMed:24038704). - The Transcriptome Response to Azole Compounds in Aspergillus fumigatus Shows Differential Gene Expression across Pathways Essential for Azole Resistance and Cell Survival
Hokken, Journal of fungi (Basel, Switzerland) 2023 - “...the down-regulated genes are siderophore biosynthesis genes SidA (Afu2g07680), and two other siderophore biosynthesis genes, (Afu3g03390) and (Afu3g03400). The other down-regulated core DEGs comprise genes involved in diverse cellular processes such as hostpathogen interaction, cell signaling, and ribosome biosynthesis. All shared DEGs are listed in Table...”
- Aspergillus Fumigatus ZnfA, a Novel Zinc Finger Transcription Factor Involved in Calcium Metabolism and Caspofungin Tolerance
Valero, Frontiers in fungal biology 2021 - “...Afu6g12870 3.04948 atm1 ABC iron exporter; transcript up-regulated in conidia exposed to neutrophils Iron homeostasis Afu3g03390 2.90033 sidJ Predicted siderophore biosynthesis lipase/esterase involved in siderophore hydrolysis Iron homeostasis Afu3g03650 3.48584 sidG Putative acetyltransferase with a predicted role in iron metabolism; located in an iron-regulated gene cluster;...”
- “...al., 2016 ; Park et al., 2016 ) and (iii) sidG (Afu3g03650) and (iv) sidJ (Afu3g03390); both of them involved in siderophore biosynthesis (Schrettl et al., 2007 ; Grndlinger et al., 2013 ). Two other genes encode two proteins involved in cell wall remodeling: fks1 (Afu6g12400),...”
- Nitrogen, Iron and Zinc Acquisition: Key Nutrients to Aspergillus fumigatus Virulence
Perez-Cuesta, Journal of fungi (Basel, Switzerland) 2021 - “...] Mevalonyl-CoA ligase Afu1g17190 sidI Extracellular siderophores non-productive Decreased [ 60 ] Fusarinine C esterase Afu3g03390 sidJ Viable Unknown [ 61 ] GNAT-type acetyltransferase Afu1g04450 sidL Intracellular siderophores non-productive Unknown [ 62 ] Triacetylfusarinine C esterase Afu3g03660 estB Viable Unknown [ 63 ] Iron vacuolar transporter...”
- Genomic Organization and Expression of Iron Metabolism Genes in the Emerging Pathogenic Mold Scedosporium apiospermum
Le, Frontiers in microbiology 2018 - “...KEZ44717.1 SidL Transacetylase AFUA_1G04450 SAPIO_CDS2796 (7e-120/42%) 100 KEZ44711.1 EstB Triacetylfusarinine C esterase AFUA_3G03660 SidJ Lipase/Esterase AFUA_3G03390 PptA Phosphopantetheinyl transferase AFUA_2G08590 SAPIO_CDS5197 (3e-26/31%) 74 KEZ42787.1 AgaA Arginase AFUA_3G11430 SAPIO_CDS10183 (5e-153/64%) 98 KEZ38874.1 AmcA Mitochondrial ornithine carrier protein AFUA_8G02760 SAPIO_CDS3378 (6e-87/48%) 92 KEZ44391.1 SIDEROPHORE TRANSPORT SYSTEMS MirB MFS...”
- Functional Investigation of Iron-Responsive Microsomal Proteins, including MirC, in Aspergillus fumigatus
Mulvihill, Frontiers in microbiology 2017 - “...1.73 4.72E-02 5 11.4 AFUA_7G06060 Putative siderophore biosynthesis lipase/esterase. SidJ . 1.15 4.65E-03 15 66.7 AFUA_3G03390 hapX expression is up-regulated in mirC under iron-replete but not iron-deplete conditions compared to WT qRT-PCR analysis of A. fumigatus hapX expression in the mirC and WT strains was carried...”
- Transcript levels of the Aspergillus fumigatus Cdc42 module, polarisome, and septin genes show little change from dormancy to polarity establishment
Oda, Medical mycology 2017 - “...Afu5g03010 Afu5g08830 Afu5g03760 Afu4g07300 Afu1g05790 Afu3g03390 Afu2g07680 Afu2g07800 Afu5g11380 Afu4g03760 Afu7g05950 Afu2g07810 Afu1g10780 Afu7g02570...”
- Regulation of Secondary Metabolism by the Velvet Complex Is Temperature-Responsive in Aspergillus
Lind, G3 (Bethesda, Md.) 2016 - “..., Afu3g03315 , Afu3g03320 , Afu3g03330 , Afu3g03340 , Afu3g03350 , Afu3g03370 , Afu3g03380 , Afu3g03390 , Afu3g03400 , Afu3g03410 , Afu3g03420 , Afu3g03430 , Afu3g03440 , Afu3g03445 , Afu3g03450 , Afu3g03460 Inglis et al. (2013) Cluster 13 Hexadehydroastechrome (HAS) cluster Afu3g12890 , Afu3g12900 , Afu3g12910...”
- Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus
Wiemann, Frontiers in microbiology 2014 - “...name/Predicted function log(2) value OE:: hasA vs. WT OE:: hasA vs. OE:: hasA / hasD AFUA_3G03390 Siderophore esterase 0.56 1.78 AFUA_3G03400 sidF 0.59 2.06 AFUA_3G03410 enoyl-CoA hydratase 0.29 2.33 AFUA_3G03420 sidD 0.06 1.50 AFUA_3G03430 sidT 0.60 1.50 AFUA_3G03440 Siderophore transporter 0.62 2.20 Several of the genes...”
- More
AO090103000170 No description from Aspergillus oryzae RIB40
Aligns to 4:348 / 353 (97.7%), covers 98.0% of PF08538, 329.2 bits
NFIA_005560 siderophore biosynthesis lipase/esterase, putative from Aspergillus fischeri NRRL 181
Aligns to 4:349 / 354 (97.7%), covers 97.7% of PF08538, 326.0 bits
AT5G19050 hypothetical protein from Arabidopsis thaliana
Aligns to 73:349 / 361 (76.7%), covers 86.0% of PF08538, 234.6 bits
XP_817130 hypothetical protein, conserved from Trypanosoma cruzi
Aligns to 1:282 / 324 (87.0%), covers 82.6% of PF08538, 63.6 bits
- The paraflagellar rod of kinetoplastid parasites: from structure to components and function
Portman, International journal for parasitology 2010 - “...found Not found Not found PFC18 Tb10.6k15.1510 410c11.p1k_1 XP_815947 LmjF36.5870 LbrM35_V2.6170 LinJ36_V3.6130 PFC19 Tb10.6k15.0140 758b01.p1k_15 XP_817130 LmjF36.4780 LbrM35_V2.5030 LinJ36_V3.5010 PFC20 Tb10.389.0100 1205b11.p1k_21 XP_819266 Not found Not found Not found TczAC/GRESAG 4 Tb10.61.0280 189g01.p1k_3 XP_806389 LmjF17.0190 LbrM17_V2.0130 LinJ17_V3.0130 FCaBP Tb927.8.5440 20a04.p1k_4 XP_808305 Not found LbrM16_V2.0930 LinJ16_V30930 LdCof...”
ACIAD1134 esterase from Acinetobacter sp. ADP1
Aligns to 122:185 / 294 (21.8%), covers 17.1% of PF08538, 27.4 bits
Or search for genetic data about PF08538 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory